GENE：PLEKHF1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | PLEKHF1 |
| FullNmae | pleckstrin homology and FYVE domain containing 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:20764 |
| EnsembleID | ENSG00000166289 |
| Uniprot | Q96S99 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| PLEKHF1 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| PLEKHF1 | autophagy | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| PLEKHF1 | autophagy | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| PLEKHF1 | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| PLEKHF1 | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| PLEKHF1 | GO:0005515,GO:0005634,GO:0005764,GO:0005764,GO:0005765,GO:0005768,GO:0005769,GO:0006915,GO:0007032,GO:0007032,GO:0008333,GO:0010008,GO:0010314,GO:0010508,GO:0010508,GO:0016050,GO:0032266,GO:0035091,GO:0046872,GO:0048471,GO:0070273,GO:0072659,GO:2001244 |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | PLEKHF1 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | PLEKHF1 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | PLEKHF1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| YBX1 | PLEKHF1 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | PLEKHF1 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | PLEKHF1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | PLEKHF1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | PLEKHF1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | PLEKHF1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | PLEKHF1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | PLEKHF1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | PLEKHF1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | PLEKHF1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | PLEKHF1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | PLEKHF1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | PLEKHF1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | PLEKHF1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CAVIN2 | PLEKHF1 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| CHIC2 | PLEKHF1 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| PLEKHF1 | KIFBP | 14525934 16189514 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid | ComPPI,HPRD,IntAct |
| PLEKHF1 | L3MBTL3 | 24234451 25348397 25416956 | physical association | physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |