Gene Information gene info

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GENE：NFKBIB

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol NFKBIB
FullNmae NFKB inhibitor beta
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7798
EnsembleID ENSG00000104825
Uniprot Q15653

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
NFKBIB necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
NFKBIB immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
NFKBIB GO:0003713,GO:0005515,GO:0005634,GO:0005829,GO:0006351,GO:0006954,GO:0007165,GO:0007253,GO:0043122,GO:0045893,GO:0071222

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
NFKBIB hsa:4793 path:hsa04062 Chemokine signaling pathway - Homo sapiens (human)
NFKBIB hsa:4793 path:hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
NFKBIB hsa:4793 path:hsa04622 RIG-I-like receptor signaling pathway - Homo sapiens (human)
NFKBIB hsa:4793 path:hsa04623 Cytosolic DNA-sensing pathway - Homo sapiens (human)
NFKBIB hsa:4793 path:hsa04658 Th1 and Th2 cell differentiation - Homo sapiens (human)
NFKBIB hsa:4793 path:hsa04659 Th17 cell differentiation - Homo sapiens (human)
NFKBIB hsa:4793 path:hsa04660 T cell receptor signaling pathway - Homo sapiens (human)
NFKBIB hsa:4793 path:hsa04662 B cell receptor signaling pathway - Homo sapiens (human)
NFKBIB hsa:4793 path:hsa04722 Neurotrophin signaling pathway - Homo sapiens (human)
NFKBIB hsa:4793 path:hsa04920 Adipocytokine signaling pathway - Homo sapiens (human)
NFKBIB hsa:4793 path:hsa05130 Pathogenic Escherichia coli infection - Homo sapiens (human)
NFKBIB hsa:4793 path:hsa05131 Shigellosis - Homo sapiens (human)
NFKBIB hsa:4793 path:hsa05140 Leishmaniasis - Homo sapiens (human)
NFKBIB hsa:4793 path:hsa05145 Toxoplasmosis - Homo sapiens (human)
NFKBIB hsa:4793 path:hsa05162 Measles - Homo sapiens (human)
NFKBIB hsa:4793 path:hsa05164 Influenza A - Homo sapiens (human)
NFKBIB hsa:4793 path:hsa05169 Epstein-Barr virus infection - Homo sapiens (human)
NFKBIB hsa:4793 path:hsa05171 Coronavirus disease - COVID-19 - Homo sapiens (human)
NFKBIB hsa:4793 path:hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
NFKBIB RELA 14685242 16226509 16792530 23180781 8887627 9135156 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
PDE8A NFKBIB 15596729 23180781 physical association anti tag coimmunoprecipitation InnateDB
DNAJA3 NFKBIB 15601829 23180781 physical association anti tag coimmunoprecipitation InnateDB
NFKBIB REL 16226509 23180781 8887627 9135156 physical association anti tag coimmunoprecipitation InnateDB
CSNK2A1 NFKBIB 23180781 8887627 physical association affinity chromatography technology InnateDB
IKBKB NFKBIB 10320352 10593898 10723127 11470788 15084594 17047224 23109003 23180781 29145629 9135156 9315679 9721103 9914500 enzymatic reaction,physical association,chemical activation reaction anti tag coimmunoprecipitation,surface plasmon resonance,inferred by curator InnateDB,Reactome,SignaLink
NFKBIB HIF1AN 23180781 24145445 physical association anti tag coimmunoprecipitation InnateDB
APP NFKBIB 21832049 23180781 physical association protein array InnateDB
NFKB1 NFKBIB 24243840 29145629 physical association inferred by curator Reactome
RELA NFKBIB 24243840 29145629 physical association inferred by curator Reactome
REL NFKBIB 24243840 29145629 physical association inferred by curator Reactome
NFKBIB FBXW11 10066435 10230406 10321728 10514424 29145629 9859996 9990852 physical association inferred by curator Reactome
NFKBIB BTRC 10066435 10230406 10321728 10514424 29145629 9859996 9990852 physical association inferred by curator Reactome
SKP1 NFKBIB 10066435 10230406 10321728 10514424 29145629 9859996 9990852 physical association inferred by curator Reactome
CUL1 NFKBIB 10066435 10230406 10321728 10514424 29145629 9859996 9990852 physical association inferred by curator Reactome
CHUK NFKBIB 10593898 15084594 23109003 29145629 9135156 9315679 9721103 9914500 enzymatic reaction,chemical activation reaction inferred by curator Reactome,SignaLink
NFKBIB IKBKG 10593898 29145629 9135156 9315679 9721103 9914500 enzymatic reaction inferred by curator Reactome
NFKBIB NFKB1 12670396 15084594 23109003 chemical activation reaction N/A SignaLink

Source Target Pmid Interactiontype Methods Database
NFKBIB CHUK 20005715 interaction type N/A PSP
NFKBIB NGFR 20005715 interaction type N/A PSP
NFKBIB RXRA 20005715 interaction type N/A PSP
NFKBIB MCC 20005715 interaction type N/A PSP
NFKBIB VCP 20005715 interaction type N/A PSP
NFKBIB NKIRAS1 20005715 interaction type N/A PSP
NFKBIB FBXW11 20005715 interaction type N/A PSP,SignaLink
NFKBIB BTRC 20005715 interaction type N/A PSP
NFKBIB BTRC 10514424 20005715 21071413 N/A N/A SignaLink
NFKBIB CHUK 18988627 20005715 21071413 9252186 9346485 9689078 N/A N/A SignaLink
NFKBIB RXRA 18988627 20005715 7776974 9452433 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
GATA1 NFKBIB 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 NFKBIB 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 NFKBIB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 NFKBIB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 NFKBIB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS NFKBIB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A NFKBIB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SRY NFKBIB 12475944 trascriptional regulation,stimulation inferred by curator TFlink
MYC NFKBIB N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000042E1F NFKBIB 25416803 26286834 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS00001481F9 NFKBIB 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000024CEE0 NFKBIB 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000075BDAA NFKBIB 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000075B538 NFKBIB 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00000EC1BE NFKBIB 25416803 27418678 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CSNK2A1 NFKBIB 22135298 phosphorylation N/A PhosphoSite
FBXW11 NFKBIB 25361965 interaction type N/A PTMCode2
NFKBIB FBXW11 25361965 interaction type N/A PTMCode2
NKIRAS2 NFKBIB 25361965 interaction type N/A PTMCode2
NFKBIB NKIRAS2 25361965 interaction type N/A PTMCode2
NFKBIB BTRC 25361965 interaction type N/A PTMCode2
BTRC NFKBIB 25361965 interaction type N/A PTMCode2
NFKBIB CHUK 25361965 interaction type N/A PTMCode2
CHUK NFKBIB 25361965 interaction type N/A PTMCode2
NFKBIB NKIRAS1 25361965 interaction type N/A PTMCode2
NKIRAS1 NFKBIB 25361965 interaction type N/A PTMCode2
NFKBIB RELA 25361965 interaction type N/A PTMCode2
RELA NFKBIB 25361965 interaction type N/A PTMCode2
NFKBIB RXRA 25361965 interaction type N/A PTMCode2
RXRA NFKBIB 25361965 interaction type N/A PTMCode2
NFKB2 NFKBIB 25361965 interaction type N/A PTMCode2
NFKBIB NFKB2 25361965 interaction type N/A PTMCode2
RELB NFKBIB 25361965 interaction type N/A PTMCode2
NFKBIB RELB 25361965 interaction type N/A PTMCode2
REL NFKBIB 25361965 interaction type N/A PTMCode2
NFKBIB REL 25361965 interaction type N/A PTMCode2
NFKB1 NFKBIB 25361965 interaction type N/A PTMCode2
NFKBIB NFKB1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
KPNA2 NFKBIB 14525934 14743216 24234451 25348397 physical association experimental interaction detection,physical interaction,in vitro,tandem affinity purification ComPPI,HPRD,IntAct
FHL3 NFKBIB 25348397 N/A physical interaction ComPPI
HSPA8 NFKBIB 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
SLPI NFKBIB 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
POLR2L NFKBIB 14525934 14743216 24234451 25348397 physical association experimental interaction detection,physical interaction,in vitro,tandem affinity purification ComPPI,HPRD,IntAct
BAG3 NFKBIB 25348397 N/A physical interaction ComPPI
ACTG1 NFKBIB 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TUBB NFKBIB 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
VCP NFKBIB 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RPL11 NFKBIB 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
CALM1 NFKBIB 25348397 N/A tandem affinity purification ComPPI
SKP1 NFKBIB 14525934 14743216 25348397 N/A experimental interaction detection,physical interaction,in vitro,tandem affinity purification ComPPI,HPRD
HSP90AB1 NFKBIB 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
REL NFKBIB 14525934 14743216 24234451 25348397 9135156 physical association experimental interaction detection,physical interaction,in vitro,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
TBP NFKBIB 14743216 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
SFPQ NFKBIB 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
NCOR2 NFKBIB 25348397 N/A physical interaction ComPPI
POLR1G NFKBIB 14525934 14743216 24234451 25348397 physical association experimental interaction detection,physical interaction,in vitro,tandem affinity purification ComPPI,HPRD,IntAct
POLR1E NFKBIB 14525934 14743216 24234451 25348397 physical association experimental interaction detection,physical interaction,in vitro,tandem affinity purification ComPPI,HPRD,IntAct
UBB NFKBIB 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
HSP90AA1 NFKBIB 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
BTRC NFKBIB 10514424 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
HSPA5 NFKBIB 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
IKBKB NFKBIB 14525934 14743216 24234451 25348397 9689078 9721103 physical association experimental interaction detection,physical interaction,in vitro,tandem affinity purification ComPPI,HPRD,IntAct
HNRNPU NFKBIB 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
DNAJA3 NFKBIB 25348397 N/A physical interaction ComPPI
NFKBIA NFKBIB 14525934 14743216 24234451 25348397 physical association experimental interaction detection,physical interaction,in vitro,tandem affinity purification ComPPI,HPRD,IntAct
CSNK2A1 NFKBIB 25348397 N/A physical interaction ComPPI
PPARG NFKBIB 25348397 N/A physical interaction ComPPI
IQGAP1 NFKBIB 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RELA NFKBIB 10498867 12672800 14525934 14685242 21988832 24234451 25348397 8816457 association,physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,two hybrid array,in vitro,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
IQGAP2 NFKBIB 14743216 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
EXOC4 NFKBIB 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
EPRS1 NFKBIB 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
XPO1 NFKBIB 25348397 N/A physical interaction ComPPI
NFKBIB NKIRAS2 10657303 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
NFKBIB NKIRAS1 10657303 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
NFKBIB MCC 14525934 14743216 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
NFKBIB CHUK 14525934 14743216 24234451 25348397 9252186 9689078 physical association experimental interaction detection,physical interaction,in vitro,tandem affinity purification ComPPI,HPRD,IntAct
NFKBIB NGFR 12034707 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
NFKBIB NFKB1 14525934 14743216 24234451 25348397 physical association experimental interaction detection,physical interaction,in vitro,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
NFKBIB NFKB2 14525934 14743216 24234451 25348397 physical association experimental interaction detection,physical interaction,in vitro,tandem affinity purification ComPPI,HPRD,IntAct
NFKBIB PDCD2 14525934 14743216 24234451 25348397 physical association experimental interaction detection,physical interaction,in vitro,tandem affinity purification ComPPI,HPRD,IntAct
NFKBIB CUL1 14525934 14743216 25348397 N/A experimental interaction detection,physical interaction,in vitro,tandem affinity purification ComPPI,HPRD
NFKBIB MTIF2 14525934 14743216 24234451 25348397 physical association experimental interaction detection,physical interaction,in vitro,tandem affinity purification ComPPI,HPRD,IntAct
NFKBIB RASAL2 14525934 14743216 24234451 25348397 physical association experimental interaction detection,physical interaction,in vitro,tandem affinity purification ComPPI,HPRD,IntAct
NFKBIB LRPPRC 14525934 14743216 24234451 25348397 physical association experimental interaction detection,physical interaction,in vitro,tandem affinity purification ComPPI,HPRD,IntAct
NFKBIB POLR1B 14525934 14743216 24234451 25348397 physical association experimental interaction detection,physical interaction,in vitro,tandem affinity purification ComPPI,HPRD,IntAct
NFKBIB POLR2H 14525934 14743216 24234451 25348397 physical association experimental interaction detection,physical interaction,in vitro,tandem affinity purification ComPPI,HPRD,IntAct
NFKBIB POLR1D 25348397 N/A physical interaction,in vitro,tandem affinity purification ComPPI
NFKBIB POLR1D 14525934 14743216 24234451 25348397 physical association experimental interaction detection,physical interaction,in vitro,tandem affinity purification ComPPI,HPRD,IntAct
NFKBIB RXRA 14525934 25348397 27898060 7776974 9452433 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD,OmniPath
NFKBIB ESR2 25348397 N/A physical interaction ComPPI
NFKBIB IKBKG 14525934 14743216 24234451 25348397 physical association experimental interaction detection,physical interaction,tandem affinity purification ComPPI,HPRD,IntAct
NFKBIB BRAP 25348397 N/A physical interaction ComPPI
NFKBIB APP 25348397 N/A physical interaction ComPPI
NFKBIB BAK1 25348397 N/A physical interaction ComPPI
NFKBIB CDC25A 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
NFKBIB GIT2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
NFKBIB TSPAN1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
NFKBIB VPS52 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
NFKBIB HIF1AN 25348397 N/A physical interaction ComPPI
NFKBIB BIRC7 25348397 N/A physical interaction ComPPI
NFKBIB FBXW11 14743216 24234451 25241761 25348397 physical association physical interaction,tandem affinity purification,proximity ligation assay ComPPI,IntAct
NFKBIB POLR1C 14525934 14743216 24234451 25348397 physical association experimental interaction detection,physical interaction,tandem affinity purification ComPPI,HPRD,IntAct
NFKBIB BAG2 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
NFKBIB HSPA1L 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
NFKBIB S100A8 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
NFKBIB IARS1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
NFKBIB LYZ 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
NFKBIB TIMM50 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
NFKBIB CLTC 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
NFKBIB RPL35A 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
NFKBIB RPL7 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
NFKBIB SRPRB 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
NFKBIB MYO9A 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
NFKBIB CCAR2 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
NFKBIB RPLP0P6 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
NFKBIB KIF18A 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
NFKBIB POLR1H 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
NFKBIB DSP 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
NFKBIB CCDC28A 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
NFKBIB NCL 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
NFKBIB TUBA3C 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
NFKBIB RPL30 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
NFKBIB HNRNPM 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
NFKBIB TUBA1A 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
NFKBIB NDUFB7 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ZBTB7A NFKBIB 25348397 N/A physical interaction ComPPI
HSPA9 NFKBIB 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
POLR1A NFKBIB 14525934 14743216 24234451 25348397 physical association experimental interaction detection,physical interaction,in vitro,tandem affinity purification ComPPI,HPRD,IntAct
NFKBIB NFKBIB 14743216 24234451 physical association tandem affinity purification IntAct
CALM2 NFKBIB 14743216 24234451 physical association tandem affinity purification IntAct
MAP3K7 NFKBIB 27898060 9480845 inhibition N/A OmniPath
CHUK NFKBIB 10593965 10723801 11485410 14743216 15145317 15836773 16260493 17072322 22351927 27898060 8657102 9252186 9346485 9689078 stimulant N/A OmniPath
NKIRAS2 NFKBIB 10657303 18434448 27898060 stimulant N/A OmniPath
RPS6KA1 NFKBIB 16822942 27898060 9278383 N/A N/A OmniPath
APP NFKBIB 21832049 27898060 N/A N/A OmniPath
NFKBIB APP 21832049 27898060 N/A N/A OmniPath
NFKBIB NFKB1 10497169 11571291 14743216 15145317 15371334 16513645 27898060 7867065 8816457 9597130 inhibition N/A OmniPath
REL NFKBIB 10706725 11571291 14743216 15145317 15371334 16226509 26186194 27898060 8887627 9135156 N/A N/A OmniPath
IKBKG NFKBIB 10723801 11485410 14743216 15145317 15836773 16260493 16301747 17072322 21862596 27898060 stimulant N/A OmniPath
RELA NFKBIB 10497169 10498867 11571291 12672800 14685242 14743216 15145317 15371334 16189514 16226509 16513645 21988832 22081069 26186194 27898060 8816457 8887627 9135156 9597130 stimulant N/A OmniPath
NFKBIB RELA 10497169 10498867 11571291 12672800 14685242 14743216 15145317 15371334 16189514 16226509 16513645 21988832 22081069 26186194 27898060 8816457 8887627 9135156 9597130 N/A N/A OmniPath
CSNK2A1 NFKBIB 12732617 27898060 8887627 9278383 N/A N/A OmniPath
HIF1AN NFKBIB 24145445 27898060 N/A N/A OmniPath
IKBKB NFKBIB 10320352 10593965 10723801 11470788 14743216 15145317 15218526 15836773 16260493 17072322 27898060 8657102 9346241 9346485 9689078 9721103 inhibition,stimulant N/A OmniPath
NFKBIB IKBKB 10320352 10593965 11470788 14743216 16260493 27898060 9346485 9689078 9721103 N/A N/A OmniPath
PDE8A NFKBIB 15596729 27898060 N/A N/A OmniPath
NFKBIB DNAJA3 15601829 27898060 N/A N/A OmniPath

Visualization










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