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GENE：RRN3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol RRN3
FullNmae RRN3 homolog, RNA polymerase I transcription factor
LocusType gene with protein product
Status Approved
HGNC_id HGNC:30346
EnsembleID ENSG00000085721
Uniprot Q9NYV6

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
RRN3 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
RRN3 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
RRN3 GO:0001042,GO:0001164,GO:0001181,GO:0001188,GO:0001701,GO:0005634,GO:0005654,GO:0005730,GO:0006361,GO:0007000,GO:0007028,GO:0042254,GO:0045893,GO:0048144,GO:0048872,GO:0072332,GO:1902254,GO:2000142

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ESR1 RRN3 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 RRN3 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 RRN3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA RRN3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 RRN3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS RRN3 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000DDD35 RRN3 20371350 21572407 25416803 mrna cleavage,inhibition nucleotide sequence identification,clip TarBase
URS00002B2B5C RRN3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000353492 RRN3 21572407 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00001A7F58 RRN3 21572407 22473208 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00002FC5B0 RRN3 21572407 22473208 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00000B989F RRN3 21572407 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00000C85B2 RRN3 21572407 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000486E0B RRN3 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001E0AEA RRN3 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000024CEE0 RRN3 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000025EABA RRN3 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 RRN3 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 RRN3 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F RRN3 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA RRN3 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 RRN3 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 RRN3 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000006F90B RRN3 21572407 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CSNK2A1 RRN3 22135298 phosphorylation N/A PhosphoSite
PRKAA1 RRN3 22135298 phosphorylation N/A PhosphoSite
MAPK3 RRN3 22135298 phosphorylation N/A PhosphoSite
CDK2 RRN3 22135298 phosphorylation N/A PhosphoSite
MAPK9 RRN3 22135298 phosphorylation N/A PhosphoSite
RPS6KA3 RRN3 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
SET RRN3 17318177 24234451 25348397 physical association pull down ComPPI,IntAct
TBP RRN3 25348397 N/A physical interaction ComPPI
UBTF RRN3 25348397 N/A physical interaction ComPPI
TAF1A RRN3 25348397 N/A physical interaction ComPPI
POLR1E RRN3 19214185 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CDK2 RRN3 25348397 N/A physical interaction ComPPI
PPP2R2A RRN3 25348397 N/A physical interaction ComPPI
TAF1B RRN3 11250903 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
TAF1C RRN3 25348397 N/A physical interaction,in vitro,in vivo ComPPI
ELAVL1 RRN3 25348397 N/A physical interaction ComPPI
EIF3L RRN3 12393749 14525934 15004009 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
POLR1A RRN3 11250903 14525934 19214185 24234451 25348397 association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
RRN3 POLR1B 11250903 14525934 15004009 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
RRN3 MYO1C 14525934 15558034 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
RRN3 CCNE1 25348397 N/A physical interaction ComPPI
RRN3 RBM15 25348397 N/A physical interaction ComPPI
RRN3 ACTA1 25348397 N/A physical interaction ComPPI
RRN3 POLR1F 25348397 N/A physical interaction ComPPI
RRN3 UNK 25348397 N/A physical interaction ComPPI
RRN3 POLR1C 25348397 N/A physical interaction ComPPI
RRN3 TMEM108 25348397 N/A physical interaction ComPPI
TAF1D RRN3 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MAPK9 RRN3 15805466 27898060 inhibition,stimulant N/A OmniPath
CDK2 RRN3 15004009 27898060 stimulant N/A OmniPath
MAPK3 RRN3 12620228 21098478 27898060 stimulant N/A OmniPath
RPS6KA3 RRN3 15558034 18498750 27898060 N/A N/A OmniPath
CSNK2A1 RRN3 12124936 18559419 24297901 27898060 inhibition N/A OmniPath
RPS6KA2 RRN3 12620228 27898060 N/A N/A OmniPath
PRKAA1 RRN3 19815529 27898060 inhibition N/A OmniPath

Visualization










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