Gene Information gene info

GENE:PTPN1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PTPN1
FullNmae protein tyrosine phosphatase non-receptor type 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9642
EnsembleID ENSG00000196396
Uniprot P18031

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PTPN1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PTPN1 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
PTPN1 GO:0003723,GO:0004725,GO:0004725,GO:0004726,GO:0005158,GO:0005515,GO:0005737,GO:0005737,GO:0005759,GO:0005769,GO:0005769,GO:0005769,GO:0005783,GO:0005783,GO:0005829,GO:0005886,GO:0006470,GO:0008270,GO:0008286,GO:0009966,GO:0009968,GO:0019899,GO:0019901,GO:0019901,GO:0030036,GO:0030061,GO:0030100,GO:0030948,GO:0030968,GO:0030971,GO:0031904,GO:0032991,GO:0033157,GO:0034620,GO:0035335,GO:0035335,GO:0035335,GO:0035791,GO:0036498,GO:0038020,GO:0043407,GO:0043507,GO:0045296,GO:0046627,GO:0046875,GO:0051721,GO:0060338,GO:0060397,GO:0061098,GO:0070373,GO:0070373,GO:0097443,GO:0098554,GO:1902202,GO:1902236,GO:1903896,GO:1903898,GO:1903898,GO:1990264,GO:2000646

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PTPN1 hsa:5770 path:hsa04520 Adherens junction - Homo sapiens (human)
PTPN1 hsa:5770 path:hsa04910 Insulin signaling pathway - Homo sapiens (human)
PTPN1 hsa:5770 path:hsa04931 Insulin resistance - Homo sapiens (human)
PTPN1 hsa:5770 path:hsa05208 Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CTNNB1 PTPN1 17087658 23180781 physical association anti tag coimmunoprecipitation InnateDB
CDH1 PTPN1 17087658 23180781 physical association anti tag coimmunoprecipitation InnateDB
PTPN1 CLK2 10480872 23180781 phosphorylation reaction in-gel kinase assay InnateDB
CAPN1 PTPN1 12857726 23180781 cleavage reaction protease assay InnateDB
PTPN1 CAPN2 23180781 9470132 cleavage reaction protease assay InnateDB
BCAR1 PTPN1 23180781 9407132 physical association anti tag coimmunoprecipitation InnateDB
EGFR PTPN1 15982634 23180781 physical association anti tag coimmunoprecipitation InnateDB
AKT1 PTPN1 11579209 23180781 phosphorylation reaction in-gel kinase assay InnateDB
INSR PTPN1 11579209 12237455 12612081 14722096 17481567 23180781 dephosphorylation reaction,physical association anti tag coimmunoprecipitation,fluorescent resonance energy transfer,peptide array,solid phase assay InnateDB
PTPN1 LAT 12857726 23180781 physical association in gel phosphatase assay InnateDB
SRC PTPN1 12857726 23180781 physical association affinity chromatography technology InnateDB
PTPN1 NTRK1 12237455 23180781 physical association peptide array InnateDB
NTRK2 PTPN1 12237455 23180781 physical association peptide array InnateDB
NTRK3 PTPN1 12237455 23180781 physical association peptide array InnateDB
LTK PTPN1 12237455 23180781 physical association peptide array InnateDB
STAT5A PTPN1 12237455 23180781 dephosphorylation reaction,physical association peptide array InnateDB
STAT5B PTPN1 12237455 23180781 physical association peptide array InnateDB
GH2 PTPN1 12907755 24243840 29145629 physical association inferred by curator Reactome
GHR PTPN1 12907755 24243840 29145629 physical association inferred by curator Reactome
GH1 PTPN1 12907755 24243840 29145629 physical association inferred by curator Reactome
PTPN1 IFNGR2 24243840 29145629 dephosphorylation reaction inferred by curator Reactome
IFNGR1 PTPN1 24243840 29145629 dephosphorylation reaction inferred by curator Reactome
PTPN1 JAK1 11694501 24243840 29145629 dephosphorylation reaction inferred by curator Reactome
IFNG PTPN1 24243840 29145629 dephosphorylation reaction inferred by curator Reactome
PTPN1 STAT2 11694501 29145629 dephosphorylation reaction inferred by curator Reactome
PTPN1 TYK2 11694501 23331499 29145629 dephosphorylation reaction,stimulation inferred by curator Reactome,SignaLink,SignaLink
IFNAR1 PTPN1 11694501 29145629 dephosphorylation reaction inferred by curator Reactome
PTPN1 PTPN1 16582879 26467481 dephosphorylation reaction,down-regulates activity N/A Signor
PTPN1 IRS1 10660596 11579209 18988627 21071413 23331499 stimulation N/A SignaLink,SignaLink
PTPN1 JAK2 11694501 15821101 18988627 23331499 stimulation N/A SignaLink,SignaLink
PTPN1 STAT3 15821101 23331499 stimulation N/A SignaLink,SignaLink
PTPN1 PPP2R2A 23590304 dephosphorylation reaction,stimulation N/A SignaLink
GRAP PTPN1 10660596 23331499 stimulation N/A SignaLink
PTPN1 IGF1R 11884589 23331499 8999839 stimulation N/A SignaLink
PTPN1 INSR 11506178 12237455 15632081 16582879 23331499 8826975 9355745 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
BCAR1 PTPN1 20005715 interaction type N/A PSP
CAV1 PTPN1 20005715 interaction type N/A PSP
CRK PTPN1 20005715 interaction type N/A PSP,SignaLink
GRB2 PTPN1 20005715 interaction type N/A PSP
IRS1 PTPN1 20005715 interaction type N/A PSP
LAT PTPN1 20005715 interaction type N/A PSP,SignaLink
NFKBIA PTPN1 20005715 interaction type N/A PSP
BCAR1 PTPN1 15588985 15866871 18988627 20005715 21071413 8940134 N/A N/A SignaLink
CAV1 PTPN1 12176037 18988627 20005715 21071413 N/A N/A SignaLink
NFKBIA PTPN1 20005715 N/A N/A SignaLink
GRB2 PTPN1 10660596 20005715 21071413 N/A N/A SignaLink
IRS1 PTPN1 10660596 20005715 20005715 21071413 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR PTPN1 20610535 22282656 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 PTPN1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 PTPN1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 PTPN1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 PTPN1 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 PTPN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PTPN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PTPN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 PTPN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PTPN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PTPN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PTPN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PTPN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF PTPN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 PTPN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 PTPN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR PTPN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 PTPN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 PTPN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MYC PTPN1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00003380CC PTPN1 22807119 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS000055128B PTPN1 19826008 rna interference,inhibition array technology,experimental interaction detection,western blot,detection by mass spectrometry,rna immunoprecipitation,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000085F64 PTPN1 23280316 rna interference,inhibition western blot miRSponge
URS000055128B PTPN1 19826008 25416803 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,detection by mass spectrometry,rna immunoprecipitation,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00003380CC PTPN1 22807119 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS0000085F64 PTPN1 23280316 25416803 mrna cleavage,inhibition western blot TarBase
URS00000ED600 PTPN1 20215506 25416803 mrna cleavage,inhibition array technology TarBase
URS000003ABC4 PTPN1 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00001DABC0 PTPN1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000383DF4 PTPN1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000B989F PTPN1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000496C56 PTPN1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000319E1 PTPN1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000037B2E0 PTPN1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002C02E4 PTPN1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000118224 PTPN1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00004283FE PTPN1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075AEA5 PTPN1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075B13F PTPN1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000039A25B PTPN1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000008AA34 PTPN1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000080D0A PTPN1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00003A8BB2 PTPN1 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CDK1 PTPN1 22135298 phosphorylation N/A PhosphoSite
CLK1 PTPN1 22135298 phosphorylation N/A PhosphoSite
CLK2 PTPN1 22135298 phosphorylation N/A PhosphoSite
PLK1 PTPN1 22135298 phosphorylation N/A PhosphoSite
PRKCA PTPN1 22135298 phosphorylation N/A PhosphoSite
EGFR PTPN1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
AKT1 PTPN1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
STAT3 PTPN1 25361965 interaction type N/A PTMCode2
PTPN1 STAT3 25361965 interaction type N/A PTMCode2
GSK3B PTPN1 25361965 interaction type N/A PTMCode2
PTPN1 GSK3B 25361965 interaction type N/A PTMCode2
TYK2 PTPN1 25361965 interaction type N/A PTMCode2
PTPN1 TYK2 25361965 interaction type N/A PTMCode2
MAPK1 PTPN1 25361965 interaction type N/A PTMCode2
PTPN1 MAPK1 25361965 interaction type N/A PTMCode2
CSNK2A1 PTPN1 25361965 interaction type N/A PTMCode2
PTPN1 CSNK2A1 25361965 interaction type N/A PTMCode2
IGF1R PTPN1 25361965 interaction type N/A PTMCode2
PTPN1 IGF1R 25361965 interaction type N/A PTMCode2
CAPN1 PTPN1 25361965 interaction type N/A PTMCode2
PTPN1 CAPN1 25361965 interaction type N/A PTMCode2
PLD2 PTPN1 25361965 interaction type N/A PTMCode2
PTPN1 PLD2 25361965 interaction type N/A PTMCode2
MET PTPN1 25361965 interaction type N/A PTMCode2
PTPN1 MET 25361965 interaction type N/A PTMCode2
CAV1 PTPN1 25361965 interaction type N/A PTMCode2
PTPN1 CAV1 25361965 interaction type N/A PTMCode2
STAT5A PTPN1 25361965 interaction type N/A PTMCode2
PTPN1 STAT5A 25361965 interaction type N/A PTMCode2
ITGB3 PTPN1 25361965 interaction type N/A PTMCode2
PTPN1 ITGB3 25361965 interaction type N/A PTMCode2
EPOR PTPN1 25361965 interaction type N/A PTMCode2
PTPN1 EPOR 25361965 interaction type N/A PTMCode2
SRC PTPN1 25361965 interaction type N/A PTMCode2
PTPN1 SRC 25361965 interaction type N/A PTMCode2
CTTN PTPN1 25361965 interaction type N/A PTMCode2
PTPN1 CTTN 25361965 interaction type N/A PTMCode2
CSF1R PTPN1 25361965 interaction type N/A PTMCode2
PTPN1 CSF1R 25361965 interaction type N/A PTMCode2
GLRX PTPN1 25361965 interaction type N/A PTMCode2
PTPN1 GLRX 25361965 interaction type N/A PTMCode2
PTPN1 EGFR 25361965 interaction type N/A PTMCode2
CDH2 PTPN1 25361965 interaction type N/A PTMCode2
PTPN1 CDH2 25361965 interaction type N/A PTMCode2
IRS1 PTPN1 25361965 interaction type N/A PTMCode2
PTPN1 IRS1 25361965 interaction type N/A PTMCode2
PTPN1 AKT1 25361965 interaction type N/A PTMCode2
GRB2 PTPN1 25361965 interaction type N/A PTMCode2
PTPN1 GRB2 25361965 interaction type N/A PTMCode2
CRK PTPN1 25361965 interaction type N/A PTMCode2
PTPN1 CRK 25361965 interaction type N/A PTMCode2
PTPN1 ABL1 25361965 interaction type N/A PTMCode2
ABL1 PTPN1 25361965 interaction type N/A PTMCode2
PTPN1 JAK2 25361965 interaction type N/A PTMCode2
JAK2 PTPN1 25361965 interaction type N/A PTMCode2
INSR PTPN1 25361965 interaction type N/A PTMCode2
PTPN1 INSR 25361965 interaction type N/A PTMCode2
CTNNB1 PTPN1 25361965 interaction type N/A PTMCode2
PTPN1 CTNNB1 25361965 interaction type N/A PTMCode2
BCR PTPN1 25361965 interaction type N/A PTMCode2
PTPN1 BCR 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PIN1 PTPN1 14525934 25348397 9499405 N/A experimental interaction detection,in vitro ComPPI,HPRD
LAT PTPN1 12857726 14525934 24234451 25348397 dephosphorylation reaction,colocalization,physical association cosedimentation,cosedimentation in solution,experimental interaction detection,pull down,physical interaction,phosphatase assay,in vitro ComPPI,HPRD,IntAct
AGR3 PTPN1 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
LRATD2 PTPN1 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
TOMM22 PTPN1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
LMNA PTPN1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
ACTB PTPN1 25348397 N/A physical interaction ComPPI
TYK2 PTPN1 11694501 14525934 24234451 25348397 physical association coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
SNAI1 PTPN1 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CRK PTPN1 25348397 N/A physical interaction ComPPI
TMEM41A PTPN1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TIMMDC1 PTPN1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
NDUFAF4 PTPN1 25348397 N/A physical interaction ComPPI
MAPK1 PTPN1 12082107 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
SRC PTPN1 11007774 12468645 12857726 14525934 15866871 16115959 16537444 17092689 17974954 24234451 25348397 8647855 9261115 9600099 dephosphorylation reaction,phosphorylation reaction,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,physical interaction,protein kinase assay,phosphatase assay,in vitro,in vivo,bimolecular fluorescence complementation ComPPI,HPRD,IntAct
ROS1 PTPN1 17416557 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
GRB2 PTPN1 10660596 12388170 14525934 24234451 25348397 association coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
JUN PTPN1 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
COP1 PTPN1 25348397 N/A physical interaction ComPPI
PIAS1 PTPN1 14525934 17159996 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,in vivo ComPPI,HPRD,IntAct
ITGB1 PTPN1 21806020 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
RHOB PTPN1 14722096 24234451 25348397 colocalization fluorescence microscopy ComPPI,IntAct
GSK3B PTPN1 14525934 24234451 25348397 7514173 dephosphorylation reaction experimental interaction detection,physical interaction,phosphatase assay,in vitro ComPPI,HPRD,IntAct
ABCD3 PTPN1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
AIP PTPN1 25348397 N/A physical interaction ComPPI
PDGFRB PTPN1 12614164 14525934 19167335 24234451 25348397 7545675 9355745 dephosphorylation reaction,physical association anti tag coimmunoprecipitation,experimental interaction detection,affinity technology,phosphatase assay,in vivo ComPPI,HPRD,IntAct
RRAS2 PTPN1 11788587 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
GHR PTPN1 12907755 24234451 25348397 dephosphorylation reaction,physical association array technology,far western blotting,physical interaction,phosphatase assay ComPPI,IntAct
MVP PTPN1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ACTN1 PTPN1 14525934 16291744 24234451 25348397 dephosphorylation reaction experimental interaction detection,phosphatase assay,in vitro,in vivo ComPPI,HPRD,IntAct
NTRK1 PTPN1 12237455 14525934 24234451 25348397 N/A experimental interaction detection,filter binding,physical interaction,in vitro ComPPI,HPRD,IntAct
CANX PTPN1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
CDH1 PTPN1 25348397 N/A physical interaction ComPPI
ITGB3 PTPN1 16115959 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
PTPN1 GLRX 10350489 14525934 25348397 27898060 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
PTPN1 NTRK2 12237455 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PTPN1 CAV1 12176037 14525934 16388599 24234451 25348397 phosphorylation reaction,colocalization,physical association anti tag coimmunoprecipitation,coimmunoprecipitation,cosedimentation through density gradient,experimental interaction detection,physical interaction,phosphatase assay,in vivo ComPPI,HPRD,IntAct
PTPN1 STAT5A 12237455 14525934 24234451 25348397 dephosphorylation reaction experimental interaction detection,filter binding,physical interaction,phosphatase assay,in vitro ComPPI,HPRD,IntAct
PTPN1 CLK2 10480872 11579209 14525934 24234451 25348397 phosphorylation reaction experimental interaction detection,physical interaction,protein kinase assay,in vitro,in vivo ComPPI,HPRD,IntAct
PTPN1 STAT5B 12237455 14525934 24234451 25348397 N/A experimental interaction detection,filter binding,physical interaction,in vitro ComPPI,HPRD,IntAct
PTPN1 CLK1 10480872 11579209 14525934 24234451 25348397 phosphorylation reaction experimental interaction detection,protein kinase assay,in vitro,in vivo ComPPI,HPRD,IntAct
PTPN1 CDH2 11106648 12377785 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PTPN1 CSNK2A1 14525934 24234451 25348397 8491187 9600099 phosphorylation reaction experimental interaction detection,physical interaction,protein kinase assay,in vitro,in vivo ComPPI,HPRD,IntAct
PTPN1 CTNNB1 12377785 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PTPN1 CAPN2 14525934 24234451 25348397 9407132 enzymatic reaction experimental interaction detection,protease assay,in vitro ComPPI,HPRD,IntAct
PTPN1 TRPV6 15894168 17197020 24234451 25348397 dephosphorylation reaction,physical association anti tag coimmunoprecipitation,phosphatase assay,in vivo,bimolecular fluorescence complementation ComPPI,IntAct
PTPN1 EGFR 10889023 11506178 12573287 14525934 24234451 24658140 25348397 25796184 7540771 8621392 9050838 9355745 phosphorylation reaction,colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,ubiquitin reconstruction,physical interaction,fluorescence microscopy,protein kinase assay,in vitro,in vivo ComPPI,HPRD,IntAct
PTPN1 ESR1 14525934 24234451 25348397 7539106 dephosphorylation reaction experimental interaction detection,phosphatase assay,in vitro ComPPI,HPRD,IntAct
PTPN1 IRS1 10660596 11579209 14525934 24234451 25348397 dephosphorylation reaction experimental interaction detection,physical interaction,phosphatase assay,in vivo ComPPI,HPRD,IntAct
PTPN1 INSR 11163213 11506178 11579209 12237455 12634852 14525934 14722096 15588987 16582879 16926280 17092689 17159996 17481567 19029027 21806020 24234451 25348397 8702689 8826975 8999839 9355745 dephosphorylation reaction,phosphorylation reaction,colocalization,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,bioluminescence resonance energy transfer,coimmunoprecipitation,experimental interaction detection,filter binding,fluorescent resonance energy transfer,pull down,x-ray crystallography,physical interaction,genetic interference,protein kinase assay,phosphatase assay,in vitro,in vivo,bimolecular fluorescence complementation ComPPI,HPRD,IntAct
PTPN1 JAK2 11694501 11970898 14525934 15821101 21806020 24234451 25348397 dephosphorylation reaction,physical association coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,phosphatase assay,in vivo ComPPI,HPRD,IntAct
PTPN1 BCR 14525934 25348397 9566916 N/A experimental interaction detection,pull down,in vitro,in vivo ComPPI,HPRD
PTPN1 LTK 12237455 14525934 24234451 25348397 N/A experimental interaction detection,filter binding,physical interaction,in vitro ComPPI,HPRD,IntAct
PTPN1 AKT1 11579209 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PTPN1 BCAR1 10889023 14525934 15588985 15866871 24234451 25348397 8940134 9407132 9418872 dephosphorylation reaction,association,physical association anti bait coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,filter binding,physical interaction,phosphatase assay ComPPI,HPRD,IntAct
PTPN1 NTRK3 12237455 14525934 24234451 25348397 N/A experimental interaction detection,filter binding,physical interaction ComPPI,HPRD,IntAct
PTPN1 STAM2 25348397 N/A physical interaction ComPPI
PTPN1 ILF3 25348397 N/A physical interaction ComPPI
PTPN1 SLC25A3 25348397 N/A physical interaction ComPPI
PTPN1 MCAT 25348397 N/A physical interaction ComPPI
PTPN1 MARCKSL1 25348397 N/A physical interaction ComPPI
PTPN1 LAMTOR3 25348397 N/A physical interaction ComPPI
PTPN1 HNRNPU 25348397 N/A physical interaction ComPPI
PTPN1 ZMPSTE24 25348397 N/A physical interaction ComPPI
PTPN1 STAT3 11970898 15821101 24234451 25348397 dephosphorylation reaction physical interaction,phosphatase assay ComPPI,IntAct
PTPN1 ATP4A 25348397 N/A physical interaction ComPPI
PTPN1 IL1B 25348397 N/A physical interaction ComPPI
PTPN1 ASGR2 25348397 N/A physical interaction ComPPI
PTPN1 HMOX2 25348397 N/A physical interaction ComPPI
PTPN1 SLC39A4 25348397 N/A physical interaction ComPPI
PTPN1 LYPD3 25348397 N/A physical interaction ComPPI
PTPN1 ENPP6 25348397 N/A physical interaction ComPPI
PTPN1 ZACN 25348397 N/A physical interaction ComPPI
PTPN1 PLTP 25348397 N/A physical interaction ComPPI
PTPN1 LYPD6 25348397 N/A physical interaction ComPPI
PTPN1 BCAS3 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PTPN1 CASC3 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PTPN1 CASZ1 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PTPN1 CCL5 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PTPN1 CDH13 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PTPN1 DIRAS3 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PTPN1 KLK7 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PTPN1 MRC2 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PTPN1 RHOBTB2 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PTPN1 VPS45 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PTPN1 HERC2 25348397 N/A physical interaction ComPPI
PTPN1 HERC2P3 25348397 N/A physical interaction ComPPI
PTPN1 TCTN2 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
PTPN1 TCTN3 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
PTPN1 EVC2 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
PTPN1 TMEM17 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
PTPN1 TMEM216 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
PTPN1 ATP6V0A1 25348397 N/A physical interaction ComPPI
PTPN1 COL5A1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PTPN1 STOM 25348397 N/A physical interaction ComPPI
PTPN1 FLOT2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PTPN1 GALNT2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PTPN1 MSN 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PTPN1 PHB 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PTPN1 SMARCD2 25348397 N/A physical interaction ComPPI
PTPN1 ATP6V0D1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PTPN1 GOSR1 25348397 N/A physical interaction ComPPI
PTPN1 FLOT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PTPN1 PHB2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PTPN1 LTN1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PTPN1 GOLIM4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PTPN1 BCOR 25348397 N/A physical interaction ComPPI
PTPN1 WRAP53 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PTPN1 MREG 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PTPN1 PCNP 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PTPN1 KIDINS220 25348397 N/A physical interaction ComPPI
PTPN1 RNF213 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PTPN1 ARHGAP39 25348397 N/A physical interaction ComPPI
PTPN1 CAVIN1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PTPN1 APLP2 25348397 N/A physical interaction ComPPI
PTPN1 GOLM2 25348397 N/A physical interaction ComPPI
PTPN1 SNRPD2 25348397 N/A physical interaction ComPPI
PTPN1 TOMM70 25348397 N/A physical interaction ComPPI
PTPN1 CTDNEP1 25348397 N/A physical interaction ComPPI
PTPN1 C5AR2 25348397 N/A physical interaction ComPPI
PTPN1 TMEM63A 25348397 N/A physical interaction ComPPI
PTPN1 C3AR1 25348397 N/A physical interaction ComPPI
PTPN1 GPR21 25348397 N/A physical interaction ComPPI
PTPN1 GHITM 25348397 N/A physical interaction ComPPI
PTPN1 SLCO6A1 25348397 N/A physical interaction ComPPI
PTPN1 TMPRSS3 25348397 N/A physical interaction ComPPI
PTPN1 AMTN 25348397 N/A physical interaction ComPPI
PTPN1 MRAP2 25348397 N/A physical interaction ComPPI
PTPN1 ADGRG5 25348397 N/A physical interaction ComPPI
PTPN1 FAM234B 25348397 N/A physical interaction ComPPI
PTPN1 SLC39A12 25348397 N/A physical interaction ComPPI
PTPN1 APLNR 25348397 N/A physical interaction ComPPI
PTPN1 DUSP1 25348397 N/A physical interaction ComPPI
PTPN1 PISD 25348397 N/A physical interaction ComPPI
PTPN1 COX11 25348397 N/A physical interaction ComPPI
PTPN1 NARS1 25348397 N/A physical interaction ComPPI
PTPN1 PTRH2 25348397 N/A physical interaction ComPPI
PTPN1 TBC1D15 25348397 N/A physical interaction ComPPI
PTPN1 PFN2 25348397 N/A physical interaction ComPPI
PTPN1 ARL1 25348397 N/A physical interaction ComPPI
PTPN1 DHCR24 25348397 N/A physical interaction ComPPI
PTPN1 RAB5C 25348397 N/A physical interaction ComPPI
PTPN1 PGRMC1 25348397 N/A physical interaction ComPPI
PTPN1 SEC61A1 25348397 N/A physical interaction ComPPI
PTPN1 CDIPT 25348397 N/A physical interaction ComPPI
PTPN1 SLC27A4 25348397 N/A physical interaction ComPPI
PTPN1 DHCR7 25348397 N/A physical interaction ComPPI
PTPN1 TRIP13 25348397 N/A physical interaction ComPPI
PTPN1 HEATR3 25348397 N/A physical interaction ComPPI
PTPN1 PCMT1 25348397 N/A physical interaction ComPPI
PTPN1 ARF1 25348397 N/A physical interaction ComPPI
PTPN1 CCDC47 25348397 N/A physical interaction ComPPI
PTPN1 CDK4 25348397 N/A physical interaction ComPPI
PTPN1 FLAD1 25348397 N/A physical interaction ComPPI
PTPN1 RMDN3 20627780 21972092 24234451 25348397 27898060 colocalization,physical association physical interaction,fluorescence microscopy,proximity ligation assay ComPPI,IntAct,OmniPath
PTPN1 EPS15 25348397 N/A dephosphorylation reaction,phosphatase assay ComPPI
PTPN1 PSTPIP1 24234451 25348397 9857189 physical association coimmunoprecipitation ComPPI,IntAct
PTPN1 MET 16537444 18579758 22789536 24234451 25348397 dephosphorylation reaction,physical association anti bait coimmunoprecipitation,cross-linking study,phosphatase assay ComPPI,IntAct
PTPN1 ABL1 16537444 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
PTPN1 EPOR 14527337 24234451 25348397 dephosphorylation reaction,physical association coimmunoprecipitation,pull down,phosphatase assay ComPPI,IntAct
PTPN1 PRKCG 17092689 24234451 25348397 physical association bimolecular fluorescence complementation ComPPI,IntAct
PTPN1 CTTN 18387954 24234451 25348397 physical association pull down ComPPI,IntAct
PTPN1 CAPN1 19712109 24234451 25348397 9407132 cleavage reaction,enzymatic reaction,physical association enzyme linked immunosorbent assay,protease assay ComPPI,IntAct
PTPN1 SLC4A1 24234451 25348397 27898060 8615784 colocalization,physical association coimmunoprecipitation,cosedimentation,cosedimentation in solution ComPPI,IntAct,OmniPath
PTPN1 TXN 24234451 24976139 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
PTPN1 AQP6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PTPN1 ELOVL4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PTPN1 PTPN2 24234451 25348397 28330616 physical association pull down ComPPI,IntAct
PTPN1 COX14 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PTPN1 LAMP1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PTPN1 RAB9A 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PTPN1 TGOLN2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PTPN1 TOMM20 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PTPN1 STING1 24234451 25348397 29251827 association anti bait coimmunoprecipitation ComPPI,IntAct
NFKBIA PTPN1 14525934 24234451 25348397 8940099 dephosphorylation reaction experimental interaction detection,phosphatase assay,in vivo ComPPI,HPRD,IntAct
CSNK2A2 PTPN1 14525934 25348397 8491187 9600099 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
ASS1 PTPN1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
ARF4 PTPN1 25348397 N/A physical interaction ComPPI
ATF2 PTPN1 22304920 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IGF1R PTPN1 14525934 15976035 16926280 24234451 25348397 8999839 physical association bioluminescence resonance energy transfer,coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
PLGRKT PTPN1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
ILVBL PTPN1 25348397 N/A physical interaction ComPPI
MGST3 PTPN1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
ATP6V1B2 PTPN1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DCUN1D5 PTPN1 25348397 N/A physical interaction ComPPI
HSCB PTPN1 24234451 25348397 28380382 association anti bait coimmunoprecipitation ComPPI,IntAct
TMEM86B PTPN1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
THRSP PTPN1 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CDK1 PTPN1 14525934 8491187 9600099 N/A experimental interaction detection HPRD
PTPN1 PTPN1 11506178 24234451 dephosphorylation reaction phosphatase assay IntAct
SRC PTPN1 11007774 12468645 12857726 16115959 16537444 17092689 17974954 27898060 8647855 9261115 9600099 N/A N/A OmniPath
PTPN1 SRC 11007774 12468645 12857726 15866871 16115959 16537444 17092689 17974954 27898060 8647855 9261115 9600099 stimulant N/A OmniPath
PTPN1 PLCG1 21123182 27898060 N/A N/A OmniPath
PRKCA PTPN1 27898060 8491187 N/A N/A OmniPath
PTPN1 NTRK2 12237455 27898060 N/A N/A OmniPath
PTPN1 CTNNB1 12377785 17087658 27898060 9786960 stimulant N/A OmniPath
PTPN1 EPOR 14527337 27898060 N/A N/A OmniPath
PTPN1 CTTN 18387954 27898060 N/A N/A OmniPath
PTPN1 TRPV6 15894168 17197020 27898060 inhibition N/A OmniPath
PTPN1 NTRK1 12237455 27898060 N/A N/A OmniPath
EGFR PTPN1 10889023 11506178 12573287 15982634 24658140 25402006 25796184 27898060 7540771 8491187 8621392 9050838 9355745 inhibition,stimulant N/A OmniPath
PTPN1 EGFR 10889023 11506178 12424235 12573287 15982634 21123182 24658140 25402006 25796184 27898060 7540771 8621392 9050838 9355745 inhibition N/A OmniPath
PTPN1 ACTN1 16291744 27898060 inhibition,stimulant N/A OmniPath
PTPN1 CAV1 12176037 16388599 27898060 inhibition N/A OmniPath
PTPN1 PRKCD 11350745 27898060 inhibition N/A OmniPath
PTPN1 STAT6 18716132 27898060 N/A N/A OmniPath
PTPN1 PDGFRB 12614164 18567737 19167335 27898060 7545675 7693671 9355745 inhibition N/A OmniPath
PTPN1 LAT 12857726 27898060 inhibition N/A OmniPath
PTPN1 IGF1R 11884589 15976035 16926280 27898060 8702689 8999839 inhibition,stimulant N/A OmniPath
PTPN1 STAT5A 10993888 12237455 27898060 inhibition N/A OmniPath
PTPN1 ESR1 27898060 7539106 N/A N/A OmniPath
PTPN1 AKT1 11579209 15632081 27898060 inhibition N/A OmniPath
AKT1 PTPN1 10480872 11579209 15632081 17081983 18691976 27898060 inhibition N/A OmniPath
PTPN1 IRS1 10660596 11579209 1157921 15632081 27898060 inhibition,stimulant N/A OmniPath
PTPN1 PTK2 16291744 27898060 9418872 inhibition N/A OmniPath
PTPN1 PTPN6 21123182 27898060 N/A N/A OmniPath
PTPN1 GAB1 21123182 27898060 N/A N/A OmniPath
PTPN1 TYK2 11694501 15780598 27898060 inhibition,stimulant N/A OmniPath
PTPN1 ABL1 16537444 27898060 9566916 inhibition N/A OmniPath
PTPN1 NFKBIA 27898060 8940099 inhibition N/A OmniPath
CDK1 PTPN1 23348582 27898060 8491187 9600099 N/A N/A OmniPath
PTPN1 CRK 12799422 27898060 inhibition N/A OmniPath
PTPN1 RAF1 27898060 7604263 N/A N/A OmniPath
PTPN1 GHR 12907755 27898060 N/A N/A OmniPath
PTPN1 BCAR1 10889023 15588985 15866871 27898060 8940134 9407132 9418872 N/A N/A OmniPath
BCAR1 PTPN1 10889023 15588985 15866871 27898060 8940134 9407132 9418872 N/A N/A OmniPath
PTPN1 BCR 27898060 9566916 inhibition N/A OmniPath
PTPN1 PTPN11 21123182 27898060 N/A N/A OmniPath
CSNK2A1 PTPN1 18691976 20068231 27898060 8491187 9600099 N/A N/A OmniPath
PTPN1 MET 16537444 18579758 18819921 22789536 27898060 inhibition N/A OmniPath
AKT2 PTPN1 11579209 27898060 inhibition N/A OmniPath
INSR PTPN1 11106648 11163213 11506178 11579209 12237455 12612081 12634852 14722096 15588987 16271887 16582879 16926280 17092689 17159996 17481567 19029027 21806020 27898060 8491187 8702689 8826975 8999839 9355745 inhibition N/A OmniPath
PTPN1 INSR 11163213 11506178 11579209 12237455 12612081 12634852 14722096 15588987 15632081 16271887 16582879 16926280 17092689 17159996 17481567 19029027 21806020 27898060 8702689 8826975 8999839 9355745 inhibition,stimulant N/A OmniPath
PTPN1 GSK3B 27898060 7514173 N/A N/A OmniPath
PTPN1 STAT3 11970898 15821101 27898060 inhibition,stimulant N/A OmniPath
PTPN1 JAK2 11694501 11970898 15780598 158211 15821101 21806020 27898060 inhibition,stimulant N/A OmniPath
PTPN1 STAT5B 10993888 12237455 27898060 inhibition N/A OmniPath
PTPN1 ROS1 17416557 27898060 inhibition N/A OmniPath
GRAP PTPN1 10660596 27898060 stimulant N/A OmniPath
PTPN1 DOK1 14766979 27898060 inhibition N/A OmniPath
CLK1 PTPN1 10480872 11106648 11579209 18691976 27898060 8491187 8999839 stimulant N/A OmniPath
CSNK2A2 PTPN1 18691976 20068231 27898060 8491187 9600099 N/A N/A OmniPath
EPHB3 PTPN1 11579209 27898060 N/A N/A OmniPath
PTPN1 EPHA3 21135139 27898060 inhibition N/A OmniPath
CLK2 PTPN1 10480872 11579209 18691976 23481236 27898060 stimulant N/A OmniPath
PTPN1 NSF 19208619 27898060 inhibition N/A OmniPath
PTPN1 STAM2 20504764 27898060 stimulant N/A OmniPath
PTPN1 MAPK15 16336213 27898060 inhibition N/A OmniPath

Visualization