Gene Information gene info

GENE:PTPRC

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PTPRC
FullNmae protein tyrosine phosphatase receptor type C
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9666
EnsembleID ENSG00000081237
Uniprot P08575

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PTPRC immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PTPRC apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PTPRC apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
PTPRC GO:0000165,GO:0001779,GO:0001915,GO:0001916,GO:0001960,GO:0002244,GO:0002639,GO:0002925,GO:0004725,GO:0004725,GO:0004725,GO:0004725,GO:0005001,GO:0005102,GO:0005515,GO:0005886,GO:0005886,GO:0005886,GO:0005925,GO:0006469,GO:0006469,GO:0006469,GO:0006470,GO:0006470,GO:0006933,GO:0007159,GO:0007166,GO:0008201,GO:0009897,GO:0009898,GO:0009986,GO:0010332,GO:0010468,GO:0016020,GO:0016020,GO:0016311,GO:0019901,GO:0030183,GO:0030217,GO:0030506,GO:0030507,GO:0030667,GO:0030890,GO:0031668,GO:0031953,GO:0032059,GO:0032677,GO:0032703,GO:0032743,GO:0032760,GO:0034113,GO:0035584,GO:0042100,GO:0042102,GO:0042110,GO:0042492,GO:0043395,GO:0043410,GO:0044770,GO:0044855,GO:0045059,GO:0045060,GO:0045121,GO:0045588,GO:0045860,GO:0046425,GO:0046633,GO:0046641,GO:0048304,GO:0048539,GO:0048864,GO:0050731,GO:0050731,GO:0050764,GO:0050852,GO:0050852,GO:0050853,GO:0050857,GO:0051209,GO:0051607,GO:0051726,GO:0061097,GO:0061099,GO:0070062,GO:0070373,GO:0070374,GO:0097191,GO:0098857,GO:1903615,GO:1903979,GO:1904044,GO:1904155,GO:1905451,GO:2000473,GO:2000648,GO:2001238

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PTPRC hsa:5788 path:hsa04514 Cell adhesion molecules - Homo sapiens (human)
PTPRC hsa:5788 path:hsa04660 T cell receptor signaling pathway - Homo sapiens (human)
PTPRC hsa:5788 path:hsa04666 Fc gamma R-mediated phagocytosis - Homo sapiens (human)
PTPRC hsa:5788 path:hsa05132 Salmonella infection - Homo sapiens (human)
PTPRC hsa:5788 path:hsa05340 Primary immunodeficiency - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
FYN PTPRC 10591186 10648627 12218089 12414720 12731048 19290918 19909365 20814939 21378271 22683124 22863785 23620508 23886063 24440149 25312647 26192618 27192565 9738502 interaction type N/A ACSN
CD4 PTPRC 10398592 10652356 12731048 12740575 17544292 19290918 20814939 21127503 22513334 23620508 26192618 3263576 8478617 8986721 9438848 9738502 9751747 interaction type N/A ACSN
LCK PTPRC 10652356 12414720 12731048 12740575 17544292 19290918 20814939 21127503 22513334 23620508 23886063 25312647 26192618 3263576 8478617 8986721 9438848 9738502 9751747 interaction type N/A ACSN
B2M PTPRC 10358761 10559964 11154916 11509172 11717192 14508489 16181333 22076556 22790179 24457417 26192618 8642276 interaction type N/A ACSN
CD247 PTPRC 12414720 19290918 23620508 23886063 25312647 26192618 interaction type N/A ACSN
PTPRC SH2D1B 12414720 19290918 23620508 23886063 25312647 26192618 interaction type N/A ACSN
PTPRC SLAMF7 12414720 19290918 23620508 23886063 25312647 26192618 interaction type N/A ACSN
IRAK4 PTPRC 16574867 23180781 physical association anti tag coimmunoprecipitation InnateDB
CD22 PTPRC 15240561 16408005 23180781 7537381 physical association anti tag coimmunoprecipitation,pull down InnateDB
LGALS1 PTPRC 10490978 19635795 23180781 physical association anti tag coimmunoprecipitation,cross-linking study InnateDB
LGALS3 PTPRC 16393961 23180781 physical association pull down InnateDB
FLOT1 PTPRC 17634952 23180781 physical association anti tag coimmunoprecipitation InnateDB
PTPRC JAK3 11994288 23331499 stimulation N/A SignaLink,SignaLink
PTPRC JAK1 11201744 11994288 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
GAB1 PTPRC 20005715 interaction type N/A PSP,SignaLink
GRB2 PTPRC 20005715 interaction type N/A PSP
IRS1 PTPRC 20005715 interaction type N/A PSP
LCP2 PTPRC 20005715 interaction type N/A PSP
PPFIA1 PTPRC 20005715 interaction type N/A PSP
PRKCSH PTPRC 20005715 interaction type N/A PSP
PXN PTPRC 20005715 interaction type N/A PSP,SignaLink
SKAP1 PTPRC 11909961 20005715 21071413 interaction type N/A PSP,SignaLink
GRB2 PTPRC 20005715 N/A N/A SignaLink
IRS1 PTPRC 20005715 20005715 N/A N/A SignaLink
LCP2 PTPRC 18988627 20005715 20005715 8703037 N/A N/A SignaLink
PPFIA1 PTPRC 18988627 20005715 20005715 9624153 N/A N/A SignaLink
PRKCSH PTPRC 18988627 20005715 20005715 21071413 9148925 9148925 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR PTPRC 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 PTPRC 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 PTPRC 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 PTPRC 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 PTPRC 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 PTPRC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PTPRC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PTPRC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 PTPRC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PTPRC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HIF1A PTPRC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 PTPRC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 PTPRC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 PTPRC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ESR2 PTPRC 11517296 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 PTPRC N/A trascriptional regulation,stimulation inferred by curator TFlink
MYB PTPRC N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001FA076 PTPRC 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00000C36BD PTPRC 19536157 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CSK PTPRC 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
LCK PTPRC 25361965 interaction type N/A PTMCode2
PTPRC LCK 25361965 interaction type N/A PTMCode2
PTPRC FCGR3A 25361965 interaction type N/A PTMCode2
FCGR3A PTPRC 25361965 interaction type N/A PTMCode2
PTPRC CD1D 25361965 interaction type N/A PTMCode2
CD1D PTPRC 25361965 interaction type N/A PTMCode2
PTPRC FYN 25361965 interaction type N/A PTMCode2
FYN PTPRC 25361965 interaction type N/A PTMCode2
PTPRC CD2 25361965 interaction type N/A PTMCode2
CD2 PTPRC 25361965 interaction type N/A PTMCode2
PTPRC JAK2 25361965 interaction type N/A PTMCode2
JAK2 PTPRC 25361965 interaction type N/A PTMCode2
PTPRC CXCR4 25361965 interaction type N/A PTMCode2
CXCR4 PTPRC 25361965 interaction type N/A PTMCode2
PTPRC PTPN6 25361965 interaction type N/A PTMCode2
PTPN6 PTPRC 25361965 interaction type N/A PTMCode2
PTPRC JAK3 25361965 interaction type N/A PTMCode2
JAK3 PTPRC 25361965 interaction type N/A PTMCode2
CD4 PTPRC 25361965 interaction type N/A PTMCode2
PTPRC CD4 25361965 interaction type N/A PTMCode2
PRKCSH PTPRC 25361965 interaction type N/A PTMCode2
PTPRC PRKCSH 25361965 interaction type N/A PTMCode2
PTPRC CSK 25361965 interaction type N/A PTMCode2
IFNAR1 PTPRC 25361965 interaction type N/A PTMCode2
PTPRC IFNAR1 25361965 interaction type N/A PTMCode2
ZAP70 PTPRC 25361965 interaction type N/A PTMCode2
PTPRC ZAP70 25361965 interaction type N/A PTMCode2
CD247 PTPRC 25361965 interaction type N/A PTMCode2
PTPRC CD247 25361965 interaction type N/A PTMCode2
JAK1 PTPRC 25361965 interaction type N/A PTMCode2
PTPRC JAK1 25361965 interaction type N/A PTMCode2
LCP2 PTPRC 25361965 interaction type N/A PTMCode2
PTPRC LCP2 25361965 interaction type N/A PTMCode2
CD8A PTPRC 25361965 interaction type N/A PTMCode2
PTPRC CD8A 25361965 interaction type N/A PTMCode2
SEMA4D PTPRC 25361965 interaction type N/A PTMCode2
PTPRC SEMA4D 25361965 interaction type N/A PTMCode2
DPP4 PTPRC 25361965 interaction type N/A PTMCode2
PTPRC DPP4 25361965 interaction type N/A PTMCode2
GRB2 PTPRC 25361965 interaction type N/A PTMCode2
PTPRC GRB2 25361965 interaction type N/A PTMCode2
CD22 PTPRC 25361965 interaction type N/A PTMCode2
PTPRC CD22 25361965 interaction type N/A PTMCode2
CD44 PTPRC 25361965 interaction type N/A PTMCode2
PTPRC CD44 25361965 interaction type N/A PTMCode2
INSR PTPRC 25361965 interaction type N/A PTMCode2
PTPRC INSR 25361965 interaction type N/A PTMCode2
CD79A PTPRC 25361965 interaction type N/A PTMCode2
PTPRC CD79A 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
LCP2 PTPRC 25348397 N/A in vivo ComPPI
PKP4 PTPRC 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
WAS PTPRC 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
TYK2 PTPRC 25348397 N/A in vitro ComPPI
LSM1 PTPRC 25348397 N/A in vivo ComPPI
PPFIA1 PTPRC 25348397 N/A in vitro ComPPI
PTPN6 PTPRC 25348397 N/A in vivo ComPPI
CD44 PTPRC 25348397 N/A physical interaction ComPPI
ERBB2 PTPRC 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
CD4 PTPRC 25348397 N/A physical interaction,in vivo ComPPI
CBL PTPRC 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
TEC PTPRC 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
LYN PTPRC 25348397 N/A physical interaction,in vitro,in vivo ComPPI
FCGR3A PTPRC 25348397 27898060 8157290 N/A in vivo ComPPI,OmniPath
LCK PTPRC 10369126 19167335 24234451 25348397 7507203 8576115 dephosphorylation reaction,phosphorylation reaction,physical association affinity chromatography technology,anti bait coimmunoprecipitation,pull down,dephosphorylation reaction,physical interaction,protein kinase assay,phosphatase assay,in vitro,in vivo,protein phosphatase assay ComPPI,IntAct
SLAMF1 PTPRC 25348397 N/A physical interaction ComPPI
CD2 PTPRC 1970422 1976695 25348397 27898060 N/A physical interaction,in vitro,in vivo ComPPI,OmniPath
MAPK3 PTPRC 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
SKAP1 PTPRC 25348397 N/A two hybrid,physical interaction,in vitro,in vivo ComPPI
GRB2 PTPRC 25348397 N/A in vitro,in vivo ComPPI
SEMA4D PTPRC 10648410 11254687 24234451 25348397 27898060 8955171 physical association anti bait coimmunoprecipitation,physical interaction,in vitro,in vivo ComPPI,IntAct,OmniPath
ZAP70 PTPRC 25348397 N/A in vitro ComPPI
U2AF2 PTPRC 25348397 N/A physical interaction ComPPI
PDGFRB PTPRC 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
CD28 PTPRC 1355979 25348397 27898060 N/A in vivo ComPPI,OmniPath
TIE1 PTPRC 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
GHR PTPRC 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
GAB1 PTPRC 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
IFNAR1 PTPRC 25348397 N/A in vitro,in vivo ComPPI
NTRK1 PTPRC 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
JAK1 PTPRC 25348397 N/A in vitro ComPPI
PDPK1 PTPRC 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
LEPR PTPRC 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
PXN PTPRC 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
CSNK2A1 PTPRC 25348397 N/A in vivo ComPPI
CD247 PTPRC 25348397 N/A physical interaction,in vitro ComPPI
UHRF2 PTPRC 21952639 24234451 25348397 physical association physical interaction,antibody array ComPPI,IntAct
ANP32A PTPRC 1655467 25348397 27898060 N/A in vitro,in vivo ComPPI,OmniPath
GRIN2B PTPRC 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
CSK PTPRC 19167335 24234451 25348397 7507203 dephosphorylation reaction,phosphorylation reaction protein kinase assay,phosphatase assay ComPPI,IntAct
NSF PTPRC 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
MET PTPRC 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
CSNK2A2 PTPRC 25348397 N/A in vivo ComPPI
EGFR PTPRC 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
EPOR PTPRC 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
CD8A PTPRC 25348397 N/A physical interaction,in vivo ComPPI
RASA1 PTPRC 25348397 N/A in vitro,in vivo ComPPI
JAK3 PTPRC 25348397 N/A in vitro ComPPI
IRS1 PTPRC 25348397 27898060 8557683 N/A in vivo ComPPI,OmniPath
DPP4 PTPRC 1680916 25348397 27898060 N/A coimmunoprecipitation,physical interaction,in vivo ComPPI,OmniPath
JAK2 PTPRC 25348397 N/A in vitro ComPPI
PTPRC ITGAL 15946252 24234451 25348397 27898060 physical association two hybrid,pull down,in vitro,in vivo ComPPI,IntAct,OmniPath
PTPRC CXCR4 25348397 N/A in vivo ComPPI
PTPRC EZR 25348397 N/A in vitro ComPPI
PTPRC FYN 25348397 N/A in vitro,in vivo ComPPI
PTPRC INSR 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay,in vitro ComPPI,IntAct
PTPRC LGALS1 10369126 24234451 25348397 N/A affinity chromatography technology,physical interaction,enzymatic study,in vitro,in vivo ComPPI,IntAct
PTPRC MBL2 25348397 N/A in vitro,in vivo ComPPI
PTPRC PAEP 25348397 N/A physical interaction,in vitro,in vivo ComPPI
PTPRC GANAB 10921916 11564800 25348397 27898060 9148925 N/A physical interaction,in vitro,in vivo ComPPI,OmniPath
PTPRC PRKCSH 25348397 N/A physical interaction,in vitro,in vivo ComPPI
PTPRC PPFIBP2 25348397 N/A in vitro ComPPI
PTPRC PTPRCAP 25348397 27898060 8537410 9188717 N/A physical interaction,in vitro ComPPI,OmniPath
PTPRC RNF11 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PTPRC CD22 10648410 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction,in vivo ComPPI,IntAct
PTPRC CD79A 25348397 N/A physical interaction ComPPI
PTPRC CD79B 25348397 N/A physical interaction ComPPI
PTPRC FBXO6 25348397 N/A physical interaction ComPPI
PTPRC CDH2 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
PTPRC CTNNB1 12370829 19167335 24234451 25348397 dephosphorylation reaction,physical association pull down,phosphatase assay ComPPI,IntAct
PTPRC TEK 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
PTPRC TNK2 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
PTPRC CD244 23346089 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
CD1D PTPRC 10473580 25348397 27898060 N/A physical interaction,in vivo ComPPI,OmniPath
PLK3 PTPRC 25348397 N/A physical interaction ComPPI
PTPRC PTPRC 15978577 24234451 association tox-r dimerization assay,comigration in sds page IntAct
PTPRC LCK 10330160 10369126 11259588 11369760 12589038 15085197 19167335 2141630 2530588 27898060 7507203 8433999 8441403 8473339 8576115 8663450 9973453 inhibition,stimulant N/A OmniPath
PTPRC LYN 10415030 12393728 27898060 7499277 7516335 stimulant N/A OmniPath
PTPRC FYN 11909961 12589038 1533589 27898060 8980254 9368621 9535845 stimulant N/A OmniPath
PTPRC JAK3 11994288 27898060 stimulant N/A OmniPath
PTPRC JAK1 11201744 11994288 1199429 27898060 inhibition,stimulant N/A OmniPath
PTPRC TYK2 11201744 27898060 N/A N/A OmniPath
CSNK2A1 PTPRC 10066810 27898060 stimulant N/A OmniPath
PTPRC JAK2 11201744 27898060 N/A N/A OmniPath
PTPRC CD247 27898060 7526385 inhibition N/A OmniPath
CSK PTPRC 19167335 27898060 7507203 stimulant N/A OmniPath
CSNK2A2 PTPRC 10066810 27898060 stimulant N/A OmniPath
PTPRC SKAP1 11909961 27898060 stimulant N/A OmniPath
GRK1 PTPRC 27898060 9111075 N/A N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00009AE26E PTPRC 27087310 direct interaction,inhibition N/A NPInter

Visualization