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GENE：PRKCH

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PRKCH
FullNmae protein kinase C eta
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9403
EnsembleID ENSG00000027075
Uniprot C0HM02|P24723

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PRKCH necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PRKCH GO:0004672,GO:0004674,GO:0004697,GO:0004698,GO:0004699,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005829,GO:0005886,GO:0005911,GO:0006468,GO:0006468,GO:0007165,GO:0010744,GO:0018105,GO:0019899,GO:0030154,GO:0031267,GO:0034351,GO:0035556,GO:0045618,GO:0046872,GO:0050861,GO:0051092,GO:0060252,GO:0070062,GO:0070528,GO:0106310,GO:1903078,GO:2000810

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PRKCH hsa:5583 path:hsa04270 Vascular smooth muscle contraction - Homo sapiens (human)
PRKCH hsa:5583 path:hsa04750 Inflammatory mediator regulation of TRP channels - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR PRKCH 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 PRKCH 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ETS1 PRKCH 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 PRKCH 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 PRKCH 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
HIF1A PRKCH 18971253 19828020 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
FOXA1 PRKCH 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 PRKCH 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TFAP2C PRKCH 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 PRKCH 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 PRKCH 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 PRKCH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PRKCH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PRKCH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 PRKCH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PRKCH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PRKCH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF PRKCH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 PRKCH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 PRKCH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 PRKCH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 PRKCH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR PRKCH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 PRKCH 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001B9F58 PRKCH 19536157 24374217 25416803 mrna cleavage,inhibition clip TarBase
URS0000105D19 PRKCH 24374217 25416803 mrna cleavage,inhibition clip TarBase
URS0000077AED PRKCH 24374217 25416803 mrna cleavage,inhibition clip TarBase
URS00005DEC41 PRKCH 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00000BF7F9 PRKCH 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000015D23B PRKCH 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00000C0D3F PRKCH 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000046CDA6 PRKCH 19536157 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PRKCH ITGB2 22135298 phosphorylation N/A PhosphoSite
PRKCH PTPN11 22135298 phosphorylation N/A PhosphoSite
PRKCH GSK3B 22135298 phosphorylation N/A PhosphoSite
PRKCH PRKD1 22135298 phosphorylation N/A PhosphoSite
PRKCH PRKD2 22135298 phosphorylation N/A PhosphoSite
PRKCH GSTP1 22135298 phosphorylation N/A PhosphoSite
PRKCH GSK3A 22135298 phosphorylation N/A PhosphoSite
PRKCH SRC 25361965 interaction type N/A PTMCode2
SRC PRKCH 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
HSP90AB1 PRKCH 22939624 24234451 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
OCLN PRKCH 25348397 N/A pull down,phosphorylation reaction,physical interaction,protein kinase assay ComPPI
PTPN11 PRKCH 11781100 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PRKCA PRKCH 25348397 N/A physical interaction ComPPI
SRC PRKCH 14525934 25348397 8621384 N/A experimental interaction detection,in vitro ComPPI,HPRD
PRKD1 PRKCH 10867018 11741879 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
NFE2L2 PRKCH 25348397 N/A physical interaction ComPPI
AKAP13 PRKCH 25348397 N/A physical interaction ComPPI
HSP90AA1 PRKCH 25348397 N/A physical interaction ComPPI
NUMB PRKCH 14525934 17203073 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PRKCH CDK2 11175348 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PRKCH FYN 14525934 25348397 8621384 N/A experimental interaction detection,in vitro ComPPI,HPRD
PRKCH PARD6A 14525934 17335965 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PRKCH ZBTB8OS 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
PRKCH MGMT 25348397 N/A physical interaction ComPPI
PRKCH VHL 25348397 N/A physical interaction ComPPI
PRKCH PPP1R14A 25348397 N/A physical interaction ComPPI
PRKCH HSP90AA2P 25348397 N/A physical interaction ComPPI
PRKCH GSK3A 25348397 N/A physical interaction ComPPI
PRKCH BANP 25348397 N/A physical interaction ComPPI
PRKCH RIPK4 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
ITGB2 PRKCH 25348397 N/A in vitro ComPPI
PLEC PRKCH 24234451 30021884 physical association cross-linking study IntAct
H3-4 PRKCH 24234451 30021884 physical association cross-linking study IntAct
PRKCH ANXA1 24103589 27898060 stimulant N/A OmniPath
PRKCH PRKD1 10197446 10867018 11741879 15024053 27898060 stimulant N/A OmniPath
PRKCH NOS3 24379783 27898060 inhibition N/A OmniPath
PRKCH GSK3A 11884598 27898060 inhibition N/A OmniPath
PRKCH ITGB2 11700305 27898060 N/A N/A OmniPath
PRKCH PTPN11 11781100 27898060 N/A N/A OmniPath
PRKCH GSK3B 19836308 27898060 inhibition N/A OmniPath
PRKCH PRKD2 12058027 17962809 27898060 stimulant N/A OmniPath

Visualization










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