Gene Information gene info

  1. Home

GENE：TERT

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TERT
FullNmae telomerase reverse transcriptase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11730
EnsembleID ENSG00000164362
Uniprot O14746

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TERT apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TERT apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
TERT GO:0000049,GO:0000333,GO:0000333,GO:0000333,GO:0000333,GO:0000723,GO:0000781,GO:0000781,GO:0000783,GO:0001172,GO:0001223,GO:0003677,GO:0003720,GO:0003720,GO:0003721,GO:0003721,GO:0003721,GO:0003721,GO:0003723,GO:0003964,GO:0003964,GO:0003968,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0005697,GO:0005697,GO:0005697,GO:0005697,GO:0005730,GO:0005730,GO:0005829,GO:0005886,GO:0006278,GO:0007004,GO:0007004,GO:0007004,GO:0007004,GO:0007005,GO:0010629,GO:0016605,GO:0016607,GO:0022616,GO:0030177,GO:0030422,GO:0031379,GO:0031647,GO:0031647,GO:0032092,GO:0042162,GO:0042635,GO:0042645,GO:0042802,GO:0042803,GO:0042803,GO:0043524,GO:0045766,GO:0046326,GO:0046686,GO:0046872,GO:0051000,GO:0051087,GO:0070034,GO:0070034,GO:0070034,GO:0070200,GO:0071456,GO:0071897,GO:0090399,GO:0098680,GO:0140745,GO:1900087,GO:1902895,GO:1903620,GO:1904707,GO:1904751,GO:1904754,GO:1990572,GO:2000352,GO:2000648,GO:2000773,GO:2000773,GO:2001240

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TERT hsa:7015 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
TERT hsa:7015 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)
TERT hsa:7015 path:hsa05200 Pathways in cancer - Homo sapiens (human)
TERT hsa:7015 path:hsa05225 Hepatocellular carcinoma - Homo sapiens (human)
TERT hsa:7015 path:hsa05226 Gastric cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TERT CIB1 15190070 23180781 physical association two hybrid,pull down InnateDB
ABL1 TERT 10837221 23180781 phosphorylation reaction,physical association anti tag coimmunoprecipitation,protein kinase assay InnateDB
HSP90AA1 TERT 12586360 15843522 23180781 physical association anti tag coimmunoprecipitation InnateDB
MCRS1 TERT 15044100 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
PINX1 TERT 11701125 23180781 physical association anti tag coimmunoprecipitation InnateDB
TERT AKT1 15843522 23180781 physical association anti tag coimmunoprecipitation InnateDB
MTOR TERT 15843522 23180781 physical association anti tag coimmunoprecipitation InnateDB
RPS6KB1 TERT 15843522 23180781 physical association anti tag coimmunoprecipitation InnateDB
TERT TEP1 23180781 9837921 phosphorylation reaction anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ESR1 TERT 10805720 12122114 16690106 18754863 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay TFlink
ESR2 TERT 12122114 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
ETS1 TERT 18971253 20019798 20842112 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
MYC TERT 10022128 10637317 11274400 12695333 12941894 14611815 15595642 15958520 17706770 18093727 18226852 18754863 19912441 21132266 21553143 22207128 24705139 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
NFATC2 TERT 19843528 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SP1 TERT 10637317 12151407 14611815 18093727 18754863 19843528 19912441 21132266 21553143 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SP3 TERT 12151407 17548428 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
USF2 TERT 12044867 12941894 12970752 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
MZF1 TERT 10871406 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
PAX8 TERT 18632625 trascriptional regulation,stimulation electrophoretic mobility shift assay TFlink
CTCF TERT 16326864 17267411 19914212 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay TFlink
CEBPA TERT 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 TERT 18971253 21411498 22207128 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 TERT 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 TERT 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 TERT 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HIF1A TERT 15048086 18754863 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A TERT 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF TERT 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 TERT 18971253 trascriptional regulation,stimulation inferred by curator TFlink
BMI1 TERT 19903340 trascriptional regulation,stimulation inferred by curator TFlink
DNMT1 TERT 19914212 trascriptional regulation,stimulation inferred by curator TFlink
ETS2 TERT 14611815 trascriptional regulation,stimulation inferred by curator TFlink
ETV4 TERT 14678994 trascriptional regulation,stimulation inferred by curator TFlink
EWSR1 TERT 14678994 trascriptional regulation,stimulation inferred by curator TFlink
FLI1 TERT 14611815 14678994 trascriptional regulation,stimulation inferred by curator TFlink
HDAC1 TERT 19587703 trascriptional regulation,stimulation inferred by curator TFlink
HOXA7 TERT 20686504 trascriptional regulation,stimulation inferred by curator TFlink
ID2 TERT 14611815 trascriptional regulation,stimulation inferred by curator TFlink
JUN TERT 20842112 trascriptional regulation,stimulation inferred by curator TFlink
MAX TERT 12941894 trascriptional regulation,stimulation inferred by curator TFlink
MEN1 TERT 18754863 trascriptional regulation,stimulation inferred by curator TFlink
MXD1 TERT 19912441 21411498 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 TERT 18541630 trascriptional regulation,stimulation inferred by curator TFlink
PAX5 TERT 19806612 trascriptional regulation,stimulation inferred by curator TFlink
PITX1 TERT 21300782 trascriptional regulation,stimulation inferred by curator TFlink
RELA TERT 18541630 trascriptional regulation,stimulation inferred by curator TFlink
SIRT1 TERT 24416313 trascriptional regulation,stimulation inferred by curator TFlink
SMAD3 TERT 16785237 20842112 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 TERT 10637317 14611815 18093727 18754863 19843528 19912441 21132266 21553143 trascriptional regulation,stimulation inferred by curator TFlink
STAT3 TERT 20171193 23158658 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 TERT 19587703 trascriptional regulation,stimulation inferred by curator TFlink
TP53 TERT 10778946 18754863 trascriptional regulation,stimulation inferred by curator TFlink
TP73 TERT 16205639 trascriptional regulation,stimulation inferred by curator TFlink
USF1 TERT 12044867 12941894 12970752 trascriptional regulation,stimulation inferred by curator TFlink
WT1 TERT 18754863 20842112 trascriptional regulation,stimulation inferred by curator TFlink
RARB TERT N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00004CCA62 TERT 23055531 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS00004CCA62 TERT 23055531 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00000AA464 TERT 20304954 25416803 mrna cleavage,inhibition array technology TarBase
URS0000237AF9 TERT 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00005FDCD1 TERT 24481448 25416803 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS00000F4AC3 TERT 20371350 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00004B4B85 TERT 25416803 28291810 mrna cleavage,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000134ADC TERT 25416803 26507454 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase
URS00002971AB TERT 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00003CC709 TERT 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000008A99 TERT 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000D5659 TERT 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000A9FB9 TERT 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00004818BD TERT 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000072E4C TERT 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
SRC TERT 22135298 phosphorylation N/A PhosphoSite
AKT1 TERT 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
PTGES3 TERT 25361965 interaction type N/A PTMCode2
TERT PTGES3 25361965 interaction type N/A PTMCode2
TERT NCL 25361965 interaction type N/A PTMCode2
NCL TERT 25361965 interaction type N/A PTMCode2
TERT HSP90AA1 25361965 interaction type N/A PTMCode2
HSP90AA1 TERT 25361965 interaction type N/A PTMCode2
TERT SMG5 25361965 interaction type N/A PTMCode2
SMG5 TERT 25361965 interaction type N/A PTMCode2
TERT DKC1 25361965 interaction type N/A PTMCode2
DKC1 TERT 25361965 interaction type N/A PTMCode2
TERT ABL1 25361965 interaction type N/A PTMCode2
ABL1 TERT 25361965 interaction type N/A PTMCode2
TERT RELA 25361965 interaction type N/A PTMCode2
RELA TERT 25361965 interaction type N/A PTMCode2
MKRN1 TERT 25361965 interaction type N/A PTMCode2
TERT MKRN1 25361965 interaction type N/A PTMCode2
RPS6KB1 TERT 25361965 interaction type N/A PTMCode2
TERT RPS6KB1 25361965 interaction type N/A PTMCode2
YWHAB TERT 25361965 interaction type N/A PTMCode2
TERT YWHAB 25361965 interaction type N/A PTMCode2
SMG6 TERT 25361965 interaction type N/A PTMCode2
TERT SMG6 25361965 interaction type N/A PTMCode2
TERT AKT1 25361965 interaction type N/A PTMCode2
XPO1 TERT 25361965 interaction type N/A PTMCode2
TERT XPO1 25361965 interaction type N/A PTMCode2
PML TERT 25361965 interaction type N/A PTMCode2
TERT PML 25361965 interaction type N/A PTMCode2
TEP1 TERT 25361965 interaction type N/A PTMCode2
TERT TEP1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SMARCE1 TERT 19571879 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DAXX TERT 25348397 N/A physical interaction ComPPI
DYNLL1 TERT 25348397 N/A physical interaction ComPPI
ATP5F1B TERT 25348397 N/A physical interaction ComPPI
COIL TERT 24234451 24550003 25348397 colocalization fluorescence microscopy ComPPI,IntAct
GNL3L TERT 25348397 N/A physical interaction ComPPI
TGFBR2 TERT 25348397 N/A physical interaction ComPPI
PRKCA TERT 25348397 N/A in vitro,in vivo ComPPI
SRC TERT 25348397 N/A in vitro,in vivo ComPPI
CIB1 TERT 25348397 N/A two hybrid,physical interaction,in vitro,in vivo ComPPI
YWHAZ TERT 25348397 N/A physical interaction ComPPI
TUBA1B TERT 25348397 N/A physical interaction ComPPI
HSP90AA1 TERT 25348397 N/A physical interaction,in vivo ComPPI
ENO1 TERT 25348397 N/A physical interaction ComPPI
RUVBL1 TERT 18358808 24234451 25348397 colocalization,association,physical association anti tag coimmunoprecipitation,cosedimentation through density gradient,pull down,physical interaction,fluorescence microscopy,in vivo ComPPI,IntAct
XRCC5 TERT 25348397 N/A physical interaction,in vitro,in vivo ComPPI
SMARCA4 TERT 19571879 24234451 24550003 25348397 colocalization,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction,fluorescence microscopy ComPPI,IntAct
HSPA1A TERT 25348397 N/A physical interaction ComPPI
HSPA1B TERT 25348397 N/A physical interaction ComPPI
PTGES3 TERT 25348397 N/A physical interaction,in vitro,in vivo ComPPI
TEP1 TERT 25348397 N/A physical interaction,in vitro,in vivo ComPPI
XRCC6 TERT 25348397 N/A physical interaction,in vitro,in vivo ComPPI
UBR5 TERT 25348397 N/A physical interaction ComPPI
TERT XPO1 25348397 N/A two hybrid,in vitro,in vivo ComPPI
TERT PINX1 11701125 15381700 24234451 25348397 27898060 physical association anti tag coimmunoprecipitation,physical interaction,in vitro,in vivo ComPPI,IntAct,OmniPath
TERT SMG6 12699629 22011238 24234451 25348397 27898060 physical association anti tag coimmunoprecipitation,physical interaction,in vitro,in vivo ComPPI,IntAct,OmniPath
TERT MCRS1 25348397 N/A physical interaction,in vitro,in vivo ComPPI
TERT SMG5 12699629 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction,in vitro ComPPI,IntAct
TERT MTOR 25348397 N/A physical interaction,in vivo ComPPI
TERT RPS6KB1 25348397 N/A physical interaction,in vivo ComPPI
TERT TPP1 17237767 24234451 25348397 physical association molecular sieving,pull down,physical interaction,in vivo ComPPI,IntAct
TERT RUVBL2 18358808 24234451 25348397 colocalization,association anti tag coimmunoprecipitation,physical interaction,fluorescence microscopy,in vivo ComPPI,IntAct
TERT RELA 12517770 25348397 27898060 N/A physical interaction,in vitro,in vivo ComPPI,OmniPath
TERT AKT1 18775701 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction,in vitro,in vivo ComPPI,IntAct
TERT NCL 15371412 25348397 27898060 N/A physical interaction ComPPI,OmniPath
TERT HSP90AA2P 25348397 N/A physical interaction ComPPI
TERT PML 19567472 24234451 25348397 27898060 colocalization,physical association anti tag coimmunoprecipitation,physical interaction,fluorescence microscopy ComPPI,IntAct,OmniPath
TERT MKRN9P 25348397 N/A physical interaction ComPPI
TERT MKRN1 25348397 N/A physical interaction ComPPI
TERT NAT10 25348397 N/A physical interaction ComPPI
TERT MDM2 25348397 N/A physical interaction ComPPI
TERT TERF1 25348397 N/A physical interaction ComPPI
TERT POT1 25348397 N/A physical interaction ComPPI
TERT STUB1 25348397 N/A physical interaction ComPPI
TERT DYRK2 25348397 N/A physical interaction ComPPI
TERT DDB1 25348397 N/A physical interaction ComPPI
TERT DCAF1 23362280 23612978 25348397 27898060 N/A physical interaction ComPPI,OmniPath
TERT DKC1 18358808 19179534 23474713 24234451 25348397 association,physical association anti tag coimmunoprecipitation,cosedimentation through density gradient,physical interaction ComPPI,IntAct
TERT SLC7A11 25348397 N/A physical interaction ComPPI
TERT UBE2D3 23741361 25348397 27898060 N/A physical interaction ComPPI,OmniPath
TERT U2SURP 25348397 N/A physical interaction ComPPI
TERT IREB2 25348397 N/A physical interaction ComPPI
TERT GLA 25348397 N/A physical interaction ComPPI
TERT SERBP1 25348397 N/A physical interaction ComPPI
TERT PHF20L1 25348397 N/A physical interaction ComPPI
TERT FAAP24 25348397 N/A physical interaction ComPPI
TERT PFDN1 25348397 N/A physical interaction ComPPI
TERT CCT5 25348397 N/A physical interaction ComPPI
TERT EIF2S1 25348397 N/A physical interaction ComPPI
TERT TIMM21 25348397 N/A physical interaction ComPPI
TERT PABPC1 25348397 N/A physical interaction ComPPI
TERT ANXA2P2 25348397 N/A physical interaction ComPPI
TERT ANXA2 25348397 N/A physical interaction ComPPI
TERT DDX51 25348397 N/A physical interaction ComPPI
TERT PBK 25348397 N/A physical interaction ComPPI
TERT STEAP4 25348397 N/A physical interaction ComPPI
TERT ACAA2 25348397 N/A physical interaction ComPPI
TERT PPIA 25348397 N/A physical interaction ComPPI
TERT HSPA4 25348397 N/A physical interaction ComPPI
TERT FOXO3 25348397 N/A physical interaction ComPPI
TERT ACD 23103865 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TERT SMARCA2 19571879 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TERT CTNNB1 19571879 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TERT SMARCC2 19571879 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TERT UPF1 21829167 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
TERT WRAP53 19179534 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
TERT TERF2 24234451 24550003 25348397 colocalization fluorescence microscopy ComPPI,IntAct
TERT GNL3 24234451 24550003 25348397 colocalization,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,fluorescence microscopy ComPPI,IntAct
TERT AGO2 24234451 24550003 25348397 colocalization fluorescence microscopy ComPPI,IntAct
YWHAQ TERT 25348397 N/A two hybrid,physical interaction,in vitro,in vivo ComPPI
TERT TERT 23474713 24234451 physical association transmission electron microscopy,pull down,electron tomography IntAct
SRC TERT 12808100 18829466 24413564 27898060 inhibition N/A OmniPath
LCK TERT 10224060 27898060 N/A N/A OmniPath
MYC TERT 27898060 9988278 inhibition,stimulant N/A OmniPath
AKT1 TERT 10224060 15843522 18775701 22366458 22902867 25999477 27898060 stimulant N/A OmniPath
MEN1 TERT 12837246 27898060 inhibition N/A OmniPath
ABL1 TERT 10837221 20841568 27898060 inhibition N/A OmniPath
SMARCA4 TERT 19571879 24550003 27898060 stimulant N/A OmniPath
PTPN11 TERT 19737086 27898060 stimulant N/A OmniPath
POT1 TERT 17237768 27898060 stimulant N/A OmniPath
ACD TERT 17237768 27898060 stimulant N/A OmniPath

Visualization










  Return