Gene Information gene info

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GENE：SHH

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SHH
FullNmae sonic hedgehog signaling molecule
LocusType gene with protein product
Status Approved
HGNC_id HGNC:10848
EnsembleID ENSG00000164690
Uniprot Q15465

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SHH apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SHH apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
SHH GO:0000122,GO:0000139,GO:0001569,GO:0001570,GO:0001656,GO:0001658,GO:0001708,GO:0001708,GO:0001755,GO:0001947,GO:0002052,GO:0002076,GO:0002320,GO:0003140,GO:0004175,GO:0005113,GO:0005113,GO:0005509,GO:0005509,GO:0005515,GO:0005539,GO:0005576,GO:0005615,GO:0005615,GO:0005615,GO:0005783,GO:0005788,GO:0005789,GO:0005794,GO:0005829,GO:0005886,GO:0006606,GO:0006897,GO:0007224,GO:0007224,GO:0007224,GO:0007224,GO:0007228,GO:0007267,GO:0007389,GO:0007398,GO:0007405,GO:0007411,GO:0007417,GO:0007418,GO:0007442,GO:0007507,GO:0007596,GO:0008209,GO:0008233,GO:0008270,GO:0008284,GO:0008284,GO:0009880,GO:0009949,GO:0009953,GO:0009986,GO:0010468,GO:0010628,GO:0010629,GO:0014003,GO:0014706,GO:0014856,GO:0014858,GO:0016015,GO:0016015,GO:0016539,GO:0016540,GO:0021513,GO:0021522,GO:0021794,GO:0021904,GO:0021930,GO:0021938,GO:0021978,GO:0030162,GO:0030177,GO:0030324,GO:0030326,GO:0030336,GO:0030539,GO:0030850,GO:0030878,GO:0030900,GO:0030901,GO:0030902,GO:0031016,GO:0031069,GO:0032435,GO:0033077,GO:0033085,GO:0033089,GO:0033092,GO:0034244,GO:0035115,GO:0035116,GO:0036484,GO:0042098,GO:0042127,GO:0042130,GO:0042307,GO:0042475,GO:0042481,GO:0042733,GO:0043010,GO:0043066,GO:0043237,GO:0043369,GO:0045059,GO:0045060,GO:0045109,GO:0045121,GO:0045445,GO:0045596,GO:0045880,GO:0045880,GO:0045893,GO:0045944,GO:0046632,GO:0046638,GO:0046639,GO:0048468,GO:0048538,GO:0048557,GO:0048617,GO:0048643,GO:0048645,GO:0048663,GO:0048706,GO:0048709,GO:0048711,GO:0048714,GO:0048745,GO:0048754,GO:0048839,GO:0048859,GO:0048864,GO:0051155,GO:0051781,GO:0060020,GO:0060021,GO:0060070,GO:0060174,GO:0060251,GO:0060428,GO:0060439,GO:0060445,GO:0060447,GO:0060458,GO:0060459,GO:0060463,GO:0060484,GO:0060516,GO:0060523,GO:0060662,GO:0060664,GO:0060685,GO:0060738,GO:0060767,GO:0060769,GO:0060782,GO:0060783,GO:0060840,GO:0060916,GO:0061053,GO:0061189,GO:0062023,GO:0071285,GO:0071542,GO:0072089,GO:0072091,GO:0072136,GO:0072205,GO:0090090,GO:0090162,GO:0090370,GO:0097152,GO:0097190,GO:0097264,GO:0098528,GO:0140853,GO:1900175,GO:1900180,GO:1904339,GO:1905327,GO:2000062,GO:2000063,GO:2000357,GO:2000358,GO:2000729,GO:2001054

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SHH hsa:6469 path:hsa04340 Hedgehog signaling pathway - Homo sapiens (human)
SHH hsa:6469 path:hsa04360 Axon guidance - Homo sapiens (human)
SHH hsa:6469 path:hsa05200 Pathways in cancer - Homo sapiens (human)
SHH hsa:6469 path:hsa05205 Proteoglycans in cancer - Homo sapiens (human)
SHH hsa:6469 path:hsa05217 Basal cell carcinoma - Homo sapiens (human)
SHH hsa:6469 path:hsa05226 Gastric cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SHH VEGFA 18754008 20495383 22354771 24856585 26192618 interaction type N/A ACSN
SHH SMO 18754008 20495383 22354771 24856585 26192618 interaction type N/A ACSN
SHH SHH 14556242 15618519 16880529 22298955 26467481 9811851 interaction type,bind,up-regulates activity,down-regulates activity N/A Signor
SHH PTCH2 23331499 9811851 stimulation N/A SignaLink,SignaLink
HHIP SHH 10050855 23331499 stimulation N/A SignaLink,SignaLink
GAS1 SHH 11572986 18988627 23331499 stimulation N/A SignaLink,SignaLink
LRP2 SHH 11964399 23331499 stimulation N/A SignaLink,SignaLink
DISP1 SHH 14556242 23331499 stimulation N/A SignaLink,SignaLink
SHH PTCH1 14556242 23331499 stimulation N/A SignaLink,SignaLink
BOC SHH 16647304 23331499 stimulation N/A SignaLink,SignaLink
CDO1 SHH 16647304 23331499 stimulation N/A SignaLink,SignaLink
GPC3 SHH 18505598 23331499 stimulation N/A SignaLink,SignaLink
EXTL1 SHH 11944914 23331499 stimulation N/A SignaLink
DISP2 SHH 15645143 23331499 stimulation N/A SignaLink
DISP3 SHH 15645143 23331499 stimulation N/A SignaLink
HHAT SHH 18534984 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ESR1 SHH 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ETS1 SHH 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 SHH 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 SHH 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 SHH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA SHH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SHH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 SHH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 SHH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 SHH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SHH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF SHH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 SHH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PAX3 SHH 20569257 trascriptional regulation,stimulation inferred by curator TFlink
SOX9 SHH 20569257 trascriptional regulation,stimulation inferred by curator TFlink
STAT3 SHH 22554932 trascriptional regulation,stimulation inferred by curator TFlink
GLI3 SHH N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 SHH 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B7E30 SHH 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000913AC SHH 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000012930C SHH 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000005481D SHH 23706177 25416803 mrna cleavage,inhibition clip TarBase
URS00005586D0 SHH 23706177 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
SHH GAS1 25361965 interaction type N/A PTMCode2
GAS1 SHH 25361965 interaction type N/A PTMCode2
SHH SUFU 25361965 interaction type N/A PTMCode2
SUFU SHH 25361965 interaction type N/A PTMCode2
SHH PTCH2 25361965 interaction type N/A PTMCode2
PTCH2 SHH 25361965 interaction type N/A PTMCode2
HHIP SHH 25361965 interaction type N/A PTMCode2
SHH HHIP 25361965 interaction type N/A PTMCode2
ADCYAP1 SHH 25361965 interaction type N/A PTMCode2
SHH ADCYAP1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
DERL2 SHH 25348397 N/A physical interaction ComPPI
SYVN1 SHH 25348397 N/A physical interaction ComPPI
ADCYAP1 SHH 12417650 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
SHH PTCH2 14525934 25348397 9811851 N/A experimental interaction detection,in vivo ComPPI,HPRD
SHH HHIP 10050855 14525934 19561609 24234451 25348397 physical association experimental interaction detection,nuclear magnetic resonance,enzyme linked immunosorbent assay,in vivo,solid phase assay,bio-layer interferometry ComPPI,HPRD,IntAct
SHH GAS1 11572986 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
SHH DERL1 25348397 N/A physical interaction ComPPI
SHH SEL1L 25348397 N/A physical interaction ComPPI
SHH EDEM1 25348397 N/A physical interaction ComPPI
SHH EDEM2 25348397 N/A physical interaction ComPPI
SHH EDEM3 25348397 N/A physical interaction ComPPI
SHH PTCH1 14525934 19561609 24234451 25348397 9811851 N/A experimental interaction detection,nuclear magnetic resonance ComPPI,HPRD,IntAct
SHH SHH 11395778 14525934 N/A experimental interaction detection HPRD
SHH GLI2 22298955 27898060 stimulant N/A OmniPath
HHIP SHH 10050855 19561609 27898060 inhibition,stimulant N/A OmniPath
SHH SMO 16867986 16885213 27898060 stimulant N/A OmniPath
SHH PTCH1 14556242 15618519 19561609 20083481 27898060 9811851 inhibition,stimulant N/A OmniPath
SHH PTCH2 27898060 9811851 inhibition,stimulant N/A OmniPath
SHH BOC 17086203 27898060 stimulant N/A OmniPath
BOC SHH 16647304 27898060 stimulant N/A OmniPath
HHAT SHH 15075292 18534984 27898060 stimulant N/A OmniPath
DISP1 SHH 22902404 27898060 stimulant N/A OmniPath
BMP2 SHH 19855020 27898060 inhibition N/A OmniPath
GAS1 SHH 11572986 27898060 inhibition,stimulant N/A OmniPath
LRP2 SHH 11964399 27898060 stimulant N/A OmniPath
SHH LRP2 22340494 27898060 N/A N/A OmniPath
DISP2 SHH 15645143 27898060 stimulant N/A OmniPath
SHH CP 14556242 15618519 17419683 27898060 9811851 inhibition N/A OmniPath
CDO1 SHH 16647304 27898060 stimulant N/A OmniPath
EXTL1 SHH 15614771 27898060 inhibition N/A OmniPath
SHH GPC5 21339334 27898060 N/A N/A OmniPath

Visualization










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