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GENE：SGPP1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SGPP1
FullNmae sphingosine-1-phosphate phosphatase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:17720
EnsembleID ENSG00000126821
Uniprot Q9BX95

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SGPP1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SGPP1 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
SGPP1 GO:0005789,GO:0005789,GO:0005886,GO:0006668,GO:0006670,GO:0030148,GO:0035621,GO:0042392,GO:0042392,GO:0042392,GO:0045616,GO:0045682,GO:0046839,GO:0070780,GO:0097191,GO:0097193

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SGPP1 hsa:81537 path:hsa00600 Sphingolipid metabolism - Homo sapiens (human)
SGPP1 hsa:81537 path:hsa01100 Metabolic pathways - Homo sapiens (human)
SGPP1 hsa:81537 path:hsa04071 Sphingolipid signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
GATA2 SGPP1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
NR1I2 SGPP1 19129222 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 SGPP1 20953172 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 SGPP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA SGPP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SGPP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 SGPP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 SGPP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS SGPP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 SGPP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000F31F4 SGPP1 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000EED18 SGPP1 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00000B59A2 SGPP1 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00001A7F58 SGPP1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002FC5B0 SGPP1 22473208 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
YIPF3 SGPP1 25348397 N/A physical interaction ComPPI
SLC7A1 SGPP1 25348397 N/A physical interaction ComPPI
SLAMF1 SGPP1 25348397 N/A physical interaction ComPPI
RHOT2 SGPP1 25348397 N/A physical interaction ComPPI
PTH1R SGPP1 25348397 N/A physical interaction ComPPI
TUBG1 SGPP1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UBC SGPP1 25348397 N/A physical interaction ComPPI
SYP SGPP1 25348397 N/A physical interaction ComPPI
ELAVL1 SGPP1 25348397 N/A physical interaction ComPPI
MAS1 SGPP1 25348397 N/A physical interaction ComPPI
DLK1 SGPP1 25348397 N/A physical interaction ComPPI
GOLT1B SGPP1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SGPP1 SLC15A1 25348397 N/A physical interaction ComPPI
SGPP1 TM2D2 25348397 N/A physical interaction ComPPI

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