GENE：TNFRSF12A
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | TNFRSF12A |
| FullNmae | TNF receptor superfamily member 12A |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:18152 |
| EnsembleID | ENSG00000006327 |
| Uniprot | Q9NP84 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| TNFRSF12A | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| TNFRSF12A | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| TNFRSF12A | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| TNFRSF12A | GO:0001525,GO:0005515,GO:0005886,GO:0005886,GO:0006915,GO:0007155,GO:0030154,GO:0043065,GO:0061041,GO:2001238,GO:2001238 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| TNFRSF12A | hsa:51330 | path:hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CTCF | TNFRSF12A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | TNFRSF12A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | TNFRSF12A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | TNFRSF12A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | TNFRSF12A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MAML1 | TNFRSF12A | 18503747 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NR1I2 | TNFRSF12A | 21072196 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00005651EE | TNFRSF12A | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000006FDD4 | TNFRSF12A | 22473208 25416803 26367773 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay | TarBase |
| URS00004DA9DB | TNFRSF12A | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001DA458 | TNFRSF12A | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| TNFSF12 | TNFRSF12A | 25361965 | interaction type | N/A | PTMCode2 |
| TNFRSF12A | TNFSF12 | 25361965 | interaction type | N/A | PTMCode2 |
| TRAF5 | TNFRSF12A | 25361965 | interaction type | N/A | PTMCode2 |
| TNFRSF12A | TRAF5 | 25361965 | interaction type | N/A | PTMCode2 |
| TNFRSF12A | RAC1 | 25361965 | interaction type | N/A | PTMCode2 |
| RAC1 | TNFRSF12A | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| RAC1 | TNFRSF12A | 14525934 14573547 25348397 27898060 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD,OmniPath |
| KRTAP3-3 | TNFRSF12A | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| TRAF3 | TNFRSF12A | 11728344 14525934 25348397 | N/A | two hybrid,experimental interaction detection,in vitro,two hybrid | ComPPI,HPRD |
| TRAF1 | TNFRSF12A | 11728344 12529173 14525934 25348397 | N/A | two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid | ComPPI,HPRD |
| TRAF2 | TNFRSF12A | 11728344 12529173 14525934 21525013 24234451 25348397 | association,physical association | anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid | ComPPI,HPRD,IntAct |
| TRAF5 | TNFRSF12A | 12529173 14525934 25348397 | N/A | two hybrid,experimental interaction detection,in vitro,two hybrid | ComPPI,HPRD |
| BIRC2 | TNFRSF12A | 21525013 24234451 25348397 | association,physical association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| TNFRSF12A | TNFSF12 | 11728344 12529173 14525934 23438059 24234451 25348397 | N/A | experimental interaction detection,surface plasmon resonance,enzyme linked immunosorbent assay,in vivo,surface plasmon resonance array | ComPPI,HPRD,IntAct |
| TNFRSF12A | SLC30A2 | 24234451 25348397 25416956 | physical association | physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
| TNFSF12 | TNFRSF12A | 11728344 12529173 12787562 23438059 23750247 27898060 | stimulant | N/A | OmniPath |