GENE:PTPN2
GeneInfo:
GeneAttribute | GeneDescription |
---|---|
GeneSymbol | PTPN2 |
FullNmae | protein tyrosine phosphatase non-receptor type 2 |
LocusType | gene with protein product |
Status | Approved |
HGNC_id | HGNC:9650 |
EnsembleID | ENSG00000175354 |
Uniprot | P17706 |
Protein Structure:
Gene Description in Publicaton:
GeneSymbol | CellDeathType | PMID | Description | GeneType |
---|---|---|---|---|
PTPN2 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
PTPN2 | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
PTPN2 | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
GeneSymbol | Go id |
---|---|
PTPN2 | GO:0000122,GO:0004725,GO:0004725,GO:0004725,GO:0004725,GO:0004726,GO:0005178,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0005737,GO:0005783,GO:0005793,GO:0005829,GO:0005829,GO:0005886,GO:0008285,GO:0008286,GO:0010804,GO:0010888,GO:0019901,GO:0019901,GO:0019905,GO:0030183,GO:0030217,GO:0030218,GO:0030971,GO:0031904,GO:0035335,GO:0035335,GO:0038020,GO:0042059,GO:0042532,GO:0042593,GO:0045650,GO:0045722,GO:0046426,GO:0046627,GO:0050728,GO:0050860,GO:0050922,GO:0060334,GO:0060336,GO:0060339,GO:0070104,GO:0070373,GO:0070373,GO:0097677,GO:1902202,GO:1902206,GO:1902215,GO:1902227,GO:1902233,GO:1902237,GO:1903899,GO:2000587 |
KEGG Annotation:
GeneSymbol | GeneID | Pathway | Pathway Name |
---|---|---|---|
PTPN2 | hsa:5771 | path:hsa04630 | JAK-STAT signaling pathway - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
PTPN2 | STAT1 | 12138178 12171910 12270932 12923054 15699106 19833085 23180781 23331499 26192618 | interaction type,dephosphorylation reaction,stimulation,physical association | anti tag coimmunoprecipitation,dephosphorylation reaction | ACSN,InnateDB,SignaLink,SignaLink |
PTPN2 | STAT6 | 17210636 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
PTPN2 | KPNB1 | 23180781 9261175 | physical association | anti tag coimmunoprecipitation,gst pull down | InnateDB |
PTPN2 | TRAF2 | 15616169 15696169 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
PTPN2 | JAK1 | 11909529 23331499 | stimulation | N/A | SignaLink,SignaLink |
PTPN2 | STAT5A | 11773439 23331499 | stimulation | N/A | SignaLink |
PTPN2 | INSR | 15632081 23331499 | stimulation | N/A | SignaLink |
PTPN2 | JAK3 | 15780598 23331499 | stimulation | N/A | SignaLink |
PTPN2 | STAT3 | 12359225 23331499 | interaction type | N/A | SignaLink |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
AR | PTPN2 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
ETS1 | PTPN2 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
YBX1 | PTPN2 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
FOXP3 | PTPN2 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
SMARCA4 | PTPN2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
CEBPA | PTPN2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
CTCF | PTPN2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
E2F1 | PTPN2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
E2F4 | PTPN2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
EGR1 | PTPN2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
FOXA1 | PTPN2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
FOS | PTPN2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
GATA2 | PTPN2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
HNF4A | PTPN2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
MITF | PTPN2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
RUNX1 | PTPN2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
SPI1 | PTPN2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
URS000055128B | PTPN2 | 23579275 25416803 | mrna cleavage,inhibition | western blot,chromatin immunoprecipitation assay,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
URS00003BD367 | PTPN2 | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00003380CC | PTPN2 | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
URS0000008A99 | PTPN2 | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
URS000048D44E | PTPN2 | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
URS0000086A4D | PTPN2 | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
URS00001481F9 | PTPN2 | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
URS0000221168 | PTPN2 | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
URS00003E226A | PTPN2 | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
URS00005CC20C | PTPN2 | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
URS000075BDAA | PTPN2 | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
URS00000EC1BE | PTPN2 | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
STAT3 | PTPN2 | 25361965 | interaction type | N/A | PTMCode2 |
PTPN2 | STAT3 | 25361965 | interaction type | N/A | PTMCode2 |
FKBP4 | PTPN2 | 25361965 | interaction type | N/A | PTMCode2 |
PTPN2 | FKBP4 | 25361965 | interaction type | N/A | PTMCode2 |
EGFR | PTPN2 | 25361965 | interaction type | N/A | PTMCode2 |
PTPN2 | EGFR | 25361965 | interaction type | N/A | PTMCode2 |
ITGA1 | PTPN2 | 25361965 | interaction type | N/A | PTMCode2 |
PTPN2 | ITGA1 | 25361965 | interaction type | N/A | PTMCode2 |
PTPN2 | STAT5A | 25361965 | interaction type | N/A | PTMCode2 |
STAT5A | PTPN2 | 25361965 | interaction type | N/A | PTMCode2 |
PTPN2 | JAK1 | 25361965 | interaction type | N/A | PTMCode2 |
JAK1 | PTPN2 | 25361965 | interaction type | N/A | PTMCode2 |
PTPN2 | SRC | 25361965 | interaction type | N/A | PTMCode2 |
SRC | PTPN2 | 25361965 | interaction type | N/A | PTMCode2 |
PTPN2 | JAK3 | 25361965 | interaction type | N/A | PTMCode2 |
JAK3 | PTPN2 | 25361965 | interaction type | N/A | PTMCode2 |
INSR | PTPN2 | 25361965 | interaction type | N/A | PTMCode2 |
PTPN2 | INSR | 25361965 | interaction type | N/A | PTMCode2 |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
BYSL | PTPN2 | 25348397 | N/A | physical interaction | ComPPI |
WASL | PTPN2 | 16293614 24234451 25348397 | dephosphorylation reaction | phosphatase assay | ComPPI,IntAct |
CDC42 | PTPN2 | 16293614 24234451 25348397 | phosphorylation reaction | phosphatase assay | ComPPI,IntAct |
KPNA5 | PTPN2 | 25348397 | N/A | physical interaction | ComPPI |
ANP32B | PTPN2 | 25348397 | N/A | physical interaction | ComPPI |
BAG3 | PTPN2 | 25348397 | N/A | physical interaction | ComPPI |
PSMC6 | PTPN2 | 25348397 | N/A | physical interaction | ComPPI |
STAT1 | PTPN2 | 25348397 | N/A | physical interaction,in vitro | ComPPI |
PSMD14 | PTPN2 | 25348397 | N/A | physical interaction | ComPPI |
KPNA1 | PTPN2 | 25348397 | N/A | physical interaction | ComPPI |
PTPN6 | PTPN2 | 25348397 | N/A | physical interaction | ComPPI |
MRM3 | PTPN2 | 25348397 | N/A | physical interaction | ComPPI |
NMNAT1 | PTPN2 | 25348397 | N/A | physical interaction | ComPPI |
OCLN | PTPN2 | 25348397 | N/A | physical interaction | ComPPI |
SRC | PTPN2 | 25348397 | N/A | physical interaction,in vitro,in vivo | ComPPI |
SHC1 | PTPN2 | 25348397 | N/A | in vitro,in vivo | ComPPI |
KPNB1 | PTPN2 | 25348397 27898060 9261175 | N/A | in vitro | ComPPI,OmniPath |
PDGFRB | PTPN2 | 25348397 | N/A | in vitro,in vivo | ComPPI |
GHR | PTPN2 | 12907755 24234451 25348397 | dephosphorylation reaction,physical association | array technology,far western blotting,physical interaction,phosphatase assay,in vitro | ComPPI,IntAct |
UBC | PTPN2 | 25348397 | N/A | physical interaction | ComPPI |
JAK1 | PTPN2 | 25348397 | N/A | in vitro,in vivo | ComPPI |
PTPN1 | PTPN2 | 24234451 25348397 28330616 | physical association | pull down | ComPPI,IntAct |
PTPN2 | ITGA1 | 15592458 24234451 25348397 | colocalization,physical association | anti bait coimmunoprecipitation,two hybrid,fluorescence microscopy,in vitro | ComPPI,IntAct |
PTPN2 | JAK3 | 25348397 | N/A | in vitro,in vivo | ComPPI |
PTPN2 | STAT5A | 25348397 | N/A | in vitro,in vivo | ComPPI |
PTPN2 | STAT5B | 25348397 | N/A | in vitro,in vivo | ComPPI |
PTPN2 | FKBP4 | 25348397 | N/A | in vitro | ComPPI |
PTPN2 | STAT3 | 25348397 | N/A | physical interaction,in vitro,in vivo | ComPPI |
PTPN2 | CDK2 | 25348397 | N/A | in vitro,in vivo | ComPPI |
PTPN2 | CDK5 | 25348397 | N/A | in vitro,in vivo | ComPPI |
PTPN2 | EGFR | 25348397 | N/A | physical interaction,genetic,in vitro,in vivo | ComPPI |
PTPN2 | INSR | 25348397 | N/A | anti bait coimmunoprecipitation,in vitro,in vivo | ComPPI |
PTPN2 | SFN | 15778465 24234451 25348397 | physical association | physical interaction,tandem affinity purification | ComPPI,IntAct |
PTPN2 | UCHL5 | 19615732 24234451 25348397 | physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
PTPN2 | TRAF2 | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | KATNB1 | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | HSPD1 | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | STAT6 | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | SLC39A4 | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | COL5A1 | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | EEF1AKNMT | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | VARS1 | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | TCTN2 | 24234451 25348397 26638075 | association | physical interaction,proximity-dependent biotin identification | ComPPI,IntAct |
PTPN2 | TMEM17 | 24234451 25348397 26638075 | association | physical interaction,proximity-dependent biotin identification | ComPPI,IntAct |
PTPN2 | TMEM216 | 24234451 25348397 26638075 | association | physical interaction,proximity-dependent biotin identification | ComPPI,IntAct |
PTPN2 | PSMC1 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
PTPN2 | APLP2 | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | APP | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | GOLM2 | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | CSPG5 | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | GOLIM4 | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | HADHA | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | HARS1 | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | HMGN5 | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | NUP50 | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | PSMC2 | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | PSMC4 | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | PSMC5 | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | PSMD1 | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | PSMD10 | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | PSMD2 | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | PSMD4 | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | PSMD6 | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | SETD7 | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | C5AR2 | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | B4GAT1 | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | C3AR1 | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | ASGR1 | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | TNFSF8 | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | SLC39A5 | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | PTPN20 | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | ANP32C | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | TXNDC5 | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | ANP32E | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | RCL1 | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | BRIX1 | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | GAR1 | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | PNO1 | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | GADD45GIP1 | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | ZC3HAV1L | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | DIMT1 | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | NSUN5 | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | DNAJC10 | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | C8ORF33 | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | G3BP1 | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | FTSJ3 | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | EIF2S1 | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | PSMD13 | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | RBM34 | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | CASKIN1 | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | PSMC3IP | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | GTPBP10 | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | PSMD8 | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | RPL3L | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | TFB1M | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | RPP30 | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | DUSP10 | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | EXOSC4 | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | GRSF1 | 25348397 | N/A | physical interaction | ComPPI |
PTPN2 | TMED9 | 25348397 | N/A | two hybrid | ComPPI |
PTPN2 | TMED10 | 25348397 | N/A | two hybrid | ComPPI |
PTPN2 | GOLGB1 | 25348397 | N/A | confocal microscopy | ComPPI |
PTPN2 | LMAN1 | 25348397 | N/A | confocal microscopy | ComPPI |
KPNA6 | PTPN2 | 25348397 | N/A | physical interaction | ComPPI |
CALU | PTPN2 | 25348397 | N/A | physical interaction | ComPPI |
TRMT61B | PTPN2 | 25348397 | N/A | physical interaction | ComPPI |
HNRNPM | PTPN2 | 24234451 30021884 | physical association | cross-linking study | IntAct |
CDK5 | PTPN2 | 15030318 18669648 18767875 19413330 19651622 20068231 27898060 | N/A | N/A | OmniPath |
PTPN2 | SRC | 15696169 22080863 27898060 | inhibition | N/A | OmniPath |
PTPN2 | GJA1 | 24849651 27898060 | stimulant | N/A | OmniPath |
PTPN2 | FKBP4 | 12552015 15509512 27898060 | inhibition | N/A | OmniPath |
PTPN2 | FYN | 22080863 27898060 | inhibition | N/A | OmniPath |
PTPN2 | EGFR | 10488121 11479308 11514572 15588985 15592458 27898060 9488479 | inhibition | N/A | OmniPath |
PTPN2 | CAV1 | 20940300 27898060 | N/A | N/A | OmniPath |
PTPN2 | STAT6 | 17210636 27898060 | inhibition | N/A | OmniPath |
PTPN2 | PDGFRB | 14966296 15588985 27898060 | stimulant | N/A | OmniPath |
TRAF2 | PTPN2 | 15616169 15696169 27898060 | N/A | N/A | OmniPath |
PTPN2 | JAK3 | 11909529 15588985 15780598 27898060 | inhibition,stimulant | N/A | OmniPath |
PTPN2 | KDR | 18840653 19737086 27898060 | inhibition | N/A | OmniPath |
PTPN2 | STAT5A | 11773439 15588985 15780598 27898060 | inhibition,stimulant | N/A | OmniPath |
CDK2 | PTPN2 | 15030318 18669648 18767875 19413330 19651622 20068231 27898060 | N/A | N/A | OmniPath |
PTPN2 | WASL | 16293614 27898060 | inhibition | N/A | OmniPath |
PTPN2 | STAT1 | 12138178 12171910 12923054 14600148 15780598 19171783 19737086 27898060 | inhibition,stimulant | N/A | OmniPath |
PTPN2 | JAK1 | 11909529 15588985 15780598 27898060 | inhibition,stimulant | N/A | OmniPath |
PTPN2 | SHC1 | 15588985 27898060 9488479 | inhibition | N/A | OmniPath |
CDK1 | PTPN2 | 15030318 18669648 18767875 19413330 19651622 20068231 27898060 | N/A | N/A | OmniPath |
PTPN2 | MET | 18819921 27898060 | inhibition | N/A | OmniPath |
PTPN2 | INSR | 10734133 12612081 1373652 15192089 15588985 15632081 27898060 | inhibition,stimulant | N/A | OmniPath |
PTPN2 | STAT3 | 12138178 12359225 15588985 15780598 19737086 27898060 | inhibition | N/A | OmniPath |
PTPN2 | STAT5B | 11773439 15588985 27898060 | inhibition | N/A | OmniPath |