GENE：TIMP3
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | TIMP3 |
| FullNmae | TIMP metallopeptidase inhibitor 3 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:11822 |
| EnsembleID | ENSG00000100234 |
| Uniprot | P35625 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| TIMP3 | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| TIMP3 | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| TIMP3 | GO:0002020,GO:0005515,GO:0005576,GO:0005604,GO:0005615,GO:0005634,GO:0007601,GO:0008191,GO:0008191,GO:0009725,GO:0010951,GO:0031012,GO:0031089,GO:0034097,GO:0046872,GO:0051045,GO:0051045,GO:0062023,GO:0070373,GO:0071310,GO:1903984,GO:1904684 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| TIMP3 | hsa:7078 | path:hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| TIMP3 | hsa:7078 | path:hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | TIMP3 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | TIMP3 | 20019798 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA1 | TIMP3 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | TIMP3 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| YBX1 | TIMP3 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| PRDM14 | TIMP3 | 20953172 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | TIMP3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | TIMP3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | TIMP3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | TIMP3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | TIMP3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | TIMP3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | TIMP3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| DNMT1 | TIMP3 | 22982189 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ELF3 | TIMP3 | 12407165 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SP1 | TIMP3 | 15468069 20056610 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| DAND5 | TIMP3 | 15468069 20056610 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| STAT1 | TIMP3 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| STAT3 | TIMP3 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| STAT5A | TIMP3 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| STAT5B | TIMP3 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | TIMP3 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000009262D | TIMP3 | 18591254 20346171 21820586 \N | rna interference,inhibition | array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | miRSponge |
| URS0000170CF4 | TIMP3 | 19962668 22009755 22681957 | rna interference,inhibition | experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay | miRSponge |
| URS0000153377 | TIMP3 | 19962668 22009755 22681957 | rna interference,inhibition | experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay | miRSponge |
| URS0000170CF4 | TIMP3 | 19962668 22009755 22681957 22743998 24064622 25416803 | mrna cleavage,inhibition | experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay | miRDeathDB,TarBase |
| URS0000153377 | TIMP3 | 19962668 22009755 22681957 22743998 24064622 25416803 | mrna cleavage,inhibition | experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay | miRDeathDB,TarBase |
| URS000009262D | TIMP3 | 18591254 18927107 20346171 21820586 23504349 24574341 25416803 | mrna cleavage,inhibition | array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay | miR2Disease,TarBase |
| URS0000237AF9 | TIMP3 | 18185580 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00000BE495 | TIMP3 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000137EDE | TIMP3 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00000A057E | TIMP3 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000000B1C9 | TIMP3 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00002075FA | TIMP3 | 23990326 25416803 28255358 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| KDR | TIMP3 | 25361965 | interaction type | N/A | PTMCode2 |
| TIMP3 | KDR | 25361965 | interaction type | N/A | PTMCode2 |
| MMP2 | TIMP3 | 25361965 | interaction type | N/A | PTMCode2 |
| TIMP3 | MMP2 | 25361965 | interaction type | N/A | PTMCode2 |
| TIMP3 | MMP3 | 25361965 | interaction type | N/A | PTMCode2 |
| MMP3 | TIMP3 | 25361965 | interaction type | N/A | PTMCode2 |
| TIMP3 | MMP14 | 25361965 | interaction type | N/A | PTMCode2 |
| MMP14 | TIMP3 | 25361965 | interaction type | N/A | PTMCode2 |
| TIMP3 | ADAM17 | 25361965 | interaction type | N/A | PTMCode2 |
| ADAM17 | TIMP3 | 25361965 | interaction type | N/A | PTMCode2 |
| TIMP3 | EFEMP1 | 25361965 | interaction type | N/A | PTMCode2 |
| EFEMP1 | TIMP3 | 25361965 | interaction type | N/A | PTMCode2 |
| TIMP3 | MMP9 | 25361965 | interaction type | N/A | PTMCode2 |
| MMP9 | TIMP3 | 25361965 | interaction type | N/A | PTMCode2 |
| MMP13 | TIMP3 | 25361965 | interaction type | N/A | PTMCode2 |
| TIMP3 | MMP13 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| MMP3 | TIMP3 | 11827795 14525934 25348397 | N/A | experimental interaction detection,physical interaction,protease assay,in vitro,in vivo | ComPPI,HPRD |
| MMP14 | TIMP3 | 14525934 25348397 8663332 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| IFI30 | TIMP3 | 25348397 | N/A | physical interaction | ComPPI |
| KDR | TIMP3 | 12652295 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| JUN | TIMP3 | 24234451 25348397 25609649 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| MMP13 | TIMP3 | 14525934 25348397 9065415 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| TIMP3 | ADAM17 | 12044879 14525934 19666115 25348397 27898060 | N/A | experimental interaction detection,physical interaction,in vitro,tandem affinity purification | ComPPI,HPRD,OmniPath |
| TIMP3 | EFEMP1 | 15123717 25348397 27898060 | N/A | two hybrid,in vitro,in vivo | ComPPI,OmniPath |
| TIMP3 | MMP2 | 10196161 14525934 25348397 7782289 | N/A | experimental interaction detection,physical interaction,protease assay,in vitro | ComPPI,HPRD |
| TIMP3 | MMP9 | 11827795 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| TIMP3 | ADAMTS4 | 25348397 | N/A | protease assay | ComPPI |
| TIMP3 | MMP1 | 25348397 | N/A | protease assay | ComPPI |
| TIMP3 | ADAMTS5 | 19643179 22406378 24234451 25348397 27898060 | protein cleavage | protease assay | ComPPI,IntAct,OmniPath |
| TIMP3 | ADAM15 | 25348397 | N/A | tandem affinity purification | ComPPI |
| TIMP3 | AGTR2 | 18344519 24234451 25348397 | physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,physical interaction | ComPPI,IntAct |
| TIMP3 | COLEC11 | 25348397 | N/A | physical interaction | ComPPI |
| TIMP3 | ASGR2 | 25348397 | N/A | physical interaction | ComPPI |
| TIMP3 | TIMP2 | 25348397 | N/A | physical interaction | ComPPI |
| TIMP3 | COLEC10 | 25348397 | N/A | physical interaction | ComPPI |
| TIMP3 | NELL1 | 25348397 | N/A | physical interaction | ComPPI |
| TIMP3 | CRP | 25348397 | N/A | physical interaction | ComPPI |
| TIMP3 | ADPGK | 25348397 | N/A | physical interaction | ComPPI |
| TIMP3 | KLRG2 | 25348397 | N/A | physical interaction | ComPPI |
| TIMP3 | APP | 25348397 | N/A | physical interaction | ComPPI |
| TIMP3 | CSN1S1 | 25348397 | N/A | physical interaction | ComPPI |
| TIMP3 | VWCE | 25348397 | N/A | physical interaction | ComPPI |
| TIMP3 | DKK3 | 25348397 | N/A | physical interaction | ComPPI |
| TIMP3 | FAM136A | 25348397 | N/A | physical interaction | ComPPI |
| TIMP3 | IGFBP1 | 25348397 | N/A | physical interaction | ComPPI |
| TIMP3 | DEFA1 | 25348397 | N/A | physical interaction | ComPPI |
| TIMP3 | ZUP1 | 25348397 | N/A | physical interaction | ComPPI |
| VIM | TIMP3 | 24234451 30021884 | physical association | cross-linking study | IntAct |
| GNRHR | TIMP3 | 17201186 27898060 | inhibition | N/A | OmniPath |
| TIMP3 | AGTR2 | 18344519 27898060 | N/A | N/A | OmniPath |