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GENE：TIMM50

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TIMM50
FullNmae translocase of inner mitochondrial membrane 50
LocusType gene with protein product
Status Approved
HGNC_id HGNC:23656
EnsembleID ENSG00000105197
Uniprot Q3ZCQ8

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TIMM50 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TIMM50 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
TIMM50 GO:0001836,GO:0003723,GO:0004721,GO:0004722,GO:0004725,GO:0005134,GO:0005515,GO:0005654,GO:0005739,GO:0005743,GO:0005743,GO:0005744,GO:0005744,GO:0005744,GO:0006470,GO:0006886,GO:0007006,GO:0016607,GO:0030150,GO:0043021

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TIMM50 GFI1 19506020 23180781 physical association two hybrid InnateDB
SUZ12 TIMM50 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB
RNF2 TIMM50 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB
ADRB2 TIMM50 23180781 23798571 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 TIMM50 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 TIMM50 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 TIMM50 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 TIMM50 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS TIMM50 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A TIMM50 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF TIMM50 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000AA464 TIMM50 21512034 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS00003D5391 TIMM50 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00005651EE TIMM50 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000005481D TIMM50 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000153377 TIMM50 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000000B1C9 TIMM50 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000324096 TIMM50 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002A8BC6 TIMM50 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075A760 TIMM50 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002152A8 TIMM50 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000137EDE TIMM50 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000019907A TIMM50 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001C0099 TIMM50 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000EE7F0 TIMM50 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000451A1 TIMM50 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000016FD1A TIMM50 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000435A77 TIMM50 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000021D7C8 TIMM50 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003ACE11 TIMM50 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001F0C23 TIMM50 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000021D08 TIMM50 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000331800 TIMM50 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002B0920 TIMM50 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000003FD55 TIMM50 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00004AC389 TIMM50 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000016D2D4 TIMM50 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000035CC3E TIMM50 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000A057E TIMM50 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002004E0 TIMM50 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075D15B TIMM50 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000028D811 TIMM50 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000572E11 TIMM50 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000209F04 TIMM50 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002E728C TIMM50 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000033EBB8 TIMM50 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000039E1E1 TIMM50 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00003380CC TIMM50 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000315338 TIMM50 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00002C0FCB TIMM50 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001C11BC TIMM50 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000251D0B TIMM50 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000221168 TIMM50 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000031602A TIMM50 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00005CC20C TIMM50 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000475586 TIMM50 25416803 27418678 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
TIMM23 TIMM50 25361965 interaction type N/A PTMCode2
TIMM50 TIMM23 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
CHCHD2 TIMM50 25348397 N/A physical interaction ComPPI
CTDSP2 TIMM50 25348397 N/A physical interaction ComPPI
VAMP2 TIMM50 25348397 N/A physical interaction ComPPI
BMI1 TIMM50 25348397 N/A physical interaction ComPPI
TUBA3E TIMM50 20360068 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
KEAP1 TIMM50 25348397 N/A physical interaction ComPPI
MCM2 TIMM50 25348397 N/A physical interaction ComPPI
MAP1LC3B TIMM50 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
SLC25A6 TIMM50 25348397 N/A physical interaction ComPPI
NDUFAF4 TIMM50 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
ERBB2 TIMM50 24189400 24234451 25348397 association tandem affinity purification ComPPI,IntAct
SLA TIMM50 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
SHC1 TIMM50 25348397 N/A physical interaction ComPPI
ARAF TIMM50 12620389 24234451 25348397 25852190 association,physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
PPP1R15A TIMM50 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
JUN TIMM50 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
CUL3 TIMM50 25348397 N/A physical interaction ComPPI
YWHAZ TIMM50 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TUBG1 TIMM50 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UBC TIMM50 25348397 N/A physical interaction ComPPI
ILK TIMM50 23455922 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
DNM1 TIMM50 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
WASF1 TIMM50 25348397 N/A physical interaction ComPPI
IKBKB TIMM50 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TNFRSF1A TIMM50 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
NFKBIA TIMM50 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
CFTR TIMM50 25348397 N/A physical interaction ComPPI
IRAK1 TIMM50 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NFATC2 TIMM50 25348397 N/A physical interaction ComPPI
RELA TIMM50 25348397 N/A tandem affinity purification ComPPI
TRAF1 TIMM50 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
MTMR11 TIMM50 25348397 N/A physical interaction ComPPI
NFKBIB TIMM50 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
ABI1 TIMM50 25348397 N/A physical interaction ComPPI
CUL1 TIMM50 25348397 N/A physical interaction ComPPI
ADRB2 TIMM50 25348397 N/A physical interaction ComPPI
CBX5 TIMM50 20562864 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SYNCRIP TIMM50 25348397 N/A physical interaction ComPPI
EGFR TIMM50 25348397 N/A physical interaction ComPPI
TUBA1A TIMM50 24234451 25348397 27291054 association pull down ComPPI,IntAct
PHB2 TIMM50 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
RAF1 TIMM50 12620389 14525934 24234451 25348397 25852190 association,physical association anti tag coimmunoprecipitation,two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
RNF2 TIMM50 25348397 N/A physical interaction ComPPI
ABI2 TIMM50 25348397 N/A physical interaction ComPPI
GABARAP TIMM50 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
HDAC6 TIMM50 23752268 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MAP1LC3A TIMM50 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
NOS2 TIMM50 25348397 N/A physical interaction ComPPI
RIPK1 TIMM50 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RIPK3 TIMM50 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TNFRSF1B TIMM50 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
MAP3K14 TIMM50 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
MAGED1 TIMM50 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TAB2 TIMM50 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
CUL7 TIMM50 25348397 N/A physical interaction ComPPI
TIMM23 TIMM50 12437924 12437925 14517234 14525934 14532110 14981507 15044455 15797382 15878866 15992824 16107694 16943180 17959826 18003975 18400944 18426906 19017642 19144822 19506038 20053669 21704637 21969381 22065641 22613836 23260140 23403928 24061477 24234451 25348397 25765297 27898060 physical association anti tag coimmunoprecipitation,experimental interaction detection,in vitro ComPPI,HPRD,IntAct,OmniPath
TIMM17B TIMM50 23263864 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TIMM13 TIMM50 25348397 N/A physical interaction ComPPI
CYFIP1 TIMM50 25348397 N/A physical interaction ComPPI
CYFIP2 TIMM50 25348397 N/A physical interaction ComPPI
NFKB2 TIMM50 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
SMURF1 TIMM50 25348397 N/A physical interaction ComPPI
TRIM25 TIMM50 25348397 N/A physical interaction ComPPI
NCKAP1 TIMM50 25348397 N/A physical interaction ComPPI
BRK1 TIMM50 25348397 N/A physical interaction ComPPI
SRSF5 TIMM50 25348397 N/A physical interaction ComPPI
AMFR TIMM50 25348397 N/A physical interaction ComPPI
BRAF TIMM50 12620389 24234451 25348397 physical association two hybrid ComPPI,IntAct
RPS6KB2 TIMM50 25348397 N/A physical interaction ComPPI
KDM1A TIMM50 25348397 N/A physical interaction ComPPI
PAFAH1B2 TIMM50 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
MAP3K3 TIMM50 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TNFRSF10B TIMM50 25348397 N/A physical interaction ComPPI
ESRRB TIMM50 25348397 N/A physical interaction ComPPI
CBX7 TIMM50 24234451 25348397 27705803 association tandem affinity purification ComPPI,IntAct
TCF3 TIMM50 25348397 N/A physical interaction ComPPI
PPEF1 TIMM50 24234451 25348397 28330616 association pull down ComPPI,IntAct
PAN2 TIMM50 25348397 N/A physical interaction ComPPI
AKTIP TIMM50 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TOMM7 TIMM50 25348397 N/A physical interaction ComPPI
SUZ12 TIMM50 25348397 N/A physical interaction ComPPI
TSC22D1 TIMM50 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TIMM50 RYK 25348397 N/A physical interaction ComPPI
TIMM50 TOMM70 25348397 N/A physical interaction ComPPI
TIMM50 SDHA 25348397 N/A physical interaction ComPPI
TIMM50 SFXN1 24234451 25348397 29568061 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
TIMM50 TOMM40 25348397 N/A physical interaction ComPPI
TIMM50 SDHB 25348397 N/A physical interaction ComPPI
TIMM50 CD55 25348397 N/A physical interaction ComPPI
TIMM50 SFXN3 25348397 N/A physical interaction ComPPI
TIMM50 ACAD9 25348397 N/A physical interaction ComPPI
TIMM50 FBXO6 25348397 N/A physical interaction ComPPI
TIMM50 DNAJA4 24234451 25036637 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TIMM50 TP53 25348397 N/A physical interaction ComPPI
TIMM50 FUS 25348397 N/A physical interaction ComPPI
TIMM50 ERLIN2 21343306 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
TIMM50 OBSL1 25348397 N/A physical interaction ComPPI
TIMM50 CCDC8 25348397 N/A physical interaction ComPPI
TIMM50 TUBA1C 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TIMM50 NDUFA4 25348397 N/A physical interaction ComPPI
TIMM50 NMES1 25348397 N/A physical interaction ComPPI
TIMM50 COQ9 25348397 N/A physical interaction ComPPI
TIMM50 PTPMT1 25348397 N/A physical interaction ComPPI
TIMM50 CISD3 25348397 N/A physical interaction ComPPI
TIMM50 CHCHD10 25348397 N/A physical interaction ComPPI
TIMM50 NDUFAF8 24234451 25348397 27499296 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TIMM50 TRUB2 25348397 N/A physical interaction ComPPI
TIMM50 NME4 25348397 N/A physical interaction ComPPI
TIMM50 OCIAD1 25348397 N/A physical interaction ComPPI
TIMM50 COQ8B 25348397 N/A physical interaction ComPPI
TIMM50 DPF3 25348397 N/A physical interaction ComPPI
TIMM50 ZNF746 25348397 N/A physical interaction ComPPI
TIMM50 ZNF852 25348397 N/A physical interaction ComPPI
TIMM50 ZNF629 25348397 N/A physical interaction ComPPI
TIMM50 ZSCAN20 25348397 N/A physical interaction ComPPI
TIMM50 WASF3 25348397 N/A physical interaction ComPPI
TIMM50 MUC5B 25348397 N/A physical interaction ComPPI
TIMM50 WASF2 25348397 N/A physical interaction ComPPI
TIMM50 GNE 25348397 N/A physical interaction ComPPI
TIMM50 DPP9 25348397 N/A physical interaction ComPPI
TIMM50 BPIFB1 25348397 N/A physical interaction ComPPI
TIMM50 ZNF100 25348397 N/A physical interaction ComPPI
TIMM50 ZNF624 25348397 N/A physical interaction ComPPI
TIMM50 JCHAIN 25348397 N/A physical interaction ComPPI
TIMM50 ZKSCAN8 25348397 N/A physical interaction ComPPI
TIMM50 NFKBIE 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TIMM50 IKBKG 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TIMM50 MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TIMM50 RELB 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TIMM50 GABARAPL1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
TIMM50 TIMM21 23260140 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
TIMM50 COX15 23260140 24234451 25348397 association blue native page ComPPI,IntAct
TIMM50 CBX6 24234451 25348397 27705803 association tandem affinity purification ComPPI,IntAct
TIMM50 L3MBTL1 24234451 25348397 27705803 association tandem affinity purification ComPPI,IntAct
TIMM50 RIPK4 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
TIMM50 TUBB3 24234451 25348397 27291054 association pull down ComPPI,IntAct
TIMM50 KSR1 24234451 25348397 27086506 association anti tag coimmunoprecipitation ComPPI,IntAct
TIMM50 AIFM1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
TIMM50 COX14 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
TIMM50 COX6B1 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
TIMM50 COQ10A 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
TIMM50 MICOS13 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
PELO TIMM50 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct

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