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GENE：SLC25A4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SLC25A4
FullNmae solute carrier family 25 member 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:10990
EnsembleID ENSG00000151729
Uniprot P12235

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SLC25A4 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
SLC25A4 GO:0000002,GO:0005471,GO:0005515,GO:0005739,GO:0005739,GO:0005743,GO:0005743,GO:0005757,GO:0005886,GO:0006091,GO:0008637,GO:0015078,GO:0015207,GO:0015853,GO:0015866,GO:0016020,GO:0017077,GO:0031966,GO:0046902,GO:0060546,GO:0140021,GO:1901029,GO:1901526,GO:1902600,GO:1990544,GO:1990845

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SLC25A4 hsa:291 path:hsa04020 Calcium signaling pathway - Homo sapiens (human)
SLC25A4 hsa:291 path:hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human)
SLC25A4 hsa:291 path:hsa04217 Necroptosis - Homo sapiens (human)
SLC25A4 hsa:291 path:hsa04218 Cellular senescence - Homo sapiens (human)
SLC25A4 hsa:291 path:hsa04613 Neutrophil extracellular trap formation - Homo sapiens (human)
SLC25A4 hsa:291 path:hsa05010 Alzheimer disease - Homo sapiens (human)
SLC25A4 hsa:291 path:hsa05012 Parkinson disease - Homo sapiens (human)
SLC25A4 hsa:291 path:hsa05016 Huntington disease - Homo sapiens (human)
SLC25A4 hsa:291 path:hsa05017 Spinocerebellar ataxia - Homo sapiens (human)
SLC25A4 hsa:291 path:hsa05020 Prion disease - Homo sapiens (human)
SLC25A4 hsa:291 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
SLC25A4 hsa:291 path:hsa05164 Influenza A - Homo sapiens (human)
SLC25A4 hsa:291 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)
SLC25A4 hsa:291 path:hsa05208 Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human)
SLC25A4 hsa:291 path:hsa05415 Diabetic cardiomyopathy - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CDK2 SLC25A4 21319273 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 SLC25A4 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 SLC25A4 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 SLC25A4 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 SLC25A4 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 SLC25A4 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 SLC25A4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA SLC25A4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SLC25A4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 SLC25A4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 SLC25A4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 SLC25A4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS SLC25A4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SLC25A4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF SLC25A4 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001A7F58 SLC25A4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001597DC SLC25A4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000324096 SLC25A4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001067D1 SLC25A4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000214763 SLC25A4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000272039 SLC25A4 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
SRC SLC25A4 22135298 phosphorylation N/A PhosphoSite
LCK SLC25A4 22135298 phosphorylation N/A PhosphoSite
SLC25A4 BAX 25361965 interaction type N/A PTMCode2
BAX SLC25A4 25361965 interaction type N/A PTMCode2
SLC25A4 PPID 25361965 interaction type N/A PTMCode2
PPID SLC25A4 25361965 interaction type N/A PTMCode2
PPIF SLC25A4 25361965 interaction type N/A PTMCode2
SLC25A4 PPIF 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
UBL4A SLC25A4 25348397 N/A physical interaction ComPPI
MCM2 SLC25A4 25348397 N/A physical interaction ComPPI
NDUFAF4 SLC25A4 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
GRB2 SLC25A4 12577067 24234451 25348397 association pull down ComPPI,IntAct
JUN SLC25A4 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
AR SLC25A4 12039962 14525934 16120611 24234451 25348397 physical association two hybrid,experimental interaction detection,in vitro,in vivo,gal4 vp16 complementation,two hybrid ComPPI,HPRD,IntAct
COPS5 SLC25A4 25348397 N/A physical interaction ComPPI
PRKCE SLC25A4 12663490 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
RPS3A SLC25A4 25348397 N/A physical interaction ComPPI
NFKBIA SLC25A4 11287411 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
VDAC1 SLC25A4 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
ABCE1 SLC25A4 25348397 N/A physical interaction ComPPI
PCNT SLC25A4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CDK2 SLC25A4 25348397 N/A physical interaction ComPPI
NR4A1 SLC25A4 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
TUBB4B SLC25A4 25348397 N/A physical interaction ComPPI
TNFRSF1B SLC25A4 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
UQCRC1 SLC25A4 25348397 N/A physical interaction ComPPI
PRKN SLC25A4 25348397 N/A physical interaction ComPPI
NR3C1 SLC25A4 12039962 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
NFKB1 SLC25A4 24234451 25348397 25609649 association tandem affinity purification ComPPI,IntAct
BAX SLC25A4 14525934 25348397 27898060 9748162 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD,OmniPath
AP2M1 SLC25A4 25348397 N/A physical interaction ComPPI
SKI SLC25A4 25348397 N/A physical interaction ComPPI
TCF3 SLC25A4 25348397 N/A physical interaction ComPPI
FAF2 SLC25A4 25348397 N/A physical interaction ComPPI
PPIF SLC25A4 14525934 25348397 9874241 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SCGB2A2 SLC25A4 25348397 N/A physical interaction ComPPI
RRP1B SLC25A4 20926688 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PPID SLC25A4 12149099 14525934 14729611 15033717 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
RPSA SLC25A4 25348397 N/A physical interaction ComPPI
CHRM4 SLC25A4 25348397 N/A physical interaction ComPPI
RPS2 SLC25A4 25348397 N/A physical interaction ComPPI
SLC25A5 SLC25A4 25348397 N/A physical interaction ComPPI
ATP6V0D1 SLC25A4 25348397 N/A physical interaction ComPPI
BCL2L13 SLC25A4 22921587 24234451 25348397 N/A pull down ComPPI,IntAct
SLC25A4 MGMT 25348397 N/A physical interaction ComPPI
SLC25A4 MRPL58 20186120 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SLC25A4 RPL10L 25348397 N/A physical interaction ComPPI
SLC25A4 GALNT2 25348397 N/A physical interaction ComPPI
SLC25A4 CLN3 25348397 N/A physical interaction ComPPI
SLC25A4 CLN5 25348397 N/A physical interaction ComPPI
SLC25A4 MOV10 25348397 N/A physical interaction ComPPI
SLC25A4 NXF1 25348397 N/A physical interaction ComPPI
SLC25A4 ISLR 25348397 N/A physical interaction ComPPI
SLC25A4 SLC25A24 25348397 N/A physical interaction ComPPI
SLC25A4 CFAP97 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SLC25A4 GAN 25348397 N/A physical interaction ComPPI
SLC25A4 UBXN8 25348397 N/A physical interaction ComPPI
SLC25A4 COQ9 25348397 N/A physical interaction ComPPI
SLC25A4 NDUFA4 25348397 N/A physical interaction ComPPI
SLC25A4 ZNF746 25348397 N/A physical interaction ComPPI
SLC25A4 GLMP 25348397 N/A physical interaction ComPPI
SLC25A4 NEK4 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
SLC25A4 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
SLC25A4 SOAT1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
SLC25A4 E2F3 22157815 24234451 25348397 association pull down ComPPI,IntAct
SLC25A4 LRRK2 21370995 24234451 24725412 25348397 association,physical association anti tag coimmunoprecipitation,tandem affinity purification ComPPI,IntAct
SLC25A4 COQ2 24234451 25348397 29128334 association cross-linking study ComPPI,IntAct
SLC25A4 COX6B1 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
SRC SLC25A4 20007455 27898060 N/A N/A OmniPath

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