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GENE：TMBIM6

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TMBIM6
FullNmae transmembrane BAX inhibitor motif containing 6
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11723
EnsembleID ENSG00000139644
Uniprot P55061

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TMBIM6 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TMBIM6 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TMBIM6 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
TMBIM6 GO:0002638,GO:0005515,GO:0005634,GO:0005737,GO:0005783,GO:0005789,GO:0005886,GO:0006914,GO:0010523,GO:0016020,GO:0016020,GO:0019899,GO:0019899,GO:0031625,GO:0031966,GO:0031966,GO:0032091,GO:0032469,GO:0033119,GO:0033119,GO:0034620,GO:0034620,GO:0036483,GO:0043066,GO:0060698,GO:0060702,GO:0060702,GO:1902065,GO:1902236,GO:1903298,GO:1990441,GO:2001234,GO:2001234

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TMBIM6 hsa:7009 path:hsa05130 Pathogenic Escherichia coli infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
BCL2 TMBIM6 11704864 17446862 22039431 23064052 23377657 23430059 23850759 26192618 8929532 9660918 association N/A ACSN
TMBIM6 TP63 21072181 23180781 physical association anti tag coimmunoprecipitation InnateDB
TMBIM6 CEBPD 21072181 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 TMBIM6 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
PRDM14 TMBIM6 20953172 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 TMBIM6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA TMBIM6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF TMBIM6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 TMBIM6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 TMBIM6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 TMBIM6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 TMBIM6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS TMBIM6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A TMBIM6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 TMBIM6 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000338542 TMBIM6 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS00005651EE TMBIM6 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000021D7C8 TMBIM6 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002075FA TMBIM6 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F TMBIM6 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 TMBIM6 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 TMBIM6 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 TMBIM6 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 TMBIM6 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00001B341F TMBIM6 20371350 22473208 23446348 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS0000330617 TMBIM6 20371350 22473208 23446348 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00002E92A8 TMBIM6 20371350 23446348 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000006FDD4 TMBIM6 22473208 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000B989F TMBIM6 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000BE495 TMBIM6 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000049FAE8 TMBIM6 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00005ACA7C TMBIM6 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00005F9738 TMBIM6 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000585553 TMBIM6 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000195F5B TMBIM6 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000085F64 TMBIM6 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000237AF9 TMBIM6 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00003E5ECC TMBIM6 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00004214BB TMBIM6 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000192A75 TMBIM6 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000075AB0E TMBIM6 20371350 23446348 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000008C563 TMBIM6 20371350 23446348 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000019D79B TMBIM6 20371350 21572407 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000037E170 TMBIM6 20371350 21572407 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000025EABA TMBIM6 20371350 21572407 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000006372A TMBIM6 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000753AD TMBIM6 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000049704B TMBIM6 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000C4DB5 TMBIM6 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000010BD8D TMBIM6 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000009265 TMBIM6 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000058863C TMBIM6 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00003FBC84 TMBIM6 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000065FDF TMBIM6 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002ECEE4 TMBIM6 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000043D2C1 TMBIM6 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00004BC299 TMBIM6 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001EE123 TMBIM6 20371350 21572407 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00004F24A9 TMBIM6 20371350 21572407 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000028DE3F TMBIM6 20371350 23446348 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS0000321A1A TMBIM6 20371350 23446348 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000013ABA3 TMBIM6 20371350 23446348 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS0000202460 TMBIM6 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000821E0 TMBIM6 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000083D87 TMBIM6 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000EBD4B TMBIM6 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000209F04 TMBIM6 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000425000 TMBIM6 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
TRAF6 TMBIM6 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
GLP1R TMBIM6 25348397 N/A physical interaction ComPPI
KEAP1 TMBIM6 25348397 N/A physical interaction ComPPI
BCL2L1 TMBIM6 14525934 25348397 9660918 N/A experimental interaction detection,in vivo ComPPI,HPRD
SLC7A1 TMBIM6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SIT1 TMBIM6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SLAMF6 TMBIM6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TREML1 TMBIM6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CD247 TMBIM6 24234451 24502978 25348397 association pull down ComPPI,IntAct
IER3 TMBIM6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MAPK6 TMBIM6 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
TNFRSF17 TMBIM6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CHRND TMBIM6 25348397 N/A physical interaction ComPPI
CERS2 TMBIM6 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
BCL2 TMBIM6 14525934 25348397 9660918 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
EBP TMBIM6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HTR2C TMBIM6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TMBIM6 BFAR 25348397 N/A physical interaction ComPPI
TMBIM6 VTI1A 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
TMBIM6 HSD11B1 25348397 N/A physical interaction ComPPI
TMBIM6 POMK 25348397 N/A physical interaction ComPPI
TMBIM6 SERINC2 25348397 N/A physical interaction ComPPI
TMBIM6 CLEC5A 25348397 N/A physical interaction ComPPI
TMBIM6 ADAM33 25348397 N/A physical interaction ComPPI
TMBIM6 KIAA2013 25348397 N/A physical interaction ComPPI
TMBIM6 ODF4 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TMBIM6 ASIC4 25348397 N/A physical interaction ComPPI
TMBIM6 SPPL2B 25348397 N/A physical interaction ComPPI
TMBIM6 RNF185 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TMBIM6 C5ORF46 25348397 N/A physical interaction ComPPI
TMBIM6 CLCC1 25348397 N/A physical interaction ComPPI
TMBIM6 TMCO3 25348397 N/A physical interaction ComPPI
TMBIM6 MPPE1 25348397 N/A physical interaction ComPPI
TMBIM6 IL17RC 25348397 N/A physical interaction ComPPI
TMBIM6 TRPM8 25348397 N/A physical interaction ComPPI
TMBIM6 ATG9A 25348397 N/A physical interaction ComPPI
TMBIM6 ST8SIA4 25348397 N/A physical interaction ComPPI
TMBIM6 TMEM63A 25348397 N/A physical interaction ComPPI
TMBIM6 RNF170 25348397 N/A physical interaction ComPPI
TMBIM6 HERPUD2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TMBIM6 MS4A3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TMBIM6 GJA5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TMBIM6 JSRP1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TMBIM6 CREB3L1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TMBIM6 MFSD14B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TMBIM6 FGFBP2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TMBIM6 MMGT1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TMBIM6 PI16 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TMBIM6 STEAP1B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TMBIM6 ADIPOR2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TMBIM6 TMUB1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TMBIM6 GPX8 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TMBIM6 KCNC1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TMBIM6 SCN3B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TMBIM6 SOAT2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TMBIM6 UGT2B11 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TMBIM6 CDC7 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TMBIM6 FAM209A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TMBIM6 KCNA10 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TMBIM6 ERP29 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TMBIM6 GPHB5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TMBIM6 GZMK 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TMBIM6 GPR151 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TMBIM6 DMBX1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TMBIM6 CLDN22 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TMBIM6 LRRC59 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TMBIM6 SLC41A3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MANBAL TMBIM6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TMBIM6 TMBIM6 14525934 9660918 N/A experimental interaction detection HPRD

Source Target Pmid Interactiontype Methods Database
URS00009B700B TMBIM6 27087310 direct interaction,inhibition N/A NPInter

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