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GENE：SYVN1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SYVN1
FullNmae synoviolin 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:20738
EnsembleID ENSG00000162298
Uniprot Q86TM6

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SYVN1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SYVN1 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
SYVN1 GO:0000836,GO:0000839,GO:0000839,GO:0002327,GO:0005515,GO:0005654,GO:0005737,GO:0005783,GO:0005783,GO:0005789,GO:0005789,GO:0005790,GO:0006511,GO:0006511,GO:0016020,GO:0016567,GO:0016567,GO:0030433,GO:0030433,GO:0030433,GO:0030970,GO:0036503,GO:0036503,GO:0036513,GO:0044322,GO:0044322,GO:0046872,GO:0050821,GO:0051082,GO:0051087,GO:0051117,GO:0061630,GO:0061630,GO:0061630,GO:0061630,GO:0070936,GO:1902236,GO:1902236,GO:1990381

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SYVN1 hsa:84447 path:hsa04120 Ubiquitin mediated proteolysis - Homo sapiens (human)
SYVN1 hsa:84447 path:hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
NDUFB9 SYVN1 12847084 16186509 18199748 18360008 19509052 26192618 interaction type N/A ACSN
SYVN1 SEL1L 12847084 16186509 18199748 18360008 19509052 26192618 interaction type N/A ACSN
SYVN1 NDUFS2 12847084 15186778 15526035 15807660 16186509 16200211 16218961 17344420 18199748 18360008 18485875 19131594 19509052 20025615 20816094 26192618 interaction type N/A ACSN
SYVN1 NDUFV2 12847084 15186778 15526035 15807660 16186509 16200211 16218961 17344420 18199748 18360008 18485875 19131594 19509052 20025615 20816094 26192618 interaction type N/A ACSN
ATF6 SYVN1 17991856 18360008 23850759 26192618 26587781 interaction type N/A ACSN

Source Target Pmid Interactiontype Methods Database
ETS1 SYVN1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 SYVN1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TP53 SYVN1 16980608 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 SYVN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 SYVN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS SYVN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 SYVN1 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00003D5391 SYVN1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00005586D0 SYVN1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000366551 SYVN1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000018CD09 SYVN1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002C0FCB SYVN1 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
ERLIN1 SYVN1 21343306 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
YIPF3 SYVN1 25348397 N/A physical interaction ComPPI
PSMD7 SYVN1 25348397 N/A physical interaction ComPPI
VCP SYVN1 20414249 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DERL2 SYVN1 25348397 N/A physical interaction ComPPI
PSMB2 SYVN1 25348397 N/A physical interaction ComPPI
HMOX1 SYVN1 25348397 N/A physical interaction ComPPI
HEY2 SYVN1 25348397 N/A physical interaction ComPPI
PMP22 SYVN1 25348397 N/A physical interaction ComPPI
USP7 SYVN1 14525934 16713569 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
UBE2D2 SYVN1 11724934 21987572 25348397 27898060 N/A physical interaction ComPPI,OmniPath
PSMA3 SYVN1 25348397 N/A physical interaction ComPPI
CLU SYVN1 25348397 N/A physical interaction ComPPI
BAG6 SYVN1 25348397 N/A physical interaction ComPPI
HSPA5 SYVN1 25348397 N/A physical interaction ComPPI
SERPINA1 SYVN1 25348397 N/A physical interaction ComPPI
PSMA1 SYVN1 25348397 N/A physical interaction ComPPI
PSMA6 SYVN1 25348397 N/A physical interaction ComPPI
PSMA5 SYVN1 25348397 N/A physical interaction ComPPI
HEY1 SYVN1 25348397 N/A physical interaction ComPPI
PSMD1 SYVN1 25348397 N/A physical interaction ComPPI
SYVN1 ERN1 14525934 18369366 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
SYVN1 SVIP 25348397 N/A physical interaction ComPPI
SYVN1 SELENOS 25348397 N/A physical interaction ComPPI
SYVN1 GPR37 25348397 N/A physical interaction ComPPI
SYVN1 UBE2J1 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SYVN1 UBE2U 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SYVN1 UBE2Z 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SYVN1 HERPUD1 16289116 21149444 23867461 25348397 26424800 26471130 27898060 N/A physical interaction ComPPI,OmniPath
SYVN1 DERL1 16186510 16289116 16619026 16873066 18407841 19864457 20005842 23867461 24292014 24807418 25348397 26471130 27898060 N/A physical interaction ComPPI,OmniPath
SYVN1 SEL1L 25348397 N/A physical interaction ComPPI
SYVN1 HTT 17141218 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SYVN1 AMFR 25348397 N/A physical interaction ComPPI
SYVN1 WFS1 25348397 N/A physical interaction ComPPI
SYVN1 ATF6 25348397 N/A physical interaction ComPPI
SYVN1 ATP6AP1 25348397 N/A physical interaction ComPPI
SYVN1 APP 25348397 N/A physical interaction ComPPI
SYVN1 PDIA2 25348397 N/A physical interaction ComPPI
SYVN1 TP53 14525934 17170702 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,imaging technique ComPPI,HPRD,IntAct
SYVN1 PSMD2 25348397 N/A physical interaction ComPPI
SYVN1 ERLIN2 21343306 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SYVN1 TMUB1 21343306 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SYVN1 HLA-A 25348397 N/A physical interaction ComPPI
SYVN1 HFE 25348397 N/A physical interaction ComPPI
SYVN1 SGK1 25348397 N/A physical interaction ComPPI
SYVN1 FAM8A1 25348397 N/A physical interaction ComPPI
SYVN1 TYR 25348397 N/A physical interaction ComPPI
SYVN1 SARAF 25348397 N/A physical interaction ComPPI
SYVN1 AUP1 25348397 N/A physical interaction ComPPI
SYVN1 UBXN8 25348397 N/A physical interaction ComPPI
SYVN1 ERLEC1 25348397 N/A physical interaction ComPPI
SYVN1 OS9 25348397 N/A physical interaction ComPPI
SYVN1 ASGR2 25348397 N/A physical interaction ComPPI
SYVN1 SHH 25348397 N/A physical interaction ComPPI
SYVN1 APOB 25348397 N/A physical interaction ComPPI
SYVN1 ATN1 14525934 16713569 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SYVN1 UBE2D3 12646171 20237263 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SYVN1 ASGR1 25348397 N/A physical interaction ComPPI
SYVN1 BSG 25348397 N/A physical interaction ComPPI
SYVN1 YOD1 25348397 N/A physical interaction ComPPI
SYVN1 ATXN3 25348397 N/A physical interaction ComPPI
SYVN1 USP19 25348397 N/A physical interaction ComPPI
SYVN1 STXBP5L 25348397 N/A physical interaction ComPPI
SYVN1 RER1 25348397 N/A physical interaction ComPPI
SYVN1 HMGCR 25348397 N/A physical interaction ComPPI
SYVN1 PSMA7 25348397 N/A physical interaction ComPPI
SYVN1 PSMA2 25348397 N/A physical interaction ComPPI
SYVN1 PSMB7 25348397 N/A physical interaction ComPPI
SYVN1 PSMB6 25348397 N/A physical interaction ComPPI
SYVN1 POR 25348397 N/A physical interaction ComPPI
SYVN1 FDFT1 25348397 N/A physical interaction ComPPI
SYVN1 MYH9 25348397 N/A physical interaction ComPPI
SYVN1 TMEM129 25348397 N/A physical interaction ComPPI
SYVN1 MBTPS2 25348397 N/A physical interaction ComPPI
SYVN1 WBP1 25348397 N/A physical interaction ComPPI
SYVN1 NAAA 25348397 N/A physical interaction ComPPI
SYVN1 GLRA2 25348397 N/A physical interaction ComPPI
SYVN1 PPARGC1B 25348397 25698262 27898060 N/A physical interaction ComPPI,OmniPath
SYVN1 UBAC2 25348397 N/A physical interaction ComPPI
SYVN1 FAF2 25348397 N/A physical interaction ComPPI
SYVN1 GABRA1 25348397 N/A physical interaction ComPPI
SYVN1 EGFL6 25348397 N/A physical interaction ComPPI
SYVN1 HTR3A 25348397 N/A physical interaction ComPPI
SYVN1 SLC24A5 25348397 N/A physical interaction ComPPI
SYVN1 UBXN6 18656546 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PSMB4 SYVN1 25348397 N/A physical interaction ComPPI
PSMB1 SYVN1 25348397 N/A physical interaction ComPPI
PSMB3 SYVN1 25348397 N/A physical interaction ComPPI
IGF1R SYVN1 25348397 N/A physical interaction ComPPI
HMGB2 SYVN1 11390656 16270032 19324879 19394298 20005842 27898060 N/A N/A OmniPath
PRC1 SYVN1 16619026 22298424 24292014 27898060 N/A N/A OmniPath
SYVN1 NPLOC4 16179953 16619026 27898060 N/A N/A OmniPath
CREB3L2 SYVN1 22705851 27898060 N/A N/A OmniPath

Visualization










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