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GENE：STRADB

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol STRADB
FullNmae STE20 related adaptor beta
LocusType gene with protein product
Status Approved
HGNC_id HGNC:13205
EnsembleID ENSG00000082146
Uniprot Q9C0K7

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
STRADB apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
STRADB apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
STRADB GO:0000902,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005737,GO:0005829,GO:0005829,GO:0006611,GO:0006611,GO:0007049,GO:0007254,GO:0016235,GO:0032147,GO:0032147,GO:0043539,GO:1902554,GO:1902554,GO:2001240

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
STRADB hsa:55437 path:hsa04150 mTOR signaling pathway - Homo sapiens (human)
STRADB hsa:55437 path:hsa04152 AMPK signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
STRADB XIAP 12048196 23180781 physical association two hybrid,gst pull down InnateDB
STRADB MAP3K7 12048196 23180781 physical association anti tag coimmunoprecipitation InnateDB
TRAF6 STRADB 12048196 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
GRB2 STRADB 20005715 interaction type N/A PSP

Source Target Pmid Interactiontype Methods Database
AR STRADB 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
FOXP3 STRADB 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 STRADB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA STRADB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF STRADB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 STRADB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 STRADB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 STRADB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 STRADB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 STRADB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A STRADB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF STRADB 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000AA464 STRADB 20304954 25416803 mrna cleavage,inhibition array technology TarBase
URS0000171CD1 STRADB 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000003ABC4 STRADB 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000041CB9C STRADB 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000040EE1D STRADB 20371350 22815788 25416803 mrna cleavage,inhibition array technology,quantitative reverse transcription pcr,clip TarBase
URS00000F0F49 STRADB 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000007D64A STRADB 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000D2680 STRADB 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00004AF715 STRADB 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000821E0 STRADB 22815788 25416803 mrna cleavage,inhibition array technology,quantitative reverse transcription pcr TarBase
URS000000C73C STRADB 22815788 25416803 mrna cleavage,inhibition array technology,quantitative reverse transcription pcr TarBase
URS00003E5E03 STRADB 20371350 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
STRADB CAB39 25361965 interaction type N/A PTMCode2
CAB39 STRADB 25361965 interaction type N/A PTMCode2
STRADB TRAF6 25361965 interaction type N/A PTMCode2
TRAF6 STRADB 25361965 interaction type N/A PTMCode2
STRADB STK11 25361965 interaction type N/A PTMCode2
STK11 STRADB 25361965 interaction type N/A PTMCode2
STRADB XIAP 25361965 interaction type N/A PTMCode2
XIAP STRADB 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
TRAF6 STRADB 12048196 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
XIAP STRADB 12048196 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
GRB2 STRADB 18624398 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RPS6KA2 STRADB 25348397 N/A physical interaction ComPPI
NBEA STRADB 25348397 N/A physical interaction ComPPI
RPS6KA3 STRADB 25348397 N/A physical interaction ComPPI
CCT7 STRADB 25348397 N/A physical interaction ComPPI
STK11 STRADB 14525934 14676191 20562859 24234451 25348397 colocalization,association,physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,fluorescence microscopy,protein kinase assay,in vivo ComPPI,HPRD,IntAct
MAP3K7 STRADB 12048196 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
STRADB CAB39 14525934 14676191 23414517 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,two hybrid fragment pooling approach,fluorescence microscopy,in vivo ComPPI,HPRD,IntAct
STRADB ELAVL1 25348397 N/A physical interaction ComPPI
STRADB PIP4K2A 25348397 N/A physical interaction ComPPI
STRADB CCT6B 25348397 N/A physical interaction ComPPI
STRADB CCT2 25348397 N/A physical interaction ComPPI
STRADB CCT3 25348397 N/A physical interaction ComPPI
STRADB NEB 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
MAP3K7 STRADB 12048196 27898060 N/A N/A OmniPath
STRADB TRAF6 12048196 27898060 N/A N/A OmniPath
TRAF6 STRADB 12048196 27898060 N/A N/A OmniPath

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