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GENE：TCF7L2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TCF7L2
FullNmae transcription factor 7 like 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11641
EnsembleID ENSG00000148737
Uniprot Q9NQB0

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TCF7L2 pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TCF7L2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TCF7L2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TCF7L2 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TCF7L2 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
TCF7L2 GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000978,GO:0000981,GO:0001568,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0006357,GO:0006357,GO:0008013,GO:0008013,GO:0008013,GO:0009749,GO:0010909,GO:0016605,GO:0016922,GO:0019901,GO:0031016,GO:0032024,GO:0032092,GO:0032350,GO:0032993,GO:0042593,GO:0043433,GO:0043565,GO:0043565,GO:0043570,GO:0044334,GO:0045295,GO:0045444,GO:0045721,GO:0045892,GO:0045892,GO:0045944,GO:0048625,GO:0048660,GO:0050679,GO:0051897,GO:0060070,GO:0060070,GO:0061629,GO:0070016,GO:0070369,GO:0071664,GO:0090090,GO:1900182,GO:1990841,GO:1990907,GO:2000675,GO:2001237

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TCF7L2 hsa:6934 path:hsa04310 Wnt signaling pathway - Homo sapiens (human)
TCF7L2 hsa:6934 path:hsa04390 Hippo signaling pathway - Homo sapiens (human)
TCF7L2 hsa:6934 path:hsa04520 Adherens junction - Homo sapiens (human)
TCF7L2 hsa:6934 path:hsa04916 Melanogenesis - Homo sapiens (human)
TCF7L2 hsa:6934 path:hsa04934 Cushing syndrome - Homo sapiens (human)
TCF7L2 hsa:6934 path:hsa04936 Alcoholic liver disease - Homo sapiens (human)
TCF7L2 hsa:6934 path:hsa05132 Salmonella infection - Homo sapiens (human)
TCF7L2 hsa:6934 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
TCF7L2 hsa:6934 path:hsa05167 Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)
TCF7L2 hsa:6934 path:hsa05200 Pathways in cancer - Homo sapiens (human)
TCF7L2 hsa:6934 path:hsa05210 Colorectal cancer - Homo sapiens (human)
TCF7L2 hsa:6934 path:hsa05213 Endometrial cancer - Homo sapiens (human)
TCF7L2 hsa:6934 path:hsa05215 Prostate cancer - Homo sapiens (human)
TCF7L2 hsa:6934 path:hsa05216 Thyroid cancer - Homo sapiens (human)
TCF7L2 hsa:6934 path:hsa05217 Basal cell carcinoma - Homo sapiens (human)
TCF7L2 hsa:6934 path:hsa05221 Acute myeloid leukemia - Homo sapiens (human)
TCF7L2 hsa:6934 path:hsa05224 Breast cancer - Homo sapiens (human)
TCF7L2 hsa:6934 path:hsa05225 Hepatocellular carcinoma - Homo sapiens (human)
TCF7L2 hsa:6934 path:hsa05226 Gastric cancer - Homo sapiens (human)
TCF7L2 hsa:6934 path:hsa05412 Arrhythmogenic right ventricular cardiomyopathy - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CTNNB1 TCF7L2 10080941 23180781 physical association solid phase assay InnateDB
TCF7L2 JUN 16007074 23180781 physical association anti tag coimmunoprecipitation InnateDB
MYC TCF7L2 16007074 23180781 physical association anti tag coimmunoprecipitation InnateDB
TCF7L2 EP300 12446687 23180781 physical association anti tag coimmunoprecipitation InnateDB
TCF7L2 CTNNB1 12446687 23180781 physical association anti tag coimmunoprecipitation InnateDB
EP300 TCF7L2 12446687 23180781 physical association pull down InnateDB
TCF7L2 ELAVL1 19322201 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR TCF7L2 12799378 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 TCF7L2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 TCF7L2 21878914 22951069 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXA1 TCF7L2 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TP73 TCF7L2 21245298 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
FOXP3 TCF7L2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 TCF7L2 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 TCF7L2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA TCF7L2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF TCF7L2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 TCF7L2 18798221 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 TCF7L2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS TCF7L2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 TCF7L2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A TCF7L2 18971253 22951069 trascriptional regulation,stimulation inferred by curator TFlink
MITF TCF7L2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 TCF7L2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 TCF7L2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 TCF7L2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 TCF7L2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 TCF7L2 14990988 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA2 TCF7L2 22951069 trascriptional regulation,stimulation inferred by curator TFlink
HOXB1 TCF7L2 15126340 trascriptional regulation,stimulation inferred by curator TFlink
HOXB13 TCF7L2 15928669 trascriptional regulation,stimulation inferred by curator TFlink
LEF1 TCF7L2 19174556 trascriptional regulation,stimulation inferred by curator TFlink
RUNX3 TCF7L2 24447505 trascriptional regulation,stimulation inferred by curator TFlink
TP63 TCF7L2 22232078 trascriptional regulation,stimulation inferred by curator TFlink
VHL TCF7L2 16407833 trascriptional regulation,stimulation inferred by curator TFlink
ZIC2 TCF7L2 21908606 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000005481D TCF7L2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000521626 TCF7L2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001A4ABF TCF7L2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003AFAD1 TCF7L2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000045DBD TCF7L2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000039607D TCF7L2 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000006372A TCF7L2 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00005ACA7C TCF7L2 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000060B2B TCF7L2 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002E177F TCF7L2 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000367985 TCF7L2 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000AA464 TCF7L2 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000055BBE5 TCF7L2 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000171525 TCF7L2 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000012A1DD TCF7L2 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000049FAE8 TCF7L2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00004977C5 TCF7L2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00005D986D TCF7L2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 TCF7L2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000224AEA TCF7L2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000037D7E5 TCF7L2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00003883FE TCF7L2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA TCF7L2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 TCF7L2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F TCF7L2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 TCF7L2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 TCF7L2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 TCF7L2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 TCF7L2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000251D0B TCF7L2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001C11BC TCF7L2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000031602A TCF7L2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002C0FCB TCF7L2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000315338 TCF7L2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000338542 TCF7L2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002FC5B0 TCF7L2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000040EC3B TCF7L2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004505E4 TCF7L2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000076B539 TCF7L2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000017EA6A TCF7L2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003E226A TCF7L2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003AA845 TCF7L2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000044FD7 TCF7L2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000029D9F1 TCF7L2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000C0D3F TCF7L2 25416803 25961460 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
NLK TCF7L2 22135298 phosphorylation N/A PhosphoSite
TNIK TCF7L2 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
UBE2I TCF7L2 21988832 24234451 25348397 colocalization,physical association two hybrid,physical interaction,confocal microscopy ComPPI,IntAct
CDC73 TCF7L2 25348397 N/A physical interaction ComPPI
DAXX TCF7L2 16569639 19563778 24234451 25348397 27898060 colocalization,physical association anti tag coimmunoprecipitation,two hybrid,physical interaction,fluorescence microscopy,in vivo ComPPI,IntAct,OmniPath
MAD2L2 TCF7L2 25348397 N/A physical interaction ComPPI
CTNNBIP1 TCF7L2 25348397 N/A in vitro,in vivo ComPPI
XIAP TCF7L2 25348397 N/A physical interaction ComPPI
NLK TCF7L2 25348397 N/A physical interaction ComPPI
TLE3 TCF7L2 25348397 N/A physical interaction ComPPI
SMAD7 TCF7L2 25348397 N/A physical interaction ComPPI
AR TCF7L2 25348397 N/A physical interaction ComPPI
EP300 TCF7L2 25348397 N/A physical interaction,in vitro,in vivo ComPPI
CTBP1 TCF7L2 25348397 N/A physical interaction ComPPI
PSMA3 TCF7L2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
JUP TCF7L2 25348397 N/A physical interaction,in vitro ComPPI
TCF7L2 CSNK2A1 25348397 N/A in vitro ComPPI
TCF7L2 CTNNB1 11713475 11713476 16442529 16569639 16724116 17283121 18772112 19202075 19816403 20126258 22014570 22056988 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,x-ray crystallography,physical interaction,in vitro,in vivo ComPPI,IntAct
TCF7L2 PSEN1 11504726 16306047 25348397 27898060 N/A physical interaction,in vitro,in vivo ComPPI,OmniPath
TCF7L2 DAZAP2 25348397 N/A physical interaction ComPPI
TCF7L2 PARP1 17283121 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TCF7L2 XRCC6 17283121 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TCF7L2 XRCC5 17283121 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TCF7L2 ELAVL1 25348397 N/A physical interaction ComPPI
TCF7L2 ZBTB33 25348397 N/A physical interaction ComPPI
TCF7L2 FBLN1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TCF7L2 PML 25348397 N/A physical interaction ComPPI
TCF7L2 MEN1 25348397 N/A physical interaction ComPPI
TCF7L2 USP4 25348397 N/A physical interaction ComPPI
TCF7L2 HBP1 25348397 N/A physical interaction ComPPI
TCF7L2 FUS 25348397 N/A physical interaction ComPPI
TCF7L2 RNF138 25348397 N/A physical interaction ComPPI
TCF7L2 HIC1 16724116 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction,imaging technique ComPPI,IntAct
TCF7L2 KMT5A 25348397 N/A physical interaction ComPPI
TCF7L2 LEF1 25348397 N/A physical interaction ComPPI
TCF7L2 RNF43 25348397 N/A physical interaction ComPPI
TCF7L2 PRMT6 25348397 N/A physical interaction ComPPI
TCF7L2 UHRF2 25348397 N/A physical interaction ComPPI
TCF7L2 HNRNPL 25348397 N/A physical interaction ComPPI
TCF7L2 UBR5 25348397 N/A physical interaction ComPPI
TCF7L2 RUNX3 18772112 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,chromatin immunoprecipitation assay ComPPI,IntAct
TCF7L2 TNIK 19816403 24234451 25348397 association anti bait coimmunoprecipitation,pull down ComPPI,IntAct
TCF7L2 JRK 21399610 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TCF7L2 FOXM1 22014570 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,chromatin immunoprecipitation assay ComPPI,IntAct
TCF7L2 E2F3 22157815 24234451 25348397 association pull down ComPPI,IntAct
CSNK2A2 TCF7L2 25348397 N/A in vitro ComPPI
IKZF5 TCF7L2 25348397 N/A physical interaction ComPPI
TCF7L2 TGIF1 24234451 25873176 association chromatin immunoprecipitation assay IntAct
CTNNB1 TCF7L2 10080941 11713475 11713476 12446687 12861022 15684397 16230076 16306047 16442529 16569639 16630820 16724116 17050667 17053159 17143293 17145710 17283121 17914096 18391971 18772112 19304756 19443654 19503085 19805521 21670201 22014570 22155184 26350900 27898060 stimulant N/A OmniPath
SOX4 TCF7L2 17875931 27898060 stimulant N/A OmniPath
MAPK3 TCF7L2 11711551 27898060 N/A N/A OmniPath
SOX17 TCF7L2 17875931 27898060 inhibition N/A OmniPath
SMAD2 TCF7L2 15292219 27898060 stimulant N/A OmniPath
TCF7L2 EP300 12446687 12861022 27898060 N/A N/A OmniPath
NLK TCF7L2 12556497 12901858 27898060 inhibition N/A OmniPath
JUN TCF7L2 16007074 27898060 stimulant N/A OmniPath
SMAD3 TCF7L2 15292219 27898060 stimulant N/A OmniPath
TNIK TCF7L2 19816403 20530691 27898060 stimulant N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00009C436D TCF7L2 27087310 direct interaction,inhibition N/A NPInter

Visualization










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