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GENE：SENP1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SENP1
FullNmae SUMO specific peptidase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:17927
EnsembleID ENSG00000079387
Uniprot Q9P0U3

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SENP1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SENP1 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
SENP1 GO:0004175,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0005737,GO:0005925,GO:0006508,GO:0006919,GO:0016925,GO:0016926,GO:0016926,GO:0016929,GO:0016929,GO:0031965,GO:0045944,GO:0070139,GO:0097190

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SENP1 EGR1 19032775 23180781 physical association anti tag coimmunoprecipitation InnateDB
ISG15 SENP1 16009940 23180781 physical association unspecified method InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 SENP1 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 SENP1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 SENP1 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 SENP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA SENP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SENP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 SENP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 SENP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 SENP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF SENP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000AA464 SENP1 20304954 25416803 mrna cleavage,inhibition array technology TarBase
URS00000ED600 SENP1 20215506 25416803 mrna cleavage,inhibition array technology TarBase
URS0000345DEB SENP1 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00000EED18 SENP1 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00000B59A2 SENP1 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS000035CC3E SENP1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000042E1F SENP1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 SENP1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000427B68 SENP1 20371350 21572407 23313552 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00004719AB SENP1 20371350 21572407 23313552 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002C28B2 SENP1 20371350 21572407 23313552 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000016E46F SENP1 20371350 21572407 23313552 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001C04A2 SENP1 20371350 21572407 23313552 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000122ED0 SENP1 20371350 21572407 23313552 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002F8148 SENP1 20371350 21572407 23313552 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000324096 SENP1 20371350 21572407 23313552 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000B7E30 SENP1 20371350 21572407 23313552 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000028DE3F SENP1 20371350 21572407 23313552 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000272039 SENP1 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000116F83 SENP1 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000023F8DA SENP1 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000482389 SENP1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000018CD09 SENP1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000034979B SENP1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 SENP1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 SENP1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 SENP1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA SENP1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00004F4657 SENP1 25416803 25645686 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
BAG3 SENP1 25348397 N/A physical interaction ComPPI
ISG15 SENP1 25348397 N/A physical interaction ComPPI
LMNA SENP1 24234451 25348397 29568061 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
SUMO1 SENP1 15896780 17099698 22878415 24234451 25348397 cleavage reaction,physical association coimmunoprecipitation,cross-linking study,fluorescent resonance energy transfer,isothermal titration calorimetry,x-ray crystallography,physical interaction,two hybrid array,enzymatic study,two hybrid prey pooling approach ComPPI,IntAct
HDAC4 SENP1 25348397 N/A physical interaction ComPPI
BLK SENP1 25348397 N/A physical interaction ComPPI
KPNB1 SENP1 25348397 N/A physical interaction ComPPI
APC SENP1 25348397 N/A physical interaction ComPPI
PARP1 SENP1 25348397 N/A physical interaction ComPPI
LRP1 SENP1 25348397 N/A physical interaction ComPPI
F9 SENP1 25348397 N/A physical interaction ComPPI
PROZ SENP1 25348397 N/A physical interaction ComPPI
HNRNPL SENP1 25348397 N/A physical interaction ComPPI
RABGAP1 SENP1 25348397 N/A physical interaction ComPPI
SP100 SENP1 25348397 N/A physical interaction ComPPI
SUMO2 SENP1 17099698 24234451 25348397 physical association two hybrid,fluorescent resonance energy transfer,isothermal titration calorimetry,physical interaction,two hybrid array,enzymatic study,two hybrid prey pooling approach ComPPI,IntAct
SUMO3 SENP1 22878415 24234451 25348397 cleavage reaction physical interaction,enzymatic study ComPPI,IntAct
RANGAP1 SENP1 16553580 17099698 24234451 25027693 25348397 27898060 physical association isothermal titration calorimetry,x-ray crystallography,physical interaction,enzymatic study ComPPI,IntAct,OmniPath
ARRB2 SENP1 25348397 N/A physical interaction ComPPI
CAV3 SENP1 25348397 N/A physical interaction ComPPI
HDAC2 SENP1 25348397 N/A physical interaction ComPPI
SKP2 SENP1 25348397 N/A physical interaction ComPPI
HIPK2 SENP1 25348397 N/A physical interaction ComPPI
UBE2K SENP1 25348397 N/A physical interaction ComPPI
NUP153 SENP1 25348397 N/A physical interaction ComPPI
RANBP2 SENP1 25348397 N/A physical interaction ComPPI
PRDM1 SENP1 25348397 N/A physical interaction ComPPI
ELAVL1 SENP1 25348397 N/A physical interaction ComPPI
PHF12 SENP1 25348397 N/A physical interaction ComPPI
PML SENP1 25348397 N/A physical interaction ComPPI
NUP107 SENP1 25348397 N/A physical interaction ComPPI
RUVBL2 SENP1 25348397 N/A physical interaction ComPPI
NUP43 SENP1 25348397 N/A physical interaction ComPPI
SIRT6 SENP1 25348397 N/A physical interaction ComPPI
ARL11 SENP1 25348397 N/A physical interaction ComPPI
GCM1 SENP1 25348397 N/A physical interaction ComPPI
NACC1 SENP1 25348397 N/A physical interaction ComPPI
IL13RA2 SENP1 25348397 N/A physical interaction ComPPI
HERC2 SENP1 25348397 N/A physical interaction ComPPI
USP25 SENP1 25348397 N/A physical interaction ComPPI
APP SENP1 25348397 N/A physical interaction ComPPI
TP53 SENP1 25348397 N/A physical interaction ComPPI
TRMT1 SENP1 25348397 N/A physical interaction ComPPI
HDAC1 SENP1 25348397 N/A physical interaction ComPPI
HERC2P3 SENP1 25348397 N/A physical interaction ComPPI
RIPK4 SENP1 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
SENP1 SCARA3 25348397 N/A physical interaction ComPPI
SENP1 ZNF420 25348397 N/A physical interaction ComPPI
SENP1 SUMO1P1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SENP1 TRIM28 17942393 27898060 inhibition N/A OmniPath
ISG15 SENP1 16009940 27898060 N/A N/A OmniPath
SENP1 HIF1A 17981124 27898060 stimulant N/A OmniPath

Visualization










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