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GENE：CASP7

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CASP7
FullNmae caspase 7
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1508
EnsembleID ENSG00000165806
Uniprot P55210

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CASP7 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CASP7 apoptosis 40533441 X-linked inhibitor of apoptosis (XIAP) inhibits caspases 3, 7, and 9, thereby preventing cell apoptosis. retulator signature

Go Annotation:

GeneSymbol Go id
CASP7 GO:0003723,GO:0004190,GO:0004197,GO:0005515,GO:0005615,GO:0005634,GO:0005654,GO:0005737,GO:0005737,GO:0005829,GO:0005829,GO:0006508,GO:0006915,GO:0006915,GO:0007507,GO:0008233,GO:0008234,GO:0009411,GO:0016485,GO:0030163,GO:0032991,GO:0042742,GO:0044346,GO:0051146,GO:0051402,GO:0051604,GO:0070227,GO:0071222,GO:0072734,GO:0097153,GO:0097153,GO:0097194,GO:0097194,GO:0097200,GO:0097200,GO:0097200,GO:1905686

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CASP7 hsa:840 path:hsa04148 Efferocytosis - Homo sapiens (human)
CASP7 hsa:840 path:hsa04210 Apoptosis - Homo sapiens (human)
CASP7 hsa:840 path:hsa04215 Apoptosis - multiple species - Homo sapiens (human)
CASP7 hsa:840 path:hsa04623 Cytosolic DNA-sensing pathway - Homo sapiens (human)
CASP7 hsa:840 path:hsa04668 TNF signaling pathway - Homo sapiens (human)
CASP7 hsa:840 path:hsa04932 Non-alcoholic fatty liver disease - Homo sapiens (human)
CASP7 hsa:840 path:hsa05010 Alzheimer disease - Homo sapiens (human)
CASP7 hsa:840 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
CASP7 hsa:840 path:hsa05130 Pathogenic Escherichia coli infection - Homo sapiens (human)
CASP7 hsa:840 path:hsa05132 Salmonella infection - Homo sapiens (human)
CASP7 hsa:840 path:hsa05133 Pertussis - Homo sapiens (human)
CASP7 hsa:840 path:hsa05134 Legionellosis - Homo sapiens (human)
CASP7 hsa:840 path:hsa05200 Pathways in cancer - Homo sapiens (human)
CASP7 hsa:840 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
XIAP CASP7 11257230 11257231 11359776 15200957 19559631 23180781 9230442 9525868 9545235 protein cleavage,physical association affinity chromatography technology,anti tag coimmunoprecipitation,gst pull down,x-ray crystallography,protease assay InnateDB
CTSG CASP7 15650747 23180781 cleavage reaction protease assay InnateDB
GZMB CASP7 15569669 15650747 17283187 19103589 23180781 cleavage reaction,protein cleavage protease assay InnateDB
BIRC2 CASP7 16339151 23180781 physical association gst pull down InnateDB
BIRC3 CASP7 16339151 23180781 physical association gst pull down InnateDB
CASP9 CASP7 16352606 23180781 physical association anti tag coimmunoprecipitation InnateDB
COPS6 CASP7 17337451 23180781 cleavage reaction cleavage reaction InnateDB
EGFR CASP7 11226410 23180781 cleavage reaction protease assay InnateDB
CASP7 PLA2G4A 23180781 9875225 cleavage reaction enzymatic study,protease assay InnateDB
CASP7 PARP1 23180781 9875225 cleavage reaction enzymatic study,protease assay InnateDB
HDAC7 CASP7 18458084 23180781 cleavage reaction protease assay InnateDB
PTGES3 CASP7 19559631 23180781 protein cleavage protease assay InnateDB
ARHGDIA CASP7 19559631 23180781 protein cleavage protease assay InnateDB
IL33 CASP7 19559631 23180781 protein cleavage protease assay InnateDB
EGR1 CASP7 19032775 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 CASP7 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 CASP7 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SREBF1 CASP7 19323650 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SREBF2 CASP7 19323650 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 CASP7 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
CEBPA CASP7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CASP7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 CASP7 12766778 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 CASP7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 CASP7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 CASP7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A CASP7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 CASP7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
IRF1 CASP7 10918594 trascriptional regulation,stimulation inferred by curator TFlink
RUNX3 CASP7 15930301 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000600E6 CASP7 17242205 22986525 25416803 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000028BB8 CASP7 17612493 25416803 mrna cleavage,inhibition array technology TarBase
URS00003380CC CASP7 17612493 25416803 mrna cleavage,inhibition array technology TarBase
URS00000F31F4 CASP7 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B59A2 CASP7 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS000003ABC4 CASP7 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00005651EE CASP7 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000039E1E1 CASP7 23807165 25416803 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS00001EFBE3 CASP7 25416803 27449900 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000184017 CASP7 25416803 26307684 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000EED18 CASP7 25416803 28097098 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
PAK2 CASP7 22135298 phosphorylation N/A PhosphoSite
GZMB CASP7 25361965 interaction type N/A PTMCode2
CASP7 GZMB 25361965 interaction type N/A PTMCode2
BIRC7 CASP7 25361965 interaction type N/A PTMCode2
CASP7 BIRC7 25361965 interaction type N/A PTMCode2
VIM CASP7 25361965 interaction type N/A PTMCode2
CASP7 VIM 25361965 interaction type N/A PTMCode2
CASP7 BIRC5 25361965 interaction type N/A PTMCode2
BIRC5 CASP7 25361965 interaction type N/A PTMCode2
CASP7 CASP2 25361965 interaction type N/A PTMCode2
CASP2 CASP7 25361965 interaction type N/A PTMCode2
CASP7 CLSPN 25361965 interaction type N/A PTMCode2
CLSPN CASP7 25361965 interaction type N/A PTMCode2
CASP7 CASP9 25361965 interaction type N/A PTMCode2
CASP9 CASP7 25361965 interaction type N/A PTMCode2
CASP7 XIAP 25361965 interaction type N/A PTMCode2
XIAP CASP7 25361965 interaction type N/A PTMCode2
CASP7 DFFA 25361965 interaction type N/A PTMCode2
DFFA CASP7 25361965 interaction type N/A PTMCode2
CASP7 CAST 25361965 interaction type N/A PTMCode2
CAST CASP7 25361965 interaction type N/A PTMCode2
TNFRSF1A CASP7 25361965 interaction type N/A PTMCode2
CASP7 TNFRSF1A 25361965 interaction type N/A PTMCode2
BIRC2 CASP7 25361965 interaction type N/A PTMCode2
CASP7 BIRC2 25361965 interaction type N/A PTMCode2
BIRC3 CASP7 25361965 interaction type N/A PTMCode2
CASP7 BIRC3 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
KRT18 CASP7 14525934 25348397 9298992 N/A experimental interaction detection,in vitro ComPPI,HPRD
CDC42 CASP7 11278572 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PAK2 CASP7 21555521 24234451 25348397 phosphorylation reaction,colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,protein kinase assay,confocal microscopy ComPPI,IntAct
CRYAB CASP7 25348397 N/A physical interaction ComPPI
VIM CASP7 10469173 11423904 11514563 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SAT1 CASP7 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
STAT1 CASP7 25348397 N/A physical interaction ComPPI
VCP CASP7 25348397 N/A physical interaction ComPPI
XIAP CASP7 11257230 11257231 11359776 14525934 24234451 25348397 9230442 9525868 physical association experimental interaction detection,pull down,x-ray crystallography,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
CASP9 CASP7 18723680 24234451 25348397 cleavage reaction cleavage reaction,physical interaction,protease assay ComPPI,IntAct
ROCK1 CASP7 25348397 N/A physical interaction ComPPI
RAD21 CASP7 11875078 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CTSG CASP7 14525934 15650747 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
RAC1 CASP7 11278572 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
RNF7 CASP7 10082581 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
ARHGDIB CASP7 18723680 24234451 25348397 cleavage reaction cleavage reaction,protease assay ComPPI,IntAct
SP1 CASP7 25348397 N/A physical interaction ComPPI
LYN CASP7 12586738 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASP3 CASP7 25348397 N/A physical interaction ComPPI
RB1 CASP7 11420704 14525934 15735701 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
AR CASP7 14525934 25348397 9535906 N/A experimental interaction detection,in vitro ComPPI,HPRD
ARHGDIA CASP7 25348397 N/A physical interaction ComPPI
SRF CASP7 11387340 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
EIF2AK2 CASP7 11555640 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CASP6 CASP7 18723680 24234451 25348397 cleavage reaction cleavage reaction,protease assay ComPPI,IntAct
PARP1 CASP7 25348397 N/A physical interaction ComPPI
HSPA5 CASP7 11943137 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CASP7 TNFRSF1A 11755217 14525934 21157428 24234451 25348397 colocalization experimental interaction detection,physical interaction,fluorescence microscopy,in vitro ComPPI,HPRD,IntAct
CASP7 MEF2A 11904443 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASP7 MEF2D 11904443 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CASP7 PSEN2 10069390 14525934 25348397 9219695 9990034 N/A experimental interaction detection,in vivo ComPPI,HPRD
CASP7 BIRC2 11084335 14525934 24234451 25348397 9384571 physical association experimental interaction detection,pull down,physical interaction,enzymatic study,in vitro ComPPI,HPRD,IntAct
CASP7 BIRC3 14525934 25348397 9384571 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CASP7 CASP10 14525934 25348397 8962078 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CASP7 NEDD4 14525934 25348397 9593687 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CASP7 GOLGA3 10791974 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CASP7 BIRC5 11024045 11170436 14525934 25348397 9850056 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CASP7 PSIP1 12181742 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASP7 PSME3 11859414 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASP7 BIRC7 11024045 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CASP7 GORASP1 11815631 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CASP7 DCTN1 11425872 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
CASP7 UBE4B 25348397 N/A in vitro ComPPI
CASP7 CAST 10731697 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASP7 RAD51 10998058 14525934 25348397 27898060 9607320 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
CASP7 DFFA 10318789 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CASP7 STK24 12107159 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CASP7 CLSPN 14525934 16123041 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CASP7 PRKCZ 11016947 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASP7 DSP 14525934 15500642 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASP7 RASA1 10200531 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASP7 PSEN1 10069390 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CASP7 MAX 11535131 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CASP7 MAPT 25348397 N/A in vitro,in vivo ComPPI
CASP7 CASP8 25348397 N/A physical interaction ComPPI
CASP7 BIRC6 25348397 N/A physical interaction ComPPI
CASP7 TERF1 21044950 24234451 25348397 physical association physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
CASP7 COPS6 25348397 N/A physical interaction ComPPI
CASP7 CCT2 25348397 N/A physical interaction ComPPI
CASP7 PLA2G4B 25348397 N/A physical interaction ComPPI
CASP7 PTGES3 18723680 24234451 25348397 cleavage reaction cleavage reaction,physical interaction,protease assay ComPPI,IntAct
CASP7 SPTAN1 25348397 N/A physical interaction ComPPI
CASP7 GZMB 14525934 25348397 8631895 N/A experimental interaction detection,physical interaction ComPPI,HPRD
CASP7 CAPN1 25348397 N/A physical interaction ComPPI
CASP7 CNDP2 25348397 N/A physical interaction ComPPI
CASP7 EEF2 25348397 N/A physical interaction ComPPI
CASP7 GNS 25348397 N/A physical interaction ComPPI
CASP7 PEPD 25348397 N/A physical interaction ComPPI
CASP7 CTSA 25348397 N/A physical interaction ComPPI
CASP7 EIF4H 25348397 N/A physical interaction ComPPI
CASP7 GBP2 25348397 N/A physical interaction ComPPI
CASP7 MVD 25348397 N/A physical interaction ComPPI
CASP7 RPS6KA1 25348397 N/A physical interaction ComPPI
CASP7 BAX 25348397 N/A physical interaction ComPPI
CASP7 FBXW11 25348397 N/A physical interaction ComPPI
CASP7 PANX1 20944749 24234451 25348397 protein cleavage protease assay,protein cleavage ComPPI,IntAct
CASP7 IKBKE 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CASP7 NUCB2 18154733 24234451 25348397 cleavage reaction protease assay ComPPI,IntAct
CASP7 SMPD1 21157428 24234451 25348397 colocalization,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,fluorescence microscopy ComPPI,IntAct
CASP7 NEDD8 22584050 24234451 25348397 physical association pull down ComPPI,IntAct
CASP7 MAGEA11 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CASP7 NIF3L1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CASP2 CASP7 11399776 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CFLAR CASP7 14525934 25348397 9228018 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
GINS2 CASP7 25348397 N/A physical interaction ComPPI
CASP7 CASP7 11257230 11752425 14525934 24234451 physical association experimental interaction detection,x-ray crystallography HPRD,IntAct
CASP7 PTMA 10675528 14525934 N/A experimental interaction detection HPRD
CASP1 CASP7 18667412 27898060 stimulant N/A OmniPath
EGFR CASP7 11226410 27898060 N/A N/A OmniPath
CASP7 ITGB4 17178732 27898060 inhibition,stimulant N/A OmniPath
CASP7 DFFA 10318789 27898060 inhibition,stimulant N/A OmniPath
CASP7 EIF2AK2 11555640 27898060 N/A N/A OmniPath
CASP3 CASP7 17899380 27898060 stimulant N/A OmniPath
BIRC6 CASP7 15200957 15507451 27898060 inhibition N/A OmniPath
CASP9 CASP7 16352606 17899380 27898060 9598997 9651578 9922454 stimulant N/A OmniPath
XIAP CASP7 10508158 11257230 11257231 11257232 11359776 11447297 11583623 14512414 15200957 15580265 18521960 19559631 19698783 23074197 23979166 27898060 9230442 9384571 9525868 9545235 inhibition N/A OmniPath
CASP7 IL33 19559631 27898060 N/A N/A OmniPath
CASP12 CASP7 12209154 27898060 stimulant N/A OmniPath
CASP7 NEDD4 27898060 9593687 N/A N/A OmniPath
CASP7 MAX 11535131 27898060 N/A N/A OmniPath
CASP8 CASP7 10872455 11832478 18073771 18329793 27898060 8962078 9463409 9545235 9727491 stimulant N/A OmniPath
E2F1 CASP7 18319725 18660752 27898060 inhibition,stimulant N/A OmniPath
CASP10 CASP7 27898060 8755496 8962078 stimulant N/A OmniPath
CASP7 GOLGA3 10791974 27898060 N/A N/A OmniPath
BIRC2 CASP7 11084335 15580265 16339151 19258326 27898060 9384571 inhibition N/A OmniPath
BIRC3 CASP7 16339151 27898060 9384571 inhibition N/A OmniPath
CASP7 VIM 10469173 11423904 11514563 27898060 inhibition,stimulant N/A OmniPath
BIRC5 CASP7 11024045 11170436 27898060 9384571 9850056 inhibition N/A OmniPath
CASP7 PSEN1 10069390 27898060 N/A N/A OmniPath
CASP7 TNFRSF1A 11755217 21157428 27898060 inhibition,stimulant N/A OmniPath
CASP7 PARP1 11058599 11170436 1558065 16374543 18723680 22451931 27898060 9463409 9875225 inhibition N/A OmniPath
PAK2 CASP7 21555521 27898060 inhibition N/A OmniPath
CASP7 MEF2D 11904443 27898060 N/A N/A OmniPath
CASP7 PSEN2 10069390 27898060 9219695 9990034 N/A N/A OmniPath
PLA2G4A CASP7 27898060 9875225 N/A N/A OmniPath
CASP7 PROKR1 11555640 27898060 inhibition N/A OmniPath
CASP7 MEF2B 11904443 27898060 inhibition N/A OmniPath
NAIP CASP7 11896143 27898060 inhibition,stimulant N/A OmniPath
CASP7 GAS2 1056466 10564664 27898060 N/A N/A OmniPath

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