GENE：SFRP1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | SFRP1 |
| FullNmae | secreted frizzled related protein 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:10776 |
| EnsembleID | ENSG00000104332 |
| Uniprot | Q8N474 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| SFRP1 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| SFRP1 | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| SFRP1 | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| SFRP1 | GO:0001649,GO:0001657,GO:0001954,GO:0002244,GO:0003402,GO:0004197,GO:0005109,GO:0005515,GO:0005576,GO:0005615,GO:0005615,GO:0005615,GO:0005829,GO:0005886,GO:0008201,GO:0008284,GO:0008285,GO:0008584,GO:0008585,GO:0009267,GO:0009410,GO:0009950,GO:0009986,GO:0010564,GO:0010629,GO:0010719,GO:0010975,GO:0014034,GO:0014070,GO:0017147,GO:0017147,GO:0017147,GO:0017147,GO:0030177,GO:0030178,GO:0030178,GO:0030279,GO:0030279,GO:0030307,GO:0030308,GO:0030316,GO:0030336,GO:0030509,GO:0030514,GO:0033689,GO:0035019,GO:0035567,GO:0042802,GO:0043065,GO:0043065,GO:0043066,GO:0043547,GO:0044344,GO:0044345,GO:0045578,GO:0045600,GO:0045668,GO:0045671,GO:0045765,GO:0045880,GO:0045892,GO:0045892,GO:0045893,GO:0045893,GO:0046676,GO:0046851,GO:0048147,GO:0048546,GO:0050679,GO:0050680,GO:0050732,GO:0051496,GO:0051894,GO:0060070,GO:0060070,GO:0060218,GO:0060346,GO:0060527,GO:0060687,GO:0060766,GO:0062023,GO:0062023,GO:0070062,GO:0071305,GO:0071347,GO:0071356,GO:0071363,GO:0071380,GO:0071391,GO:0071392,GO:0071456,GO:0071481,GO:0071504,GO:0071542,GO:0071560,GO:0071773,GO:0090090,GO:0090090,GO:0090090,GO:0090179,GO:0090244,GO:0090246,GO:0090263,GO:0090263,GO:0097191,GO:1902043,GO:1904956,GO:2000041,GO:2000052,GO:2000054,GO:2000080,GO:2000270,GO:2000271 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| SFRP1 | hsa:6422 | path:hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GATA2 | SFRP1 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| PRDM14 | SFRP1 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| CEBPA | SFRP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | SFRP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | SFRP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | SFRP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | SFRP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | SFRP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | SFRP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | SFRP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| DNMT1 | SFRP1 | 23770846 24374650 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| DNMT3A | SFRP1 | 24374650 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EZH2 | SFRP1 | 21515604 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GLI1 | SFRP1 | 19930158 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HDAC1 | SFRP1 | 23770846 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MYC | SFRP1 | 20697356 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000237AF9 | SFRP1 | 18185580 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS0000239117 | SFRP1 | 23591200 24504368 25416803 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS00005FDE70 | SFRP1 | 24305703 25416803 | mrna cleavage,inhibition | western blot,immunohistochemistry,miRNA interference luciferase reporter assay | TarBase |
| URS0000007340 | SFRP1 | 24517116 25416803 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS000034B6F5 | SFRP1 | 24855559 25416803 27043663 | mrna cleavage,inhibition | experimental interaction detection,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS000014F13C | SFRP1 | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003AD2AA | SFRP1 | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002394F5 | SFRP1 | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075AAA0 | SFRP1 | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000050CCE0 | SFRP1 | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001EFBE3 | SFRP1 | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000334286 | SFRP1 | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001CE046 | SFRP1 | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004AC389 | SFRP1 | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000016D2D4 | SFRP1 | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005CC20C | SFRP1 | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001B341F | SFRP1 | 24625818 25416803 28099945 28401000 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay | TarBase |
| URS00000B0E50 | SFRP1 | 25416803 26468775 | mrna cleavage,inhibition | western blot,rna immunoprecipitation,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay,miRNA interference luciferase reporter assay | TarBase |
| URS00000EC1BE | SFRP1 | 25416803 28107193 | mrna cleavage,inhibition | western blot | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PPP1CC | SFRP1 | 25348397 | N/A | physical interaction | ComPPI |
| PPP1CB | SFRP1 | 25348397 | N/A | physical interaction | ComPPI |
| PPP1CA | SFRP1 | 25348397 | N/A | physical interaction | ComPPI |
| SFRP1 | FZD6 | 10347172 14525934 24234451 25348397 | physical association | anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD,IntAct |
| SFRP1 | WNT4 | 11287180 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| SFRP1 | WNT2 | 10347172 14525934 24234451 25348397 | physical association | anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD,IntAct |
| SFRP1 | WNT1 | 10347172 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| SFRP1 | KIAA1522 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| TMEM86B | SFRP1 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| SFRP1 | SFRP1 | 10347172 24234451 | physical association | anti tag coimmunoprecipitation | IntAct |
| SFRP1 | WNT2 | 10347172 27898060 | inhibition | N/A | OmniPath |
| SFRP1 | WNT1 | 10347172 10523516 1052352 27898060 | inhibition,stimulant | N/A | OmniPath |
| PAX6 | SFRP1 | 20027618 27898060 | stimulant | N/A | OmniPath |
| SFRP1 | FZD2 | 27898060 6172602 | inhibition | N/A | OmniPath |
| SFRP1 | WNT4 | 11287180 27898060 | inhibition,stimulant | N/A | OmniPath |