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GENE：RIPK3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol RIPK3
FullNmae receptor interacting serine/threonine kinase 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:10021
EnsembleID ENSG00000129465
Uniprot Q9Y572

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
RIPK3 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
RIPK3 necroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
RIPK3 cuproptosis 36118866 A cuproptosis-related score model incorporating TRAF2, TRADD, USP21, FAS, MLKL, TNFRSF10B, MAPK8, TRAF5, and RIPK3 was developed. retulator signature
RIPK3 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
RIPK3 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
RIPK3 GO:0001914,GO:0002819,GO:0003713,GO:0004672,GO:0004672,GO:0004672,GO:0004674,GO:0004674,GO:0004674,GO:0004704,GO:0005515,GO:0005524,GO:0005634,GO:0005634,GO:0005737,GO:0005829,GO:0005829,GO:0007165,GO:0007249,GO:0010922,GO:0032147,GO:0032649,GO:0032991,GO:0033077,GO:0036211,GO:0038061,GO:0042802,GO:0042981,GO:0043029,GO:0044877,GO:0045893,GO:0046006,GO:0046777,GO:0048535,GO:0048536,GO:0048538,GO:0051092,GO:0051607,GO:0060545,GO:0060545,GO:0070235,GO:0070266,GO:0070266,GO:0070301,GO:0072593,GO:0097190,GO:0097300,GO:0097527,GO:0097527,GO:0097528,GO:0106310,GO:1990000,GO:2000379,GO:2000452,GO:2001244

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
RIPK3 hsa:11035 path:hsa04217 Necroptosis - Homo sapiens (human)
RIPK3 hsa:11035 path:hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
RIPK3 hsa:11035 path:hsa04623 Cytosolic DNA-sensing pathway - Homo sapiens (human)
RIPK3 hsa:11035 path:hsa04668 TNF signaling pathway - Homo sapiens (human)
RIPK3 hsa:11035 path:hsa05132 Salmonella infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
RIPK1 RIPK3 10521396 11003656 11274345 1134007 11583996 12215447 12702723 12724420 12887920 15592525 15760909 16469705 16498403 16940415 17462996 17603935 18570872 18621737 18641653 19037093 19131965 19498109 19524512 19524513 19597341 19632174 19838173 19935698 20125124 20531300 20823910 20861672 21133840 21232017 22265414 22421439 22427918 23010170 23069999 23073834 23377657 23627914 24366341 26024392 26192618 26587781 26653790 26807733 26853145 26900751 26972597 27558815 27833036 27959630 27984721 28498367 28574505 28645028 9217161 9488730 9759866 interaction type N/A ACSN
RIPK3 GLUD1 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26192618 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028 interaction type N/A ACSN
RIPK3 GLUL 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26192618 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028 interaction type N/A ACSN
RIPK3 MLKL 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16469705 16498403 16940415 17462996 17603935 18641653 19037093 19090789 19498109 19524512 19524513 19597341 19632174 19838173 20531300 20823910 20861672 21133840 21232017 22265414 22421439 22427918 23010170 23069999 23073834 23180781 23377657 23612963 23627914 24366341 26024392 26192618 26587781 26653790 26807733 26853145 26900751 26972597 27558815 27833036 27959630 27984721 28498367 28574505 28645028 9217161 9242610 9488730 9759866 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
RIPK3 PGAM5 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26192618 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028 interaction type N/A ACSN
RIPK3 PYGL 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 21903422 22265414 22421439 23010170 23073834 23180781 23627914 24366341 26024392 26192618 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
RIPK3 CFLAR 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16498403 16940415 17462996 18641653 19090789 19498109 19524512 19524513 19597341 19632174 19838173 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 24366341 26024392 26192618 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9242610 9488730 9759866 interaction type N/A ACSN
FADD RIPK3 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16498403 16940415 17462996 18641653 19498109 19524512 19524513 19597341 19632174 19838173 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 24366341 26024392 26192618 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9488730 9759866 interaction type N/A ACSN
RIPK3 FAF1 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16498403 16940415 17462996 18641653 19498109 19524512 19524513 19597341 19632174 19838173 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 24366341 26024392 26192618 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9488730 9759866 interaction type N/A ACSN
RIPK3 FASLG 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16498403 16940415 17462996 18641653 19498109 19524512 19524513 19597341 19632174 19838173 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 24366341 26024392 26192618 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9488730 9759866 interaction type N/A ACSN
RIPK3 FAS 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16498403 16940415 17462996 18641653 19498109 19524512 19524513 19597341 19632174 19838173 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 24366341 26024392 26192618 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9488730 9759866 interaction type N/A ACSN
RIPK3 DAXX 26192618 interaction type N/A ACSN
TRAF2 RIPK3 26192618 interaction type N/A ACSN
RIPK3 ZBP1 19590578 23180781 physical association anti tag coimmunoprecipitation InnateDB
RIPK3 FKBP4 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
RIPK3 INPP5K 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
RIPK3 CDC37 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
RIPK3 CTNND1 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
RIPK3 STIP1 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
RIPK3 RIPK1 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
RIPK3 FKBP5 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
CORO1C RIPK3 20005715 interaction type N/A PSP
FADD RIPK3 20005715 interaction type N/A PSP
GNB4 RIPK3 20005715 interaction type N/A PSP
GNG12 RIPK3 20005715 interaction type N/A PSP
PPP1R9B RIPK3 20005715 interaction type N/A PSP
SPTBN1 RIPK3 20005715 interaction type N/A PSP
TICAM1 RIPK3 20005715 interaction type N/A PSP
TRAF2 RIPK3 20005715 interaction type N/A PSP
YWHAE RIPK3 20005715 interaction type N/A PSP

Source Target Pmid Interactiontype Methods Database
YBX1 RIPK3 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
HNF4A RIPK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
RIPK3 DAXX 22135298 phosphorylation N/A PhosphoSite
RIPK3 MLKL 22135298 phosphorylation N/A PhosphoSite
RIPK3 TICAM1 25361965 interaction type N/A PTMCode2
TICAM1 RIPK3 25361965 interaction type N/A PTMCode2
RIPK3 RIPK1 25361965 interaction type N/A PTMCode2
RIPK1 RIPK3 25361965 interaction type N/A PTMCode2
RIPK3 FADD 25361965 interaction type N/A PTMCode2
FADD RIPK3 25361965 interaction type N/A PTMCode2
RIPK3 CASP8 25361965 interaction type N/A PTMCode2
CASP8 RIPK3 25361965 interaction type N/A PTMCode2
RIPK3 ZBP1 25361965 interaction type N/A PTMCode2
ZBP1 RIPK3 25361965 interaction type N/A PTMCode2
TNFRSF1A RIPK3 25361965 interaction type N/A PTMCode2
RIPK3 TNFRSF1A 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
GNAI3 RIPK3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
DAXX RIPK3 25348397 N/A physical interaction ComPPI
HSPA8 RIPK3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
PPP1CC RIPK3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
VIM RIPK3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
ACTG1 RIPK3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TUBB RIPK3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
PPP1CB RIPK3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
CALM1 RIPK3 25348397 N/A tandem affinity purification ComPPI
XIAP RIPK3 21931591 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
MYL6B RIPK3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
HSP90AB1 RIPK3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RFX6 RIPK3 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CTNND1 RIPK3 25348397 N/A physical interaction ComPPI
PRKDC RIPK3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
NONO RIPK3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
FLNA RIPK3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
PPP1R12A RIPK3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
ACTN4 RIPK3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
UBB RIPK3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
HSP90AA1 RIPK3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RUVBL1 RIPK3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
STIP1 RIPK3 25348397 N/A physical interaction ComPPI
HSPA5 RIPK3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
PRDX1 RIPK3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
CASP8 RIPK3 19524512 19524513 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TNFRSF1A RIPK3 10339433 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CAPZA1 RIPK3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
C1QBP RIPK3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
PPP1R9B RIPK3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
IQGAP1 RIPK3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
CAD RIPK3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
DDX5 RIPK3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
SPTAN1 RIPK3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
FADD RIPK3 19524513 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TPM3 RIPK3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
EPRS1 RIPK3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TRAF2 RIPK3 10339433 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
CLTC RIPK3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
SPTBN1 RIPK3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
YWHAE RIPK3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
FKBP4 RIPK3 25348397 N/A physical interaction ComPPI
CCT5 RIPK3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
CCT7 RIPK3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RAI14 RIPK3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
EPHA4 RIPK3 25348397 N/A physical interaction ComPPI
HSPA9 RIPK3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RIPK1 RIPK3 10339433 14525934 19524512 19524513 22265413 22265414 22817896 24234451 25348397 26559832 phosphorylation reaction,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,circular dichroism,two hybrid,electron microscopy,experimental interaction detection,fluorescence technology,molecular sieving,pull down,physical interaction,protein kinase assay,in vivo,comigration in sds page,solid state nmr,two hybrid ComPPI,HPRD,IntAct
RIPK3 TICAM1 14525934 15064760 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
RIPK3 BIRC2 21931591 24234451 25348397 ubiquitination reaction,physical association anti tag coimmunoprecipitation,pull down,physical interaction,enzymatic study ComPPI,IntAct
RIPK3 BIRC3 21931591 24234451 25348397 ubiquitination reaction,physical association anti tag coimmunoprecipitation,pull down,physical interaction,enzymatic study ComPPI,IntAct
RIPK3 CDC37 14743216 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
RIPK3 FKBP5 25348397 N/A physical interaction ComPPI
RIPK3 INPP5K 25348397 N/A physical interaction ComPPI
RIPK3 PYGL 25348397 N/A physical interaction ComPPI
RIPK3 AMY1C 25348397 N/A physical interaction ComPPI
RIPK3 ZG16B 25348397 N/A physical interaction ComPPI
RIPK3 PTPRK 25348397 N/A physical interaction ComPPI
RIPK3 SRPK2 25348397 N/A physical interaction ComPPI
RIPK3 MLKL 22265413 22265414 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction,protein kinase assay ComPPI,IntAct
RIPK3 AIFM1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RIPK3 SCIN 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RIPK3 HSPA1L 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RIPK3 GNB2 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RIPK3 DBN1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RIPK3 SLC25A5 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RIPK3 CORO1C 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RIPK3 RUVBL2 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RIPK3 MYO1C 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RIPK3 GNB4 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RIPK3 DNAJA1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RIPK3 HNRNPH1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RIPK3 MYO1B 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RIPK3 TIAF1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RIPK3 WDR61 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RIPK3 MYH10 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RIPK3 SLC25A3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RIPK3 TIMM50 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RIPK3 GNB1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RIPK3 TUBB2B 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RIPK3 HADHA 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RIPK3 AIF1L 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RIPK3 MYO6 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RIPK3 BASP1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RIPK3 TUBB4A 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RIPK3 ATAD3A 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RIPK3 MPRIP 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RIPK3 SPECC1L 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RIPK3 DAPK1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RIPK3 DDX3X 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RIPK3 HNRNPA1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RIPK3 CCT2 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RIPK3 TPM1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RIPK3 MYL6 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RIPK3 CAPZB 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RIPK3 TUBA3C 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RIPK3 LIMA1 25348397 N/A tandem affinity purification ComPPI
RIPK3 MYL12A 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RIPK3 RPS27 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RIPK3 MYO1D 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RIPK3 ZBP1 19590578 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
RIPK3 PGAM5 22265414 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
RPL23 RIPK3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
GNG12 RIPK3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
EEF1D RIPK3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
EEF1A2 RIPK3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
CALM2 RIPK3 14743216 24234451 physical association tandem affinity purification IntAct
RIPK3 RIPK3 14743216 22817896 24234451 physical association circular dichroism,electron microscopy,fluorescence technology,molecular sieving,tandem affinity purification IntAct
TRAF2 RIPK3 10339433 27898060 N/A N/A OmniPath
RIPK3 DAXX 12968034 15128734 22199361 23260419 27898060 N/A N/A OmniPath
RIPK3 RIPK1 10339433 11734559 19524512 19524513 21903422 22265413 22265414 22817896 22864571 27898060 stimulant N/A OmniPath
TNFRSF1A RIPK3 10339433 27898060 N/A N/A OmniPath
RIPK3 MLKL 22265413 23612963 24703947 25801023 26184911 27898060 stimulant N/A OmniPath
RIPK3 GLUD1 19632174 27898060 stimulant N/A OmniPath
RIPK3 PYGL 19632174 21903422 27898060 stimulant N/A OmniPath

Visualization










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