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GENE：TP53BP2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TP53BP2
FullNmae tumor protein p53 binding protein 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:12000
EnsembleID ENSG00000143514
Uniprot Q13625

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TP53BP2 mpt 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TP53BP2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TP53BP2 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TP53BP2 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
TP53BP2 GO:0002039,GO:0002039,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005737,GO:0005737,GO:0005829,GO:0007049,GO:0007165,GO:0017124,GO:0030054,GO:0042802,GO:0045786,GO:0048471,GO:0051059,GO:0072332,GO:1900119

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TP53BP2 hsa:7159 path:hsa04390 Hippo signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR TP53BP2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F1 TP53BP2 15592436 15706352 18971253 19610065 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
ESR1 TP53BP2 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ETS1 TP53BP2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 TP53BP2 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 TP53BP2 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 TP53BP2 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 TP53BP2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 TP53BP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF TP53BP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 TP53BP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 TP53BP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS TP53BP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RB1 TP53BP2 19610065 trascriptional regulation,stimulation inferred by curator TFlink
TP53 TP53BP2 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000009262D TP53BP2 18829576 rna interference,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS000009262D TP53BP2 18829576 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000FC8EB TP53BP2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000070B1D TP53BP2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000153377 TP53BP2 22815788 25416803 mrna cleavage,inhibition array technology,quantitative reverse transcription pcr TarBase
URS00000EED18 TP53BP2 25416803 28097098 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
MAPK1 TP53BP2 22135298 phosphorylation N/A PhosphoSite
TP53BP2 TP73 25361965 interaction type N/A PTMCode2
TP73 TP53BP2 25361965 interaction type N/A PTMCode2
TP53BP2 RELA 25361965 interaction type N/A PTMCode2
RELA TP53BP2 25361965 interaction type N/A PTMCode2
TP63 TP53BP2 25361965 interaction type N/A PTMCode2
TP53BP2 TP63 25361965 interaction type N/A PTMCode2
TP53 TP53BP2 25361965 interaction type N/A PTMCode2
TP53BP2 TP53 25361965 interaction type N/A PTMCode2
BCL2 TP53BP2 25361965 interaction type N/A PTMCode2
TP53BP2 BCL2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
TXLNA TP53BP2 25348397 N/A two hybrid,physical interaction ComPPI
TBC1D22B TP53BP2 25348397 N/A two hybrid,physical interaction ComPPI
LMO4 TP53BP2 25348397 N/A two hybrid,physical interaction ComPPI
TCL1A TP53BP2 25348397 N/A two hybrid,physical interaction ComPPI
YES1 TP53BP2 11278422 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
NDC80 TP53BP2 25348397 N/A two hybrid,physical interaction ComPPI
SGF29 TP53BP2 25348397 N/A physical interaction ComPPI
UBASH3A TP53BP2 25348397 N/A two hybrid,physical interaction ComPPI
POLR2L TP53BP2 25348397 N/A two hybrid,physical interaction ComPPI
PPP1CC TP53BP2 14525934 18448430 21988832 21998301 24234451 24366813 25348397 28330616 8549741 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,peptide array,pull down,physical interaction,in vitro,in vivo,proximity-dependent biotin identification,two hybrid ComPPI,HPRD,IntAct
ANXA1 TP53BP2 24234451 24366813 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ATPAF2 TP53BP2 25348397 N/A two hybrid,physical interaction ComPPI
NUTF2 TP53BP2 24234451 24855949 25348397 association pull down ComPPI,IntAct
AMOT TP53BP2 24234451 24255178 25348397 colocalization physical interaction,proximity-dependent biotin identification ComPPI,IntAct
YWHAG TP53BP2 14525934 15324660 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PPP1R2B TP53BP2 25348397 N/A physical interaction ComPPI
PPP1CB TP53BP2 24234451 24366813 25348397 28330616 association anti tag coimmunoprecipitation,two hybrid,pull down,physical interaction,proximity-dependent biotin identification ComPPI,IntAct
RAN TP53BP2 24234451 24855949 25348397 association,physical association far western blotting,pull down,surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
BCL2L2 TP53BP2 18448430 18719108 24234451 25348397 N/A peptide array,surface plasmon resonance,physical interaction,surface plasmon resonance array ComPPI,IntAct
TP53BP2 ZNF26 25348397 N/A two hybrid,physical interaction ComPPI
TP53BP2 H2BC4 25348397 N/A two hybrid,physical interaction ComPPI
TP53BP2 DCUN1D1 25348397 N/A two hybrid,physical interaction ComPPI
TP53BP2 SUMO2 14525934 16620772 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
TP53BP2 SUMO3 14525934 16620772 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
TP53BP2 WWP1 14525934 25348397 9169421 N/A experimental interaction detection,in vitro ComPPI,HPRD
TP53BP2 WWP2 14525934 25348397 9169421 N/A experimental interaction detection,in vitro ComPPI,HPRD
TP53BP2 MAGI1 14525934 25348397 9169421 N/A experimental interaction detection,in vitro ComPPI,HPRD
TP53BP2 YAP1 11278422 14525934 24234451 24255178 24366813 25348397 25751139 colocalization,association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,two hybrid fragment pooling approach,in vitro,in vivo,tandem affinity purification,proximity-dependent biotin identification ComPPI,HPRD,IntAct
TP53BP2 NAE1 12694406 14525934 25348397 8626687 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
TP53BP2 EEF1A1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
TP53BP2 PTN 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
TP53BP2 UNC119 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
TP53BP2 UTP14A 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
TP53BP2 KIF5A 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
TP53BP2 ATXN7 16713569 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TP53BP2 USP4 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
TP53BP2 MRPL20 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
TP53BP2 BCL2 14525934 18719108 24234451 25348397 8668206 N/A affinity chromatography technology,two hybrid,coimmunoprecipitation,experimental interaction detection,fluorescence technology,peptide array,surface plasmon resonance,physical interaction,biochemical,enzyme linked immunosorbent assay,in vitro,proximity ligation assay,surface plasmon resonance array,two hybrid ComPPI,HPRD,IntAct
TP53BP2 PPP1CA 14525934 15231748 21998301 22321011 24234451 24366813 25348397 28330616 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,pull down,physical interaction,proximity-dependent biotin identification,two hybrid ComPPI,HPRD,IntAct
TP53BP2 RELA 10498867 14525934 18448430 24234451 25348397 N/A two hybrid,experimental interaction detection,fluorescence technology,peptide array,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
TP53BP2 EEF1A1P5 25348397 N/A physical interaction ComPPI
TP53BP2 TP53 14525934 14985081 18275817 21513714 24234451 25348397 8016121 8668206 8875926 association,physical association affinity chromatography technology,anti bait coimmunoprecipitation,two hybrid,coimmunoprecipitation,experimental interaction detection,pull down,x-ray crystallography,physical interaction,biochemical,solid phase assay ComPPI,HPRD,IntAct
TP53BP2 BECN1 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TP53BP2 MAPK8IP2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TP53BP2 CSNK2B 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TP53BP2 PLK1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TP53BP2 PPHLN1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TP53BP2 WWTR1 25348397 N/A physical interaction ComPPI
TP53BP2 YWHAE 25348397 N/A physical interaction ComPPI
TP53BP2 SIAH2 25348397 N/A physical interaction ComPPI
TP53BP2 SIAH1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TP53BP2 AMOTL2 24234451 24255178 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TP53BP2 LATS2 25348397 N/A physical interaction ComPPI
TP53BP2 YWHAB 24234451 24255178 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TP53BP2 PRKAB2 25348397 N/A physical interaction ComPPI
TP53BP2 GRB2 25348397 N/A physical interaction ComPPI
TP53BP2 H2BC11 25348397 N/A physical interaction ComPPI
TP53BP2 TRAF4 25348397 N/A physical interaction ComPPI
TP53BP2 TANK 25348397 N/A physical interaction ComPPI
TP53BP2 BAIAP2 25348397 N/A physical interaction ComPPI
TP53BP2 NXF1 25348397 N/A physical interaction ComPPI
TP53BP2 HNRNPUL1 25348397 N/A physical interaction ComPPI
TP53BP2 PRPF31 25348397 N/A physical interaction ComPPI
TP53BP2 MTMR14 25348397 N/A physical interaction ComPPI
TP53BP2 OTUB2 25348397 N/A physical interaction ComPPI
TP53BP2 CCDC92 25348397 N/A physical interaction ComPPI
TP53BP2 PLEKHN1 25348397 N/A physical interaction ComPPI
TP53BP2 ZGPAT 25348397 N/A physical interaction ComPPI
TP53BP2 SSX2IP 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
TP53BP2 CWF19L2 25348397 N/A physical interaction ComPPI
TP53BP2 NUTM1 25348397 N/A physical interaction ComPPI
TP53BP2 EP300 21513714 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TP53BP2 FRMD6 25348397 N/A physical interaction ComPPI
TP53BP2 SRGAP3 25348397 N/A physical interaction ComPPI
TP53BP2 HOMER1 25348397 N/A physical interaction ComPPI
TP53BP2 RASSF8 24234451 24366813 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TP53BP2 RASSF7 24234451 24366813 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TP53BP2 CCDC85B 24234451 24366813 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TP53BP2 CCDC85C 24234451 24366813 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TP53BP2 CPVL 24234451 24366813 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TP53BP2 HSPH1 24234451 24366813 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TP53BP2 HSPA4 24234451 24366813 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TP53BP2 PPP1R2 24234451 24366813 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TP53BP2 PARD3 24234451 24366813 25344754 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TP53BP2 RASSF9 24234451 24366813 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TP53BP2 PPP1R3A 25348397 N/A physical interaction ComPPI
TP53BP2 RASSF10 24234451 24366813 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TP53BP2 ITCH 24234451 25348397 25436413 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TP53BP2 STAM2 25348397 N/A physical interaction ComPPI
TP53BP2 MED4 25348397 N/A physical interaction ComPPI
TP53BP2 OFD1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
TP53BP2 PCM1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
TP53BP2 CEP97 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
TP53BP2 CEP104 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
TP53BP2 CEP162 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
TP53BP2 CEP120 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
TP53BP2 CEP152 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
TP53BP2 CNTROB 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
TP53BP2 CEP128 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
TP53BP2 CEP135 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
TP53BP2 CEP44 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
TP53BP2 CEP89 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
TP53BP2 CNTRL 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
TP53BP2 FBF1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
TP53BP2 NINL 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
TP53BP2 NIN 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
TP53BP2 ODF2 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
TP53BP2 RPGRIP1L 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
TP53BP2 SCLT1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
TP53BP2 DYNLT1 25348397 N/A physical interaction ComPPI
TP53BP2 RPGRIP1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
TP53BP2 CENPJ 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
TP53BP2 YWHAH 17979178 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
TP53BP2 YWHAZ 15161933 24234451 25348397 26496610 association,physical association anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
TP53BP2 PARD6A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TP53BP2 PARD6B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TP53BP2 CDH1 24234451 25344754 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TP53BP2 PRPF19 25348397 N/A physical interaction ComPPI
TP53BP2 P4HA3 25348397 N/A physical interaction ComPPI
TP53BP2 APC2 10646860 24234451 25348397 27898060 colocalization,physical association two hybrid,pull down,physical interaction,confocal microscopy ComPPI,IntAct,OmniPath
TP53BP2 PPP1R7 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
TP53BP2 CTNNB1 24234451 25344754 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TP53BP2 TP63 18275817 24234451 25348397 N/A physical interaction,solid phase assay ComPPI,IntAct
TP53BP2 TP73 18275817 24234451 25348397 N/A physical interaction,solid phase assay ComPPI,IntAct
TP53BP2 APP 11278849 14525934 24234451 25348397 physical association two hybrid,experimental interaction detection,pull down,enzyme linked immunosorbent assay,two hybrid ComPPI,HPRD,IntAct
TP53BP2 CRK 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
TP53BP2 IRS4 25348397 N/A pull down ComPPI
TP53BP2 NUP153 24234451 24855949 25348397 association pull down ComPPI,IntAct
TP53BP2 TCTE1 24234451 25348397 26638075 association proximity-dependent biotin identification ComPPI,IntAct
BCL2L1 TP53BP2 21900206 24234451 25348397 physical association two hybrid,peptide array,physical interaction,surface plasmon resonance array ComPPI,IntAct
YWHAQ TP53BP2 25348397 N/A physical interaction ComPPI
TP53BP2 TP53BP2 18448430 24234451 N/A fluorescence technology,peptide array,pull down IntAct
H1-2 TP53BP2 24234451 30021884 physical association cross-linking study IntAct
PLEC TP53BP2 24234451 30021884 physical association cross-linking study IntAct
TP53BP2 TP53 11839776 14985081 16139958 18275817 21513714 27898060 8016121 8668206 8875926 stimulant N/A OmniPath
MAPK1 TP53BP2 24312625 27898060 N/A N/A OmniPath
TP53BP2 PPP1R14A 27898060 8549741 inhibition N/A OmniPath

Visualization










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