GENE:PTH
GeneInfo:
GeneAttribute | GeneDescription |
---|---|
GeneSymbol | PTH |
FullNmae | parathyroid hormone |
LocusType | gene with protein product |
Status | Approved |
HGNC_id | HGNC:9606 |
EnsembleID | ENSG00000152266 |
Uniprot | P01270 |
Protein Structure:
Gene Description in Publicaton:
GeneSymbol | CellDeathType | PMID | Description | GeneType |
---|---|---|---|---|
PTH | pyroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
PTH | autophagy | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
PTH | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
PTH | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
GeneSymbol | Go id |
---|---|
PTH | GO:0001501,GO:0005179,GO:0005179,GO:0005515,GO:0005515,GO:0005576,GO:0005576,GO:0005615,GO:0006366,GO:0006874,GO:0007186,GO:0007189,GO:0007189,GO:0007202,GO:0007266,GO:0007267,GO:0008628,GO:0009059,GO:0009410,GO:0009967,GO:0010288,GO:0010468,GO:0010628,GO:0010629,GO:0010960,GO:0030282,GO:0030501,GO:0031856,GO:0031857,GO:0032331,GO:0033280,GO:0045453,GO:0045471,GO:0045725,GO:0045944,GO:0046058,GO:0046326,GO:0046686,GO:0048018,GO:0048873,GO:0051428,GO:0051428,GO:0055062,GO:0060732,GO:0071107,GO:0071774,GO:0071864,GO:0071866,GO:0090290,GO:1900158 |
KEGG Annotation:
GeneSymbol | GeneID | Pathway | Pathway Name |
---|---|---|---|
PTH | hsa:5741 | path:hsa04080 | Neuroactive ligand-receptor interaction - Homo sapiens (human) |
PTH | hsa:5741 | path:hsa04928 | Parathyroid hormone synthesis, secretion and action - Homo sapiens (human) |
PTH | hsa:5741 | path:hsa04961 | Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human) |
PTH | hsa:5741 | path:hsa05323 | Rheumatoid arthritis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
CTCF | PTH | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
FOXA1 | PTH | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
APEX1 | PTH | 14633989 | trascriptional regulation,stimulation | inferred by curator | TFlink |
GCM2 | PTH | 20558332 | trascriptional regulation,stimulation | inferred by curator | TFlink |
RUNX2 | PTH | 11814673 | trascriptional regulation,stimulation | inferred by curator | TFlink |
VDR | PTH | 17095575 7489414 | trascriptional regulation,stimulation | inferred by curator | TFlink |
CREB1 | PTH | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
SP1 | PTH | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
FEZ1 | PTH | 14525934 16169070 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid | ComPPI,HPRD,IntAct |
PTH1R | PTH | 14525934 25348397 9108031 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
PTH | MEP1A | 11278902 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
PTH | BAG6 | 14525934 16169070 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid | ComPPI,HPRD,IntAct |
PTH | ARFGEF3 | 25348397 | N/A | physical interaction | ComPPI |
PTH2R | PTH | 14525934 25348397 9482662 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
PTH | PTH | 10837469 14525934 | N/A | experimental interaction detection | HPRD |
PTH | PTH1R | 18981475 27898060 9108031 | stimulant | N/A | OmniPath |
PTH | PTH2R | 11861531 27898060 7797535 9482662 | stimulant | N/A | OmniPath |