Gene Information gene info

  1. Home

GENE：SGPL1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SGPL1
FullNmae sphingosine-1-phosphate lyase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:10817
EnsembleID ENSG00000166224
Uniprot O95470

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SGPL1 pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SGPL1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SGPL1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SGPL1 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
SGPL1 GO:0001553,GO:0001570,GO:0001822,GO:0005515,GO:0005783,GO:0005783,GO:0005789,GO:0005789,GO:0006631,GO:0006672,GO:0007283,GO:0008117,GO:0008117,GO:0008117,GO:0008117,GO:0008117,GO:0008209,GO:0008210,GO:0009791,GO:0010761,GO:0030097,GO:0030148,GO:0030149,GO:0030149,GO:0030149,GO:0030149,GO:0030170,GO:0033327,GO:0040014,GO:0048008,GO:0048705,GO:0060021,GO:0060325,GO:0097190

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SGPL1 hsa:8879 path:hsa00600 Sphingolipid metabolism - Homo sapiens (human)
SGPL1 hsa:8879 path:hsa01100 Metabolic pathways - Homo sapiens (human)
SGPL1 hsa:8879 path:hsa04071 Sphingolipid signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
STING1 SGPL1 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR SGPL1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 SGPL1 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 SGPL1 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ETS1 SGPL1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 SGPL1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 SGPL1 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 SGPL1 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 SGPL1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 SGPL1 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 SGPL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA SGPL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SGPL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 SGPL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 SGPL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS SGPL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SGPL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 SGPL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 SGPL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA4 SGPL1 21184844 trascriptional regulation,stimulation inferred by curator TFlink
SP1 SGPL1 21184844 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 SGPL1 21184844 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000338542 SGPL1 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS00002971AB SGPL1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001B341F SGPL1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000029EBD SGPL1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000013ABA3 SGPL1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000153377 SGPL1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000330617 SGPL1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000F7766 SGPL1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00005BB0FD SGPL1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000035AC91 SGPL1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000023BE29 SGPL1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000029D9F1 SGPL1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000044FD7 SGPL1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000045E0EC SGPL1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000025EABA SGPL1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000006F90B SGPL1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000005D4F5 SGPL1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000308E4D SGPL1 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00001F0C23 SGPL1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000279B6F SGPL1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000030F801 SGPL1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000015A0D9 SGPL1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002E92A8 SGPL1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 SGPL1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 SGPL1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 SGPL1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F SGPL1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA SGPL1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 SGPL1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 SGPL1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000122F23 SGPL1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000008A99 SGPL1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001A122A SGPL1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00004AE8D3 SGPL1 23313552 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000033B91D SGPL1 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00005A8A8D SGPL1 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000006DA05 SGPL1 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000018E72A SGPL1 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002E728C SGPL1 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002B0B46 SGPL1 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000076E54 SGPL1 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000076B539 SGPL1 23313552 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00001FC26E SGPL1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003E226A SGPL1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000475586 SGPL1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000010BD8D SGPL1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004AD450 SGPL1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003B59DF SGPL1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000047A67D SGPL1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000045147B SGPL1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000209F04 SGPL1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000075AAA0 SGPL1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000209905 SGPL1 25416803 27935985 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
ATP5PO SGPL1 25348397 N/A physical interaction ComPPI
BCL2L2 SGPL1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MED21 SGPL1 25348397 N/A physical interaction ComPPI
MARCHF5 SGPL1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TMEM242 SGPL1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ERBB2 SGPL1 24189400 24234451 25348397 association tandem affinity purification ComPPI,IntAct
RPL10 SGPL1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPP1R15A SGPL1 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
JUN SGPL1 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
PKN2 SGPL1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NTRK1 SGPL1 25348397 N/A physical interaction ComPPI
CDH5 SGPL1 25348397 N/A physical interaction ComPPI
EFNA5 SGPL1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
VDAC1 SGPL1 25348397 N/A physical interaction ComPPI
STX4 SGPL1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MORF4L1 SGPL1 25348397 N/A physical interaction ComPPI
VDAC2 SGPL1 25348397 N/A physical interaction ComPPI
ANKRD12 SGPL1 25348397 N/A physical interaction ComPPI
EGFR SGPL1 24189400 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
PLP2 SGPL1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
IMMT SGPL1 25348397 N/A physical interaction ComPPI
ELAVL1 SGPL1 25348397 N/A physical interaction ComPPI
SRPK2 SGPL1 25348397 N/A physical interaction ComPPI
TSPAN4 SGPL1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ESRRB SGPL1 25348397 N/A physical interaction ComPPI
AQP3 SGPL1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
IQCB1 SGPL1 21565611 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CNTRL SGPL1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
SEMA7A SGPL1 25348397 N/A physical interaction ComPPI
P2RX1 SGPL1 25348397 N/A physical interaction ComPPI
TOMM40 SGPL1 25348397 N/A physical interaction ComPPI
SCAMP5 SGPL1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRIM9 SGPL1 25348397 N/A physical interaction ComPPI
MIP SGPL1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
AIFM1 SGPL1 25348397 N/A physical interaction ComPPI
CYC1 SGPL1 25348397 N/A physical interaction ComPPI
TMEM216 SGPL1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
VDAC3 SGPL1 25348397 N/A physical interaction ComPPI
UQCRQ SGPL1 25348397 N/A physical interaction ComPPI
ATP5MG SGPL1 25348397 N/A physical interaction ComPPI
MTCH2 SGPL1 25348397 N/A physical interaction ComPPI
FA2H SGPL1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
IL13RA2 SGPL1 25348397 N/A physical interaction ComPPI
TMBIM4 SGPL1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ATP5PB SGPL1 25348397 N/A physical interaction ComPPI
PPP6R1 SGPL1 24234451 24255178 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ZNRF4 SGPL1 25348397 N/A physical interaction ComPPI
STING1 SGPL1 21903422 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PSAT1 SGPL1 25348397 N/A physical interaction ComPPI
SGPL1 BTN2A1 25348397 N/A physical interaction ComPPI
SGPL1 TXNDC15 25348397 N/A physical interaction ComPPI
SGPL1 VSIG4 25348397 N/A physical interaction ComPPI
SGPL1 ISLR 25348397 N/A physical interaction ComPPI
SGPL1 TRARG1 25348397 N/A physical interaction ComPPI
SGPL1 TECR 25348397 N/A physical interaction ComPPI
SGPL1 TM9SF4 25348397 N/A physical interaction ComPPI
SGPL1 TCTN2 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
SGPL1 TCTN3 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
SGPL1 CACNG5 25348397 N/A physical interaction ComPPI
SGPL1 PACC1 25348397 N/A physical interaction ComPPI
SGPL1 TPTE 25348397 N/A physical interaction ComPPI
SGPL1 TMEM176A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SGPL1 IFITM3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SGPL1 RNASE10 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PDCD11 SGPL1 24234451 30021884 physical association cross-linking study IntAct
STING1 SGPL1 21903422 27898060 N/A N/A OmniPath

Visualization










  Return