GENE：SCN2A
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | SCN2A |
| FullNmae | sodium voltage-gated channel alpha subunit 2 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:10588 |
| EnsembleID | ENSG00000136531 |
| Uniprot | Q99250 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| SCN2A | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| SCN2A | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| SCN2A | GO:0001518,GO:0005248,GO:0005248,GO:0005516,GO:0005886,GO:0005891,GO:0006814,GO:0007399,GO:0007613,GO:0008331,GO:0008340,GO:0008627,GO:0014704,GO:0016020,GO:0021542,GO:0021675,GO:0030315,GO:0030424,GO:0033268,GO:0033270,GO:0034706,GO:0034765,GO:0035725,GO:0042552,GO:0042734,GO:0051402,GO:0071456,GO:0098703,GO:0098978 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| SCN2A | hsa:6326 | path:hsa04742 | Taste transduction - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | SCN2A | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | SCN2A | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | SCN2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | SCN2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | SCN2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | SCN2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | SCN2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ANK3 | SCN2A | 12036953 14525934 25348397 27898060 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD,OmniPath |
| SCN2A | SCN4B | 12930796 14525934 25348397 27898060 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD,OmniPath |
| SCN2A | MPP3 | 14525934 16169070 24234451 25348397 | physical association | two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid | ComPPI,HPRD,IntAct |
| SCN2A | ARHGEF10L | 14525934 16169070 24234451 25348397 | physical association | two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid | ComPPI,HPRD,IntAct |
| SCN2A | RNF130 | 14525934 16169070 24234451 25348397 | physical association | two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid | ComPPI,HPRD,IntAct |
| ATP5F1A | SCN2A | 24234451 30021884 | physical association | cross-linking study | IntAct |
| ATP5PD | SCN2A | 24234451 30021884 | physical association | cross-linking study | IntAct |
| PPP2CA | SCN2A | 27898060 8262976 | N/A | N/A | OmniPath |
| KDM1A | SCN2A | 16140033 27898060 | inhibition | N/A | OmniPath |
| FGF12 | SCN2A | 20679355 27898060 | inhibition | N/A | OmniPath |
| FGF11 | SCN2A | 20679355 27898060 | inhibition | N/A | OmniPath |
| FGF14 | SCN2A | 20679355 27898060 | inhibition | N/A | OmniPath |
| FGF13 | SCN2A | 20679355 27898060 | inhibition | N/A | OmniPath |