Gene Information gene info

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GENE：SIRT1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SIRT1
FullNmae sirtuin 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:14929
EnsembleID ENSG00000096717
Uniprot Q96EB6

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SIRT1 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SIRT1 mitotic_cd 35639235 SIRT1 regulates mitotic catastrophe via autophagy and BubR1 signaling. retulator signature
SIRT1 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SIRT1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SIRT1 autophagy 35909524 The levels and function of SIRT1 are also regulated by the autophagy process. retulator signature
SIRT1 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
SIRT1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SIRT1 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
SIRT1 GO:0000012,GO:0000122,GO:0000122,GO:0000183,GO:0000183,GO:0000183,GO:0000720,GO:0000731,GO:0000785,GO:0000791,GO:0000792,GO:0000978,GO:0001525,GO:0001542,GO:0001650,GO:0001678,GO:0001934,GO:0001938,GO:0002039,GO:0002039,GO:0002821,GO:0003713,GO:0003714,GO:0003714,GO:0003714,GO:0003714,GO:0004407,GO:0005515,GO:0005634,GO:0005634,GO:0005635,GO:0005637,GO:0005637,GO:0005654,GO:0005654,GO:0005654,GO:0005677,GO:0005730,GO:0005737,GO:0005739,GO:0005829,GO:0006325,GO:0006346,GO:0006476,GO:0006476,GO:0006642,GO:0006974,GO:0006979,GO:0007179,GO:0007283,GO:0007346,GO:0007517,GO:0008284,GO:0009267,GO:0010629,GO:0010824,GO:0010868,GO:0010875,GO:0010883,GO:0010906,GO:0016239,GO:0016567,GO:0016567,GO:0016605,GO:0016922,GO:0017136,GO:0017136,GO:0018394,GO:0019213,GO:0019899,GO:0030225,GO:0030512,GO:0031065,GO:0031393,GO:0031507,GO:0031648,GO:0032007,GO:0032041,GO:0032071,GO:0032088,GO:0032868,GO:0032922,GO:0032922,GO:0033210,GO:0033553,GO:0033553,GO:0033558,GO:0033558,GO:0034391,GO:0034979,GO:0034979,GO:0034979,GO:0035356,GO:0035358,GO:0042127,GO:0042149,GO:0042326,GO:0042393,GO:0042542,GO:0042595,GO:0042632,GO:0042771,GO:0042802,GO:0042981,GO:0043065,GO:0043065,GO:0043066,GO:0043124,GO:0043161,GO:0043280,GO:0043398,GO:0043425,GO:0043433,GO:0043518,GO:0043524,GO:0043536,GO:0044321,GO:0045348,GO:0045599,GO:0045722,GO:0045739,GO:0045766,GO:0045766,GO:0045786,GO:0045892,GO:0045892,GO:0045892,GO:0045944,GO:0046015,GO:0046628,GO:0046872,GO:0046969,GO:0046969,GO:0046970,GO:0050872,GO:0051019,GO:0051097,GO:0051152,GO:0051658,GO:0051897,GO:0051898,GO:0055089,GO:0060766,GO:0060907,GO:0061773,GO:0070301,GO:0070403,GO:0070577,GO:0070857,GO:0070914,GO:0070932,GO:0071356,GO:0071456,GO:0071479,GO:0071900,GO:0090335,GO:0090400,GO:0097009,GO:0106230,GO:0106231,GO:0140297,GO:0140861,GO:0140937,GO:0141050,GO:0160012,GO:1900034,GO:1901984,GO:1902166,GO:1902176,GO:1902237,GO:1904179,GO:1990254,GO:1990830,GO:1990841,GO:2000111,GO:2000480,GO:2000481,GO:2000655,GO:2000757,GO:2000773,GO:2000773,GO:2000774,GO:2000781

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SIRT1 hsa:23411 path:hsa00760 Nicotinate and nicotinamide metabolism - Homo sapiens (human)
SIRT1 hsa:23411 path:hsa01100 Metabolic pathways - Homo sapiens (human)
SIRT1 hsa:23411 path:hsa04068 FoxO signaling pathway - Homo sapiens (human)
SIRT1 hsa:23411 path:hsa04148 Efferocytosis - Homo sapiens (human)
SIRT1 hsa:23411 path:hsa04152 AMPK signaling pathway - Homo sapiens (human)
SIRT1 hsa:23411 path:hsa04211 Longevity regulating pathway - Homo sapiens (human)
SIRT1 hsa:23411 path:hsa04213 Longevity regulating pathway - multiple species - Homo sapiens (human)
SIRT1 hsa:23411 path:hsa04218 Cellular senescence - Homo sapiens (human)
SIRT1 hsa:23411 path:hsa04310 Wnt signaling pathway - Homo sapiens (human)
SIRT1 hsa:23411 path:hsa04922 Glucagon signaling pathway - Homo sapiens (human)
SIRT1 hsa:23411 path:hsa04936 Alcoholic liver disease - Homo sapiens (human)
SIRT1 hsa:23411 path:hsa05031 Amphetamine addiction - Homo sapiens (human)
SIRT1 hsa:23411 path:hsa05206 MicroRNAs in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SIRT1 STK11 15205477 15744310 15989956 18687677 19590512 19960022 26192618 interaction type N/A ACSN
SIRT1 PPARGC1A 15205477 15744310 15989956 18687677 19590512 19960022 26192618 interaction type N/A ACSN
FOS SIRT1 20042607 23180781 physical association affinity chromatography technology InnateDB
SIRT1 JUN 20042607 23180781 physical association affinity chromatography technology InnateDB
ELAVL1 SIRT1 17317627 23180781 physical association affinity chromatography technology,anti tag coimmunoprecipitation InnateDB
ATG7 SIRT1 18296641 23180781 physical association deacetylase assay InnateDB
SIRT1 TNF 21245135 23180781 physical association anti tag coimmunoprecipitation InnateDB
RELB SIRT1 21245135 23180781 physical association anti tag coimmunoprecipitation InnateDB
SIRT1 RELA 21245135 23180781 physical association anti tag coimmunoprecipitation InnateDB
KAT8 SIRT1 21502975 23180781 physical association pull down InnateDB
HES1 SIRT1 12535671 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
SIRT1 HES2 12535671 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
SIRT1 TP73 16998810 23180781 physical association anti tag coimmunoprecipitation InnateDB
RELA SIRT1 23180781 25217963 physical association anti tag coimmunoprecipitation InnateDB
SIRT1 MMP9 23180781 25217963 physical association anti tag coimmunoprecipitation InnateDB
SIRT1 SMAD7 17098745 21071413 23331499 stimulation N/A SignaLink,SignaLink
SIRT1 STAT5A 23980167 deacetylation reaction,inhibition N/A SignaLink
NR0B2 SIRT1 20375098 interaction type,stimulation N/A SignaLink
SIRT1 NR5A2 20375098 deacetylation reaction,inhibition N/A SignaLink
SIRT1 FOXO4 10102273 15126506 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 SIRT1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
MYC SIRT1 12695333 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
RELA SIRT1 20617556 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
CEBPA SIRT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 SIRT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 SIRT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 SIRT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS SIRT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF SIRT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 SIRT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ATF4 SIRT1 21801305 22363646 trascriptional regulation,stimulation inferred by curator TFlink
BRCA1 SIRT1 18851829 20160719 21407215 9000507 trascriptional regulation,stimulation inferred by curator TFlink
CIITA SIRT1 22064865 trascriptional regulation,stimulation inferred by curator TFlink
DDIT3 SIRT1 21801305 trascriptional regulation,stimulation inferred by curator TFlink
FOXL2 SIRT1 19010791 trascriptional regulation,stimulation inferred by curator TFlink
FOXO3 SIRT1 23525956 trascriptional regulation,stimulation inferred by curator TFlink
GTF2I SIRT1 21407215 trascriptional regulation,stimulation inferred by curator TFlink
HIC1 SIRT1 19525223 19649206 22064865 trascriptional regulation,stimulation inferred by curator TFlink
SP1 SIRT1 23843607 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 SIRT1 23843607 trascriptional regulation,stimulation inferred by curator TFlink
TP53 SIRT1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000028BB8 SIRT1 19819989 \N rna interference,inhibition western blot,miRNA interference luciferase reporter assay miRSponge
URS000018C928 SIRT1 21720722 rna interference,inhibition experimental interaction detection,miRNA interference luciferase reporter assay miRSponge
URS000013ABA3 SIRT1 19786632 rna interference,inhibition western blot,miRNA interference luciferase reporter assay miRSponge
URS0000060B2B SIRT1 19786632 \N rna interference,inhibition western blot,miRNA interference luciferase reporter assay miRSponge
URS00000EED18 SIRT1 18755897 18834855 19221490 19461653 20185821 20470934 20627091 \N rna interference,inhibition experimental interaction detection,western blot,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00001F5B39 SIRT1 21418558 rna interference,inhibition western blot,miRNA interference luciferase reporter assay miRSponge
URS00003758F0 SIRT1 21418558 rna interference,inhibition western blot,miRNA interference luciferase reporter assay miRSponge
URS00001F5B39 SIRT1 19960022 21418558 22743998 25416803 26988912 27421775 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRDeathDB,TarBase
URS00003758F0 SIRT1 19960022 21418558 22743998 25416803 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay miRDeathDB,TarBase
URS00000EED18 SIRT1 18755897 18834855 18927107 19221490 19461653 20185821 20470934 20627091 21297663 21909380 23292172 23954321 24504520 25348795 25395581 25416803 25526086 25585539 25826085 26802970 27247228 27767101 28236278 28250026 mrna cleavage,inhibition experimental interaction detection,western blot,northern blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay miR2Disease,TarBase
URS0000060B2B SIRT1 19786632 25172416 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000028BB8 SIRT1 19819989 25416803 28383763 mrna cleavage,inhibition array technology,western blot,chromatin immunoprecipitation assay,rna immunoprecipitation,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000013ABA3 SIRT1 19786632 25416803 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS0000508C13 SIRT1 21898400 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000018C928 SIRT1 21720722 25416803 mrna cleavage,inhibition experimental interaction detection,miRNA interference luciferase reporter assay TarBase
URS00000F31F4 SIRT1 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B59A2 SIRT1 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00001597DC SIRT1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000031E12 SIRT1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000029D9F1 SIRT1 23768087 25416803 25998694 27156885 27748572 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000272A3D SIRT1 23728341 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000170CF4 SIRT1 24892674 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000019F055 SIRT1 25416803 26612257 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000096022 SIRT1 25416803 26662303 26912776 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00001D69F6 SIRT1 23877372 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00001E0AEA SIRT1 23752207 25416803 mrna cleavage,inhibition experimental interaction detection,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000338542 SIRT1 22473208 25416803 27646435 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS000032BD73 SIRT1 25416803 27090017 27166997 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS0000183BED SIRT1 25416803 26687158 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000029EBD SIRT1 25416803 27145368 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS0000171525 SIRT1 25416803 27917915 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
CSNK2A1 SIRT1 22135298 phosphorylation N/A PhosphoSite
CDK1 SIRT1 22135298 phosphorylation N/A PhosphoSite
HIPK2 SIRT1 22135298 phosphorylation N/A PhosphoSite
MAPK8 SIRT1 22135298 phosphorylation N/A PhosphoSite
SIRT1 HES1 25361965 interaction type N/A PTMCode2
HES1 SIRT1 25361965 interaction type N/A PTMCode2
SIRT1 MYOD1 25361965 interaction type N/A PTMCode2
MYOD1 SIRT1 25361965 interaction type N/A PTMCode2
SIRT1 RRP8 25361965 interaction type N/A PTMCode2
RRP8 SIRT1 25361965 interaction type N/A PTMCode2
SIRT1 PER2 25361965 interaction type N/A PTMCode2
PER2 SIRT1 25361965 interaction type N/A PTMCode2
SIRT1 KAT2B 25361965 interaction type N/A PTMCode2
KAT2B SIRT1 25361965 interaction type N/A PTMCode2
SIRT1 HDAC4 25361965 interaction type N/A PTMCode2
HDAC4 SIRT1 25361965 interaction type N/A PTMCode2
SIRT1 TP53 25361965 interaction type N/A PTMCode2
TP53 SIRT1 25361965 interaction type N/A PTMCode2
SIRT1 WRN 25361965 interaction type N/A PTMCode2
WRN SIRT1 25361965 interaction type N/A PTMCode2
SIRT1 CTTN 25361965 interaction type N/A PTMCode2
CTTN SIRT1 25361965 interaction type N/A PTMCode2
SIRT1 CLOCK 25361965 interaction type N/A PTMCode2
CLOCK SIRT1 25361965 interaction type N/A PTMCode2
SIRT1 HNF4A 25361965 interaction type N/A PTMCode2
HNF4A SIRT1 25361965 interaction type N/A PTMCode2
SIRT1 HIC1 25361965 interaction type N/A PTMCode2
HIC1 SIRT1 25361965 interaction type N/A PTMCode2
SIRT1 ACACA 25361965 interaction type N/A PTMCode2
ACACA SIRT1 25361965 interaction type N/A PTMCode2
SIRT1 MAPK10 25361965 interaction type N/A PTMCode2
MAPK10 SIRT1 25361965 interaction type N/A PTMCode2
SIRT1 JUN 25361965 interaction type N/A PTMCode2
JUN SIRT1 25361965 interaction type N/A PTMCode2
SIRT1 AR 25361965 interaction type N/A PTMCode2
AR SIRT1 25361965 interaction type N/A PTMCode2
SIRT1 SUV39H1 25361965 interaction type N/A PTMCode2
SUV39H1 SIRT1 25361965 interaction type N/A PTMCode2
SIRT1 FOXO1 25361965 interaction type N/A PTMCode2
FOXO1 SIRT1 25361965 interaction type N/A PTMCode2
SIRT1 ARNTL 25361965 interaction type N/A PTMCode2
ARNTL SIRT1 25361965 interaction type N/A PTMCode2
SIRT1 DOT1L 25361965 interaction type N/A PTMCode2
DOT1L SIRT1 25361965 interaction type N/A PTMCode2
SIRT1 RELA 25361965 interaction type N/A PTMCode2
RELA SIRT1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
KPNA2 SIRT1 19343720 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
HNRNPK SIRT1 25348397 N/A physical interaction ComPPI
NUDT21 SIRT1 25348397 N/A physical interaction ComPPI
HOXB9 SIRT1 25348397 N/A physical interaction ComPPI
NOS3 SIRT1 20479254 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
UBE2I SIRT1 25348397 N/A physical interaction ComPPI
SNW1 SIRT1 19934264 24234451 25348397 colocalization,association,physical association anti tag coimmunoprecipitation,two hybrid,pull down,physical interaction,fluorescence microscopy ComPPI,IntAct
CHCHD2 SIRT1 19343720 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
HOXB5 SIRT1 25348397 N/A physical interaction ComPPI
KPNA3 SIRT1 19343720 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
NOC4L SIRT1 18235501 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
KRT79 SIRT1 25348397 N/A physical interaction ComPPI
NPM1 SIRT1 25348397 N/A physical interaction ComPPI
RARA SIRT1 19934264 24234451 25348397 association anti bait coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
CDK6 SIRT1 22094256 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
GTF2A1 SIRT1 25348397 N/A physical interaction ComPPI
ZNF707 SIRT1 25348397 N/A physical interaction ComPPI
H2BC4 SIRT1 19343720 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
MAP1LC3B SIRT1 18296641 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction,deacetylase assay ComPPI,IntAct
HEY2 SIRT1 12535671 14525934 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
NMNAT1 SIRT1 19478080 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct,OmniPath
CREBZF SIRT1 19690166 24234451 25348397 physical association anti bait coimmunoprecipitation,pull down ComPPI,IntAct
TLE1 SIRT1 17680780 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct,OmniPath
EZH2 SIRT1 22094255 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ZYX SIRT1 25348397 N/A physical interaction ComPPI
MAPK8 SIRT1 25348397 N/A physical interaction ComPPI
SMAD7 SIRT1 17098745 24234451 25348397 N/A pull down,physical interaction ComPPI,IntAct
MYOD1 SIRT1 25348397 N/A physical interaction ComPPI
PIK3R1 SIRT1 21241768 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
JUN SIRT1 24234451 25348397 25609649 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
RB1 SIRT1 17620057 24234451 25348397 deacetylation reaction physical interaction,deacetylase assay ComPPI,IntAct
HCFC1 SIRT1 21909281 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
AR SIRT1 25348397 N/A physical interaction ComPPI
VDR SIRT1 25348397 N/A physical interaction ComPPI
EP300 SIRT1 14525934 15632193 19047049 20660480 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,chromatin immunoprecipitation assay,in vitro,in vivo ComPPI,HPRD,IntAct
HIF1A SIRT1 25348397 N/A physical interaction ComPPI
FHL2 SIRT1 15692560 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
JUND SIRT1 25348397 N/A physical interaction ComPPI
MECOM SIRT1 21555002 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct,OmniPath
HDAC4 SIRT1 16166628 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
KAT2B SIRT1 19188449 24234451 25348397 deacetylation reaction,association anti bait coimmunoprecipitation,physical interaction,deacetylase assay ComPPI,IntAct
MCM10 SIRT1 25348397 N/A physical interaction ComPPI
PPARA SIRT1 19356714 25348397 27898060 N/A physical interaction ComPPI,OmniPath
NCOR1 SIRT1 15175761 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PPARGC1A SIRT1 14525934 15744310 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
NR1H3 SIRT1 14525934 17936707 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
GAPDH SIRT1 20972425 25348397 27898060 N/A physical interaction ComPPI,OmniPath
IRS2 SIRT1 17901049 21241768 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
HSP90AA1 SIRT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PICALM SIRT1 25348397 N/A physical interaction ComPPI
JAK1 SIRT1 25348397 N/A physical interaction ComPPI
LAMA3 SIRT1 19343720 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
YBX1 SIRT1 19343720 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
PARP1 SIRT1 25348397 N/A physical interaction ComPPI
WRN SIRT1 18203716 19343720 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction,deacetylase assay ComPPI,IntAct
KCNA4 SIRT1 25348397 N/A physical interaction ComPPI
KCNAB2 SIRT1 25348397 N/A physical interaction ComPPI
KCNA5 SIRT1 25348397 N/A physical interaction ComPPI
HSPA5 SIRT1 19343720 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
E2F1 SIRT1 16892051 19188449 24234451 25348397 association,physical association anti bait coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
ING1 SIRT1 25348397 N/A physical interaction ComPPI
APEX2 SIRT1 25348397 N/A physical interaction ComPPI
MYC SIRT1 21807113 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,deacetylase assay ComPPI,IntAct
KSR2 SIRT1 24234451 25348397 27086506 association anti tag coimmunoprecipitation ComPPI,IntAct
MAPT SIRT1 20869593 25348397 27898060 N/A physical interaction ComPPI,OmniPath
PTPN4 SIRT1 25348397 N/A physical interaction ComPPI
CSNK2A1 SIRT1 19236849 19680552 20439735 21968188 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction,in-gel kinase assay ComPPI,IntAct
XRCC6 SIRT1 15205477 17334224 24234451 25348397 deacetylation reaction,physical association anti bait coimmunoprecipitation,deacetylase assay ComPPI,IntAct
FGF10 SIRT1 25348397 N/A physical interaction ComPPI
SREBF1 SIRT1 20595232 20817729 25348397 27898060 N/A pull down,physical interaction ComPPI,OmniPath
THOC5 SIRT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TP73 SIRT1 16998810 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,deacetylase assay ComPPI,IntAct
EWSR1 SIRT1 25348397 N/A physical interaction ComPPI
RELA SIRT1 14525934 15152190 21081649 24234451 25348397 deacetylation reaction,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,deacetylase assay,in vivo ComPPI,HPRD,IntAct
ECT2 SIRT1 25348397 N/A physical interaction ComPPI
TSC2 SIRT1 20169165 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct,OmniPath
RAP1A SIRT1 25348397 N/A physical interaction ComPPI
BCL11A SIRT1 15639232 25348397 27898060 N/A physical interaction ComPPI,OmniPath
XPA SIRT1 20670893 24234451 25348397 deacetylation reaction,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,deacetylase assay ComPPI,IntAct
SUV39H1 SIRT1 18004385 24234451 25348397 deacetylation reaction,physical association anti tag coimmunoprecipitation,deacetylation reaction,physical interaction,deacetylase assay ComPPI,IntAct
NR1H2 SIRT1 14525934 17936707 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
NR0B2 SIRT1 20375098 21081708 24234451 25348397 27898060 colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction,fluorescence microscopy ComPPI,IntAct,OmniPath
DIAPH3 SIRT1 19343720 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
DVL1 SIRT1 20439735 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DVL2 SIRT1 20439735 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARRB2 SIRT1 25348397 N/A physical interaction ComPPI
CSNK2A2 SIRT1 19680552 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
MDM2 SIRT1 25348397 N/A physical interaction ComPPI
PAPOLA SIRT1 25348397 N/A physical interaction ComPPI
MPHOSPH8 SIRT1 25348397 N/A physical interaction ComPPI
SYNCRIP SIRT1 19343720 24234451 25348397 physical association pull down ComPPI,IntAct
VHL SIRT1 25348397 N/A physical interaction ComPPI
IRS1 SIRT1 21241768 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
HDAC2 SIRT1 19343720 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
H1-5 SIRT1 14525934 15469825 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
CTTN SIRT1 18850005 25348397 27898060 N/A physical interaction ComPPI,OmniPath
FOXO4 SIRT1 15126506 24234451 25348397 deacetylation reaction,physical association anti tag coimmunoprecipitation,physical interaction,deacetylase assay ComPPI,IntAct
HSPA4 SIRT1 25348397 N/A physical interaction ComPPI
CIITA SIRT1 21890893 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct,OmniPath
MEF2C SIRT1 25348397 N/A physical interaction ComPPI
ZBTB7A SIRT1 25348397 N/A physical interaction ComPPI
ZEB1 SIRT1 22249256 25086746 25348397 25870236 27898060 N/A physical interaction ComPPI,OmniPath
TRIM28 SIRT1 18235501 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
NDN SIRT1 25348397 N/A physical interaction ComPPI
CHEK2 SIRT1 25348397 N/A physical interaction ComPPI
KAT2A SIRT1 25348397 N/A physical interaction ComPPI
CCNB1 SIRT1 19107194 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CTNNB1 SIRT1 20439735 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TNNI2 SIRT1 25348397 N/A physical interaction ComPPI
SIRT2 SIRT1 25348397 N/A physical interaction ComPPI
MTA1 SIRT1 25348397 N/A physical interaction ComPPI
HNF4A SIRT1 25348397 N/A physical interaction,in vivo ComPPI
HSPA9 SIRT1 25348397 N/A physical interaction ComPPI
STK11 SIRT1 25348397 N/A physical interaction ComPPI
STK4 SIRT1 25348397 N/A physical interaction ComPPI
SIRT1 FOXO1 14525934 15220471 15692560 18235501 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
SIRT1 FOXO3 14525934 14976264 15126506 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,deacetylase assay,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
SIRT1 RRP8 14525934 18485871 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
SIRT1 HES1 12535671 14525934 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vivo ComPPI,HPRD,IntAct
SIRT1 USP22 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SIRT1 KAT5 25348397 N/A physical interaction ComPPI
SIRT1 HSF1 25348397 N/A physical interaction ComPPI
SIRT1 AKIP1 25348397 N/A physical interaction ComPPI
SIRT1 DOT1L 19491102 20431927 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SIRT1 CLOCK 25348397 N/A physical interaction ComPPI
SIRT1 ARNTL 25348397 N/A physical interaction ComPPI
SIRT1 SUZ12 22094255 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SIRT1 BRINP1 22446626 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SIRT1 TP53 11672523 12006491 14525934 15205477 17964266 18235501 18235502 21245319 24234451 25348397 deacetylation reaction,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,deacetylase assay,acetylase assay ComPPI,HPRD,IntAct
SIRT1 RBP1 25348397 N/A physical interaction ComPPI
SIRT1 ARID4B 25348397 N/A physical interaction ComPPI
SIRT1 ING2 25348397 N/A physical interaction ComPPI
SIRT1 BHLHE41 25348397 N/A physical interaction ComPPI
SIRT1 ESRRA 25348397 N/A physical interaction ComPPI
SIRT1 NBN 17612497 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction,deacetylase assay ComPPI,IntAct
SIRT1 HIC1 14525934 16269335 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction ComPPI,HPRD,IntAct
SIRT1 DVL1P1 25348397 N/A physical interaction ComPPI
SIRT1 MLLT3 25348397 N/A physical interaction ComPPI
SIRT1 MLLT1 25348397 N/A physical interaction ComPPI
SIRT1 SETD7 21245319 24234451 25348397 methylation reaction,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,methylation reaction,physical interaction,methyltransferase assay,methyltransferase radiometric assay ComPPI,IntAct
SIRT1 NR1H4 25348397 N/A physical interaction ComPPI
SIRT1 HNF1A 21176092 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SIRT1 SKI 25348397 N/A physical interaction ComPPI
SIRT1 ACACA 19343720 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
SIRT1 HSPD1 19343720 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
SIRT1 DYNC1H1 19343720 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
SIRT1 HSPA1L 19343720 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
SIRT1 H2BC11 25348397 N/A physical interaction ComPPI
SIRT1 H2AC21 19343720 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
SIRT1 CMYA5 19343720 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
SIRT1 EEF1G 19343720 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
SIRT1 ARHGAP29 19343720 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
SIRT1 MCF2L2 19343720 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
SIRT1 ELL3 19343720 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
SIRT1 USP9Y 19343720 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
SIRT1 NAT10 19343720 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
SIRT1 UGDH 25348397 N/A physical interaction ComPPI
SIRT1 CACNA1C 25348397 N/A pull down,physical interaction ComPPI
SIRT1 LANCL1 25348397 N/A physical interaction ComPPI
SIRT1 ATG7 18296641 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,deacetylase assay ComPPI,IntAct
SIRT1 ATG5 18296641 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SIRT1 GABARAPL1 25348397 N/A physical interaction ComPPI
SIRT1 BRD4 25348397 N/A physical interaction ComPPI
SIRT1 KAT8 21502975 22586264 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SIRT1 CSNK2B 21968188 24234451 25348397 27898060 association,physical association anti bait coimmunoprecipitation,two hybrid,pull down,physical interaction ComPPI,IntAct,OmniPath
SIRT1 DNMT1 21947282 22094255 24234451 25348397 colocalization,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,deacetylase assay,fluorescence microscopy,imaging technique ComPPI,IntAct
SIRT1 ESR1 25348397 N/A physical interaction ComPPI
SIRT1 STAT3 25348397 N/A physical interaction ComPPI
SIRT1 HSP90AA2P 25348397 N/A physical interaction ComPPI
SIRT1 ELAVL1 25348397 N/A physical interaction ComPPI
SIRT1 SATB1 25348397 N/A physical interaction ComPPI
SIRT1 MYCN 21698133 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct,OmniPath
SIRT1 PML 12006491 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SIRT1 FOS 25348397 N/A physical interaction ComPPI
SIRT1 LTA4H 25348397 N/A physical interaction ComPPI
SIRT1 NUDCD2 25348397 N/A physical interaction ComPPI
SIRT1 RBM25 25348397 N/A physical interaction ComPPI
SIRT1 SMARCD2 25348397 N/A physical interaction ComPPI
SIRT1 KYNU 25348397 N/A physical interaction ComPPI
SIRT1 AKT1 21775285 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
SIRT1 SUPT7L 25348397 N/A physical interaction ComPPI
SIRT1 ATXN7L3 25348397 N/A physical interaction ComPPI
SIRT1 CREB1 25348397 N/A physical interaction ComPPI
SIRT1 PUS7 25348397 N/A physical interaction ComPPI
SIRT1 SPDL1 25348397 N/A physical interaction ComPPI
SIRT1 TULP3 25348397 N/A physical interaction ComPPI
SIRT1 PIP5K1A 25348397 N/A physical interaction ComPPI
SIRT1 PHLDB3 25348397 N/A physical interaction ComPPI
SIRT1 AKIRIN2 25348397 N/A physical interaction ComPPI
SIRT1 IQCB1 25348397 N/A physical interaction ComPPI
SIRT1 ZNHIT6 25348397 N/A physical interaction ComPPI
SIRT1 WDR70 25348397 N/A physical interaction ComPPI
SIRT1 NOP14 25348397 N/A physical interaction ComPPI
SIRT1 SERPINB4 25348397 N/A physical interaction ComPPI
SIRT1 TSPYL1 25348397 N/A physical interaction ComPPI
SIRT1 RECQL4 25348397 N/A physical interaction ComPPI
SIRT1 SCNM1 25348397 N/A physical interaction ComPPI
SIRT1 ZNF346 25348397 N/A physical interaction ComPPI
SIRT1 SART1 18235501 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
SIRT1 TAF2 25348397 N/A physical interaction ComPPI
SIRT1 CHD3 18235501 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
SIRT1 RPTOR 21471201 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SIRT1 MTOR 21471201 24234451 25348397 phosphorylation reaction,association anti bait coimmunoprecipitation,physical interaction,protein kinase assay ComPPI,IntAct
SIRT1 EED 22094255 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SIRT1 DNMT3B 22094255 24234451 25348397 27728808 colocalization,association anti bait coimmunoprecipitation,cosedimentation through density gradient,physical interaction ComPPI,IntAct
SIRT1 UVSSA 25348397 N/A physical interaction ComPPI
SIRT1 CDKL1 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
SIRT1 CAP1 25348397 N/A physical interaction ComPPI
SIRT1 FASN 25348397 N/A physical interaction ComPPI
SIRT1 SHTN1 25348397 N/A physical interaction ComPPI
SIRT1 TPM4 25348397 N/A physical interaction ComPPI
SIRT1 POP1 25348397 N/A physical interaction ComPPI
SIRT1 PSME3 23612972 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SIRT1 CDK1 19107194 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SIRT1 FOXP3 25348397 N/A physical interaction ComPPI
SIRT1 RICTOR 25348397 N/A physical interaction ComPPI
SIRT1 EPAS1 25348397 N/A physical interaction ComPPI
SIRT1 APEX1 19934257 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,deacetylase assay,fluorescence microscopy ComPPI,IntAct
SIRT1 RPL6 25348397 N/A physical interaction ComPPI
SIRT1 RPS2 25348397 N/A physical interaction ComPPI
SIRT1 AKR1D1 25348397 N/A physical interaction ComPPI
SIRT1 CWC15 25348397 N/A physical interaction ComPPI
SIRT1 ZBTB38 25348397 N/A physical interaction ComPPI
SIRT1 TADA2B 25348397 N/A physical interaction ComPPI
SIRT1 SFRP4 25348397 N/A physical interaction ComPPI
SIRT1 CCAR2 18235501 18235502 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,molecular sieving,pull down,physical interaction ComPPI,IntAct
SIRT1 CEP44 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
SIRT1 LRPPRC 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SIRT1 FBXO7 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SIRT1 PPP4R3A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SIRT1 HNRNPA1L2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SIRT1 USP37 25348397 N/A physical interaction ComPPI
SIRT1 ZMIZ1 25348397 N/A physical interaction ComPPI
SIRT1 FOXL2 25348397 N/A physical interaction ComPPI
SIRT1 CHFR 25348397 N/A physical interaction ComPPI
SIRT1 HERC2 25348397 N/A physical interaction ComPPI
SIRT1 HERC2P3 25348397 N/A physical interaction ComPPI
SIRT1 CERKL 25348397 N/A physical interaction ComPPI
SIRT1 SOST 25348397 N/A physical interaction ComPPI
SIRT1 RBFA 25348397 N/A physical interaction ComPPI
SIRT1 ZNF785 25348397 N/A physical interaction ComPPI
SIRT1 CLK3 25348397 N/A physical interaction ComPPI
SIRT1 ZNF550 25348397 N/A physical interaction ComPPI
SIRT1 VWA3B 25348397 N/A physical interaction ComPPI
SIRT1 ZNF354C 25348397 N/A physical interaction ComPPI
SIRT1 MTFR2 25348397 N/A physical interaction ComPPI
SIRT1 ZNF669 25348397 N/A physical interaction ComPPI
SIRT1 TBCCD1 25348397 N/A physical interaction ComPPI
SIRT1 SIRT7 25348397 N/A physical interaction ComPPI
SIRT1 ITPK1 25348397 N/A deacetylation reaction,deacetylase assay ComPPI
SIRT1 DVL3 20439735 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SIRT1 KMT2A 24234451 25348397 25751424 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
SIRT1 AGO1 17932509 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
SIRT1 HCFC2 21909281 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
SIRT1 RAD50 17612497 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
SIRT1 MRE11 17612497 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
SIRT1 DYRK1A 20167603 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
SIRT1 DYRK3 20167603 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
SIRT1 NHLH2 22169038 24234451 25348397 27898060 physical association anti tag coimmunoprecipitation ComPPI,IntAct,OmniPath
H3C1 SIRT1 25348397 N/A physical interaction ComPPI
ZNF263 SIRT1 25348397 N/A physical interaction ComPPI
RPS19BP1 SIRT1 17964266 24234451 24681097 25348397 colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,pull down,physical interaction,imaging technique ComPPI,IntAct
AHCY SIRT1 25348397 N/A physical interaction ComPPI
SIRT1 SU(H) 25348397 N/A physical interaction ComPPI
HES5 SIRT1 24234451 25490446 association chromatin immunoprecipitation assay IntAct
GLI1 SIRT1 24234451 25490446 association chromatin immunoprecipitation assay IntAct
SIRT1 PPARG 20660480 24234451 association,physical association anti tag coimmunoprecipitation,pull down,chromatin immunoprecipitation assay IntAct
SIRT1 SUV39H1 18004385 19218236 27898060 stimulant N/A OmniPath
SIRT1 FOXO4 10102273 15126506 1512651 27898060 stimulant N/A OmniPath
ELAVL1 SIRT1 17317627 27898060 stimulant N/A OmniPath
SIRT1 FOXO3 14976264 15126506 20733005 21713995 24003218 27898060 inhibition,stimulant N/A OmniPath
SIRT1 PPARGC1A 15716268 15744310 19553684 20640476 24003218 27898060 stimulant N/A OmniPath
SIRT1 NCOR2 15175761 27898060 stimulant N/A OmniPath
SIRT1 FOXO1 14976264 14980222 15220471 15692560 15788402 16154098 18235501 22013015 27898060 inhibition,stimulant N/A OmniPath
SIRT1 WRN 18203716 19343720 20428248 27898060 inhibition N/A OmniPath
SIRT1 H3C1 19270680 27898060 inhibition N/A OmniPath
RPS19BP1 SIRT1 17964266 23382074 24681097 27898060 stimulant N/A OmniPath
SIRT1 KAT5 19895790 20100829 22586264 27898060 inhibition,stimulant N/A OmniPath
SIRT1 FOS 20042607 27898060 N/A N/A OmniPath
SIRT1 TP53 11672523 12006491 15205477 17964266 18235501 18235502 19047049 19680552 20167603 21149449 21245319 22389628 27898060 inhibition N/A OmniPath
SIRT1 PER2 18662546 27898060 inhibition N/A OmniPath
SIRT1 NFKBIA 15152190 19408108 27898060 inhibition,stimulant N/A OmniPath
CDK1 SIRT1 19107194 27898060 stimulant N/A OmniPath
SIRT1 APEX1 19934257 27898060 stimulant N/A OmniPath
SIRT1 XRCC6 15205477 17334224 27898060 stimulant N/A OmniPath
SIRT1 NFE2L2 20623181 27898060 inhibition N/A OmniPath
SIRT1 RELA 15152190 19408108 21081649 21454709 25217963 27898060 inhibition N/A OmniPath
SIRT1 EP300 15632193 19047049 27898060 inhibition N/A OmniPath
SIRT1 NOTCH1 22223095 27898060 inhibition N/A OmniPath
SIRT1 NCOR1 15175761 18829436 27898060 stimulant N/A OmniPath
MAPK8 SIRT1 15302935 16964243 17081983 17924679 18187866 18669648 18838864 19007248 19107194 19236849 19413330 20027304 21471201 21540183 24011073 26113041 27898060 stimulant N/A OmniPath
SIRT1 RELB 15152190 18193389 19408108 21245135 27898060 inhibition N/A OmniPath
SIRT1 NBN 17612497 27898060 stimulant N/A OmniPath
SIRT1 JUN 18676681 18823944 20042607 23382074 27898060 N/A N/A OmniPath
SIRT1 SMAD7 17098745 27898060 inhibition,stimulant N/A OmniPath
DYRK1A SIRT1 19107194 19690332 20027304 20167603 27898060 N/A N/A OmniPath
SIRT1 FOXL2 19010791 27898060 inhibition N/A OmniPath
SIRT1 CRTC1 22179316 27898060 stimulant N/A OmniPath

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