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GENE：PPIF

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PPIF
FullNmae peptidylprolyl isomerase F
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9259
EnsembleID ENSG00000108179
Uniprot P30405

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PPIF autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PPIF apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PPIF apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
PPIF GO:0000413,GO:0000413,GO:0002931,GO:0003755,GO:0003755,GO:0005515,GO:0005737,GO:0005739,GO:0005739,GO:0005757,GO:0005759,GO:0006457,GO:0008637,GO:0010849,GO:0016018,GO:0016018,GO:0016020,GO:0032780,GO:0043066,GO:0046902,GO:0046902,GO:0070266,GO:0070301,GO:0070301,GO:0071243,GO:0071277,GO:0090201,GO:0090324,GO:1902445,GO:1902445,GO:1902686,GO:2000276,GO:2001243

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PPIF hsa:10105 path:hsa04020 Calcium signaling pathway - Homo sapiens (human)
PPIF hsa:10105 path:hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human)
PPIF hsa:10105 path:hsa04613 Neutrophil extracellular trap formation - Homo sapiens (human)
PPIF hsa:10105 path:hsa05010 Alzheimer disease - Homo sapiens (human)
PPIF hsa:10105 path:hsa05012 Parkinson disease - Homo sapiens (human)
PPIF hsa:10105 path:hsa05016 Huntington disease - Homo sapiens (human)
PPIF hsa:10105 path:hsa05017 Spinocerebellar ataxia - Homo sapiens (human)
PPIF hsa:10105 path:hsa05020 Prion disease - Homo sapiens (human)
PPIF hsa:10105 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
PPIF hsa:10105 path:hsa05145 Toxoplasmosis - Homo sapiens (human)
PPIF hsa:10105 path:hsa05208 Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human)
PPIF hsa:10105 path:hsa05415 Diabetic cardiomyopathy - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ESR1 PPIF 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ETS1 PPIF 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 PPIF 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 PPIF 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA3 PPIF 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 PPIF 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 PPIF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PPIF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PPIF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 PPIF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PPIF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PPIF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PPIF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF PPIF 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000009262D PPIF 18829576 rna interference,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS000009262D PPIF 18591254 18829576 25416803 mrna cleavage,inhibition array technology,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00003D5391 PPIF 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003CF1AD PPIF 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000017EE98 PPIF 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000040EE1D PPIF 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000254A6 PPIF 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001B341F PPIF 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000330617 PPIF 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001012BC PPIF 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000355E82 PPIF 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000075B0F6 PPIF 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000001A7A PPIF 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000913AC PPIF 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000013ABA3 PPIF 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001D69F6 PPIF 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00002FC5B0 PPIF 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000AA464 PPIF 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000367985 PPIF 22473208 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
AKT2 PPIF 22135298 phosphorylation N/A PhosphoSite
PPIF SLC25A4 25361965 interaction type N/A PTMCode2
SLC25A4 PPIF 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
FKBP1A PPIF 25348397 N/A physical interaction ComPPI
PTPN11 PPIF 25348397 N/A physical interaction ComPPI
RRBP1 PPIF 25348397 N/A physical interaction ComPPI
C1QBP PPIF 20950273 24234451 25348397 27898060 N/A pull down ComPPI,IntAct,OmniPath
VDAC1 PPIF 14525934 25348397 9874241 N/A experimental interaction detection,in vitro ComPPI,HPRD
RANGAP1 PPIF 25348397 N/A physical interaction ComPPI
SYP PPIF 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SYPL1 PPIF 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ABI2 PPIF 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
BANP PPIF 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
BCL2 PPIF 19228691 24234451 25348397 physical association two hybrid ComPPI,IntAct
STX7 PPIF 25348397 N/A physical interaction ComPPI
ATP6V1E1 PPIF 25348397 N/A physical interaction ComPPI
TIMM44 PPIF 25348397 N/A physical interaction ComPPI
RBMS1 PPIF 25348397 N/A physical interaction ComPPI
PDK1 PPIF 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
HSPE1 PPIF 25348397 N/A physical interaction ComPPI
ARFIP2 PPIF 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
UBE4B PPIF 25348397 N/A physical interaction ComPPI
TBL1XR1 PPIF 25348397 N/A physical interaction ComPPI
CIDEB PPIF 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
S100A10 PPIF 25348397 N/A physical interaction ComPPI
SOD1 PPIF 25348397 N/A physical interaction ComPPI
ITPR1 PPIF 24234451 24947355 25348397 physical association proximity ligation assay ComPPI,IntAct
PPIF SLC25A4 14525934 25348397 9874241 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PPIF VDAC3 25348397 N/A physical interaction ComPPI
PPIF NABP2 25348397 N/A physical interaction ComPPI
PPIF SUGP1 25348397 N/A physical interaction ComPPI
PPIF MPLKIP 25348397 N/A physical interaction ComPPI
PPIF MRRF 25348397 N/A physical interaction ComPPI
PPIF MRPL14 25348397 N/A physical interaction ComPPI
PPIF ZC3H11A 25348397 N/A physical interaction ComPPI
PPIF SLIRP 25348397 N/A physical interaction ComPPI
PPIF TPX2 25348397 N/A physical interaction ComPPI
PPIF SRPRB 25348397 N/A physical interaction ComPPI
PPIF NDUFAF2 25348397 N/A physical interaction ComPPI
PPIF CMTM5 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PPIF GSTK1 25348397 N/A physical interaction ComPPI
PPIF AIFM3 25348397 N/A physical interaction ComPPI
PPIF GPX4 25348397 N/A physical interaction ComPPI
PPIF NME2 25348397 N/A physical interaction ComPPI
PPIF TANGO2 25348397 N/A physical interaction ComPPI
PPIF SERPINB5 25348397 N/A physical interaction ComPPI
PPIF TP53 22726440 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down ComPPI,IntAct,OmniPath
PPIF MAGEA11 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PPIF YIF1A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PPIF PRB3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PPIF FAM25C 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PPIF FKBP7 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PPIF AIFM1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PPIF HSPD1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PPIF LYRM7 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
ATF2 PPIF 22304920 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MGST3 PPIF 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
MRPL53 PPIF 25348397 N/A physical interaction ComPPI
TRMT61B PPIF 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PPIF PPIA 24234451 30021884 physical association cross-linking study IntAct

Visualization










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