Gene Information gene info

  1. Home

GENE：SPI1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SPI1
FullNmae Spi-1 proto-oncogene
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11241
EnsembleID ENSG00000066336
Uniprot P17947

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SPI1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
SPI1 GO:0000122,GO:0000122,GO:0000785,GO:0000785,GO:0000976,GO:0000976,GO:0000978,GO:0000978,GO:0000981,GO:0000981,GO:0000981,GO:0000987,GO:0000987,GO:0001216,GO:0001217,GO:0001227,GO:0001228,GO:0002314,GO:0002316,GO:0002327,GO:0002357,GO:0002572,GO:0002573,GO:0003682,GO:0003700,GO:0003700,GO:0003723,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005667,GO:0006355,GO:0006357,GO:0007179,GO:0010629,GO:0030154,GO:0030218,GO:0030225,GO:0030851,GO:0031663,GO:0032088,GO:0035019,GO:0036462,GO:0042826,GO:0043011,GO:0043314,GO:0043565,GO:0045347,GO:0045579,GO:0045646,GO:0045815,GO:0045815,GO:0045892,GO:0045892,GO:0045944,GO:0045944,GO:0045944,GO:0045944,GO:0051090,GO:0051525,GO:0060033,GO:0060090,GO:0061629,GO:0061629,GO:0070102,GO:0090402,GO:0097677,GO:0098508,GO:0120186,GO:0140297,GO:0140297,GO:0140311,GO:1900745,GO:1901223,GO:1902262,GO:1902895,GO:1902895,GO:1904151,GO:1904178,GO:1904238,GO:1905036,GO:1905453,GO:2000529

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SPI1 hsa:6688 path:hsa04380 Osteoclast differentiation - Homo sapiens (human)
SPI1 hsa:6688 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)
SPI1 hsa:6688 path:hsa05200 Pathways in cancer - Homo sapiens (human)
SPI1 hsa:6688 path:hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human)
SPI1 hsa:6688 path:hsa05221 Acute myeloid leukemia - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SPI1 TLR4 10734131 11672593 11964313 12032143 12803886 12811837 16283355 16418395 20510871 23180781 26192618 interaction type,physical association electrophoretic mobility supershift assay ACSN,InnateDB
SPI1 FLT3 10734131 11672593 11964313 12032143 12803886 12811837 16283355 16418395 20510871 26192618 interaction type N/A ACSN
FLT3LG SPI1 10477595 14670306 15749884 16418395 16713974 17404308 20547845 25215878 26192618 8920882 9268501 interaction type N/A ACSN
MIF SPI1 10878343 12782713 12803886 16283355 18490733 20861157 23390297 26192618 8195715 9637476 interaction type N/A ACSN
IRF1 SPI1 11483597 23180781 9593745 physical association anti tag coimmunoprecipitation,pull down,electrophoretic mobility shift assay InnateDB
SPI1 IRF1 23180781 9593745 physical association pull down InnateDB
SPI1 IRF8 10570299 11483597 23180781 9593745 physical association anti tag coimmunoprecipitation,pull down InnateDB
SPI1 IL1B 16439360 17283046 17386941 23180781 7799967 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
NF1 SPI1 17200120 23180781 physical association anti tag coimmunoprecipitation InnateDB
SPI1 IRF4 16272311 23180781 physical association affinity chromatography technology,anti tag coimmunoprecipitation InnateDB
SPI1 CYBB 15618156 23180781 9600921 physical association affinity chromatography technology,anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
LY96 SPI1 19632992 23180781 physical association anti tag coimmunoprecipitation InnateDB
CD68 SPI1 12676954 23180781 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
CIITA SPI1 15242870 21216962 23180781 physical association anti tag coimmunoprecipitation InnateDB
SPI1 ISG15 12055236 23180781 physical association electrophoretic mobility supershift assay InnateDB
SPI1 CSF1R 21659508 23180781 8264604 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
SPI1 MS4A1 23180781 9354667 physical association electrophoretic mobility supershift assay InnateDB
ITGAM SPI1 10411939 17203216 19747912 21402070 23180781 8095266 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay,electrophoretic mobility shift assay InnateDB
EVL SPI1 19151778 23180781 physical association anti tag coimmunoprecipitation InnateDB
SPI1 IL10 20072143 23180781 physical association anti tag coimmunoprecipitation InnateDB
SPI1 ZNF300 20471086 23180781 physical association anti tag coimmunoprecipitation InnateDB
ADGRE1 SPI1 15533720 23180781 physical association anti tag coimmunoprecipitation InnateDB
ITGAX SPI1 23180781 9295016 physical association electrophoretic mobility supershift assay InnateDB
VAV1 SPI1 19747912 23180781 physical association anti tag coimmunoprecipitation InnateDB
SPI1 PRG2 12202480 23180781 physical association electrophoretic mobility supershift assay InnateDB
CEBPE SPI1 12202480 23180781 physical association anti tag coimmunoprecipitation InnateDB
SPI1 JUN 10411939 12091339 23180781 physical association pull down InnateDB
ERG SPI1 23180781 9681824 physical association pull down InnateDB
SPI1 GATA2 10411939 23180781 physical association pull down InnateDB
SPI1 GATA1 10411939 23180781 physical association anti tag coimmunoprecipitation InnateDB
SPI1 CTSK 15304486 23180781 physical association anti tag coimmunoprecipitation InnateDB
FES SPI1 23180781 8657143 physical association electrophoretic mobility supershift assay InnateDB
LIMD1 SPI1 21402070 23180781 physical association anti tag coimmunoprecipitation InnateDB
BCL2A1 SPI1 20200559 23180781 physical association anti tag coimmunoprecipitation InnateDB
SPI1 FCER1A 23180781 24639354 physical association anti tag coimmunoprecipitation InnateDB
SPI1 MS4A2 23180781 24639354 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
GATA1 SPI1 10753833 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 SPI1 19620289 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 SPI1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA SPI1 18971253 24429361 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SPI1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 SPI1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 SPI1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 SPI1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 SPI1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR SPI1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 SPI1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPE SPI1 12202480 trascriptional regulation,stimulation inferred by curator TFlink
FOS SPI1 9988737 trascriptional regulation,stimulation inferred by curator TFlink
HOXC13 SPI1 18076876 trascriptional regulation,stimulation inferred by curator TFlink
JUN SPI1 9988737 trascriptional regulation,stimulation inferred by curator TFlink
POU2F2 SPI1 12592383 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 SPI1 12576332 18316480 trascriptional regulation,stimulation inferred by curator TFlink
SATB1 SPI1 17694175 trascriptional regulation,stimulation inferred by curator TFlink
POU2F1 SPI1 N/A trascriptional regulation,stimulation inferred by curator TFlink
SP1 SPI1 N/A trascriptional regulation,stimulation inferred by curator TFlink
SPI1 SPI1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000338542 SPI1 19386588 20680360 rna interference,inhibition experimental interaction detection,miRNA interference luciferase reporter assay miRSponge
URS00000EED18 SPI1 20598588 rna interference,inhibition experimental interaction detection,miRNA interference luciferase reporter assay miRSponge
URS00000F0F49 SPI1 20972335 rna interference,inhibition array technology,western blot,chromatin immunoprecipitation assay,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000338542 SPI1 18668040 19386588 20680360 22473208 25092144 25288398 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,rna immunoprecipitation,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS00000EED18 SPI1 20598588 25416803 mrna cleavage,inhibition experimental interaction detection,miRNA interference luciferase reporter assay TarBase
URS00000F0F49 SPI1 20972335 25416803 mrna cleavage,inhibition array technology,western blot,chromatin immunoprecipitation assay,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00001C3AC1 SPI1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000003FD55 SPI1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000032835F SPI1 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CEBPE SPI1 25361965 interaction type N/A PTMCode2
SPI1 CEBPE 25361965 interaction type N/A PTMCode2
CSNK2A1 SPI1 25361965 interaction type N/A PTMCode2
SPI1 CSNK2A1 25361965 interaction type N/A PTMCode2
SPI1 BCL6 25361965 interaction type N/A PTMCode2
BCL6 SPI1 25361965 interaction type N/A PTMCode2
SPI1 ID2 25361965 interaction type N/A PTMCode2
ID2 SPI1 25361965 interaction type N/A PTMCode2
SPI1 FUS 25361965 interaction type N/A PTMCode2
FUS SPI1 25361965 interaction type N/A PTMCode2
SPI1 ATF1 25361965 interaction type N/A PTMCode2
ATF1 SPI1 25361965 interaction type N/A PTMCode2
SPI1 DNMT3A 25361965 interaction type N/A PTMCode2
DNMT3A SPI1 25361965 interaction type N/A PTMCode2
SPI1 CREM 25361965 interaction type N/A PTMCode2
CREM SPI1 25361965 interaction type N/A PTMCode2
SPI1 IRF8 25361965 interaction type N/A PTMCode2
IRF8 SPI1 25361965 interaction type N/A PTMCode2
SPI1 NONO 25361965 interaction type N/A PTMCode2
NONO SPI1 25361965 interaction type N/A PTMCode2
SPI1 SSRP1 25361965 interaction type N/A PTMCode2
SSRP1 SPI1 25361965 interaction type N/A PTMCode2
SPI1 HOXA10 25361965 interaction type N/A PTMCode2
HOXA10 SPI1 25361965 interaction type N/A PTMCode2
SPI1 PIP 25361965 interaction type N/A PTMCode2
PIP SPI1 25361965 interaction type N/A PTMCode2
SPI1 MITF 25361965 interaction type N/A PTMCode2
MITF SPI1 25361965 interaction type N/A PTMCode2
SPI1 CEBPB 25361965 interaction type N/A PTMCode2
CEBPB SPI1 25361965 interaction type N/A PTMCode2
SPI1 FOS 25361965 interaction type N/A PTMCode2
FOS SPI1 25361965 interaction type N/A PTMCode2
SPI1 FES 25361965 interaction type N/A PTMCode2
FES SPI1 25361965 interaction type N/A PTMCode2
SPI1 CSF3R 25361965 interaction type N/A PTMCode2
CSF3R SPI1 25361965 interaction type N/A PTMCode2
SPI1 GATA2 25361965 interaction type N/A PTMCode2
GATA2 SPI1 25361965 interaction type N/A PTMCode2
SPI1 NFYA 25361965 interaction type N/A PTMCode2
NFYA SPI1 25361965 interaction type N/A PTMCode2
SPI1 JUN 25361965 interaction type N/A PTMCode2
JUN SPI1 25361965 interaction type N/A PTMCode2
SPI1 GATA1 25361965 interaction type N/A PTMCode2
GATA1 SPI1 25361965 interaction type N/A PTMCode2
SPI1 IRF4 25361965 interaction type N/A PTMCode2
IRF4 SPI1 25361965 interaction type N/A PTMCode2
SPI1 CEBPD 25361965 interaction type N/A PTMCode2
CEBPD SPI1 25361965 interaction type N/A PTMCode2
SPI1 MECP2 25361965 interaction type N/A PTMCode2
MECP2 SPI1 25361965 interaction type N/A PTMCode2
NFKB1 SPI1 25361965 interaction type N/A PTMCode2
SPI1 NFKB1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
RARA SPI1 25348397 N/A physical interaction ComPPI
VAV1 SPI1 25348397 N/A physical interaction ComPPI
TBP SPI1 14525934 25348397 8434021 N/A affinity chromatography technology,experimental interaction detection,filter binding,physical interaction,in vitro ComPPI,HPRD
MAPK8 SPI1 25348397 N/A physical interaction ComPPI
ETS2 SPI1 25348397 N/A physical interaction ComPPI
NFATC1 SPI1 14525934 15304486 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SPI1 JUN 12091339 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SPI1 CEBPB 14525934 25348397 7594592 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SPI1 NONO 14525934 25348397 27898060 8626664 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
SPI1 GATA1 10364157 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SPI1 IRF8 10734131 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SPI1 IRF4 10022840 12372320 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
SPI1 SPIB 10196196 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SPI1 CEBPA 12091339 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SPI1 CEBPE 12202480 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SPI1 PIP 11133986 14525934 25348397 27898060 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
SPI1 ATF1 14525934 25348397 7730336 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SPI1 SSRP1 14525934 25348397 7594592 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SPI1 CEBPD 14525934 25348397 7594592 N/A biophysical,experimental interaction detection,physical interaction,biochemical,in vitro ComPPI,HPRD
SPI1 CREM 14525934 25348397 7730336 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SPI1 RB1 14525934 25348397 8434021 N/A affinity chromatography technology,experimental interaction detection,filter binding,physical interaction,in vitro ComPPI,HPRD
SPI1 CREBBP 10050886 11864910 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD,OmniPath
SPI1 DNMT3B 14525934 16331260 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SPI1 DNMT3A 14525934 16331260 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SPI1 HOXA10 14525934 18692240 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
SPI1 FUS 14525934 25348397 27898060 9478924 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
SPI1 GATA2 10411939 14525934 18250304 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
SPI1 NFKB1 14525934 25348397 9094628 N/A experimental interaction detection,in vitro ComPPI,HPRD
SPI1 CSNK2A1 25348397 N/A physical interaction ComPPI
SPI1 ETS1 25348397 N/A physical interaction ComPPI
SPI1 ETV1 25348397 N/A physical interaction ComPPI
SPI1 FOS 25348397 N/A physical interaction ComPPI
SPI1 MITF 14525934 25348397 9918847 N/A experimental interaction detection,physical interaction ComPPI,HPRD
SPI1 NFYA 25348397 N/A physical interaction ComPPI
SPI1 MECP2 25348397 N/A physical interaction ComPPI
SPI1 HDAC1 25348397 N/A physical interaction ComPPI
SPI1 BCL6 19564417 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SPI1 SIN3A 25348397 N/A physical interaction ComPPI
SPI1 SKI 25348397 N/A physical interaction ComPPI
SPI1 HDAC3 25348397 N/A physical interaction ComPPI
SPI1 PML 25348397 N/A physical interaction ComPPI
SPI1 IRF1 25348397 N/A physical interaction ComPPI
SPI1 GFI1 17197705 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct,OmniPath
SPI1 GATA3 25348397 N/A physical interaction ComPPI
SPI1 TMX1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SPI1 RUNX1 25348397 N/A physical interaction ComPPI
SPI1 PRKDC 21575865 24234451 25348397 association anti tag coimmunoprecipitation,pull down ComPPI,IntAct
SPI1 XRCC5 21575865 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
SPI1 PARP1 21575865 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
SPI1 XRCC6 21575865 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
SPI1 PRKCD 24234451 24996056 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
SPI1 ERG 14525934 9681824 N/A experimental interaction detection HPRD
KAT6A SPI1 14525934 16702405 N/A experimental interaction detection HPRD
SPI1 KLF4 17762869 24234451 association chromatin immunoprecipitation assay IntAct
YTHDC1 SPI1 24234451 30021884 physical association cross-linking study IntAct
PIM1 SPI1 16371130 27898060 8387358 8887664 N/A N/A OmniPath
SPI1 EP300 16702405 17562868 27898060 N/A N/A OmniPath
SPI1 ZNF300 20471086 27898060 N/A N/A OmniPath
GATA1 SPI1 10364157 10411939 10753833 12202480 15676205 27898060 inhibition N/A OmniPath
SPI1 GATA1 10364157 10411939 10753833 12202480 15676205 27898060 inhibition N/A OmniPath
SPI1 CSF1 15676205 27898060 stimulant N/A OmniPath
SPI1 CSF3 15676205 27898060 stimulant N/A OmniPath
SPI1 IRF8 10570299 10734131 11483597 27898060 9593745 stimulant N/A OmniPath
SPI1 ITGB2 15676205 27898060 stimulant N/A OmniPath
SPI1 CSF2 15676205 27898060 stimulant N/A OmniPath
CEBPA SPI1 10397723 12091339 16983342 27898060 stimulant N/A OmniPath
SPI1 ITGAM 15676205 27898060 stimulant N/A OmniPath
STAT3 SPI1 11889125 27898060 stimulant N/A OmniPath
JUN SPI1 10411939 12091339 12393465 19181746 27898060 stimulant N/A OmniPath
SPI1 JUN 10411939 12091339 19181746 27898060 N/A N/A OmniPath
VAV1 SPI1 19747912 27898060 N/A N/A OmniPath

Visualization










  Return