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GENE：SP100

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SP100
FullNmae SP100 nuclear antigen
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11206
EnsembleID ENSG00000067066
Uniprot P23497

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SP100 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SP100 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SP100 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
SP100 GO:0000122,GO:0000723,GO:0000781,GO:0000981,GO:0000981,GO:0003677,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005737,GO:0006357,GO:0006978,GO:0010596,GO:0016604,GO:0016605,GO:0019900,GO:0019904,GO:0034340,GO:0034340,GO:0034341,GO:0034341,GO:0042802,GO:0043392,GO:0043433,GO:0045185,GO:0045765,GO:0045893,GO:0046826,GO:0046983,GO:0060333,GO:0060337,GO:0070087,GO:1902041,GO:1902044

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SP100 hsa:6672 path:hsa05168 Herpes simplex virus 1 infection - Homo sapiens (human)
SP100 hsa:6672 path:hsa05203 Viral carcinogenesis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SP100 PRDM1 20421211 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF8 SP100 22096565 23180781 physical association anti tag coimmunoprecipitation InnateDB
SP100 ACTN2 23180781 25416956 physical association two hybrid InnateDB
SP100 SUMO1 11792325 15608651 18691969 29145629 physical association inferred by curator Reactome

Source Target Pmid Interactiontype Methods Database
AR SP100 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 SP100 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 SP100 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 SP100 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA SP100 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 SP100 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 SP100 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 SP100 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS SP100 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 SP100 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 SP100 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 SP100 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR SP100 18971253 trascriptional regulation,stimulation inferred by curator TFlink
IRF9 SP100 8681971 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000324096 SP100 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS000035CC3E SP100 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000052E1A6 SP100 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000A057E SP100 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00003AFAD1 SP100 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000031BC7D SP100 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00003ACE11 SP100 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000077AED SP100 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001FFA8C SP100 23592263 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
RTP5 SP100 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
UBE2I SP100 14525934 18691969 20936779 24234451 25348397 physical association experimental interaction detection,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,in vivo ComPPI,HPRD,IntAct
TP53BP1 SP100 24234451 25348397 29656893 association proximity-dependent biotin identification ComPPI,IntAct
SNIP1 SP100 14525934 15231748 24234451 25348397 physical association two hybrid,two hybrid ComPPI,HPRD,IntAct
ZC2HC1A SP100 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
ARID3A SP100 14525934 15017387 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
GIPC2 SP100 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CBX1 SP100 25348397 N/A two hybrid,physical interaction,physical interaction ComPPI
DSTN SP100 25348397 N/A physical interaction ComPPI
SUMO1 SP100 10212234 11313457 14525934 16189514 17491593 21880768 24234451 25348397 25416956 physical association two hybrid,experimental interaction detection,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,in vitro,in vivo,bimolecular fluorescence complementation,two hybrid prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
RBM39 SP100 25348397 N/A physical interaction ComPPI
TOM1L1 SP100 25348397 N/A physical interaction ComPPI
SERPINE2 SP100 25348397 N/A physical interaction ComPPI
TRIM29 SP100 25348397 N/A physical interaction ComPPI
HMGB1 SP100 25348397 N/A physical interaction ComPPI
ACTN2 SP100 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
SP100 HIPK2 14525934 14647468 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SP100 ETS1 11909962 14525934 15247905 24234451 25348397 physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
SP100 CASP8AP2 14525934 17245429 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,imaging technique,in vivo,two hybrid ComPPI,HPRD,IntAct
SP100 SUMO2 14525934 17000644 21988832 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
SP100 CBX3 14525934 25348397 27898060 9636146 9636147 N/A two hybrid,experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD,OmniPath
SP100 MX1 25348397 N/A physical interaction ComPPI
SP100 MYB 25348397 N/A physical interaction ComPPI
SP100 NIPBL 25348397 N/A physical interaction ComPPI
SP100 PML 25348397 N/A physical interaction ComPPI
SP100 RANBP2 25348397 N/A physical interaction ComPPI
SP100 TERF1 21044950 24234451 25348397 physical association physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
SP100 TERF2IP 21044950 24234451 25348397 physical association physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
SP100 TERF2 21044950 24234451 25348397 physical association physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
SP100 AHCYL1 25348397 N/A physical interaction ComPPI
SP100 SEC23A 25348397 N/A physical interaction ComPPI
SP100 IGBP1 25348397 N/A physical interaction ComPPI
SP100 CREM 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SP100 SUMO3 17000644 24234451 25348397 physical association affinity chromatography technology,anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SP100 AGL 25348397 N/A physical interaction ComPPI
SP100 CRTAP 25348397 N/A physical interaction ComPPI
SP100 PUS1 25348397 N/A physical interaction ComPPI
SP100 SENP1 25348397 N/A physical interaction ComPPI
SP100 USPL1 25348397 N/A physical interaction ComPPI
SP100 DNMT3A 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
SP100 PHC1 25348397 N/A physical interaction ComPPI
SP100 DYRK2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
SP100 AMOTL2 25348397 N/A physical interaction ComPPI
SP100 TRAF3IP3 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
SP100 L3MBTL3 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
SP100 MOV10 25348397 N/A physical interaction ComPPI
SP100 NXF1 25348397 N/A physical interaction ComPPI
SP100 IFI16 25348397 N/A physical interaction ComPPI
SP100 LTN1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SP100 NUF2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SP100 HEMGN 22712502 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SP100 FOXL2 25348397 N/A physical interaction ComPPI
SP100 ZNF706 25348397 N/A physical interaction ComPPI
SP100 LRRK2 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
CBX5 SP100 21516116 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
LZTR1 SP100 25348397 N/A physical interaction ComPPI
VPS25 SP100 25348397 N/A physical interaction ComPPI
SP100 SP100 21880768 24234451 25416956 physical association two hybrid,two hybrid array IntAct
H1-10 SP100 24234451 30021884 physical association cross-linking study IntAct

Source Target Pmid Interactiontype Methods Database
URS00008B489F SP100 27087310 direct interaction,inhibition N/A NPInter

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