GeneInfo:
GeneAttribute
GeneDescription
GeneSymbol
RTKN2
FullNmae
rhotekin 2
LocusType
gene with protein product
Status
Approved
HGNC_id
HGNC:19364
EnsembleID
ENSG00000182010
Uniprot
Q8IZC4
Protein Structure:
Gene Description in Publicaton:
GeneSymbol
CellDeathType
PMID
Description
GeneType
RTKN2
apoptosis
38538696
The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore)
retulator signature
RTKN2
apoptosis
36341760
The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns.
regulator signature
Go Annotation:
GeneSymbol
Go id
RTKN2
GO:0005634,GO:0005737,GO:0005886,GO:0007165,GO:0008284,GO:0030097,GO:0051092,GO:1901224,GO:2001243
Protein-Protein Interaction(String):
Signalink 3.0 modificators
Source
Target
Pmid
Interactiontype
Methods
Database
AR
RTKN2
20610535
trascriptional regulation,stimulation
chromatin immunoprecipitation array
TFlink
E2F4
RTKN2
17531812
18971253
trascriptional regulation,stimulation
chromatin immunoprecipitation array,inferred by curator
TFlink
ETS1
RTKN2
18971253
20019798
trascriptional regulation,stimulation
inferred by curator,chromatin immunoprecipitation assay
TFlink
YBX1
RTKN2
19151767
trascriptional regulation,stimulation
chromatin immunoprecipitation assay
TFlink
FOXP3
RTKN2
20554955
trascriptional regulation,stimulation
chromatin immunoprecipitation array
TFlink
SMARCA4
RTKN2
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
CEBPA
RTKN2
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
CTCF
RTKN2
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
EGR1
RTKN2
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
FOXA1
RTKN2
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
GATA2
RTKN2
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
HNF4A
RTKN2
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
RUNX1
RTKN2
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
Source
Target
Pmid
Interactiontype
Methods
Database
URS00000AA464
RTKN2
20304954
25416803
mrna cleavage,inhibition
array technology
TarBase
URS00000F31F4
RTKN2
19074876
25416803
mrna cleavage,inhibition
array technology
TarBase
URS00000B59A2
RTKN2
19074876
25416803
mrna cleavage,inhibition
array technology
TarBase
URS00001A7F58
RTKN2
23622248
25416803
mrna cleavage,inhibition
clash
TarBase
URS00004AC389
RTKN2
23622248
25416803
mrna cleavage,inhibition
clash
TarBase
URS000016D2D4
RTKN2
23622248
25416803
mrna cleavage,inhibition
clash
TarBase
URS000075B0F6
RTKN2
25416803
27418678
mrna cleavage,inhibition
clip
TarBase
Source
Target
Pmid
Interactiontype
Methods
Database
SH3KBP1
RTKN2
25348397
N/A
physical interaction
ComPPI
IGHG1
RTKN2
15174051
24234451
25348397
association
anti bait coimmunoprecipitation
ComPPI,IntAct
PACSIN1
RTKN2
20936779
24234451
25348397
physical association
physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach
ComPPI,IntAct
RHOC
RTKN2
25348397
N/A
physical interaction
ComPPI
BRCA1
RTKN2
25348397
N/A
physical interaction
ComPPI
PACSIN2
RTKN2
25348397
N/A
physical interaction
ComPPI
Visualization