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GENE：PRKN

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PRKN
FullNmae parkin RBR E3 ubiquitin protein ligase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:8607
EnsembleID ENSG00000185345
Uniprot O60260

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PRKN mpt 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PRKN autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PRKN autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
PRKN apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PRKN apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
PRKN GO:0000122,GO:0000151,GO:0000151,GO:0000209,GO:0000209,GO:0000209,GO:0000266,GO:0000422,GO:0000422,GO:0000422,GO:0000423,GO:0001664,GO:0001933,GO:0001933,GO:0001964,GO:0003714,GO:0003779,GO:0004842,GO:0004842,GO:0004842,GO:0005515,GO:0005634,GO:0005737,GO:0005737,GO:0005739,GO:0005739,GO:0005741,GO:0005783,GO:0005783,GO:0005794,GO:0005794,GO:0005829,GO:0005829,GO:0005829,GO:0005829,GO:0006511,GO:0006511,GO:0006511,GO:0006511,GO:0006513,GO:0006513,GO:0006979,GO:0007005,GO:0007417,GO:0007612,GO:0008013,GO:0008270,GO:0008344,GO:0010498,GO:0010506,GO:0010628,GO:0010629,GO:0010636,GO:0010637,GO:0010821,GO:0010821,GO:0010821,GO:0010821,GO:0010906,GO:0010994,GO:0014059,GO:0014069,GO:0015631,GO:0016235,GO:0016236,GO:0016567,GO:0016567,GO:0016607,GO:0017124,GO:0019899,GO:0019900,GO:0019901,GO:0030165,GO:0030544,GO:0031072,GO:0031396,GO:0031396,GO:0031624,GO:0031624,GO:0031624,GO:0031625,GO:0031625,GO:0031647,GO:0031648,GO:0032092,GO:0032232,GO:0032368,GO:0032436,GO:0032436,GO:0033132,GO:0034599,GO:0034620,GO:0034976,GO:0035249,GO:0035519,GO:0036503,GO:0042053,GO:0042415,GO:0042417,GO:0042802,GO:0042826,GO:0042981,GO:0043005,GO:0043123,GO:0043123,GO:0043130,GO:0043161,GO:0043274,GO:0043388,GO:0043524,GO:0044314,GO:0044828,GO:0044877,GO:0045732,GO:0045944,GO:0046329,GO:0046676,GO:0048471,GO:0050821,GO:0051087,GO:0051582,GO:0051583,GO:0051865,GO:0051881,GO:0060544,GO:0060828,GO:0061630,GO:0061630,GO:0061630,GO:0061630,GO:0061630,GO:0061734,GO:0070050,GO:0070534,GO:0070534,GO:0070534,GO:0070585,GO:0070842,GO:0070936,GO:0070979,GO:0071287,GO:0085020,GO:0085020,GO:0090090,GO:0090090,GO:0090141,GO:0090201,GO:0097237,GO:0097413,GO:0097602,GO:0098691,GO:0098779,GO:0098779,GO:0098793,GO:0099073,GO:0099074,GO:0140251,GO:1900242,GO:1900407,GO:1900407,GO:1900407,GO:1900407,GO:1901800,GO:1902236,GO:1902236,GO:1902254,GO:1902283,GO:1902530,GO:1902803,GO:1903214,GO:1903265,GO:1903351,GO:1903377,GO:1903382,GO:1903542,GO:1903599,GO:1903861,GO:1904049,GO:1905281,GO:1905366,GO:1905477,GO:1905477,GO:1990000,GO:1990381,GO:1990444,GO:1990452,GO:2000377,GO:2000378

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PRKN hsa:5071 path:hsa04120 Ubiquitin mediated proteolysis - Homo sapiens (human)
PRKN hsa:5071 path:hsa04137 Mitophagy - animal - Homo sapiens (human)
PRKN hsa:5071 path:hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human)
PRKN hsa:5071 path:hsa05012 Parkinson disease - Homo sapiens (human)
PRKN hsa:5071 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
PRKN hsa:5071 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PINK1 PRKN 20966070 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR PRKN 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 PRKN 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 PRKN 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 PRKN 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
HIF1A PRKN 19828020 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
FOXP3 PRKN 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 PRKN 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 PRKN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PRKN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PRKN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PRKN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PRKN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PRKN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PRKN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF PRKN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 PRKN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR PRKN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 PRKN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 PRKN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SIM2 PRKN 15963499 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 PRKN 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS000003ABC4 PRKN 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS0000486E0B PRKN 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000032FC1A PRKN 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000047A67D PRKN 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000AA464 PRKN 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00003E226A PRKN 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000003575B PRKN 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000006FDD4 PRKN 22473208 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PINK1 PRKN 22135298 phosphorylation N/A PhosphoSite
ABL1 PRKN 22135298 phosphorylation N/A PhosphoSite
PLK1 PRKN 22135298 phosphorylation N/A PhosphoSite
CDK5 PRKN 22135298 phosphorylation N/A PhosphoSite
CSNK1A1 PRKN 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
HNRNPK PRKN 25348397 N/A physical interaction ComPPI
CHCHD3 PRKN 25348397 N/A physical interaction ComPPI
HNRNPC PRKN 25348397 N/A physical interaction ComPPI
AIMP2 PRKN 12783850 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
ATP5PO PRKN 25348397 N/A physical interaction ComPPI
HSPA8 PRKN 25348397 N/A physical interaction ComPPI
HSPA2 PRKN 25348397 N/A physical interaction ComPPI
FBP1 PRKN 25348397 N/A physical interaction ComPPI
CRX PRKN 25348397 N/A physical interaction ComPPI
UBASH3A PRKN 17599067 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
UBASH3B PRKN 17599067 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
TFRC PRKN 25348397 N/A physical interaction ComPPI
SYT11 PRKN 12925569 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
CRYAB PRKN 25348397 N/A physical interaction ComPPI
NPM1 PRKN 25348397 N/A physical interaction ComPPI
VIM PRKN 25348397 N/A physical interaction ComPPI
PCNA PRKN 25348397 N/A physical interaction ComPPI
IMPDH2 PRKN 25348397 N/A physical interaction ComPPI
PSMC3 PRKN 25348397 N/A physical interaction ComPPI
PSMC6 PRKN 25348397 N/A physical interaction ComPPI
CCND1 PRKN 25348397 N/A physical interaction ComPPI
TOMM22 PRKN 25348397 N/A physical interaction ComPPI
CALML3 PRKN 25348397 N/A physical interaction ComPPI
TUBB PRKN 25348397 N/A physical interaction,in vivo ComPPI
AMOT PRKN 25348397 N/A physical interaction ComPPI
HK2 PRKN 25348397 N/A physical interaction ComPPI
MEOX2 PRKN 25348397 N/A physical interaction ComPPI
PSMD14 PRKN 25348397 N/A physical interaction ComPPI
CASP14 PRKN 25348397 N/A physical interaction ComPPI
SET PRKN 25348397 N/A physical interaction ComPPI
PSMD7 PRKN 25348397 N/A physical interaction ComPPI
VCP PRKN 25348397 N/A physical interaction ComPPI
LMNA PRKN 25348397 N/A physical interaction ComPPI
ACTB PRKN 25348397 N/A physical interaction ComPPI
UBE2D1 PRKN 25348397 N/A physical interaction ComPPI
BCL2L2 PRKN 25348397 N/A physical interaction ComPPI
OPTN PRKN 25348397 N/A physical interaction ComPPI
MAP1LC3B PRKN 24234451 25244949 25348397 27898060 colocalization confocal microscopy ComPPI,IntAct,OmniPath
RAC1 PRKN 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PSMB2 PRKN 25348397 N/A physical interaction ComPPI
HSP90AB1 PRKN 22939624 24234451 25348397 physical association physical interaction,luminescence based mammalian interactome mapping ComPPI,IntAct
TUFM PRKN 25348397 N/A physical interaction ComPPI
FIS1 PRKN 25348397 N/A physical interaction ComPPI
UBE2R2 PRKN 25348397 N/A physical interaction ComPPI
DDX17 PRKN 25348397 N/A physical interaction ComPPI
BCL2L1 PRKN 25348397 N/A physical interaction ComPPI
MARCHF5 PRKN 25348397 N/A physical interaction ComPPI
UBE2E2 PRKN 25348397 N/A physical interaction ComPPI
UBE2E3 PRKN 25348397 N/A physical interaction ComPPI
UBE2D4 PRKN 25348397 N/A physical interaction ComPPI
TENT5C PRKN 25348397 N/A physical interaction ComPPI
H4C1 PRKN 25348397 N/A physical interaction ComPPI
RBM8A PRKN 25348397 N/A physical interaction ComPPI
DLG4 PRKN 25348397 N/A physical interaction ComPPI
PICK1 PRKN 25348397 N/A physical interaction ComPPI
MAPK1 PRKN 25348397 N/A physical interaction ComPPI
REL PRKN 25348397 N/A physical interaction ComPPI
FBXW7 PRKN 12628165 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CBX1 PRKN 25348397 N/A physical interaction ComPPI
NACA PRKN 25348397 N/A physical interaction ComPPI
SUMO1 PRKN 16955485 25348397 27898060 N/A physical interaction ComPPI,OmniPath
RHOT2 PRKN 25348397 N/A physical interaction ComPPI
HDAC4 PRKN 25348397 N/A physical interaction ComPPI
SFPQ PRKN 25348397 N/A physical interaction ComPPI
FZR1 PRKN 25348397 N/A physical interaction ComPPI
UBE2G1 PRKN 11439185 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
UBE2D2 PRKN 25348397 N/A physical interaction ComPPI
UBE2G2 PRKN 25348397 N/A physical interaction ComPPI
UBE2L3 PRKN 10888878 10973942 11078524 11278816 11431533 11590439 14525934 14559152 16096643 16332688 16714300 17553932 19240029 20089136 20940148 21209200 21292769 21376232 21532592 21694720 22008525 22271254 23707686 23727886 24234451 24328108 24784582 25101677 25348397 25375667 25527291 25583483 26254304 26387737 26746706 27898060 N/A experimental interaction detection,pull down,physical interaction,in vivo ComPPI,HPRD,IntAct,OmniPath
PSMA3 PRKN 25348397 N/A physical interaction ComPPI
PSMD11 PRKN 25348397 N/A physical interaction ComPPI
MEOX1 PRKN 25348397 N/A physical interaction ComPPI
HERC5 PRKN 25348397 N/A physical interaction ComPPI
DAP3 PRKN 25348397 N/A physical interaction ComPPI
GAPDH PRKN 18362144 24244333 25348397 27898060 N/A physical interaction ComPPI,OmniPath
RAB7A PRKN 25348397 N/A physical interaction ComPPI
TUBG1 PRKN 12928331 16714300 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SYN1 PRKN 25348397 N/A physical interaction ComPPI
PDIA6 PRKN 25348397 N/A physical interaction ComPPI
UBB PRKN 14525934 15105460 25348397 N/A experimental interaction detection,fluorescence polarization spectroscopy,physical interaction,comigration in sds page ComPPI,HPRD
UBC PRKN 25348397 N/A fluorescence polarization spectroscopy,physical interaction,physical interaction,comigration in sds page ComPPI
RPS27A PRKN 25348397 N/A fluorescence polarization spectroscopy,physical interaction,physical interaction,comigration in sds page ComPPI
UBA52 PRKN 25348397 N/A fluorescence polarization spectroscopy,physical interaction,comigration in sds page ComPPI
HSP90AA1 PRKN 25348397 N/A physical interaction ComPPI
UBE2N PRKN 25348397 N/A physical interaction ComPPI
FAF1 PRKN 25348397 N/A physical interaction ComPPI
RUVBL1 PRKN 25348397 N/A physical interaction ComPPI
CASP1 PRKN 12692130 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CKAP4 PRKN 25348397 N/A physical interaction ComPPI
SSBP1 PRKN 25348397 N/A physical interaction ComPPI
CALR PRKN 25348397 N/A physical interaction ComPPI
P4HB PRKN 25348397 N/A physical interaction ComPPI
HSPA5 PRKN 25348397 N/A physical interaction ComPPI
HSPA1A PRKN 25348397 N/A physical interaction ComPPI
HSPA1B PRKN 25348397 N/A physical interaction ComPPI
HSP90B1 PRKN 25348397 N/A physical interaction ComPPI
MCL1 PRKN 25348397 N/A physical interaction ComPPI
PRDX1 PRKN 25348397 N/A physical interaction ComPPI
GBA PRKN 25348397 N/A physical interaction ComPPI
PLK1 PRKN 25348397 N/A physical interaction ComPPI
PSMA1 PRKN 25348397 N/A physical interaction ComPPI
PSMA6 PRKN 25348397 N/A physical interaction ComPPI
PSMA5 PRKN 25348397 N/A physical interaction ComPPI
PDIA4 PRKN 25348397 N/A physical interaction ComPPI
CASP8 PRKN 12692130 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
HNRNPU PRKN 25348397 N/A physical interaction ComPPI
MAPT PRKN 25348397 N/A physical interaction ComPPI
PTPN5 PRKN 25348397 N/A physical interaction ComPPI
NEFM PRKN 25348397 N/A physical interaction ComPPI
XRCC6 PRKN 25348397 N/A physical interaction ComPPI
TXN PRKN 25348397 N/A physical interaction ComPPI
EEF1A1 PRKN 25348397 N/A physical interaction ComPPI
TUBA4A PRKN 12716939 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
HNRNPL PRKN 25348397 N/A physical interaction ComPPI
C1QBP PRKN 25348397 N/A physical interaction ComPPI
NEK2 PRKN 25348397 N/A physical interaction ComPPI
DDX5 PRKN 25348397 N/A physical interaction ComPPI
RGS2 PRKN 14525934 16169070 21900206 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
MARCKS PRKN 25348397 N/A physical interaction ComPPI
VDAC1 PRKN 25348397 N/A physical interaction ComPPI
CHPF PRKN 22082830 25348397 27898060 N/A physical interaction ComPPI,OmniPath
PSMD8 PRKN 25348397 N/A physical interaction ComPPI
SQSTM1 PRKN 23503661 25348397 26364802 26746706 27898060 N/A physical interaction ComPPI,OmniPath
TPM3 PRKN 25348397 N/A physical interaction ComPPI
PSMD1 PRKN 25348397 N/A physical interaction ComPPI
PKM PRKN 25348397 N/A physical interaction ComPPI
UBE2B PRKN 25348397 N/A physical interaction ComPPI
CASK PRKN 11679592 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
GRIN2B PRKN 11679592 14525934 24234451 25241761 25348397 physical association experimental interaction detection,physical interaction,in vitro,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
CCNA1 PRKN 25348397 N/A physical interaction ComPPI
TNFRSF17 PRKN 25348397 N/A physical interaction ComPPI
TRAF2 PRKN 25348397 N/A physical interaction ComPPI
PSMC5 PRKN 25348397 N/A physical interaction ComPPI
ARRB1 PRKN 25348397 N/A physical interaction ComPPI
ABCE1 PRKN 25348397 N/A physical interaction ComPPI
RPS6 PRKN 25348397 N/A physical interaction ComPPI
RPS25 PRKN 25348397 N/A physical interaction ComPPI
RAD23A PRKN 25348397 N/A physical interaction ComPPI
RPL12 PRKN 25348397 N/A physical interaction ComPPI
VDAC2 PRKN 25348397 N/A physical interaction ComPPI
EPS15 PRKN 25348397 N/A physical interaction ComPPI
RPL4 PRKN 25348397 N/A physical interaction ComPPI
RPLP0 PRKN 25348397 N/A physical interaction ComPPI
HNRNPA2B1 PRKN 25348397 N/A physical interaction ComPPI
SRSF1 PRKN 25348397 N/A physical interaction ComPPI
SRSF2 PRKN 25348397 N/A physical interaction ComPPI
HOMER1 PRKN 25348397 N/A physical interaction ComPPI
ARRB2 PRKN 25348397 N/A physical interaction ComPPI
DLG1 PRKN 14525934 16637659 24234451 25241761 25348397 physical association experimental interaction detection,physical interaction,in vitro,proximity ligation assay ComPPI,HPRD,IntAct
CEP55 PRKN 25348397 N/A physical interaction ComPPI
CUL1 PRKN 25348397 N/A physical interaction ComPPI
SYNCRIP PRKN 25348397 N/A physical interaction ComPPI
RPL7A PRKN 25348397 N/A physical interaction ComPPI
EGFR PRKN 25348397 N/A physical interaction ComPPI
TUBA1A PRKN 25348397 N/A physical interaction ComPPI
SEPTIN5 PRKN 11078524 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
YWHAH PRKN 14525934 16096643 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
YWHAE PRKN 25348397 N/A physical interaction ComPPI
PSMC4 PRKN 25348397 N/A physical interaction ComPPI
PIP PRKN 25348397 N/A physical interaction ComPPI
ANXA2 PRKN 25348397 N/A physical interaction ComPPI
TCP1 PRKN 25348397 N/A physical interaction ComPPI
LMNB1 PRKN 25348397 N/A physical interaction ComPPI
CDC20 PRKN 25348397 N/A physical interaction ComPPI
CDC34 PRKN 25348397 N/A physical interaction ComPPI
HSPA4 PRKN 25348397 N/A physical interaction ComPPI
YBX3 PRKN 25348397 N/A physical interaction ComPPI
FUBP1 PRKN 25348397 N/A physical interaction ComPPI
CCNB1 PRKN 25348397 N/A physical interaction ComPPI
CTNNB1 PRKN 25348397 N/A physical interaction ComPPI
SNCAIP PRKN 25348397 N/A physical interaction ComPPI
TUBB4B PRKN 25348397 N/A physical interaction ComPPI
TAX1BP1 PRKN 25348397 N/A physical interaction ComPPI
UBE2A PRKN 25348397 N/A physical interaction ComPPI
HSPA9 PRKN 21640711 24244333 25348397 27898060 N/A physical interaction ComPPI,OmniPath
AURKA PRKN 25348397 N/A physical interaction ComPPI
UBE2K PRKN 25348397 N/A physical interaction ComPPI
PSMD2 PRKN 25348397 N/A physical interaction ComPPI
UCHL1 PRKN 25348397 N/A physical interaction ComPPI
DNM1L PRKN 25348397 N/A physical interaction ComPPI
ATXN3 PRKN 20940148 22081612 24063750 25348397 27898060 N/A physical interaction ComPPI,OmniPath
CDK5 PRKN 25348397 N/A physical interaction ComPPI
RPL7 PRKN 25348397 N/A physical interaction ComPPI
ATP2B1 PRKN 25348397 N/A physical interaction ComPPI
RAD23B PRKN 25348397 N/A physical interaction ComPPI
PDCD2 PRKN 19146857 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
BCL2 PRKN 25348397 N/A physical interaction ComPPI
RGS3 PRKN 14525934 16637659 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
HTRA2 PRKN 25348397 N/A physical interaction ComPPI
COMMD1 PRKN 25348397 N/A physical interaction ComPPI
MYO6 PRKN 25348397 N/A physical interaction ComPPI
DDX3X PRKN 25348397 N/A physical interaction ComPPI
PRKN GPR37 11439185 12150907 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PRKN SEPTIN4 14525934 14559152 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
PRKN UBE2L6 11078524 14525934 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
PRKN SIM2 14525934 15963499 25348397 27898060 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
PRKN TRIP13 14525934 16189514 19060904 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PRKN PAFAH1B2 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PRKN RAD1 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
PRKN HEXD 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PRKN NDUFA4L2 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PRKN PSMA7 14525934 15987638 25348397 N/A anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
PRKN RANBP2 14525934 16332688 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,pull down,physical interaction,fluorescence microscopy,in vitro,in vivo ComPPI,HPRD,IntAct
PRKN SNCA 11588587 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PRKN CCNE1 25348397 N/A physical interaction ComPPI
PRKN CAMK2A 25348397 N/A physical interaction ComPPI
PRKN UBE2J1 25348397 N/A physical interaction ComPPI
PRKN STUB1 25348397 N/A physical interaction ComPPI
PRKN DNAJA1 25348397 N/A physical interaction ComPPI
PRKN DNAJB1 25348397 N/A physical interaction ComPPI
PRKN RNF41 25348397 N/A physical interaction ComPPI
PRKN PLCG1 25348397 N/A physical interaction ComPPI
PRKN BACH1 25348397 N/A physical interaction ComPPI
PRKN LIMK1 25348397 N/A physical interaction ComPPI
PRKN PSMA4 25348397 N/A physical interaction ComPPI
PRKN LRRK2 16352719 24234451 25348397 27898060 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct,OmniPath
PRKN PARK7 15525661 17846173 19229105 24242043 25348397 27898060 N/A physical interaction ComPPI,OmniPath
PRKN SLC6A3 17873367 25348397 27898060 N/A physical interaction ComPPI,OmniPath
PRKN APP 19610108 22954671 25348397 27898060 N/A physical interaction ComPPI,OmniPath
PRKN PINK1 20153330 23933751 24234451 24357652 25348397 colocalization,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,fluorescent resonance energy transfer,pull down,physical interaction,fluorescence microscopy ComPPI,IntAct
PRKN ZNF746 21376232 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
PRKN ABL1 25348397 N/A physical interaction ComPPI
PRKN AMBRA1 25348397 N/A physical interaction ComPPI
PRKN IKBKG 25348397 N/A physical interaction ComPPI
PRKN SLC11A2 20089134 25348397 27898060 N/A physical interaction ComPPI,OmniPath
PRKN MFN1 25348397 N/A physical interaction ComPPI
PRKN MFN2 23620051 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKN ESRRA 25348397 N/A physical interaction ComPPI
PRKN ESRRB 25348397 N/A physical interaction ComPPI
PRKN ESRRG 25348397 N/A physical interaction ComPPI
PRKN PSMD4 12634850 15194120 19240029 19875440 20810900 21348451 22350919 22517668 23503661 25348397 27898060 N/A physical interaction ComPPI,OmniPath
PRKN BAG5 25348397 N/A physical interaction ComPPI
PRKN ATXN2 25348397 N/A physical interaction ComPPI
PRKN ARIH1 25348397 N/A physical interaction ComPPI
PRKN PRPS1 25348397 N/A physical interaction ComPPI
PRKN UBE2J2 25348397 N/A physical interaction ComPPI
PRKN RHOT1 22078885 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKN UBE2E1 25348397 N/A physical interaction ComPPI
PRKN UBE2D3 25348397 N/A physical interaction ComPPI
PRKN UBE2V1 25348397 N/A physical interaction ComPPI
PRKN VDAC3 25348397 N/A physical interaction ComPPI
PRKN HK1 25348397 N/A physical interaction ComPPI
PRKN TOMM70 23068103 23503661 24149440 24244333 25348397 25591737 27898060 N/A physical interaction ComPPI,OmniPath
PRKN CISD1 25348397 N/A physical interaction ComPPI
PRKN NME2 25348397 N/A physical interaction ComPPI
PRKN UBE2M 25348397 N/A physical interaction ComPPI
PRKN CCT2 25348397 N/A physical interaction ComPPI
PRKN PACRG 25348397 N/A physical interaction ComPPI
PRKN HSP90AA2P 25348397 N/A physical interaction ComPPI
PRKN ACSL1 25348397 N/A physical interaction ComPPI
PRKN ACSL4 25348397 N/A physical interaction ComPPI
PRKN MDH1 25348397 N/A physical interaction ComPPI
PRKN MDH2 25348397 N/A physical interaction ComPPI
PRKN CPT1A 25348397 N/A physical interaction ComPPI
PRKN CYB5R3 25348397 N/A physical interaction ComPPI
PRKN MTARC1 25348397 N/A physical interaction ComPPI
PRKN TBC1D15 25348397 N/A physical interaction ComPPI
PRKN TOM1 25348397 N/A physical interaction ComPPI
PRKN CALCOCO2 25348397 N/A physical interaction ComPPI
PRKN PSMA2 25348397 N/A physical interaction ComPPI
PRKN PSMB5 25348397 N/A physical interaction ComPPI
PRKN PSMB6 25348397 N/A physical interaction ComPPI
PRKN PSMB7 25348397 N/A physical interaction ComPPI
PRKN PSMC1 25348397 N/A physical interaction ComPPI
PRKN PSMC2 25348397 N/A physical interaction ComPPI
PRKN PAAF1 25348397 N/A physical interaction ComPPI
PRKN PSMD3 25348397 N/A physical interaction ComPPI
PRKN PSMD5 25348397 N/A physical interaction ComPPI
PRKN PSMD6 25348397 N/A physical interaction ComPPI
PRKN PSMD9 25348397 N/A physical interaction ComPPI
PRKN PSMD10 25348397 N/A physical interaction ComPPI
PRKN PSMD12 25348397 N/A physical interaction ComPPI
PRKN PSMD13 25348397 N/A physical interaction ComPPI
PRKN PSME1 25348397 N/A physical interaction ComPPI
PRKN PSME2 25348397 N/A physical interaction ComPPI
PRKN PSME3 25348397 N/A physical interaction ComPPI
PRKN FBXO7 23933751 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
PRKN TOMM40 25348397 N/A physical interaction ComPPI
PRKN LRPPRC 25348397 N/A physical interaction ComPPI
PRKN CLPX 25348397 N/A physical interaction ComPPI
PRKN HSPD1 25348397 N/A physical interaction ComPPI
PRKN ATP2B3 25348397 N/A physical interaction ComPPI
PRKN H1-0 25348397 N/A physical interaction ComPPI
PRKN PRKCSH 25348397 N/A physical interaction ComPPI
PRKN TUBA1C 25348397 N/A physical interaction ComPPI
PRKN AIFM1 25348397 N/A physical interaction ComPPI
PRKN ALB 25348397 N/A physical interaction ComPPI
PRKN GSDMA 25348397 N/A physical interaction ComPPI
PRKN RCN2 25348397 N/A physical interaction ComPPI
PRKN MRPS31 25348397 N/A physical interaction ComPPI
PRKN SLC25A3 25348397 N/A physical interaction ComPPI
PRKN ATP5F1A 25348397 N/A physical interaction ComPPI
PRKN HADHB 25348397 N/A physical interaction ComPPI
PRKN EEF1A1P5 25348397 N/A physical interaction ComPPI
PRKN TUBB6 25348397 N/A physical interaction ComPPI
PRKN SLC25A13 25348397 N/A physical interaction ComPPI
PRKN H2AC1 25348397 N/A physical interaction ComPPI
PRKN MRPS7 25348397 N/A physical interaction ComPPI
PRKN OPA1 25348397 N/A physical interaction ComPPI
PRKN CBX3 25348397 N/A physical interaction ComPPI
PRKN EIF4B 25348397 N/A physical interaction ComPPI
PRKN BAG2 25348397 N/A physical interaction ComPPI
PRKN SART1 25348397 N/A physical interaction ComPPI
PRKN ATP5MF 25348397 N/A physical interaction ComPPI
PRKN MYL12B 25348397 N/A physical interaction ComPPI
PRKN MYL12A 25348397 N/A physical interaction ComPPI
PRKN ATP5F1C 25348397 N/A physical interaction ComPPI
PRKN RPS20 25348397 N/A physical interaction ComPPI
PRKN RPL13 25348397 N/A physical interaction ComPPI
PRKN RPL6 25348397 N/A physical interaction ComPPI
PRKN CCT3 25348397 N/A physical interaction ComPPI
PRKN ANXA2P2 25348397 N/A physical interaction ComPPI
PRKN TPM4 25348397 N/A physical interaction ComPPI
PRKN NDUFS4 25348397 N/A physical interaction ComPPI
PRKN INA 25348397 N/A physical interaction ComPPI
PRKN CIRBP 25348397 N/A physical interaction ComPPI
PRKN SLC25A4 25348397 N/A physical interaction ComPPI
PRKN MRPL12 25348397 N/A physical interaction ComPPI
PRKN SLC25A10 25348397 N/A physical interaction ComPPI
PRKN PRPF19 25348397 N/A physical interaction ComPPI
PRKN RFC4 25348397 N/A physical interaction ComPPI
PRKN FUS 25348397 N/A physical interaction ComPPI
PRKN NDUFS2 25348397 N/A physical interaction ComPPI
PRKN IGF2BP1 25348397 N/A physical interaction ComPPI
PRKN HSPA1L 25348397 N/A physical interaction ComPPI
PRKN RUVBL2 25348397 N/A physical interaction ComPPI
PRKN VGF 25348397 N/A physical interaction ComPPI
PRKN ZC3H15 25348397 N/A physical interaction ComPPI
PRKN GPD2 25348397 N/A physical interaction ComPPI
PRKN HSDL2 25348397 N/A physical interaction ComPPI
PRKN AMY2B 25348397 N/A physical interaction ComPPI
PRKN MARCKSL1 25348397 N/A physical interaction ComPPI
PRKN CHGA 25348397 N/A physical interaction ComPPI
PRKN ACTBL2 25348397 N/A physical interaction ComPPI
PRKN NTPCR 25348397 N/A physical interaction ComPPI
PRKN GCNT2 25348397 N/A physical interaction ComPPI
PRKN CHGB 25348397 N/A physical interaction ComPPI
PRKN HDGF 25348397 N/A physical interaction ComPPI
PRKN TGM3 25348397 N/A physical interaction ComPPI
PRKN AGK 25348397 N/A physical interaction ComPPI
PRKN MRPS28 25348397 N/A physical interaction ComPPI
PRKN MRPS18B 25348397 N/A physical interaction ComPPI
PRKN RPL26L1 25348397 N/A physical interaction ComPPI
PRKN STOML2 25348397 N/A physical interaction ComPPI
PRKN DBT 25348397 N/A physical interaction ComPPI
PRKN VAT1 25348397 N/A physical interaction ComPPI
PRKN NACA 25348397 N/A physical interaction ComPPI
PRKN NACA4P 25348397 N/A physical interaction ComPPI
PRKN NDUFA10 25348397 N/A physical interaction ComPPI
PRKN HNRNPH3 25348397 N/A physical interaction ComPPI
PRKN SRSF9 25348397 N/A physical interaction ComPPI
PRKN TUBB1 25348397 N/A physical interaction ComPPI
PRKN NIPSNAP1 25348397 N/A physical interaction ComPPI
PRKN PCCA 25348397 N/A physical interaction ComPPI
PRKN RPS19 25348397 N/A physical interaction ComPPI
PRKN PCCB 25348397 N/A physical interaction ComPPI
PRKN ACTA2 25348397 N/A physical interaction ComPPI
PRKN DDX47 25348397 N/A physical interaction ComPPI
PRKN PABPC1L 25348397 N/A physical interaction ComPPI
PRKN PRRC2C 25348397 N/A physical interaction ComPPI
PRKN MCCC2 25348397 N/A physical interaction ComPPI
PRKN HNRNPCL1 25348397 N/A physical interaction ComPPI
PRKN HNRNPDL 25348397 N/A physical interaction ComPPI
PRKN HNRNPD 25348397 N/A physical interaction ComPPI
PRKN NDUFS3 25348397 N/A physical interaction ComPPI
PRKN ATAD3B 25348397 N/A physical interaction ComPPI
PRKN RPL22 25348397 N/A physical interaction ComPPI
PRKN PABPC3 25348397 N/A physical interaction ComPPI
PRKN HNRNPA3 25348397 N/A physical interaction ComPPI
PRKN MCM7 25348397 N/A physical interaction ComPPI
PRKN TPM1 25348397 N/A physical interaction ComPPI
PRKN SLC25A1 25348397 N/A physical interaction ComPPI
PRKN ATAD3A 25348397 N/A physical interaction ComPPI
PRKN RPL8 25348397 N/A physical interaction ComPPI
PRKN PGAM5 25348397 N/A physical interaction ComPPI
PRKN RALY 25348397 N/A physical interaction ComPPI
PRKN ELAVL1 25348397 N/A physical interaction ComPPI
PRKN RPS2 25348397 N/A physical interaction ComPPI
PRKN H1-2 25348397 N/A physical interaction ComPPI
PRKN MRPS15 25348397 N/A physical interaction ComPPI
PRKN PTCD3 25348397 N/A physical interaction ComPPI
PRKN HNRNPR 25348397 N/A physical interaction ComPPI
PRKN SRSF3 25348397 N/A physical interaction ComPPI
PRKN HNRNPM 25348397 N/A physical interaction ComPPI
PRKN MRPS27 25348397 N/A physical interaction ComPPI
PRKN SERBP1 25348397 N/A physical interaction ComPPI
PRKN PRPF6 25348397 N/A physical interaction ComPPI
PRKN RPL23A 25348397 N/A physical interaction ComPPI
PRKN RPS8 25348397 N/A physical interaction ComPPI
PRKN MATR3 25348397 N/A physical interaction ComPPI
PRKN SLC25A5 25348397 N/A physical interaction ComPPI
PRKN SNRNP200 25348397 N/A physical interaction ComPPI
PRKN HNRNPH1 25348397 N/A physical interaction ComPPI
PRKN MRPS22 25348397 N/A physical interaction ComPPI
PRKN RPS16 25348397 N/A physical interaction ComPPI
PRKN RPLP0P6 25348397 N/A physical interaction ComPPI
PRKN HNRNPA1 25348397 N/A physical interaction ComPPI
PRKN SLC25A24 25348397 N/A physical interaction ComPPI
PRKN NACC1 25348397 N/A physical interaction ComPPI
PRKN TARDBP 25348397 N/A physical interaction ComPPI
PRKN BECN1 23737459 24386307 24879156 25348397 27898060 N/A physical interaction ComPPI,OmniPath
PRKN PIK3C3 25348397 N/A physical interaction ComPPI
PRKN DLX2 25348397 N/A physical interaction ComPPI
PRKN RBCK1 25348397 N/A physical interaction ComPPI
PRKN TCF4 25348397 N/A physical interaction ComPPI
PRKN DDIT4 25348397 N/A physical interaction ComPPI
PRKN AFDN 23393160 25348397 27898060 N/A physical interaction ComPPI,OmniPath
PRKN PRAME 25348397 N/A physical interaction ComPPI
PRKN PASK 25348397 N/A physical interaction ComPPI
PRKN PCYT2 25348397 N/A physical interaction ComPPI
PRKN HSD17B10 25348397 N/A physical interaction ComPPI
PRKN BIRC5 25348397 N/A physical interaction ComPPI
PRKN GRIK2 25316086 25348397 27898060 N/A physical interaction ComPPI,OmniPath
PRKN MTOR 25348397 N/A physical interaction ComPPI
PRKN RPTOR 25348397 N/A physical interaction ComPPI
PRKN AURKB 25348397 N/A physical interaction ComPPI
PRKN PTTG1 25348397 N/A physical interaction ComPPI
PRKN PTTG2 25348397 N/A physical interaction ComPPI
PRKN DYRK1A 25348397 N/A physical interaction ComPPI
PRKN APEX1 25348397 N/A physical interaction ComPPI
PRKN BNIP3 25348397 N/A physical interaction ComPPI
PRKN DDIT3 25348397 N/A physical interaction ComPPI
PRKN MAVS 25348397 N/A physical interaction ComPPI
PRKN RNF31 25348397 N/A physical interaction ComPPI
PRKN NBN 25348397 N/A physical interaction ComPPI
PRKN TP53 25348397 N/A physical interaction ComPPI
PRKN USP30 25348397 N/A physical interaction ComPPI
PRKN CCND2 25348397 N/A physical interaction ComPPI
PRKN CCND3 25348397 N/A physical interaction ComPPI
PRKN FBXO4 25348397 N/A physical interaction ComPPI
PRKN UBE2C 25348397 N/A physical interaction ComPPI
PRKN UBE2H 25348397 N/A physical interaction ComPPI
PRKN UBE2O 25348397 N/A physical interaction ComPPI
PRKN UBE2S 25348397 N/A physical interaction ComPPI
PRKN UBE2T 25348397 N/A physical interaction ComPPI
PRKN UBE2Z 25348397 N/A physical interaction ComPPI
PRKN NFKBIE 24234451 25348397 29128334 physical association anti bait coimmunoprecipitation ComPPI,IntAct
HNRNPF PRKN 25348397 N/A physical interaction ComPPI
PSMB4 PRKN 25348397 N/A physical interaction ComPPI
PSMB1 PRKN 25348397 N/A physical interaction ComPPI
PSMB3 PRKN 25348397 N/A physical interaction ComPPI
AGPS PRKN 25348397 N/A physical interaction ComPPI
EEF1A2 PRKN 25348397 N/A physical interaction ComPPI
ADRM1 PRKN 25348397 N/A physical interaction ComPPI
RPS14 PRKN 25348397 N/A physical interaction ComPPI
CYB5R1 PRKN 25348397 N/A physical interaction ComPPI
NEFL PRKN 25348397 N/A physical interaction ComPPI
BBOX1 PRKN 25348397 N/A physical interaction ComPPI
CALU PRKN 25348397 N/A physical interaction ComPPI
MRPS23 PRKN 25348397 N/A physical interaction ComPPI
PRKN PRKN 12628165 14525934 21694720 24234451 N/A experimental interaction detection,isothermal titration calorimetry,nuclear magnetic resonance,pull down HPRD,IntAct
TUBB2A PRKN 12716939 14525934 N/A experimental interaction detection HPRD
HDLBP PRKN 24234451 30021884 physical association cross-linking study IntAct
PRKN BAX 22460798 27898060 N/A N/A OmniPath
UBC PRKN 22724072 23670163 24751536 24784582 25474007 25847540 25969509 26161729 26162776 26254304 26260794 27898060 stimulant N/A OmniPath
CDK5 PRKN 17327227 19050041 27898060 inhibition,stimulant N/A OmniPath
PRKN CTNNB1 20418918 27898060 stimulant N/A OmniPath
CSNK1A1 PRKN 15557340 19050041 27898060 inhibition N/A OmniPath
PLK1 PRKN 26148234 26387737 27898060 N/A N/A OmniPath
PRKN SYT11 12925569 15194120 27898060 inhibition N/A OmniPath
PRKN CCNE1 12628165 15194120 20418918 27898060 inhibition,stimulant N/A OmniPath
PRKN SNCAIP 11590439 15603737 15894486 15944382 16049031 16096643 20089136 20418918 21590270 27898060 inhibition,stimulant N/A OmniPath
PRKN GPR37 11439185 12150907 12666095 14579121 15194120 27898060 inhibition N/A OmniPath
PRKN VDAC1 20098416 23060438 23068103 23503661 26631732 27898060 inhibition N/A OmniPath
ABL1 PRKN 20823226 21209200 27898060 inhibition N/A OmniPath
PRKN AIMP2 12783850 16049031 16135753 16714300 27898060 inhibition,stimulant N/A OmniPath
PRKN ATXN2 20418918 27898060 inhibition N/A OmniPath
PRKN HSPA1B 20418918 27898060 inhibition N/A OmniPath
PRKN PUF60 20418918 27898060 inhibition N/A OmniPath
PRKN SEPTIN5 11078524 14559152 15194120 16714300 18845538 20418918 24722188 27898060 inhibition N/A OmniPath
PINK1 PRKN 19167501 19229105 19358826 19880420 19966284 20418918 20798600 20966070 22724072 23256036 23319602 23670163 23933751 24357652 24647965 24660806 24751536 24784582 25216678 25375667 25474007 25591737 25969509 26161729 26162776 26254305 26471730 27898060 stimulant N/A OmniPath
PRKN SNCA 11588587 12666095 16714300 18195004 19651786 20418918 25861987 27898060 inhibition,stimulant N/A OmniPath
PRKN RANBP2 16332688 20418918 27898060 inhibition N/A OmniPath
PRKN JUN 20418918 27898060 inhibition N/A OmniPath
PRKN EPS15 16862145 27898060 stimulant N/A OmniPath

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