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GENE：SIVA1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SIVA1
FullNmae SIVA1 apoptosis inducing factor
LocusType gene with protein product
Status Approved
HGNC_id HGNC:17712
EnsembleID ENSG00000184990
Uniprot O15304

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SIVA1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SIVA1 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SIVA1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SIVA1 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
SIVA1 GO:0001618,GO:0005164,GO:0005175,GO:0005175,GO:0005515,GO:0005654,GO:0005737,GO:0046718,GO:0046872,GO:0097191,GO:0097191

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SIVA1 hsa:10572 path:hsa04115 p53 signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SIVA1 TRAF2 19392652 26192618 interaction type N/A ACSN
E2F1 SIVA1 15105421 15279786 17218262 17303408 17660363 18590585 26192618 7575488 interaction type N/A ACSN
MEFV SIVA1 18330885 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
SIVA1 XIAP 19584092 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
SIVA1 MAP3K7 19584092 23180781 physical association anti tag coimmunoprecipitation InnateDB
APP SIVA1 21832049 23180781 physical association protein array InnateDB

Source Target Pmid Interactiontype Methods Database
ESR1 SIVA1 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 SIVA1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 SIVA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 SIVA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 SIVA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS SIVA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SIVA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 SIVA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 SIVA1 15105421 trascriptional regulation,stimulation inferred by curator TFlink
TP53 SIVA1 15105421 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000007FBA SIVA1 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification,clip TarBase
URS000006FDD4 SIVA1 20371350 22473208 25416803 26367773 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS0000259AE4 SIVA1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000022B729 SIVA1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000070B1D SIVA1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000042619A SIVA1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00001E0AEA SIVA1 20371350 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
TYK2 SIVA1 22135298 phosphorylation N/A PhosphoSite
ABL2 SIVA1 22135298 phosphorylation N/A PhosphoSite
BCL2L1 SIVA1 25361965 interaction type N/A PTMCode2
SIVA1 BCL2L1 25361965 interaction type N/A PTMCode2
SIVA1 BCL2 25361965 interaction type N/A PTMCode2
BCL2 SIVA1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PCNA SIVA1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TYK2 SIVA1 25348397 N/A physical interaction ComPPI
XIAP SIVA1 25348397 N/A physical interaction ComPPI
UBE2D1 SIVA1 25348397 N/A physical interaction ComPPI
BCL2L1 SIVA1 12011449 14525934 14739602 24234451 25348397 physical association experimental interaction detection,pull down,in vitro,in vivo ComPPI,HPRD,IntAct
CD4 SIVA1 25348397 N/A physical interaction ComPPI
CDKN2A SIVA1 23462994 25348397 27898060 N/A physical interaction ComPPI,OmniPath
RAD18 SIVA1 25348397 N/A physical interaction ComPPI
CAMK2G SIVA1 25348397 N/A physical interaction ComPPI
TRAF2 SIVA1 25348397 N/A physical interaction ComPPI
NEDD4L SIVA1 25348397 N/A physical interaction ComPPI
MDM2 SIVA1 25348397 N/A physical interaction ComPPI
CD27 SIVA1 14525934 16683188 24234451 25348397 27898060 9177220 physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct,OmniPath
SIVA1 TNFRSF4 12478477 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
SIVA1 ABL2 11278261 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
SIVA1 LPAR2 25348397 N/A physical interaction ComPPI
SIVA1 S1PR4 25348397 N/A physical interaction ComPPI
SIVA1 PXMP2 16683188 24234451 25348397 physical association two hybrid,pull down,physical interaction ComPPI,IntAct
SIVA1 TP53 25348397 N/A physical interaction ComPPI
SIVA1 NEDD4 25348397 N/A physical interaction ComPPI
SIVA1 MAP3K7 25348397 N/A physical interaction ComPPI
SIVA1 APP 25348397 N/A physical interaction ComPPI
SIVA1 CDKN2A 25348397 N/A physical interaction ComPPI
SIVA1 BEX3 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SIVA1 TBXA2R 25348397 N/A physical interaction ComPPI
SIVA1 FOXP3 21955384 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SIVA1 TCAP 18849585 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SIVA1 MEFV 25348397 N/A physical interaction ComPPI
SIVA1 STMN1 25348397 N/A physical interaction ComPPI
SIVA1 RHOU 25348397 N/A physical interaction ComPPI
SIVA1 MYZAP 25348397 N/A two hybrid fragment pooling approach ComPPI
SIVA1 POLR2M 16169070 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
SIVA1 BCL2 14739602 24234451 25348397 physical association pull down ComPPI,IntAct
SIVA1 POLR2M 14525934 16169070 N/A two hybrid HPRD
MAP3K7 SIVA1 19584092 27898060 N/A N/A OmniPath
ABL2 SIVA1 11278261 20841568 27898060 stimulant N/A OmniPath
SIVA1 BCL2L1 12011449 14739602 27898060 inhibition N/A OmniPath
TYK2 SIVA1 20727854 27898060 N/A N/A OmniPath
MEFV SIVA1 18330885 27898060 N/A N/A OmniPath

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