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GENE：PRODH

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PRODH
FullNmae proline dehydrogenase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9453
EnsembleID ENSG00000100033
Uniprot O43272

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PRODH apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PRODH apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
PRODH GO:0004657,GO:0004657,GO:0004657,GO:0005654,GO:0005739,GO:0005739,GO:0005743,GO:0005759,GO:0006560,GO:0006562,GO:0008631,GO:0010133,GO:0010133,GO:0019470,GO:0043231,GO:0071949,GO:0071949,GO:1903376

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PRODH hsa:5625 path:hsa00330 Arginine and proline metabolism - Homo sapiens (human)
PRODH hsa:5625 path:hsa01100 Metabolic pathways - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ESR2 PRODH 20034404 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CTCF PRODH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PRODH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PRODH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF PRODH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 PRODH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MYC PRODH 22615405 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000183BED PRODH 20562915 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000183BED PRODH 20562915 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
HSPA8 PRODH 25348397 N/A physical interaction ComPPI
TUBA4A PRODH 25348397 N/A physical interaction ComPPI
BRAP PRODH 25348397 N/A physical interaction ComPPI
HSPA6 PRODH 25348397 N/A physical interaction ComPPI

Visualization










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