Gene Information gene info

  1. Home

GENE：PINK1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PINK1
FullNmae PTEN induced kinase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:14581
EnsembleID ENSG00000158828
Uniprot Q9BXM7

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PINK1 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PINK1 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
PINK1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PINK1 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
PINK1 GO:0000287,GO:0000422,GO:0000422,GO:0000423,GO:0000785,GO:0001934,GO:0002020,GO:0002020,GO:0002082,GO:0002931,GO:0004672,GO:0004674,GO:0004674,GO:0004674,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005739,GO:0005739,GO:0005739,GO:0005739,GO:0005741,GO:0005741,GO:0005741,GO:0005743,GO:0005758,GO:0005758,GO:0005783,GO:0005829,GO:0005829,GO:0005856,GO:0006468,GO:0006468,GO:0006468,GO:0006468,GO:0006511,GO:0006979,GO:0007005,GO:0010310,GO:0010629,GO:0010821,GO:0010857,GO:0010952,GO:0014046,GO:0016020,GO:0016239,GO:0016242,GO:0016301,GO:0016301,GO:0016504,GO:0016567,GO:0018105,GO:0018105,GO:0018105,GO:0022904,GO:0030097,GO:0030424,GO:0030426,GO:0031396,GO:0031396,GO:0031398,GO:0031625,GO:0032148,GO:0032226,GO:0033138,GO:0033138,GO:0033138,GO:0033603,GO:0034599,GO:0035307,GO:0035556,GO:0036289,GO:0036289,GO:0038203,GO:0042981,GO:0043123,GO:0043254,GO:0043422,GO:0043524,GO:0044297,GO:0044877,GO:0045727,GO:0046329,GO:0048471,GO:0050821,GO:0051443,GO:0051881,GO:0051881,GO:0051897,GO:0055131,GO:0061136,GO:0071456,GO:0072655,GO:0072656,GO:0090141,GO:0090200,GO:0090258,GO:0097237,GO:0097413,GO:0097449,GO:0098779,GO:0099074,GO:0106310,GO:1900407,GO:1901525,GO:1902803,GO:1902902,GO:1902958,GO:1903146,GO:1903214,GO:1903214,GO:1903214,GO:1903298,GO:1903377,GO:1903384,GO:1903384,GO:1903751,GO:1903852,GO:1903955,GO:1904544,GO:1904841,GO:1904881,GO:2000377,GO:2000377,GO:2000378,GO:2001171,GO:2001243

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PINK1 hsa:65018 path:hsa04137 Mitophagy - animal - Homo sapiens (human)
PINK1 hsa:65018 path:hsa05012 Parkinson disease - Homo sapiens (human)
PINK1 hsa:65018 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
PINK1 hsa:65018 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
BECN1 PINK1 20057503 23180781 physical association anti tag coimmunoprecipitation,two hybrid,fluorescent resonance energy transfer,pull down InnateDB
PINK1 PRKN 20966070 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR PINK1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
RELA PINK1 25108683 trascriptional regulation,stimulation inferred by curator TFlink
SMARCA4 PINK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PINK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 PINK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PINK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PINK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 PINK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001B341F PINK1 25416803 27456084 mrna cleavage,inhibition experimental interaction detection,western blot,rna immunoprecipitation,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000330617 PINK1 25416803 27456084 mrna cleavage,inhibition experimental interaction detection,western blot,rna immunoprecipitation,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
PINK1 ZNF746 22135298 phosphorylation N/A PhosphoSite
PINK1 PINK1 22135298 phosphorylation N/A PhosphoSite
PINK1 UBA52 22135298 phosphorylation N/A PhosphoSite
PINK1 RHOT1 22135298 phosphorylation N/A PhosphoSite
PINK1 PRKN 22135298 phosphorylation N/A PhosphoSite
MARK2 PINK1 22135298 phosphorylation N/A PhosphoSite
PTEN PINK1 25361965 interaction type N/A PTMCode2
PINK1 PTEN 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
VIM PINK1 25348397 N/A physical interaction ComPPI
PSMC6 PINK1 25348397 N/A physical interaction ComPPI
TOMM22 PINK1 25348397 N/A physical interaction ComPPI
TUBB PINK1 25348397 N/A physical interaction ComPPI
TRAF6 PINK1 25348397 N/A physical interaction ComPPI
BCL2L2 PINK1 25348397 N/A physical interaction ComPPI
MAP1LC3B PINK1 20153330 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,fluorescence microscopy ComPPI,IntAct
HSP90AB1 PINK1 22939624 24234451 25348397 physical association physical interaction,luminescence based mammalian interactome mapping ComPPI,IntAct
BCL2L1 PINK1 25348397 N/A physical interaction ComPPI
PRKDC PINK1 25348397 N/A physical interaction ComPPI
RHOT2 PINK1 25348397 N/A physical interaction ComPPI
TGM2 PINK1 25348397 25557247 27898060 N/A physical interaction ComPPI,OmniPath
IRS4 PINK1 25348397 N/A physical interaction ComPPI
UBB PINK1 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
UBC PINK1 25348397 N/A anti tag coimmunoprecipitation,physical interaction,physical interaction ComPPI
RPS27A PINK1 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
UBA52 PINK1 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
HSP90AA1 PINK1 25348397 N/A physical interaction ComPPI
HSPA1A PINK1 25348397 N/A physical interaction ComPPI
HSPA1B PINK1 25348397 N/A physical interaction ComPPI
MCL1 PINK1 25348397 N/A physical interaction ComPPI
IRAK1 PINK1 25348397 N/A physical interaction ComPPI
PSMD1 PINK1 25348397 N/A physical interaction ComPPI
TRAP1 PINK1 25348397 N/A anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,protein kinase assay ComPPI
NAE1 PINK1 25348397 N/A physical interaction ComPPI
TUBA1A PINK1 25348397 N/A physical interaction ComPPI
MARK2 PINK1 25348397 N/A physical interaction ComPPI
HSPA4 PINK1 25348397 N/A physical interaction ComPPI
HSH2D PINK1 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
MAP1LC3A PINK1 25348397 N/A physical interaction ComPPI
SNCAIP PINK1 25348397 N/A physical interaction ComPPI
PTEN PINK1 25348397 N/A physical interaction ComPPI
COPS8 PINK1 25348397 N/A physical interaction ComPPI
PSMD2 PINK1 25348397 N/A physical interaction ComPPI
DNM1L PINK1 25348397 N/A physical interaction ComPPI
MAP3K7 PINK1 25348397 N/A physical interaction ComPPI
HTRA2 PINK1 25348397 N/A physical interaction ComPPI
PRKN PINK1 20153330 23933751 24234451 24357652 25348397 colocalization,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,fluorescent resonance energy transfer,pull down,physical interaction,fluorescence microscopy ComPPI,IntAct
TIMM23 PINK1 24234451 24357652 25348397 colocalization cosedimentation,cosedimentation in solution ComPPI,IntAct
TOLLIP PINK1 25348397 N/A physical interaction ComPPI
CDC37 PINK1 24234451 25036637 25348397 physical association physical interaction,luminescence based mammalian interactome mapping ComPPI,IntAct
BNIP3 PINK1 25348397 N/A physical interaction ComPPI
SNCA PINK1 25348397 N/A physical interaction ComPPI
IMMT PINK1 25348397 N/A physical interaction ComPPI
RB1CC1 PINK1 25348397 N/A physical interaction ComPPI
AKT1 PINK1 25348397 N/A physical interaction ComPPI
FBXO7 PINK1 23933751 24234451 25348397 association,physical association anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
STAT3 PINK1 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
TOMM20 PINK1 20153330 24234451 24357652 25348397 colocalization physical interaction,fluorescence microscopy ComPPI,IntAct
CRLS1 PINK1 25348397 N/A physical interaction ComPPI
PARK7 PINK1 16632486 19229105 25348397 27898060 N/A physical interaction ComPPI,OmniPath
UBE2M PINK1 22388932 25348397 27898060 N/A physical interaction ComPPI,OmniPath
BAG2 PINK1 24383081 24513209 25348397 27898060 N/A physical interaction ComPPI,OmniPath
PINK1 MAP1B 25348397 N/A physical interaction ComPPI
PINK1 KIF11 25348397 N/A physical interaction ComPPI
PINK1 HSP90AA2P 25348397 N/A physical interaction ComPPI
PINK1 PGAM5 25348397 N/A physical interaction ComPPI
PINK1 PARL 25348397 N/A physical interaction ComPPI
PINK1 RHOT1 22078885 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PINK1 TOMM40 25348397 N/A physical interaction ComPPI
PINK1 TOMM70 25348397 N/A physical interaction ComPPI
PINK1 RICTOR 25348397 N/A physical interaction ComPPI
PINK1 MAPKAP1 25348397 N/A physical interaction ComPPI
PINK1 SARM1 25348397 N/A physical interaction ComPPI
PINK1 SOCS4 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,luminescence based mammalian interactome mapping,validated two hybrid ComPPI,IntAct
PINK1 APPL2 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PINK1 HSD17B10 25348397 N/A physical interaction ComPPI
PINK1 BAG5 25348397 N/A physical interaction ComPPI
PINK1 MFN2 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
PINK1 NFKBIE 24234451 25348397 29128334 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PINK1 N 25348397 N/A physical interaction ComPPI
PINK1 PINK1 14525934 14607334 N/A experimental interaction detection HPRD
ERLIN1 PINK1 24234451 30021884 physical association cross-linking study IntAct
EED PINK1 23959866 27898060 N/A N/A OmniPath
PINK1 UBC 24751536 24784582 25474007 25847540 26162776 27898060 stimulant N/A OmniPath
FOXO3 PINK1 19276113 27898060 stimulant N/A OmniPath
PINK1 CYCS 20012177 27898060 inhibition N/A OmniPath
PINK1 TRAP1 17579517 27898060 stimulant N/A OmniPath
PINK1 BECN1 20057503 27898060 stimulant N/A OmniPath
PINK1 PRKN 19167501 19229105 19358826 19880420 19966284 20418918 20798600 20966070 22724072 23256036 23319602 23670163 23933751 24357652 24647965 24660806 24751536 24784582 25216678 25375667 25474007 25591737 25969509 26161729 26162776 26254305 26471730 27898060 stimulant N/A OmniPath
PINK1 HTRA2 17906618 27898060 stimulant N/A OmniPath
PINK1 RHOT1 22078885 22396657 24671417 27898060 inhibition N/A OmniPath

Visualization










  Return