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GENE：SGMS1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SGMS1
FullNmae sphingomyelin synthase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:29799
EnsembleID ENSG00000198964
Uniprot Q86VZ5

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SGMS1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SGMS1 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
SGMS1 GO:0000138,GO:0000139,GO:0000139,GO:0002950,GO:0005634,GO:0005783,GO:0005886,GO:0006686,GO:0006686,GO:0006915,GO:0016020,GO:0016301,GO:0016310,GO:0030148,GO:0033188,GO:0033188,GO:0033188,GO:0033188,GO:0046513,GO:0046513,GO:0047493,GO:0047493,GO:2001242

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SGMS1 hsa:259230 path:hsa00600 Sphingolipid metabolism - Homo sapiens (human)
SGMS1 hsa:259230 path:hsa01100 Metabolic pathways - Homo sapiens (human)
SGMS1 hsa:259230 path:hsa04071 Sphingolipid signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR SGMS1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 SGMS1 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ETS1 SGMS1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 SGMS1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 SGMS1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 SGMS1 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 SGMS1 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 SGMS1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 SGMS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA SGMS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SGMS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 SGMS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 SGMS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 SGMS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS SGMS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SGMS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF SGMS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 SGMS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 SGMS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 SGMS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 SGMS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 SGMS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00002C0FCB SGMS1 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS0000122ED0 SGMS1 19088304 25416803 26701625 mrna cleavage,inhibition array technology,clip TarBase
URS00000DDD35 SGMS1 20371350 23592263 25416803 mrna cleavage,inhibition nucleotide sequence identification,clip TarBase
URS00000CBE63 SGMS1 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00000EC1BE SGMS1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001E0AEA SGMS1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002FC5B0 SGMS1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000037D7E5 SGMS1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00003883FE SGMS1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 SGMS1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 SGMS1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F SGMS1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA SGMS1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 SGMS1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 SGMS1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000012930C SGMS1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000330617 SGMS1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00001B341F SGMS1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000018C928 SGMS1 25416803 26561204 mrna cleavage,inhibition western blot,rna immunoprecipitation,miRNA interference luciferase reporter assay TarBase
URS0000324096 SGMS1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002F8148 SGMS1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000209905 SGMS1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000021D7C8 SGMS1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000018E72A SGMS1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001EE123 SGMS1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002CAE0C SGMS1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001FFA8C SGMS1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000C5BAA SGMS1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00003BD367 SGMS1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075ABF4 SGMS1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000202460 SGMS1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000006DA05 SGMS1 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
ATXN1 SGMS1 14525934 16713569 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
HNRNPL SGMS1 25348397 N/A physical interaction ComPPI
STK4 SGMS1 25348397 N/A physical interaction ComPPI
TRIM25 SGMS1 25348397 N/A physical interaction ComPPI

Source Target Pmid Interactiontype Methods Database
URS00008C14F1 SGMS1 27087310 direct interaction,inhibition N/A NPInter

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