Gene Information gene info

GENE:SIAH2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SIAH2
FullNmae siah E3 ubiquitin protein ligase 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:10858
EnsembleID ENSG00000181788
Uniprot O43255

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SIAH2 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SIAH2 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
SIAH2 GO:0003714,GO:0004842,GO:0004842,GO:0005515,GO:0005654,GO:0005737,GO:0005769,GO:0005829,GO:0005829,GO:0006511,GO:0006511,GO:0006915,GO:0007049,GO:0007264,GO:0008270,GO:0016567,GO:0031396,GO:0031624,GO:0042752,GO:0043025,GO:0043066,GO:0043154,GO:0043161,GO:0043231,GO:0045892,GO:0048511,GO:0060070,GO:0061630,GO:0061630,GO:0090090,GO:1990000,GO:2001237

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SIAH2 POT1 22064479 22634377 26192618 interaction type N/A ACSN
SIAH2 RAP1A 22064479 22634377 26192618 interaction type N/A ACSN
SIAH2 TERF1 22064479 22634377 26192618 interaction type N/A ACSN
SIAH2 TERF2 22064479 22634377 26192618 interaction type N/A ACSN
SIAH2 TINF2 22064479 22634377 26192618 interaction type N/A ACSN
SIAH2 TPX2 17716627 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
SIAH2 SIAH2 16899216 23180781 physical association anti tag coimmunoprecipitation InnateDB
SIAH1 SIAH2 16899216 23180781 physical association anti tag coimmunoprecipitation InnateDB
SNCA SIAH2 15064394 18070888 23180781 ubiquitination reaction enzymatic study InnateDB
SNCAIP SIAH2 15064394 23180781 ubiquitination reaction,physical association anti tag coimmunoprecipitation,enzymatic study InnateDB

Source Target Pmid Interactiontype Methods Database
AR SIAH2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 SIAH2 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 SIAH2 18414489 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation array,chromatin immunoprecipitation assay TFlink
ETS1 SIAH2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 SIAH2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 SIAH2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA3 SIAH2 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 SIAH2 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 SIAH2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 SIAH2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA SIAH2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SIAH2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS SIAH2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SIAH2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF SIAH2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000F6E49 SIAH2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000077AED SIAH2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000059EB31 SIAH2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001B9F58 SIAH2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000272039 SIAH2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000237AF9 SIAH2 25416803 25997740 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00002AB575 SIAH2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000451A1 SIAH2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000039D790 SIAH2 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CHEK2 SIAH2 22135298 phosphorylation N/A PhosphoSite
HIPK2 SIAH2 22135298 phosphorylation N/A PhosphoSite
DYRK2 SIAH2 22135298 phosphorylation N/A PhosphoSite
UBE2L6 SIAH2 25361965 interaction type N/A PTMCode2
SIAH2 UBE2L6 25361965 interaction type N/A PTMCode2
SNCAIP SIAH2 25361965 interaction type N/A PTMCode2
SIAH2 SNCAIP 25361965 interaction type N/A PTMCode2
SYP SIAH2 25361965 interaction type N/A PTMCode2
SIAH2 SYP 25361965 interaction type N/A PTMCode2
SIAH2 RBBP8 25361965 interaction type N/A PTMCode2
RBBP8 SIAH2 25361965 interaction type N/A PTMCode2
SIAH2 AKAP1 25361965 interaction type N/A PTMCode2
AKAP1 SIAH2 25361965 interaction type N/A PTMCode2
SIAH2 SNCA 25361965 interaction type N/A PTMCode2
SNCA SIAH2 25361965 interaction type N/A PTMCode2
SIAH2 DCC 25361965 interaction type N/A PTMCode2
DCC SIAH2 25361965 interaction type N/A PTMCode2
POU2AF1 SIAH2 25361965 interaction type N/A PTMCode2
SIAH2 POU2AF1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PIAS2 SIAH2 25348397 N/A physical interaction ComPPI
UBE2I SIAH2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PPP1R13B SIAH2 25348397 N/A physical interaction ComPPI
SPRY2 SIAH2 25348397 N/A physical interaction ComPPI
PPP1CC SIAH2 25348397 N/A physical interaction ComPPI
TYK2 SIAH2 25348397 N/A physical interaction ComPPI
PRR20E SIAH2 25348397 N/A physical interaction ComPPI
PRR20C SIAH2 25348397 N/A physical interaction ComPPI
PRR20D SIAH2 25348397 N/A physical interaction ComPPI
UBE2D1 SIAH2 25348397 N/A physical interaction ComPPI
TP53BP2 SIAH2 25348397 N/A physical interaction ComPPI
MCM2 SIAH2 25348397 N/A physical interaction ComPPI
EGLN3 SIAH2 15210114 16958618 25202994 25348397 27898060 N/A physical interaction ComPPI,OmniPath
VAV1 SIAH2 10207103 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
ZYX SIAH2 25348397 N/A physical interaction ComPPI
SIAH2 SYP 11786535 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
SIAH2 POU2AF1 11483518 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
SIAH2 PEG3 10681424 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
SIAH2 TRAF2 12411493 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
SIAH2 UBE2L6 11786535 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SIAH2 PEG10 12810624 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
SIAH2 DCC 14525934 25348397 9858595 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SIAH2 CACYBP 11389839 14525934 24234451 25348397 physical association two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD,IntAct
SIAH2 AFF1 14525934 15221006 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
SIAH2 RBBP8 25348397 N/A two hybrid,physical interaction ComPPI
SIAH2 HIPK3 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SIAH2 AKAP1 18323779 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SIAH2 PIAS1 25348397 N/A physical interaction ComPPI
SIAH2 PIAS3 25348397 N/A physical interaction ComPPI
SIAH2 SNCAIP 25348397 N/A physical interaction ComPPI
SIAH2 DLST 15466852 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SIAH2 SNCA 25348397 N/A physical interaction ComPPI
SIAH2 EGLN2 25348397 N/A physical interaction ComPPI
SIAH2 EGLN1 25348397 N/A physical interaction ComPPI
SIAH2 PLCE1 17998205 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SIAH2 USP13 21659512 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SIAH2 HIPK2 25348397 N/A physical interaction ComPPI
SIAH2 HDAC3 25348397 N/A physical interaction ComPPI
SIAH2 SKI 25348397 N/A physical interaction ComPPI
SIAH2 PSMD4 25348397 N/A physical interaction ComPPI
SIAH2 TINF2 22064479 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SIAH2 USP19 25348397 N/A physical interaction ComPPI
SIAH2 CEBPD 25348397 N/A physical interaction ComPPI
SIAH2 SH3RF1 21586138 24234451 25348397 25438054 27898060 association,physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct,OmniPath
SIAH2 PPP1R12A 19744480 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SIAH2 DYRK2 25348397 N/A physical interaction ComPPI
SIAH2 PML 14645235 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SIAH2 TPX2 17716627 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SIAH2 ATN1 14525934 16713569 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SIAH2 UBE2D2 25348397 N/A physical interaction ComPPI
SIAH2 KAT5 25348397 N/A physical interaction ComPPI
SIAH2 KAT2B 25348397 N/A physical interaction ComPPI
SIAH2 TNK2 25348397 N/A physical interaction ComPPI
SIAH2 AR 23518348 24234451 25348397 association physical interaction,chromatin immunoprecipitation assay ComPPI,IntAct
SIAH2 NFE2L2 25348397 N/A physical interaction ComPPI
SIAH2 UBE2D3 25348397 N/A physical interaction ComPPI
SIAH2 CCBE1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SIAH2 SETD2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SIAH2 MYD88 21988832 24234451 25348397 colocalization,physical association two hybrid,physical interaction,confocal microscopy ComPPI,IntAct
SIAH2 STAT3 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SIAH2 XAF1 25348397 N/A physical interaction ComPPI
SIAH2 OPRM1 23840749 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
SIAH2 OPRD1 25348397 N/A physical interaction ComPPI
SIAH2 OPRK1 23840749 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SIAH2 SIAH1 16899216 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SIAH2 DLD 25348397 N/A physical interaction ComPPI
SIAH2 AKR1C3 25348397 N/A physical interaction ComPPI
SIAH2 CHEK2 25348397 26751770 27898060 N/A physical interaction ComPPI,OmniPath
SIAH2 EAF2 25348397 N/A physical interaction ComPPI
SIAH2 LATS2 24234451 25348397 25438054 27898060 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct,OmniPath
SIAH2 PRICKLE3 25348397 N/A physical interaction ComPPI
SIAH2 LATS1 24234451 25348397 25438054 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SIAH2 OGDH 24234451 25348397 25438054 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SIAH2 OGDHL 24234451 25348397 25438054 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SIAH2 SH3RF3 24234451 25348397 25438054 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SIAH2 NCOR1 23518348 24234451 25348397 association chromatin immunoprecipitation assay ComPPI,IntAct
EEF1D SIAH2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
AKR1C1 SIAH2 25348397 N/A physical interaction ComPPI
SIAH2 SNCAIP 15064394 16174773 27898060 inhibition N/A OmniPath
MAPK14 SIAH2 17003045 27898060 stimulant N/A OmniPath
DYRK2 SIAH2 19043406 22878263 23000554 23044042 27898060 stimulant N/A OmniPath
SIAH2 HIPK2 19043406 19788416 25313037 27898060 inhibition N/A OmniPath
SIAH2 VAV2 10207103 27898060 inhibition N/A OmniPath

Visualization