GENE：POU4F2
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | POU4F2 |
| FullNmae | POU class 4 homeobox 2 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:9219 |
| EnsembleID | ENSG00000151615 |
| Uniprot | Q12837 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| POU4F2 | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| POU4F2 | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| POU4F2 | GO:0000122,GO:0000165,GO:0000785,GO:0000791,GO:0000978,GO:0000978,GO:0000981,GO:0000981,GO:0000981,GO:0000981,GO:0001227,GO:0001228,GO:0001228,GO:0002039,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0006357,GO:0007283,GO:0007411,GO:0007507,GO:0007605,GO:0010666,GO:0016607,GO:0030182,GO:0030520,GO:0031290,GO:0032869,GO:0043068,GO:0043433,GO:0045596,GO:0045597,GO:0045672,GO:0045773,GO:0045944,GO:0045944,GO:0046326,GO:0048675,GO:0050885,GO:0051090,GO:0060041,GO:0071345,GO:0071392,GO:0071453,GO:0072332,GO:0090259,GO:1902870,GO:1904178,GO:1990791,GO:1990841,GO:2000679 |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| YBX1 | POU4F2 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| PRDM14 | POU4F2 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| EGR1 | POU4F2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SOX2 | POU4F2 | 20739473 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000160683 | POU4F2 | 20609388 | rna interference,inhibition | experimental interaction detection,western blot,northern blot,quantitative reverse transcription pcr | miRSponge |
| URS00001CC864 | POU4F2 | 14697198 20609388 | rna interference,inhibition | experimental interaction detection,western blot,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | miRSponge |
| URS00001CC864 | POU4F2 | 14697198 20609388 25416803 | mrna cleavage,inhibition | experimental interaction detection,western blot,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS0000160683 | POU4F2 | 20609388 25416803 | mrna cleavage,inhibition | experimental interaction detection,experimental interaction detection,western blot,northern blot,quantitative reverse transcription pcr | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| KRTAP9-2 | POU4F2 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| RBPMS | POU4F2 | 25348397 | N/A | two hybrid | ComPPI |
| KRTAP10-5 | POU4F2 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| KRTAP5-9 | POU4F2 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| KRTAP10-8 | POU4F2 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| KRTAP4-12 | POU4F2 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| KRTAP12-1 | POU4F2 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| ALPP | POU4F2 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| KRTAP4-2 | POU4F2 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| CHIC2 | POU4F2 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| TGFB1 | POU4F2 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| KRT31 | POU4F2 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| LGALS13 | POU4F2 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| CCN3 | POU4F2 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| GRN | POU4F2 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| RGS19 | POU4F2 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| DLX3 | POU4F2 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| CHRD | POU4F2 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| RBP3 | POU4F2 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| ESR1 | POU4F2 | 14525934 25348397 9448000 | N/A | two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid | ComPPI,HPRD |
| POU4F2 | LCN2 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| POU4F2 | TRIM42 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| POU4F2 | KRTAP10-9 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| POU4F2 | NFKBID | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| POU4F2 | SPRY4 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| POU4F2 | LHX2 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| POU4F2 | ESR1 | 27898060 9448000 | stimulant | N/A | OmniPath |