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GENE：MAP4K1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MAP4K1
FullNmae mitogen-activated protein kinase kinase kinase kinase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6863
EnsembleID ENSG00000104814
Uniprot Q92918

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MAP4K1 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
MAP4K1 GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0006468,GO:0006468,GO:0007254,GO:0008283,GO:0008349,GO:0008349,GO:0016020,GO:0018105,GO:0035556,GO:0043410,GO:0046777,GO:0106310,GO:1904628

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MAP4K1 hsa:11184 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MAP4K1 MAP3K7 10224067 23180781 23331499 stimulation,physical association anti tag coimmunoprecipitation InnateDB,SignaLink
MAP3K1 MAP4K1 23180781 8824585 phosphorylation reaction protein kinase assay InnateDB
PLCG1 MAP4K1 17474147 23180781 physical association anti tag coimmunoprecipitation,peptide array,pull down InnateDB
MAP4K1 MAP4K1 10224067 15743830 26467481 8824585 9891069 interaction type,phosphorylation reaction,up-regulates N/A Signor
MAP4K1 MAP3K11 11053428 18988627 23331499 9003777 stimulation N/A SignaLink,SignaLink
MAP4K1 MAP3K1 23331499 9003777 stimulation N/A SignaLink
MAPK8IP1 MAP4K1 23331499 9868371 stimulation N/A SignaLink
TGFBR1 MAP4K1 10224067 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
BLNK MAP4K1 20005715 interaction type N/A PSP
CRK MAP4K1 20005715 interaction type N/A PSP
DBNL MAP4K1 20005715 interaction type N/A PSP
GRAP2 MAP4K1 20005715 interaction type N/A PSP
GRB2 MAP4K1 11279207 20005715 21071413 9346925 interaction type N/A PSP,SignaLink
LAT MAP4K1 20005715 interaction type N/A PSP,SignaLink
LCP2 MAP4K1 20005715 interaction type N/A PSP
NCK1 MAP4K1 20005715 interaction type N/A PSP
PIK3R1 MAP4K1 20005715 interaction type N/A PSP,SignaLink
SHC1 MAP4K1 20005715 interaction type N/A PSP
CRK MAP4K1 20005715 20005715 21071413 9891069 N/A N/A SignaLink
NCK1 MAP4K1 11279207 18988627 20005715 20005715 21071413 9346925 N/A N/A SignaLink
LCP2 MAP4K1 20005715 20005715 N/A N/A SignaLink
SHC1 MAP4K1 20005715 20005715 N/A N/A SignaLink
BLNK MAP4K1 11514608 18988627 20005715 20005715 N/A N/A SignaLink
DBNL MAP4K1 10567356 18988627 20005715 20005715 N/A N/A SignaLink
GRAP2 MAP4K1 11313918 15100220 18988627 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 MAP4K1 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 MAP4K1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CTCF MAP4K1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 MAP4K1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
MAP4K1 MAP3K11 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
MAP4K1 CARD11 22135298 phosphorylation N/A PhosphoSite
MAP4K1 MAP4K1 22135298 phosphorylation N/A PhosphoSite
MAP4K1 LCP2 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
PRKD1 MAP4K1 22135298 phosphorylation N/A PhosphoSite
NCK1 MAP4K1 25361965 interaction type N/A PTMCode2
MAP4K1 NCK1 25361965 interaction type N/A PTMCode2
GRAP2 MAP4K1 25361965 interaction type N/A PTMCode2
MAP4K1 GRAP2 25361965 interaction type N/A PTMCode2
MAP4K1 SHC1 25361965 interaction type N/A PTMCode2
SHC1 MAP4K1 25361965 interaction type N/A PTMCode2
MAP4K1 DBNL 25361965 interaction type N/A PTMCode2
DBNL MAP4K1 25361965 interaction type N/A PTMCode2
LCP2 MAP4K1 25361965 interaction type N/A PTMCode2
ABL1 MAP4K1 25361965 interaction type N/A PTMCode2
MAP4K1 ABL1 25361965 interaction type N/A PTMCode2
GRB2 MAP4K1 25361965 interaction type N/A PTMCode2
MAP4K1 GRB2 25361965 interaction type N/A PTMCode2
CRK MAP4K1 25361965 interaction type N/A PTMCode2
MAP4K1 CRK 25361965 interaction type N/A PTMCode2
CRKL MAP4K1 25361965 interaction type N/A PTMCode2
MAP4K1 CRKL 25361965 interaction type N/A PTMCode2
MAP3K11 MAP4K1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
LCP2 MAP4K1 11487585 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SPRY1 MAP4K1 25348397 N/A physical interaction ComPPI
LAT MAP4K1 11279207 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SKP1 MAP4K1 25348397 N/A physical interaction ComPPI
HSP90AB1 MAP4K1 22939624 24234451 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
CRK MAP4K1 11432831 14525934 17474147 24234451 25348397 9788432 9891069 physical association experimental interaction detection,peptide array,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
SYK MAP4K1 11514608 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
BLNK MAP4K1 11514608 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PPP4C MAP4K1 25348397 N/A physical interaction ComPPI
LYN MAP4K1 11514608 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PIK3R1 MAP4K1 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
SRC MAP4K1 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
CRKL MAP4K1 11279207 14525934 24234451 25348397 9788432 9891069 physical association coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
GRAP2 MAP4K1 11313918 14525934 15100220 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
HCLS1 MAP4K1 10233887 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SLAMF1 MAP4K1 20231852 24234451 25348397 27898060 association,physical association anti bait coimmunoprecipitation,pull down ComPPI,IntAct,OmniPath
FBXW7 MAP4K1 25348397 N/A physical interaction ComPPI
SHC1 MAP4K1 14525934 25348397 9346925 N/A experimental interaction detection,in vitro ComPPI,HPRD
NCK1 MAP4K1 11279207 14525934 17474147 24234451 25348397 9346925 physical association two hybrid,experimental interaction detection,peptide array,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
CASP3 MAP4K1 10602493 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
MAP4K1 GRB2 14525934 17474147 24234451 25348397 9346925 9788432 9891069 physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,peptide array,pull down,surface plasmon resonance,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
MAP4K1 MAP3K11 11053428 14525934 24234451 25348397 9346925 physical association two hybrid,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
MAP4K1 MAP3K7 10224067 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MAP4K1 DBNL 10567356 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
MAP4K1 DAPP1 14525934 14563325 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
MAP4K1 EGFR 14525934 24234451 24658140 25348397 9346925 physical association experimental interaction detection,ubiquitin reconstruction,physical interaction,in vivo ComPPI,HPRD,IntAct
MAP4K1 COPS5 25348397 N/A physical interaction ComPPI
MAP4K1 LRRK1 25348397 N/A physical interaction ComPPI
MAP4K1 HSP90AA1 25348397 N/A physical interaction ComPPI
MAP4K1 HSP90AA2P 25348397 N/A physical interaction ComPPI
MAP4K1 TMEM101 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MAP4K1 RBX1 25348397 N/A physical interaction ComPPI
MAP4K1 CUL7 25348397 N/A physical interaction ComPPI
MAP4K1 FBXW8 25348397 N/A physical interaction ComPPI
MAP4K1 H2AC4 25348397 N/A physical interaction ComPPI
MAP4K1 HSD17B10 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
MAP4K1 PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
MAP4K1 SDHA 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
MAP4K1 SOD1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
MAP4K1 CARD11 19706536 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
MAP4K1 PLCG1 17474147 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,fluorescence technology,peptide array,pull down ComPPI,IntAct
MAP4K1 ABL1 11278340 14525934 17474147 24234451 25348397 9346925 physical association two hybrid,experimental interaction detection,peptide array ComPPI,HPRD,IntAct
MAP4K1 FYN 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
MAP4K1 MAP4K1 10233887 14525934 17192257 N/A experimental interaction detection HPRD
H2BC21 MAP4K1 24234451 30021884 physical association cross-linking study IntAct
PLCG1 MAP4K1 17474147 27898060 N/A N/A OmniPath
PRKD1 MAP4K1 15743830 24362026 27898060 N/A N/A OmniPath
MAP3K7 MAP4K1 10224067 27898060 N/A N/A OmniPath
MAP4K1 MAP3K7 10224067 27898060 stimulant N/A OmniPath
MAP4K1 MAP3K1 27898060 8824585 stimulant N/A OmniPath
BRAF MAP4K1 1748651 27898060 3043188 7731720 8073291 8385802 stimulant N/A OmniPath
GRB2 MAP4K1 11279207 17474147 27898060 9346925 9788432 9891069 stimulant N/A OmniPath
ABL1 MAP4K1 11278340 17474147 27898060 9346925 stimulant N/A OmniPath
CRK MAP4K1 11279207 11432831 17474147 27898060 9788432 9891069 stimulant N/A OmniPath
RAF1 MAP4K1 27898060 7624324 stimulant N/A OmniPath
CRKL MAP4K1 11279207 27898060 9788432 9891069 stimulant N/A OmniPath
MAP4K1 MAPK1 1381507 27898060 8226933 stimulant N/A OmniPath
MAPK8IP1 MAP4K1 27898060 9868371 stimulant N/A OmniPath
MAP4K1 PAK1 11134074 27898060 N/A N/A OmniPath
MAP4K1 CARD11 19706536 27898060 N/A N/A OmniPath
MET MAP4K1 11487585 15743830 27898060 N/A N/A OmniPath
MAP4K1 MAPK8 27898060 9891069 stimulant N/A OmniPath
TGFBR1 MAP4K1 10224067 27898060 stimulant N/A OmniPath
MAP4K1 LCP2 11487585 15714472 17353368 22902619 27898060 stimulant N/A OmniPath
MAP4K1 H3-3A 10464286 27898060 N/A N/A OmniPath
LAMTOR3 MAP4K1 27898060 9733512 stimulant N/A OmniPath
SYK MAP4K1 11514608 27898060 stimulant N/A OmniPath
PPP4C MAP4K1 15364934 24362026 27898060 stimulant N/A OmniPath
MAP4K1 MAP3K11 11053428 11969422 12458207 27898060 9003777 9346925 stimulant N/A OmniPath

Visualization










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