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GENE：SH3RF1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SH3RF1
FullNmae SH3 domain containing ring finger 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:17650
EnsembleID ENSG00000154447
Uniprot Q7Z6J0

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SH3RF1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SH3RF1 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
SH3RF1 GO:0001764,GO:0005078,GO:0005515,GO:0005794,GO:0005829,GO:0005829,GO:0016567,GO:0030027,GO:0032436,GO:0043066,GO:0043066,GO:0043154,GO:0043370,GO:0046330,GO:0046330,GO:0046872,GO:0048471,GO:0051865,GO:0061630,GO:0061630,GO:1904044,GO:2000564,GO:2001237

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AKT1 SH3RF1 17535800 23180781 phosphorylation reaction in-gel kinase assay InnateDB
SH3RF1 AKT2 17535800 23180781 phosphorylation reaction in-gel kinase assay InnateDB
RAC1 SH3RF1 17535800 23180781 physical association pull down InnateDB
SH3RF1 SH3RF1 12514131 16571722 26467481 9482736 bind,up-regulates N/A Signor
SH3RF1 MAP3K10 12514131 14504284 23331499 stimulation N/A SignaLink
SH3RF1 MAP2K4 12514131 23331499 stimulation N/A SignaLink
SH3RF1 MAP3K12 12514131 23331499 stimulation N/A SignaLink
SH3RF1 MAP2K7 12514131 23331499 stimulation N/A SignaLink
SH3RF1 MAPK8 12514131 23331499 stimulation N/A SignaLink
SH3RF1 MAPK8IP1 16571722 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR SH3RF1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 SH3RF1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 SH3RF1 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 SH3RF1 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 SH3RF1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 SH3RF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA SH3RF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SH3RF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 SH3RF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 SH3RF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 SH3RF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS SH3RF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 SH3RF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SH3RF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 SH3RF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001C3AC1 SH3RF1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000065FDF SH3RF1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000235862 SH3RF1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000383DF4 SH3RF1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002578DA SH3RF1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000075A608 SH3RF1 23592263 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
AKT2 SH3RF1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
AKT1 SH3RF1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
SH3RF1 AKT1 25361965 interaction type N/A PTMCode2
SH3RF1 MAP3K11 25361965 interaction type N/A PTMCode2
MAP3K11 SH3RF1 25361965 interaction type N/A PTMCode2
SH3RF1 RAC1 25361965 interaction type N/A PTMCode2
RAC1 SH3RF1 25361965 interaction type N/A PTMCode2
SH3RF1 SIAH1 25361965 interaction type N/A PTMCode2
SIAH1 SH3RF1 25361965 interaction type N/A PTMCode2
SH3RF1 AKT2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PAK2 SH3RF1 14525934 16374509 24234451 25348397 physical association experimental interaction detection,filter binding,in vitro ComPPI,HPRD,IntAct
UBE2D1 SH3RF1 25348397 N/A physical interaction ComPPI
RAC1 SH3RF1 20696164 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,solid phase assay ComPPI,IntAct
SIAH2 SH3RF1 21586138 24234451 25348397 25438054 27898060 association,physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct,OmniPath
RACGAP1 SH3RF1 14525934 25348397 9482736 N/A experimental interaction detection,in vitro ComPPI,HPRD
SIAH1 SH3RF1 14525934 16230351 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
YWHAB SH3RF1 24234451 24255178 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UBC SH3RF1 20696164 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
UBE2N SH3RF1 25348397 N/A physical interaction ComPPI
CDH1 SH3RF1 25348397 N/A physical interaction ComPPI
MAP3K10 SH3RF1 14504284 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
MYC SH3RF1 21150319 24234451 25348397 association tandem affinity purification ComPPI,IntAct
KCNJ1 SH3RF1 19710010 25348397 27898060 N/A physical interaction ComPPI,OmniPath
MAP3K11 SH3RF1 14504284 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
ADAM15 SH3RF1 14525934 16374509 24234451 25348397 physical association experimental interaction detection,filter binding,in vitro ComPPI,HPRD,IntAct
MAP3K12 SH3RF1 25348397 N/A in vitro ComPPI
UBE2D3 SH3RF1 25348397 N/A physical interaction ComPPI
SH3RF1 SEMA6A 12421765 14525934 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SH3RF1 MAP3K9 14504284 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
SH3RF1 AKT2 17535800 24234451 25348397 phosphorylation reaction two hybrid,physical interaction,protein kinase assay,in vitro ComPPI,IntAct
SH3RF1 MAP4K3 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
SH3RF1 PDCD6IP 19393081 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SH3RF1 SH3RF2 25348397 N/A physical interaction ComPPI
SH3RF1 AKT1 17535800 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
SH3RF1 NINL 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
SH3RF1 HERPUD1 25348397 N/A physical interaction ComPPI
SH3RF1 FAT1 25348397 N/A physical interaction ComPPI
SH3RF1 TRIM25 25348397 N/A physical interaction ComPPI
TANK SH3RF1 24234451 30561431 association virotrap IntAct
ATF1 SH3RF1 12527906 27898060 stimulant N/A OmniPath
SH3RF1 RAC2 27898060 9482736 stimulant N/A OmniPath
AKT1 SH3RF1 17535800 27898060 inhibition N/A OmniPath
SH3RF1 AKT1 17535800 27898060 N/A N/A OmniPath
SH3RF1 MAP2K4 12514131 27898060 stimulant N/A OmniPath
RAC1 SH3RF1 17535800 20696164 20936779 22128169 27898060 N/A N/A OmniPath
SH3RF1 MAPK8IP1 16571722 27898060 stimulant N/A OmniPath
AKT2 SH3RF1 14504284 17535800 27898060 inhibition N/A OmniPath
SH3RF1 AKT2 14504284 17535800 27898060 N/A N/A OmniPath
GSK3B SH3RF1 17535800 27898060 N/A N/A OmniPath
SH3RF1 MAP2K7 12514131 27898060 stimulant N/A OmniPath
SH3RF1 MAPK8 27898060 9482736 stimulant N/A OmniPath
SH3RF1 MAP3K10 12514131 1450428 14504284 27898060 stimulant N/A OmniPath
SH3RF1 MAP3K11 12514131 14504284 27898060 stimulant N/A OmniPath
SH3RF1 MAP3K12 11416147 12514131 14504284 27898060 stimulant N/A OmniPath

Visualization










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