GENE：RRP8
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | RRP8 |
| FullNmae | ribosomal RNA processing 8 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:29030 |
| EnsembleID | ENSG00000132275 |
| Uniprot | O43159 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| RRP8 | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| RRP8 | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| RRP8 | GO:0000183,GO:0000183,GO:0000183,GO:0003723,GO:0005515,GO:0005654,GO:0005654,GO:0005677,GO:0005677,GO:0005730,GO:0005730,GO:0005829,GO:0005886,GO:0006364,GO:0008757,GO:0031065,GO:0032259,GO:0033553,GO:0033553,GO:0035064,GO:0035064,GO:0042149,GO:0042149,GO:0045786,GO:0045892,GO:0046015,GO:0046015,GO:0061773,GO:0072332,GO:0097009,GO:1903450 |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | RRP8 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | RRP8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | RRP8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | RRP8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | RRP8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | RRP8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000324096 | RRP8 | N/A | rna interference,inhibition | experimental interaction detection | miRSponge |
| URS0000324096 | RRP8 | 18668040 25416803 | mrna cleavage,inhibition | experimental interaction detection,experimental interaction detection,experimental interaction detection | TarBase |
| URS000011A030 | RRP8 | 22100165 22291592 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000435A77 | RRP8 | 22100165 22291592 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000458AD2 | RRP8 | 22100165 22291592 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000057FDB8 | RRP8 | 22100165 22291592 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001A405B | RRP8 | 22100165 22291592 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003538C1 | RRP8 | 22012620 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS0000021D08 | RRP8 | 22012620 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000028C188 | RRP8 | 22012620 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000075994C | RRP8 | 22012620 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000047A67D | RRP8 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000078918 | RRP8 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005ACA7C | RRP8 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075A513 | RRP8 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GAR1 | RRP8 | 25361965 | interaction type | N/A | PTMCode2 |
| RRP8 | GAR1 | 25361965 | interaction type | N/A | PTMCode2 |
| RRP8 | SUV39H1 | 25361965 | interaction type | N/A | PTMCode2 |
| SUV39H1 | RRP8 | 25361965 | interaction type | N/A | PTMCode2 |
| SIRT1 | RRP8 | 25361965 | interaction type | N/A | PTMCode2 |
| RRP8 | SIRT1 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| NOC4L | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| FXR2 | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| POP7 | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| NPM1 | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| RPL37A | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| RPF1 | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| NOL12 | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| NIFK | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| GLYR1 | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| NMNAT1 | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| RPL10A | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| PICK1 | RRP8 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| MYBBP1A | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| RPL18A | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| RBM4 | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| HERC5 | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| ILK | RRP8 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| RPL28 | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| SUV39H1 | RRP8 | 14525934 18485871 24234451 25348397 | physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD,IntAct |
| RPS6 | RRP8 | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| RPL4 | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| RPLP0 | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| H1-4 | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| RPL7A | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| RAB11A | RRP8 | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| RNF2 | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| CEBPZ | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| TAF1B | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| TAF1C | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| SIRT1 | RRP8 | 14525934 18485871 24234451 25348397 | physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD,IntAct |
| HIF1AN | RRP8 | 24234451 25348397 26972000 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| MECP2 | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| FXR1 | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| ILF2 | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| DVL3 | RRP8 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| CENPU | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| REXO4 | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| DDX54 | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| POP1 | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| ZCCHC17 | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| BET1 | RRP8 | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| RFC1 | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| IFI16 | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| RPL14 | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| RRP1B | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| RSL24D1 | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| DGCR8 | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| USP39 | RRP8 | 19615732 24234451 25348397 | physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| RRP12 | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| CENPC | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| NVL | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| RPS14 | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| RPL8 | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| DKC1 | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| FTSJ3 | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| DDX24 | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| NOC2L | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| FBL | RRP8 | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| FGF8 | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| RPL30 | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| H1-1 | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| GTPBP4 | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| MNDA | RRP8 | 24234451 25348397 25665578 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| BRIX1 | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| PDCD11 | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| TAF1D | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| SIRT7 | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| C8ORF33 | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| NOP53 | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| CCDC137 | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| PUM3 | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| DDX27 | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| ZNF689 | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| RSBN1 | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| DHX30 | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| RPL3 | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| CNBP | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| THAP11 | RRP8 | 25348397 | N/A | physical interaction | ComPPI |
| RRP8 | PRR11 | 25348397 | N/A | physical interaction | ComPPI |
| RRP8 | ZC3HAV1 | 25348397 | N/A | physical interaction | ComPPI |
| RRP8 | CENPV | 25348397 | N/A | physical interaction | ComPPI |
| RRP8 | SPTY2D1 | 25348397 | N/A | physical interaction | ComPPI |
| RRP8 | ZNF800 | 25348397 | N/A | physical interaction | ComPPI |
| RRP8 | CENPL | 25348397 | N/A | physical interaction | ComPPI |
| RRP8 | DDX51 | 25348397 | N/A | physical interaction | ComPPI |
| RRP8 | RBM34 | 25348397 | N/A | physical interaction | ComPPI |
| RRP8 | RPL18 | 25348397 | N/A | physical interaction | ComPPI |
| RRP8 | WDR3 | 25348397 | N/A | physical interaction | ComPPI |
| RRP8 | ZNF2 | 25348397 | N/A | physical interaction | ComPPI |
| RRP8 | DDX31 | 25348397 | N/A | physical interaction | ComPPI |
| RRP8 | URB2 | 25348397 | N/A | physical interaction | ComPPI |
| RRP8 | URB1 | 25348397 | N/A | physical interaction | ComPPI |
| RRP8 | STAU1 | 25348397 | N/A | physical interaction | ComPPI |
| RRP8 | KNOP1 | 25348397 | N/A | physical interaction | ComPPI |
| RRP8 | RPL26L1 | 25348397 | N/A | physical interaction | ComPPI |
| RRP8 | ZNF71 | 25348397 | N/A | physical interaction | ComPPI |
| RRP8 | ZNF48 | 25348397 | N/A | physical interaction | ComPPI |
| RRP8 | RPF2 | 25348397 | N/A | physical interaction | ComPPI |
| RRP8 | NOL6 | 25348397 | N/A | physical interaction | ComPPI |
| RRP8 | SCAF1 | 25348397 | N/A | physical interaction | ComPPI |
| RRP8 | ZNF184 | 25348397 | N/A | physical interaction | ComPPI |
| RRP8 | SRBD1 | 25348397 | N/A | physical interaction | ComPPI |
| RRP8 | TUT7 | 25348397 | N/A | physical interaction | ComPPI |
| RRP8 | PPAN | 25348397 | N/A | physical interaction | ComPPI |
| RRP8 | NEPRO | 25348397 | N/A | physical interaction | ComPPI |
| RRP8 | RBM28 | 25348397 | N/A | physical interaction | ComPPI |
| RRP8 | NSD2 | 25348397 | N/A | physical interaction | ComPPI |
| RRP8 | MAK16 | 25348397 | N/A | physical interaction | ComPPI |
| RRP8 | RPLP0P6 | 25348397 | N/A | physical interaction | ComPPI |
| RRP8 | WDR46 | 25348397 | N/A | physical interaction | ComPPI |
| RRP8 | RPL32 | 25348397 | N/A | physical interaction | ComPPI |
| RRP8 | DDX50 | 25348397 | N/A | physical interaction | ComPPI |
| RRP8 | ZNF512 | 25348397 | N/A | physical interaction | ComPPI |
| RRP8 | GNL2 | 25348397 | N/A | physical interaction | ComPPI |
| RRP8 | H1-6 | 25348397 | N/A | physical interaction | ComPPI |
| RRP8 | NAT10 | 25348397 | N/A | physical interaction | ComPPI |
| RRP8 | ZFP62 | 25348397 | N/A | physical interaction | ComPPI |
| RRP8 | NOP14 | 25348397 | N/A | physical interaction | ComPPI |
| RRP8 | DDX52 | 25348397 | N/A | physical interaction | ComPPI |
| RRP8 | ZNF668 | 25348397 | N/A | physical interaction | ComPPI |
| RRP8 | MACROH2A2 | 25348397 | N/A | physical interaction | ComPPI |
| RRP8 | RPS8 | 25348397 | N/A | physical interaction | ComPPI |
| EBNA1BP2 | RRP8 | 25348397 | N/A | physical interaction | ComPPI |