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GENE：SGK3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SGK3
FullNmae serum/glucocorticoid regulated kinase family member 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:10812
EnsembleID ENSG00000104205
Uniprot Q96BR1

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SGK3 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
SGK3 GO:0001558,GO:0004672,GO:0004674,GO:0005246,GO:0005515,GO:0005524,GO:0005769,GO:0005829,GO:0006468,GO:0015459,GO:0015459,GO:0017080,GO:0017081,GO:0018105,GO:0030334,GO:0035091,GO:0035556,GO:0042127,GO:0051090,GO:0055037,GO:0106310,GO:2001240

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SGK3 hsa:23678 path:hsa04068 FoxO signaling pathway - Homo sapiens (human)
SGK3 hsa:23678 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR SGK3 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 SGK3 18414489 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation array,chromatin immunoprecipitation assay TFlink
GATA3 SGK3 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 SGK3 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 SGK3 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 SGK3 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 SGK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA SGK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SGK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 SGK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 SGK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 SGK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SGK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 SGK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 SGK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000009262D SGK3 17991735 rna interference,inhibition array technology,quantitative reverse transcription pcr miRSponge
URS000009262D SGK3 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS000016FF9C SGK3 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS000019D79B SGK3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002FC5B0 SGK3 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00001A7F58 SGK3 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00000451A1 SGK3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 SGK3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000020579D SGK3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005651EE SGK3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002D349B SGK3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000913AC SGK3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001AFC71 SGK3 25416803 25720694 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
PDPK1 SGK3 22135298 phosphorylation N/A PhosphoSite
SGK3 ITCH 22135298 phosphorylation N/A PhosphoSite
SGK3 FLII 22135298 phosphorylation N/A PhosphoSite
SGK3 GSK3B 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
HSP90AB1 SGK3 22939624 24234451 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
GSK3B SGK3 12054501 14525934 16543730 21988832 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
SLC9A3R2 SGK3 11751930 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
HSP90AA1 SGK3 25348397 N/A physical interaction ComPPI
PDPK1 SGK3 10548550 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
GSK3A SGK3 11035810 11749387 11884598 12054501 14525934 16543730 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
NEDD4L SGK3 25348397 N/A physical interaction ComPPI
ITCH SGK3 14525934 16888620 24234451 25348397 phosphorylation reaction,colocalization,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,pull down,physical interaction,fluorescence microscopy,protein kinase assay,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
PDK1 SGK3 16888620 24234451 25348397 phosphorylation reaction,colocalization fluorescence microscopy,protein kinase assay ComPPI,IntAct
CD79B SGK3 25348397 N/A physical interaction ComPPI
ESR1 SGK3 25348397 N/A physical interaction ComPPI
SGK3 APP 25348397 N/A physical interaction ComPPI
SGK3 HSP90AA2P 25348397 N/A physical interaction ComPPI
SGK3 ICAM1 25348397 N/A physical interaction ComPPI
SGK3 SMCO1 24234451 25348397 27107012 physical association validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
PRKCA SGK3 14604990 27898060 N/A N/A OmniPath
SGK3 ITCH 16888620 27898060 N/A N/A OmniPath
SGK3 FOXO3 11154281 27898060 inhibition N/A OmniPath
PDPK1 SGK3 10548550 15209375 16790420 27898060 stimulant N/A OmniPath
SGK3 GSK3A 11035810 11749387 11884598 12054501 16543730 18691976 19413330 27898060 inhibition N/A OmniPath
SGK3 GSK3B 12054501 16543730 18669648 18691976 21988832 27898060 inhibition N/A OmniPath
SGK3 FLII 17081983 19293151 27898060 stimulant N/A OmniPath

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