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GENE：RRM2B

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol RRM2B
FullNmae ribonucleotide reductase regulatory TP53 inducible subunit M2B
LocusType gene with protein product
Status Approved
HGNC_id HGNC:17296
EnsembleID ENSG00000048392
Uniprot Q7LG56

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
RRM2B apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
RRM2B GO:0000731,GO:0001822,GO:0003014,GO:0004748,GO:0005515,GO:0005654,GO:0005739,GO:0005829,GO:0005829,GO:0005829,GO:0005971,GO:0006264,GO:0006281,GO:0006979,GO:0009185,GO:0009200,GO:0009263,GO:0009265,GO:0010971,GO:0014075,GO:0042802,GO:0046872,GO:0070318,GO:1902254

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
RRM2B hsa:50484 path:hsa00230 Purine metabolism - Homo sapiens (human)
RRM2B hsa:50484 path:hsa00240 Pyrimidine metabolism - Homo sapiens (human)
RRM2B hsa:50484 path:hsa00480 Glutathione metabolism - Homo sapiens (human)
RRM2B hsa:50484 path:hsa00983 Drug metabolism - other enzymes - Homo sapiens (human)
RRM2B hsa:50484 path:hsa01100 Metabolic pathways - Homo sapiens (human)
RRM2B hsa:50484 path:hsa01232 Nucleotide metabolism - Homo sapiens (human)
RRM2B hsa:50484 path:hsa04115 p53 signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
RRM2B RRM2 26192618 interaction type N/A ACSN

Source Target Pmid Interactiontype Methods Database
ETS1 RRM2B 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 RRM2B 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TP73 RRM2B 21245298 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
FOXP3 RRM2B 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 RRM2B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF RRM2B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 RRM2B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 RRM2B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 RRM2B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A RRM2B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 RRM2B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 RRM2B 10716435 15856024 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CREB1 RRM2B 11978967 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 RRM2B 11978967 trascriptional regulation,stimulation inferred by curator TFlink
POU2F1 RRM2B 11978967 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001E0AEA RRM2B 17612493 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
ATM RRM2B 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
MCM2 RRM2B 25348397 N/A physical interaction ComPPI
TPM2 RRM2B 25348397 N/A physical interaction ComPPI
FZR1 RRM2B 25348397 N/A physical interaction ComPPI
INPPL1 RRM2B 25348397 N/A physical interaction ComPPI
ORC4 RRM2B 24234451 25348397 25416956 physical association physical interaction,mammalian protein protein interaction trap,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
UBB RRM2B 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
UBC RRM2B 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
RPS27A RRM2B 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
UBA52 RRM2B 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
ATM RRM2B 19015526 24234451 25348397 association,physical association anti bait coimmunoprecipitation,phosphorylation reaction,physical interaction,protein kinase assay ComPPI,IntAct
RRM1 RRM2B 11517226 14525934 14583450 25348397 N/A coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
RRM2 RRM2B 14525934 14729598 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
RRM2B TP53 12615712 14525934 19015526 24234451 25348397 association anti bait coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,physical interaction,fluorescence microscopy ComPPI,HPRD,IntAct
RRM2B MDM2 19015526 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RRM2B AICDA 25348397 N/A physical interaction ComPPI
RRM2B TMOD2 25348397 N/A physical interaction ComPPI
RRM2B SRPK2 25348397 N/A physical interaction ComPPI
RRM2B ZNF131 25348397 N/A physical interaction ComPPI
RRM2B SPAG9 25348397 N/A physical interaction ComPPI
RRM2B RAD50 25348397 N/A anti bait coimmunoprecipitation,physical interaction ComPPI
RRM2B NBN 19015526 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
RRM2B MRE11 19015526 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
RRM2B ATRIP 19015526 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
RRM2B RNF41 24234451 25348397 25910212 physical association two hybrid array,two hybrid bait and prey pooling approach,validated two hybrid ComPPI,IntAct
RRM2B RRM2B 24234451 25416956 physical association two hybrid array IntAct
MDM2 RRM2B 19015526 27898060 inhibition N/A OmniPath
ATM RRM2B 19015526 27898060 stimulant N/A OmniPath
TP53 RRM2B 12565178 12615712 16713569 27898060 stimulant N/A OmniPath

Visualization










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