Gene Information gene info

GENE:PTPN2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PTPN2
FullNmae protein tyrosine phosphatase non-receptor type 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9650
EnsembleID ENSG00000175354
Uniprot P17706

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PTPN2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PTPN2 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PTPN2 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
PTPN2 GO:0000122,GO:0004725,GO:0004725,GO:0004725,GO:0004725,GO:0004726,GO:0005178,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0005737,GO:0005783,GO:0005793,GO:0005829,GO:0005829,GO:0005886,GO:0008285,GO:0008286,GO:0010804,GO:0010888,GO:0019901,GO:0019901,GO:0019905,GO:0030183,GO:0030217,GO:0030218,GO:0030971,GO:0031904,GO:0035335,GO:0035335,GO:0038020,GO:0042059,GO:0042532,GO:0042593,GO:0045650,GO:0045722,GO:0046426,GO:0046627,GO:0050728,GO:0050860,GO:0050922,GO:0060334,GO:0060336,GO:0060339,GO:0070104,GO:0070373,GO:0070373,GO:0097677,GO:1902202,GO:1902206,GO:1902215,GO:1902227,GO:1902233,GO:1902237,GO:1903899,GO:2000587

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PTPN2 hsa:5771 path:hsa04630 JAK-STAT signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PTPN2 STAT1 12138178 12171910 12270932 12923054 15699106 19833085 23180781 23331499 26192618 interaction type,dephosphorylation reaction,stimulation,physical association anti tag coimmunoprecipitation,dephosphorylation reaction ACSN,InnateDB,SignaLink,SignaLink
PTPN2 STAT6 17210636 23180781 physical association anti tag coimmunoprecipitation InnateDB
PTPN2 KPNB1 23180781 9261175 physical association anti tag coimmunoprecipitation,gst pull down InnateDB
PTPN2 TRAF2 15616169 15696169 23180781 physical association anti tag coimmunoprecipitation InnateDB
PTPN2 JAK1 11909529 23331499 stimulation N/A SignaLink,SignaLink
PTPN2 STAT5A 11773439 23331499 stimulation N/A SignaLink
PTPN2 INSR 15632081 23331499 stimulation N/A SignaLink
PTPN2 JAK3 15780598 23331499 stimulation N/A SignaLink
PTPN2 STAT3 12359225 23331499 interaction type N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR PTPN2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 PTPN2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 PTPN2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 PTPN2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 PTPN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PTPN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PTPN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 PTPN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 PTPN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PTPN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PTPN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PTPN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 PTPN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PTPN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF PTPN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 PTPN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 PTPN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000055128B PTPN2 23579275 25416803 mrna cleavage,inhibition western blot,chromatin immunoprecipitation assay,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00003BD367 PTPN2 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00003380CC PTPN2 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS0000008A99 PTPN2 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000048D44E PTPN2 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS0000086A4D PTPN2 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00001481F9 PTPN2 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS0000221168 PTPN2 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00003E226A PTPN2 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00005CC20C PTPN2 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000075BDAA PTPN2 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00000EC1BE PTPN2 25416803 27418678 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
STAT3 PTPN2 25361965 interaction type N/A PTMCode2
PTPN2 STAT3 25361965 interaction type N/A PTMCode2
FKBP4 PTPN2 25361965 interaction type N/A PTMCode2
PTPN2 FKBP4 25361965 interaction type N/A PTMCode2
EGFR PTPN2 25361965 interaction type N/A PTMCode2
PTPN2 EGFR 25361965 interaction type N/A PTMCode2
ITGA1 PTPN2 25361965 interaction type N/A PTMCode2
PTPN2 ITGA1 25361965 interaction type N/A PTMCode2
PTPN2 STAT5A 25361965 interaction type N/A PTMCode2
STAT5A PTPN2 25361965 interaction type N/A PTMCode2
PTPN2 JAK1 25361965 interaction type N/A PTMCode2
JAK1 PTPN2 25361965 interaction type N/A PTMCode2
PTPN2 SRC 25361965 interaction type N/A PTMCode2
SRC PTPN2 25361965 interaction type N/A PTMCode2
PTPN2 JAK3 25361965 interaction type N/A PTMCode2
JAK3 PTPN2 25361965 interaction type N/A PTMCode2
INSR PTPN2 25361965 interaction type N/A PTMCode2
PTPN2 INSR 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
BYSL PTPN2 25348397 N/A physical interaction ComPPI
WASL PTPN2 16293614 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
CDC42 PTPN2 16293614 24234451 25348397 phosphorylation reaction phosphatase assay ComPPI,IntAct
KPNA5 PTPN2 25348397 N/A physical interaction ComPPI
ANP32B PTPN2 25348397 N/A physical interaction ComPPI
BAG3 PTPN2 25348397 N/A physical interaction ComPPI
PSMC6 PTPN2 25348397 N/A physical interaction ComPPI
STAT1 PTPN2 25348397 N/A physical interaction,in vitro ComPPI
PSMD14 PTPN2 25348397 N/A physical interaction ComPPI
KPNA1 PTPN2 25348397 N/A physical interaction ComPPI
PTPN6 PTPN2 25348397 N/A physical interaction ComPPI
MRM3 PTPN2 25348397 N/A physical interaction ComPPI
NMNAT1 PTPN2 25348397 N/A physical interaction ComPPI
OCLN PTPN2 25348397 N/A physical interaction ComPPI
SRC PTPN2 25348397 N/A physical interaction,in vitro,in vivo ComPPI
SHC1 PTPN2 25348397 N/A in vitro,in vivo ComPPI
KPNB1 PTPN2 25348397 27898060 9261175 N/A in vitro ComPPI,OmniPath
PDGFRB PTPN2 25348397 N/A in vitro,in vivo ComPPI
GHR PTPN2 12907755 24234451 25348397 dephosphorylation reaction,physical association array technology,far western blotting,physical interaction,phosphatase assay,in vitro ComPPI,IntAct
UBC PTPN2 25348397 N/A physical interaction ComPPI
JAK1 PTPN2 25348397 N/A in vitro,in vivo ComPPI
PTPN1 PTPN2 24234451 25348397 28330616 physical association pull down ComPPI,IntAct
PTPN2 ITGA1 15592458 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,two hybrid,fluorescence microscopy,in vitro ComPPI,IntAct
PTPN2 JAK3 25348397 N/A in vitro,in vivo ComPPI
PTPN2 STAT5A 25348397 N/A in vitro,in vivo ComPPI
PTPN2 STAT5B 25348397 N/A in vitro,in vivo ComPPI
PTPN2 FKBP4 25348397 N/A in vitro ComPPI
PTPN2 STAT3 25348397 N/A physical interaction,in vitro,in vivo ComPPI
PTPN2 CDK2 25348397 N/A in vitro,in vivo ComPPI
PTPN2 CDK5 25348397 N/A in vitro,in vivo ComPPI
PTPN2 EGFR 25348397 N/A physical interaction,genetic,in vitro,in vivo ComPPI
PTPN2 INSR 25348397 N/A anti bait coimmunoprecipitation,in vitro,in vivo ComPPI
PTPN2 SFN 15778465 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
PTPN2 UCHL5 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PTPN2 TRAF2 25348397 N/A physical interaction ComPPI
PTPN2 KATNB1 25348397 N/A physical interaction ComPPI
PTPN2 HSPD1 25348397 N/A physical interaction ComPPI
PTPN2 STAT6 25348397 N/A physical interaction ComPPI
PTPN2 SLC39A4 25348397 N/A physical interaction ComPPI
PTPN2 COL5A1 25348397 N/A physical interaction ComPPI
PTPN2 EEF1AKNMT 25348397 N/A physical interaction ComPPI
PTPN2 VARS1 25348397 N/A physical interaction ComPPI
PTPN2 TCTN2 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
PTPN2 TMEM17 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
PTPN2 TMEM216 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
PTPN2 PSMC1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PTPN2 APLP2 25348397 N/A physical interaction ComPPI
PTPN2 APP 25348397 N/A physical interaction ComPPI
PTPN2 GOLM2 25348397 N/A physical interaction ComPPI
PTPN2 CSPG5 25348397 N/A physical interaction ComPPI
PTPN2 GOLIM4 25348397 N/A physical interaction ComPPI
PTPN2 HADHA 25348397 N/A physical interaction ComPPI
PTPN2 HARS1 25348397 N/A physical interaction ComPPI
PTPN2 HMGN5 25348397 N/A physical interaction ComPPI
PTPN2 NUP50 25348397 N/A physical interaction ComPPI
PTPN2 PSMC2 25348397 N/A physical interaction ComPPI
PTPN2 PSMC4 25348397 N/A physical interaction ComPPI
PTPN2 PSMC5 25348397 N/A physical interaction ComPPI
PTPN2 PSMD1 25348397 N/A physical interaction ComPPI
PTPN2 PSMD10 25348397 N/A physical interaction ComPPI
PTPN2 PSMD2 25348397 N/A physical interaction ComPPI
PTPN2 PSMD4 25348397 N/A physical interaction ComPPI
PTPN2 PSMD6 25348397 N/A physical interaction ComPPI
PTPN2 SETD7 25348397 N/A physical interaction ComPPI
PTPN2 C5AR2 25348397 N/A physical interaction ComPPI
PTPN2 B4GAT1 25348397 N/A physical interaction ComPPI
PTPN2 C3AR1 25348397 N/A physical interaction ComPPI
PTPN2 ASGR1 25348397 N/A physical interaction ComPPI
PTPN2 TNFSF8 25348397 N/A physical interaction ComPPI
PTPN2 SLC39A5 25348397 N/A physical interaction ComPPI
PTPN2 PTPN20 25348397 N/A physical interaction ComPPI
PTPN2 ANP32C 25348397 N/A physical interaction ComPPI
PTPN2 TXNDC5 25348397 N/A physical interaction ComPPI
PTPN2 ANP32E 25348397 N/A physical interaction ComPPI
PTPN2 RCL1 25348397 N/A physical interaction ComPPI
PTPN2 BRIX1 25348397 N/A physical interaction ComPPI
PTPN2 GAR1 25348397 N/A physical interaction ComPPI
PTPN2 PNO1 25348397 N/A physical interaction ComPPI
PTPN2 GADD45GIP1 25348397 N/A physical interaction ComPPI
PTPN2 ZC3HAV1L 25348397 N/A physical interaction ComPPI
PTPN2 DIMT1 25348397 N/A physical interaction ComPPI
PTPN2 NSUN5 25348397 N/A physical interaction ComPPI
PTPN2 DNAJC10 25348397 N/A physical interaction ComPPI
PTPN2 C8ORF33 25348397 N/A physical interaction ComPPI
PTPN2 G3BP1 25348397 N/A physical interaction ComPPI
PTPN2 FTSJ3 25348397 N/A physical interaction ComPPI
PTPN2 EIF2S1 25348397 N/A physical interaction ComPPI
PTPN2 PSMD13 25348397 N/A physical interaction ComPPI
PTPN2 RBM34 25348397 N/A physical interaction ComPPI
PTPN2 CASKIN1 25348397 N/A physical interaction ComPPI
PTPN2 PSMC3IP 25348397 N/A physical interaction ComPPI
PTPN2 GTPBP10 25348397 N/A physical interaction ComPPI
PTPN2 PSMD8 25348397 N/A physical interaction ComPPI
PTPN2 RPL3L 25348397 N/A physical interaction ComPPI
PTPN2 TFB1M 25348397 N/A physical interaction ComPPI
PTPN2 RPP30 25348397 N/A physical interaction ComPPI
PTPN2 DUSP10 25348397 N/A physical interaction ComPPI
PTPN2 EXOSC4 25348397 N/A physical interaction ComPPI
PTPN2 GRSF1 25348397 N/A physical interaction ComPPI
PTPN2 TMED9 25348397 N/A two hybrid ComPPI
PTPN2 TMED10 25348397 N/A two hybrid ComPPI
PTPN2 GOLGB1 25348397 N/A confocal microscopy ComPPI
PTPN2 LMAN1 25348397 N/A confocal microscopy ComPPI
KPNA6 PTPN2 25348397 N/A physical interaction ComPPI
CALU PTPN2 25348397 N/A physical interaction ComPPI
TRMT61B PTPN2 25348397 N/A physical interaction ComPPI
HNRNPM PTPN2 24234451 30021884 physical association cross-linking study IntAct
CDK5 PTPN2 15030318 18669648 18767875 19413330 19651622 20068231 27898060 N/A N/A OmniPath
PTPN2 SRC 15696169 22080863 27898060 inhibition N/A OmniPath
PTPN2 GJA1 24849651 27898060 stimulant N/A OmniPath
PTPN2 FKBP4 12552015 15509512 27898060 inhibition N/A OmniPath
PTPN2 FYN 22080863 27898060 inhibition N/A OmniPath
PTPN2 EGFR 10488121 11479308 11514572 15588985 15592458 27898060 9488479 inhibition N/A OmniPath
PTPN2 CAV1 20940300 27898060 N/A N/A OmniPath
PTPN2 STAT6 17210636 27898060 inhibition N/A OmniPath
PTPN2 PDGFRB 14966296 15588985 27898060 stimulant N/A OmniPath
TRAF2 PTPN2 15616169 15696169 27898060 N/A N/A OmniPath
PTPN2 JAK3 11909529 15588985 15780598 27898060 inhibition,stimulant N/A OmniPath
PTPN2 KDR 18840653 19737086 27898060 inhibition N/A OmniPath
PTPN2 STAT5A 11773439 15588985 15780598 27898060 inhibition,stimulant N/A OmniPath
CDK2 PTPN2 15030318 18669648 18767875 19413330 19651622 20068231 27898060 N/A N/A OmniPath
PTPN2 WASL 16293614 27898060 inhibition N/A OmniPath
PTPN2 STAT1 12138178 12171910 12923054 14600148 15780598 19171783 19737086 27898060 inhibition,stimulant N/A OmniPath
PTPN2 JAK1 11909529 15588985 15780598 27898060 inhibition,stimulant N/A OmniPath
PTPN2 SHC1 15588985 27898060 9488479 inhibition N/A OmniPath
CDK1 PTPN2 15030318 18669648 18767875 19413330 19651622 20068231 27898060 N/A N/A OmniPath
PTPN2 MET 18819921 27898060 inhibition N/A OmniPath
PTPN2 INSR 10734133 12612081 1373652 15192089 15588985 15632081 27898060 inhibition,stimulant N/A OmniPath
PTPN2 STAT3 12138178 12359225 15588985 15780598 19737086 27898060 inhibition N/A OmniPath
PTPN2 STAT5B 11773439 15588985 27898060 inhibition N/A OmniPath

Visualization