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GENE：PRKRA

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PRKRA
FullNmae protein activator of interferon induced protein kinase EIF2AK2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9438
EnsembleID ENSG00000180228
Uniprot O75569

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PRKRA apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PRKRA apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
PRKRA GO:0003723,GO:0003725,GO:0003725,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005737,GO:0005829,GO:0005829,GO:0006955,GO:0008047,GO:0008285,GO:0009615,GO:0016020,GO:0016442,GO:0019899,GO:0030422,GO:0030422,GO:0031054,GO:0034599,GO:0035196,GO:0035197,GO:0042473,GO:0042474,GO:0042802,GO:0042803,GO:0048471,GO:0048705,GO:0050821,GO:0070578,GO:0070578,GO:0070578,GO:0070883,GO:0070920,GO:0070922,GO:2001244

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PRKRA CHUK 11313968 23180781 physical association anti tag coimmunoprecipitation InnateDB
EIF2AK2 PRKRA 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
BMI1 PRKRA 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB
G3BP1 PRKRA 23180781 25784705 physical association pull down InnateDB
CAPRIN1 PRKRA 23180781 25784705 physical association anti tag coimmunoprecipitation InnateDB
PRKRA CAPRIN1 23180781 25784705 physical association pull down InnateDB
PRKRA G3BP1 23180781 25784705 physical association pull down InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 PRKRA 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 PRKRA 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 PRKRA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PRKRA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 PRKRA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PRKRA 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00003380CC PRKRA 21937511 25416803 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
EIF2AK2 PRKRA 25361965 interaction type N/A PTMCode2
PRKRA EIF2AK2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PIAS2 PRKRA 25348397 N/A two hybrid ComPPI
UBE2I PRKRA 25348397 N/A physical interaction ComPPI
CDC42 PRKRA 25348397 N/A two hybrid ComPPI
RBM3 PRKRA 25348397 N/A physical interaction ComPPI
BMI1 PRKRA 25348397 N/A physical interaction ComPPI
SHC1 PRKRA 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SETDB1 PRKRA 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
RB1 PRKRA 14525934 25348397 9010216 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
RPL18A PRKRA 25348397 N/A physical interaction ComPPI
BTRC PRKRA 25348397 N/A physical interaction ComPPI
EIF2AK2 PRKRA 11238927 11985496 14525934 21903422 23455922 24234451 25348397 9687506 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,nuclear magnetic resonance,pull down,physical interaction,two hybrid array,in vitro,in vivo,tandem affinity purification,two hybrid prey pooling approach ComPPI,HPRD,IntAct
TARBP2 PRKRA 14525934 16424907 21900206 24234451 25348397 25416956 25910212 physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,two hybrid array,in vivo,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,validated two hybrid ComPPI,HPRD,IntAct
TIRAP PRKRA 25348397 N/A in vivo ComPPI
STRBP PRKRA 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PRKRA GDF9 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PRKRA COPS6 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PRKRA DICER1 14525934 16424907 21858095 23661684 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,molecular sieving,physical interaction,in vivo,ribonuclease assay ComPPI,HPRD,IntAct
PRKRA AGO2 14525934 16424907 23661684 24234451 25348397 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,in vivo,ribonuclease assay ComPPI,HPRD,IntAct
PRKRA SYNCRIP 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKRA IGF2BP1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKRA PRPSAP1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKRA RPL36 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKRA RABEPK 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PRKRA ZFP28 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PRKRA ZNF746 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PRKRA CEBPZ 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PRKRA NKRF 21900206 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PRKRA CEP126 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PRKRA SNX5 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PRKRA SIRT7 25348397 N/A physical interaction ComPPI
PRKRA CAND1 25348397 N/A physical interaction ComPPI
PRKRA MDC1 25348397 N/A physical interaction ComPPI
PRKRA POLR2G 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PRKRA SRPK3 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
PRKRA GTPBP4 25348397 N/A physical interaction ComPPI
PRKRA STAU2 25348397 N/A physical interaction ComPPI
PRKRA CCDC124 25348397 N/A physical interaction ComPPI
PRKRA DDX50 25348397 N/A physical interaction ComPPI
PRKRA H1-0 25348397 N/A physical interaction ComPPI
PRKRA MMTAG2 25348397 N/A physical interaction ComPPI
PRKRA NOC3L 25348397 N/A physical interaction ComPPI
PRKRA NOP16 25348397 N/A physical interaction ComPPI
PRKRA TCOF1 25348397 N/A physical interaction ComPPI
PRKRA IFRD2 25348397 N/A physical interaction ComPPI
PRKRA RBM34 25348397 N/A physical interaction ComPPI
PRKRA ZNF346 25348397 N/A physical interaction ComPPI
PRKRA STAU1 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PRKRA ZMAT3 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PRKRA RALYL 25348397 N/A physical interaction ComPPI
PRKRA RASL10A 25348397 N/A physical interaction ComPPI
PRKRA EHD1 25348397 N/A physical interaction ComPPI
PRKRA IFI16 25348397 N/A physical interaction ComPPI
PRKRA FBF1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
PRKRA ELAVL2 25348397 N/A physical interaction ComPPI
PRKRA MAGEB10 25348397 N/A physical interaction ComPPI
PRKRA WDR46 25348397 N/A physical interaction ComPPI
PRKRA RPL30 25348397 N/A physical interaction ComPPI
PRKRA DGCR8 25348397 N/A physical interaction ComPPI
PRKRA G3BP1 25348397 N/A physical interaction ComPPI
PRKRA BRCA1 25348397 N/A physical interaction ComPPI
PRKRA ESR2 21182203 24234451 25348397 association affinity chromatography technology ComPPI,IntAct
PRKRA DDX58 23870315 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct,OmniPath
PRKRA LNX1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PRKRA EHHADH 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PRKRA BCAR1 24234451 25348397 28007913 association anti bait coimmunoprecipitation ComPPI,IntAct
PRKRA RPS6 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
ILF2 PRKRA 25348397 N/A physical interaction ComPPI
LYAR PRKRA 21516116 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
EBNA1BP2 PRKRA 25348397 N/A physical interaction ComPPI
PRKRA TP53 14525934 9010216 N/A experimental interaction detection HPRD
PRKRA PRKRA 14525934 16169070 21900206 24234451 25416956 physical association two hybrid,two hybrid array,two hybrid pooling approach,two hybrid prey pooling approach,two hybrid HPRD,IntAct
CHUK PRKRA 11313968 27898060 N/A N/A OmniPath
PRKRA EIF2AK2 10988289 11238927 11985496 12368348 16785445 21903422 23455922 24778252 27898060 9687506 stimulant N/A OmniPath

Visualization










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