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GENE：RBCK1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol RBCK1
FullNmae RANBP2-type and C3HC4-type zinc finger containing 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:15864
EnsembleID ENSG00000125826
Uniprot Q9BYM8

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
RBCK1 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
RBCK1 necroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
RBCK1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
RBCK1 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
RBCK1 GO:0000209,GO:0004842,GO:0004842,GO:0005515,GO:0005829,GO:0032088,GO:0042742,GO:0042802,GO:0043123,GO:0043123,GO:0043130,GO:0043130,GO:0043161,GO:0043161,GO:0046872,GO:0050852,GO:0051092,GO:0060546,GO:0071797,GO:0071797,GO:0071797,GO:0097039,GO:0097039,GO:1901224,GO:2001238

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
RBCK1 hsa:10616 path:hsa04217 Necroptosis - Homo sapiens (human)
RBCK1 hsa:10616 path:hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
RBCK1 hsa:10616 path:hsa05131 Shigellosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
RBCK1 RNF31 11280761 11460167 14660645 17301840 18264787 21133840 21232017 24699077 24958845 26192618 interaction type N/A ACSN
RBCK1 SHARPIN 11280761 11460167 14660645 17301840 18264787 21133840 21232017 21709223 23180781 24699077 24958845 26192618 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
RBCK1 IKBKG 11280761 11460167 14660645 17301840 18264787 21133840 21232017 24699077 24958845 26192618 interaction type N/A ACSN
RBCK1 TRAF6 17449468 23180781 physical association anti tag coimmunoprecipitation InnateDB
RBCK1 MAP3K7 17449468 23180781 physical association anti tag coimmunoprecipitation InnateDB
RBCK1 TAB2 17449468 23180781 physical association anti tag coimmunoprecipitation InnateDB
RBCK1 TAB3 17449468 23180781 physical association anti tag coimmunoprecipitation InnateDB
RBCK1 RIPK1 17449468 23180781 physical association anti tag coimmunoprecipitation InnateDB
RBCK1 IRF3 18711448 23180781 physical association anti tag coimmunoprecipitation InnateDB
RNF31 RBCK1 19136968 23180781 ubiquitination reaction,physical association anti tag coimmunoprecipitation,enzymatic study InnateDB
TRAF1 RBCK1 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
IKBKG RBCK1 20098747 21709223 23180781 physical association anti tag coimmunoprecipitation,protein array InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 RBCK1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 RBCK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA RBCK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF RBCK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 RBCK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 RBCK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A RBCK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 RBCK1 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00000EED18 RBCK1 21566225 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS00004A6E26 RBCK1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000002569A RBCK1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000076E54 RBCK1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001CF056 RBCK1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002B0B46 RBCK1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002E728C RBCK1 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
SOCS6 RBCK1 25361965 interaction type N/A PTMCode2
RBCK1 SOCS6 25361965 interaction type N/A PTMCode2
RNF31 RBCK1 25361965 interaction type N/A PTMCode2
RBCK1 RNF31 25361965 interaction type N/A PTMCode2
RBCK1 ATP6AP1 25361965 interaction type N/A PTMCode2
ATP6AP1 RBCK1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
TSSK3 RBCK1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
TRIM21 RBCK1 22493164 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
NDUFAF3 RBCK1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
TNFAIP3 RBCK1 23032186 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TRAF6 RBCK1 25348397 N/A physical interaction ComPPI
UBE2D1 RBCK1 25348397 N/A physical interaction ComPPI
TAB3 RBCK1 25348397 N/A physical interaction ComPPI
PCGF2 RBCK1 22493164 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D4 RBCK1 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PRKCA RBCK1 25348397 N/A physical interaction ComPPI
CREBBP RBCK1 14525934 15833741 25348397 27898060 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
USP7 RBCK1 25348397 N/A physical interaction ComPPI
UBE2G1 RBCK1 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D2 RBCK1 25348397 N/A physical interaction ComPPI
UBE2L3 RBCK1 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
UBB RBCK1 25348397 N/A isothermal titration calorimetry,pull down,physical interaction ComPPI
UBC RBCK1 17006537 18303026 19796170 20005846 22139374 23986494 25348397 27898060 N/A isothermal titration calorimetry,pull down,physical interaction ComPPI,OmniPath
RPS27A RBCK1 25348397 N/A isothermal titration calorimetry,pull down,physical interaction ComPPI
UBA52 RBCK1 25348397 N/A isothermal titration calorimetry,pull down,physical interaction ComPPI
HSP90AA1 RBCK1 25348397 N/A physical interaction ComPPI
UBE2N RBCK1 19549727 24234451 25260751 25348397 ubiquitination reaction,physical association two hybrid,physical interaction,two hybrid array,ubiquitinase assay ComPPI,IntAct
NR1I2 RBCK1 25348397 N/A physical interaction ComPPI
PSMA1 RBCK1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PRKCB RBCK1 17069764 17121852 18303026 23042805 25348397 27898060 9514928 N/A physical interaction ComPPI,OmniPath
TNFRSF1A RBCK1 25348397 N/A physical interaction ComPPI
UHRF2 RBCK1 22493164 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PDLIM7 RBCK1 25348397 N/A physical interaction ComPPI
TNF RBCK1 23032186 23104095 23955153 24234451 25348397 25911380 association anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
RABGEF1 RBCK1 25348397 N/A physical interaction ComPPI
TRAF1 RBCK1 25348397 N/A physical interaction ComPPI
LMO2 RBCK1 25348397 N/A physical interaction ComPPI
NAA10 RBCK1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
UBE2K RBCK1 25348397 N/A physical interaction ComPPI
RIPK1 RBCK1 25348397 N/A physical interaction ComPPI
MAP3K7 RBCK1 25348397 N/A physical interaction ComPPI
TAB2 RBCK1 25348397 N/A physical interaction ComPPI
PRKN RBCK1 25348397 N/A physical interaction ComPPI
PSMD4 RBCK1 25348397 N/A physical interaction ComPPI
NEDD4 RBCK1 25348397 N/A physical interaction ComPPI
UBE2D3 RBCK1 25348397 N/A physical interaction ComPPI
NR2C2 RBCK1 25348397 N/A physical interaction ComPPI
UBA1 RBCK1 24234451 25260751 25348397 ubiquitination reaction ubiquitinase assay ComPPI,IntAct
BACH1 RBCK1 14525934 17682061 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SMURF1 RBCK1 25348397 N/A physical interaction ComPPI
TRIM25 RBCK1 25348397 N/A physical interaction ComPPI
UBE2L6 RBCK1 19549727 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
BIRC3 RBCK1 23524849 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SOCS6 RBCK1 14525934 16643902 25348397 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD
LTBR RBCK1 25348397 N/A physical interaction ComPPI
ESR1 RBCK1 25348397 N/A physical interaction ComPPI
MAPKBP1 RBCK1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PML RBCK1 25348397 N/A physical interaction ComPPI
TLR3 RBCK1 25348397 N/A physical interaction ComPPI
UBE2V1 RBCK1 24234451 25260751 25348397 ubiquitination reaction ubiquitinase assay ComPPI,IntAct
NOD2 RBCK1 25348397 N/A physical interaction ComPPI
MALT1 RBCK1 25348397 N/A physical interaction ComPPI
LNX1 RBCK1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
USP49 RBCK1 25348397 N/A physical interaction ComPPI
ARPC5 RBCK1 25348397 N/A physical interaction ComPPI
PAN2 RBCK1 25348397 N/A physical interaction ComPPI
SHARPIN RBCK1 21455180 21455181 23032186 24234451 25348397 30561431 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,molecular sieving,pull down,physical interaction,virotrap ComPPI,IntAct
ARNT2 RBCK1 25348397 N/A physical interaction ComPPI
UCHL5 RBCK1 25348397 N/A physical interaction ComPPI
USP21 RBCK1 25348397 N/A physical interaction ComPPI
RNF31 RBCK1 14525934 17006537 17069764 19136968 20005846 21455180 21455181 22430200 22791023 23032187 23708998 24141947 24234451 24461064 24726327 25348397 26577923 26670046 27898060 29997244 30561431 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,bioluminescence resonance energy transfer,experimental interaction detection,isothermal titration calorimetry,molecular sieving,nuclear magnetic resonance,pull down,surface plasmon resonance,x-ray crystallography,physical interaction,in vitro,in vivo,luminescence based mammalian interactome mapping,virotrap ComPPI,HPRD,IntAct,OmniPath
USP2 RBCK1 25348397 N/A physical interaction ComPPI
ZNF414 RBCK1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
OTUB2 RBCK1 25348397 N/A physical interaction ComPPI
ENKD1 RBCK1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
OTULIN RBCK1 25348397 N/A physical interaction ComPPI
GLYCTK RBCK1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RBCK1 IKBKG 20098747 21455180 21709223 21811235 23032186 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,protein array,physical interaction ComPPI,IntAct
RBCK1 UBE2U 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RBCK1 UBE2S 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RBCK1 IREB2 12629548 17822790 25348397 27898060 N/A physical interaction ComPPI,OmniPath
RBCK1 DDX58 25348397 N/A physical interaction ComPPI
RBCK1 APP 25348397 N/A physical interaction ComPPI
RBCK1 USP15 25348397 N/A physical interaction ComPPI
RBCK1 USP32 25348397 N/A physical interaction ComPPI
RBCK1 OTUD6A 25348397 N/A physical interaction ComPPI
RBCK1 MKRN2 22493164 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RBCK1 TRIML1 22493164 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RBCK1 RNF181 22493164 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RBCK1 TRIM65 22493164 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RBCK1 HSP90AA2P 25348397 N/A physical interaction ComPPI
RBCK1 SYCE1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
RBCK1 MAP3K1 25348397 N/A physical interaction ComPPI
RBCK1 LDLRAD4 25348397 N/A physical interaction ComPPI
RBCK1 KCTD7 25348397 N/A physical interaction ComPPI
RBCK1 HOXC8 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RBCK1 KANK2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FKBPL RBCK1 25348397 N/A physical interaction ComPPI
RBCK1 RBCK1 24234451 25416956 30561431 association,physical association two hybrid array,virotrap IntAct
RBCK1 VPS37D 24234451 30561431 association virotrap IntAct
RBCK1 MELTF 24234451 30561431 association virotrap IntAct
RBCK1 MOXD1 24234451 30561431 association virotrap IntAct
RBCK1 PDPN 24234451 30561431 association virotrap IntAct
RBCK1 MINDY3 24234451 30561431 association virotrap IntAct
RBCK1 AP2A2 24234451 30561431 association virotrap IntAct
RBCK1 ULK3 24234451 30561431 association virotrap IntAct
RBCK1 ULBP3 24234451 30561431 association virotrap IntAct
RBCK1 UEVLD 24234451 30561431 association virotrap IntAct
RBCK1 UBE2V2 24234451 30561431 association virotrap IntAct
RBCK1 TNIP2 24234451 30561431 association virotrap IntAct
RBCK1 RNF115 24234451 30561431 association virotrap IntAct
RBCK1 KHNYN 24234451 30561431 association virotrap IntAct
RBCK1 CD82 24234451 30561431 association virotrap IntAct
RBCK1 UMAD1 24234451 30561431 association virotrap IntAct
RBCK1 TENM3 24234451 30561431 association virotrap IntAct
RBCK1 MSTO1 24234451 30561431 association virotrap IntAct
RBCK1 DHFR 24234451 30561431 association virotrap IntAct
RBCK1 CAPN15 24234451 30561431 association virotrap IntAct
RBCK1 AMOT 24234451 30561431 association virotrap IntAct
RBCK1 NCS1 24234451 30561431 association virotrap IntAct
RBCK1 YOD1 24234451 30561431 association virotrap IntAct
RBCK1 TNIP1 24234451 30561431 association virotrap IntAct
RBCK1 RAB9A 24234451 30561431 association virotrap IntAct
RBCK1 ATP6AP2 24234451 30561431 association virotrap IntAct
RBCK1 ZFAND2B 24234451 30561431 association virotrap IntAct
MAP3K7 RBCK1 17449468 27898060 N/A N/A OmniPath
RBCK1 MAP3K7 17449468 27898060 N/A N/A OmniPath
RBCK1 TRAF6 17449468 27898060 N/A N/A OmniPath
TRAF6 RBCK1 17449468 27898060 N/A N/A OmniPath
IKBKG RBCK1 19136968 19675569 20098747 21455180 21709223 21811235 23032186 23732909 23986494 27898060 N/A N/A OmniPath
IRF3 RBCK1 18711448 27898060 N/A N/A OmniPath
TAB2 RBCK1 17449468 27898060 N/A N/A OmniPath
RBCK1 RIPK1 17449468 27898060 inhibition N/A OmniPath
TAB3 RBCK1 17449468 27898060 N/A N/A OmniPath
RBCK1 TAB3 17449468 27898060 N/A N/A OmniPath

Visualization










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