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GENE：SORT1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SORT1
FullNmae sortilin 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11186
EnsembleID ENSG00000134243
Uniprot Q99523

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SORT1 lysosomal_cd 36341760 220 lysosome-dependent cell death genes. retulator signature
SORT1 lysosomal_cd 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
SORT1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SORT1 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
SORT1 GO:0001503,GO:0005515,GO:0005764,GO:0005765,GO:0005769,GO:0005789,GO:0005794,GO:0005794,GO:0005829,GO:0005886,GO:0005886,GO:0005905,GO:0006622,GO:0006895,GO:0006895,GO:0006897,GO:0006897,GO:0007186,GO:0007218,GO:0008333,GO:0008625,GO:0009986,GO:0010008,GO:0010465,GO:0010468,GO:0014902,GO:0016020,GO:0016050,GO:0016050,GO:0019899,GO:0030136,GO:0030140,GO:0030379,GO:0031410,GO:0031965,GO:0032509,GO:0032580,GO:0032868,GO:0038180,GO:0045599,GO:0046323,GO:0048011,GO:0048227,GO:0048406,GO:0048471,GO:0051005,GO:0090160,GO:0099558,GO:0150053,GO:1905394

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SORT1 hsa:6272 path:hsa04142 Lysosome - Homo sapiens (human)
SORT1 hsa:6272 path:hsa04722 Neurotrophin signaling pathway - Homo sapiens (human)
SORT1 hsa:6272 path:hsa04979 Cholesterol metabolism - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ELAVL1 SORT1 19322201 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR SORT1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA2 SORT1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 SORT1 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 SORT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA SORT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SORT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 SORT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 SORT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 SORT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS SORT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SORT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000EED18 SORT1 21566225 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS0000153377 SORT1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000018C928 SORT1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000236310 SORT1 22473208 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CSNK2B SORT1 22135298 phosphorylation N/A PhosphoSite
SORT1 GGA2 25361965 interaction type N/A PTMCode2
GGA2 SORT1 25361965 interaction type N/A PTMCode2
SORT1 GGA1 25361965 interaction type N/A PTMCode2
GGA1 SORT1 25361965 interaction type N/A PTMCode2
SORT1 NGF 25361965 interaction type N/A PTMCode2
NGF SORT1 25361965 interaction type N/A PTMCode2
NGFR SORT1 25361965 interaction type N/A PTMCode2
SORT1 NGFR 25361965 interaction type N/A PTMCode2
NTS SORT1 25361965 interaction type N/A PTMCode2
SORT1 NTS 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
NSMCE2 SORT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TUBB SORT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
XRCC2 SORT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CSNK1G2 SORT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NUDCD3 SORT1 24234451 25036637 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
XIAP SORT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PHC2 SORT1 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
BAD SORT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BLMH SORT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GGA2 SORT1 11331584 11390366 11821067 14525934 24234451 25348397 27898060 physical association two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct,OmniPath
TEC SORT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GRN SORT1 23236149 24070898 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction,solid phase assay ComPPI,IntAct
NTRK1 SORT1 21102451 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,physical interaction,fluorescence microscopy ComPPI,IntAct
NGF SORT1 14525934 14985763 19122660 24234451 25348397 physical association cross-linking study,experimental interaction detection,surface plasmon resonance,physical interaction,in vitro,in vivo,surface plasmon resonance array ComPPI,HPRD,IntAct
YBX1 SORT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IRF3 SORT1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
COPA SORT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
WWP2 SORT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TLN1 SORT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
APTX SORT1 25348397 N/A physical interaction ComPPI
MAP3K4 SORT1 25348397 N/A physical interaction ComPPI
NTRK2 SORT1 21102451 24234451 25348397 N/A surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
LPL SORT1 10085125 24234451 25348397 27898060 N/A surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct,OmniPath
SRSF2 SORT1 25348397 N/A physical interaction ComPPI
SPTBN2 SORT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
KLC1 SORT1 25348397 N/A physical interaction ComPPI
CDK2 SORT1 17353931 24234451 25348397 26496610 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RET SORT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SYNCRIP SORT1 25348397 N/A physical interaction ComPPI
NGFR SORT1 14525934 14985763 24234451 25348397 physical association cross-linking study,experimental interaction detection,in vivo ComPPI,HPRD,IntAct
GGA3 SORT1 25348397 N/A physical interaction ComPPI
GGA1 SORT1 11390366 14525934 20676133 24234451 25348397 physical association two hybrid,experimental interaction detection,far western blotting,pull down,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
USP11 SORT1 25348397 N/A physical interaction ComPPI
UPF1 SORT1 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
STAM SORT1 25348397 N/A physical interaction ComPPI
ASS1 SORT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ICAM5 SORT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PLCB3 SORT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EIF2B1 SORT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GOLGA3 SORT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ELAVL1 SORT1 25348397 N/A physical interaction ComPPI
CSPG4 SORT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BACE1 SORT1 25348397 N/A physical interaction ComPPI
SSR1 SORT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BDNF SORT1 14525934 15987945 19122660 24234451 25348397 N/A experimental interaction detection,surface plasmon resonance,physical interaction,in vitro,in vivo,surface plasmon resonance array ComPPI,HPRD,IntAct
MPHOSPH6 SORT1 25348397 N/A physical interaction ComPPI
SSH3 SORT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PTPRN2 SORT1 25348397 N/A physical interaction ComPPI
MYH1 SORT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LMTK2 SORT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DIS3 SORT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 LRPAP1 10085125 14525934 19122660 24234451 25348397 27898060 9013611 association protein cross-linking with a bifunctional reagent,experimental interaction detection,surface plasmon resonance,physical interaction,in vitro,surface plasmon resonance array ComPPI,HPRD,IntAct,OmniPath
SORT1 SORCS1 25348397 N/A physical interaction ComPPI
SORT1 APBB2 25348397 N/A physical interaction ComPPI
SORT1 CDK1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 HP 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 HSD17B4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 COA8 25348397 N/A physical interaction ComPPI
SORT1 MYH6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 NDUFB5 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 NHS 25348397 N/A physical interaction ComPPI
SORT1 NOP2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 PI4KA 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 PRCC 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 RAB13 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 UAP1 25348397 N/A physical interaction ComPPI
SORT1 TCOF1 25348397 N/A physical interaction ComPPI
SORT1 USP1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 YARS1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 OASL 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 KRT75 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 GTF2IRD1 25348397 N/A physical interaction ComPPI
SORT1 ARHGAP32 25348397 N/A physical interaction ComPPI
SORT1 URB2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 C2CD5 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 URB1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 USP15 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 TCIRG1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 ABCA7 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 LAMTOR5 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 TRIOBP 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
SORT1 COBLL1 25348397 N/A physical interaction ComPPI
SORT1 FNDC3A 25348397 N/A physical interaction ComPPI
SORT1 MORC2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 RRP1B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 FAF2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 MED13L 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 DICER1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 SIRT5 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 KLHDC2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 RAB11FIP5 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 LSM14A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 TXNDC11 25348397 N/A physical interaction ComPPI
SORT1 FBXL19 25348397 N/A physical interaction ComPPI
SORT1 PALMD 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 UACA 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 RBM28 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 BRIX1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 UFSP2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 DNAJA4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 DDX60 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 IPO9 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 UGGT2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 BIN3 25348397 N/A physical interaction ComPPI
SORT1 BAIAP2L1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 ZC3HAV1 25348397 N/A physical interaction ComPPI
SORT1 KIAA1191 25348397 N/A physical interaction ComPPI
SORT1 FANCM 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 TENT4B 25348397 N/A physical interaction ComPPI
SORT1 GPBP1 25348397 N/A physical interaction ComPPI
SORT1 NOL6 25348397 N/A physical interaction ComPPI
SORT1 MRPL24 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 ICE2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 ZNF768 25348397 N/A physical interaction ComPPI
SORT1 PEAK1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 MRM1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 TSEN2 25348397 N/A physical interaction ComPPI
SORT1 SBF2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 PARP9 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 UTP15 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 USP32 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 TUBA1C 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 SLC25A25 25348397 N/A physical interaction ComPPI
SORT1 MRPL55 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 EME1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 CENPV 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 PDE12 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 C2ORF69 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 LEMD2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 TMEM9 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 CDRT4 25348397 N/A physical interaction ComPPI
SORT1 SH3PXD2B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 DDX51 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 MIA3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORT1 FOXR1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
SORT1 NTS 14525934 14985763 16087676 24234451 25348397 27898060 9756851 N/A experimental interaction detection,surface plasmon resonance,surface plasmon resonance array ComPPI,HPRD,IntAct,OmniPath
SORT1 NTRK3 21102451 24234451 25348397 physical association anti bait coimmunoprecipitation,surface plasmon resonance ComPPI,IntAct
SORT1 TF 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SORT1 CNIH3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MUS81 SORT1 25348397 N/A physical interaction ComPPI
ADGRG7 SORT1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SORT1 SORT1 19122660 24234451 N/A surface plasmon resonance IntAct
NGF SORT1 14985763 19122660 27898060 N/A N/A OmniPath
CSNK2B SORT1 25805502 27898060 N/A N/A OmniPath

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