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GENE：TRAP1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TRAP1
FullNmae TNF receptor associated protein 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:16264
EnsembleID ENSG00000126602
Uniprot Q12931

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TRAP1 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TRAP1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TRAP1 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
TRAP1 GO:0003723,GO:0005164,GO:0005515,GO:0005524,GO:0005654,GO:0005739,GO:0005743,GO:0005743,GO:0005758,GO:0005759,GO:0006457,GO:0009386,GO:0016020,GO:0016887,GO:0019901,GO:0019901,GO:0051082,GO:0061077,GO:0071944,GO:0140662,GO:1901856,GO:1903427,GO:1903751

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TRAP1 hsa:10131 path:hsa05012 Parkinson disease - Homo sapiens (human)
TRAP1 hsa:10131 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TRAP1 TLR1 16482509 23180781 physical association two hybrid InnateDB
TRAP1 TLR6 16482509 23180781 physical association two hybrid InnateDB
TRAP1 GZMM 17513296 23180781 protein cleavage protease assay InnateDB
ADRB2 TRAP1 23180781 23798571 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 TRAP1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 TRAP1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 TRAP1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 TRAP1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 TRAP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF TRAP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 TRAP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 TRAP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A TRAP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF TRAP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 TRAP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 TRAP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MYB TRAP1 N/A trascriptional regulation,stimulation inferred by curator TFlink
MYC TRAP1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000079D48 TRAP1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000CF1D2 TRAP1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00004E008F TRAP1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003D5391 TRAP1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000AA464 TRAP1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000F0F49 TRAP1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000005481D TRAP1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001597DC TRAP1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000148B91 TRAP1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000021D7C8 TRAP1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001C770D TRAP1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000153377 TRAP1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000F4AC3 TRAP1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000C85B2 TRAP1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002075FA TRAP1 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
MAPK3 TRAP1 22135298 phosphorylation N/A PhosphoSite
MAPK1 TRAP1 22135298 phosphorylation N/A PhosphoSite
TRAP1 SMAD4 25361965 interaction type N/A PTMCode2
SMAD4 TRAP1 25361965 interaction type N/A PTMCode2
TRAP1 EXT2 25361965 interaction type N/A PTMCode2
EXT2 TRAP1 25361965 interaction type N/A PTMCode2
TRAP1 TGFBR2 25361965 interaction type N/A PTMCode2
TGFBR2 TRAP1 25361965 interaction type N/A PTMCode2
TRAP1 EXT1 25361965 interaction type N/A PTMCode2
EXT1 TRAP1 25361965 interaction type N/A PTMCode2
SF3A2 TRAP1 25361965 interaction type N/A PTMCode2
TRAP1 SF3A2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SF3A3 TRAP1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
SNRPB2 TRAP1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
SNW1 TRAP1 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CUL5 TRAP1 25348397 N/A physical interaction ComPPI
CDC5L TRAP1 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CBSL TRAP1 25348397 N/A physical interaction ComPPI
VAMP2 TRAP1 25348397 N/A physical interaction ComPPI
CFL1 TRAP1 25348397 N/A physical interaction ComPPI
FASTKD3 TRAP1 20869947 24234451 25348397 association tandem affinity purification ComPPI,IntAct
GABARAPL2 TRAP1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
SMAD4 TRAP1 11278302 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
RAD21 TRAP1 25348397 N/A physical interaction ComPPI
MAP1LC3B TRAP1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PRKACB TRAP1 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
TGFBR2 TRAP1 11278302 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
SF3A2 TRAP1 25348397 N/A physical interaction ComPPI
CRKL TRAP1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SND1 TRAP1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
PPP1R15A TRAP1 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
JUN TRAP1 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
RB1 TRAP1 14525934 25348397 27898060 8756626 9312071 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
USP7 TRAP1 25348397 N/A physical interaction ComPPI
EIF5B TRAP1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CUL3 TRAP1 25348397 N/A physical interaction ComPPI
PDIA3 TRAP1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
DUT TRAP1 25348397 N/A physical interaction ComPPI
GAPDH TRAP1 24113185 25348397 26344197 27898060 N/A physical interaction ComPPI,OmniPath
YWHAZ TRAP1 15161933 24234451 25348397 physical association pull down ComPPI,IntAct
HGS TRAP1 25348397 N/A physical interaction ComPPI
UBC TRAP1 25348397 N/A physical interaction ComPPI
DLD TRAP1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
UBE2N TRAP1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
NTRK1 TRAP1 25348397 N/A physical interaction ComPPI
IDH2 TRAP1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
HSPA5 TRAP1 25348397 N/A physical interaction ComPPI
MYC TRAP1 21150319 24234451 25348397 association tandem affinity purification ComPPI,IntAct
TNFRSF1A TRAP1 14525934 25348397 7876093 N/A two hybrid,experimental interaction detection,physical interaction,comigration in non denaturing gel electrophoresis,in vitro,two hybrid ComPPI,HPRD
GLRX TRAP1 25348397 N/A physical interaction ComPPI
EEF1A1 TRAP1 25348397 N/A physical interaction ComPPI
C1QBP TRAP1 25348397 N/A physical interaction ComPPI
IQGAP1 TRAP1 25348397 N/A physical interaction ComPPI
MKNK2 TRAP1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PA2G4 TRAP1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
VDAC1 TRAP1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
TPM3 TRAP1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PKM TRAP1 25348397 N/A physical interaction ComPPI
PDHA1 TRAP1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
TRAP1 TLR1 14525934 16482509 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
TRAP1 TLR6 14525934 16482509 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
TRAP1 EXT1 10545594 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
TRAP1 EXT2 25348397 N/A two hybrid,physical interaction,in vitro ComPPI
TRAP1 H2AX 20000738 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TRAP1 RYK 25348397 N/A physical interaction ComPPI
TRAP1 HDAC5 25348397 N/A physical interaction ComPPI
TRAP1 PSMC4 21979464 25348397 27898060 N/A physical interaction ComPPI,OmniPath
TRAP1 APP 25348397 N/A physical interaction ComPPI
TRAP1 WDHD1 25348397 N/A physical interaction ComPPI
TRAP1 VDAC2 25348397 N/A physical interaction ComPPI
TRAP1 TRAF3IP1 20391533 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TRAP1 FN1 19738201 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
TRAP1 ESX1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
TRAP1 FBXO6 25348397 N/A physical interaction ComPPI
TRAP1 EIF4A1 25348397 N/A physical interaction ComPPI
TRAP1 EEF1G 25348397 N/A physical interaction ComPPI
TRAP1 EEF1A1P5 25348397 N/A physical interaction ComPPI
TRAP1 RPS19 25348397 N/A physical interaction ComPPI
TRAP1 RPL7A 25348397 N/A physical interaction ComPPI
TRAP1 EIF2AK4 25348397 N/A physical interaction ComPPI
TRAP1 FKBP5 25348397 N/A physical interaction ComPPI
TRAP1 MAGED2 25348397 N/A physical interaction ComPPI
TRAP1 OGFR 25348397 N/A physical interaction ComPPI
TRAP1 CDK4 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
TRAP1 CDK9 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
TRAP1 CDK5 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
TRAP1 CEP250 25348397 N/A physical interaction ComPPI
TRAP1 CEP72 25348397 N/A physical interaction ComPPI
TRAP1 LGALS3BP 25348397 N/A physical interaction ComPPI
TRAP1 NXF1 25348397 N/A physical interaction ComPPI
TRAP1 CUL7 25348397 N/A physical interaction ComPPI
TRAP1 OBSL1 25348397 N/A physical interaction ComPPI
TRAP1 CCDC8 25348397 N/A physical interaction ComPPI
TRAP1 DND1 25348397 N/A physical interaction ComPPI
TRAP1 ALDOA 25348397 N/A physical interaction ComPPI
TRAP1 COQ3 25348397 N/A physical interaction ComPPI
TRAP1 COX6B1 25348397 N/A physical interaction ComPPI
TRAP1 LTA4H 25348397 N/A physical interaction ComPPI
TRAP1 PRDX5 25348397 N/A physical interaction ComPPI
TRAP1 AK2 25348397 N/A physical interaction ComPPI
TRAP1 ASNS 25348397 N/A physical interaction ComPPI
TRAP1 HSDL2 25348397 N/A physical interaction ComPPI
TRAP1 PCMT1 25348397 N/A physical interaction ComPPI
TRAP1 RPE 25348397 N/A physical interaction ComPPI
TRAP1 SOD1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
TRAP1 UFM1 25348397 N/A physical interaction ComPPI
TRAP1 KIF2A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TRAP1 PAX6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TRAP1 FAN1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TRAP1 DNAJC11 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TRAP1 GAN 25348397 N/A physical interaction ComPPI
TRAP1 ANXA5 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TRAP1 GPI 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TRAP1 MRPL12 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TRAP1 SLC25A10 25348397 N/A physical interaction ComPPI
TRAP1 CRNN 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TRAP1 ZNF207 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TRAP1 CPNE3 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TRAP1 CS 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TRAP1 PYGL 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TRAP1 DNAJC8 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TRAP1 PLS3 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TRAP1 CPSF6 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TRAP1 NANS 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TRAP1 SF3A1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TRAP1 ECHS1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TRAP1 SRP68 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TRAP1 MYL12B 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TRAP1 AIMP1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TRAP1 CBS 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TRAP1 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
TRAP1 DLST 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
TRAP1 HSD17B10 24234451 25348397 29128334 association,physical association cross-linking study,physical interaction,blue native page ComPPI,IntAct
TRAP1 PARK7 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
TRAP1 SOAT1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
TRAP1 EDEM3 25348397 N/A physical interaction ComPPI
TRAP1 MCPH1 25348397 N/A physical interaction ComPPI
TRAP1 TES 25348397 N/A physical interaction ComPPI
TRAP1 CDK1 25348397 N/A physical interaction ComPPI
TRAP1 MAD2L1 25348397 N/A physical interaction ComPPI
TRAP1 CCNB1 25348397 N/A physical interaction ComPPI
TRAP1 PINK1 25348397 N/A anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,protein kinase assay ComPPI
TRAP1 BIRC5 25348397 N/A anti bait coimmunoprecipitation,physical interaction ComPPI
TRAP1 CLPP 25348397 N/A anti bait coimmunoprecipitation,physical interaction ComPPI
TRAP1 HLA-B 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TRAP1 PEX14 19197237 24234451 25348397 colocalization fluorescence microscopy ComPPI,IntAct
TRAP1 MAP1LC3A 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
TRAP1 GABARAPL1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
TRAP1 GABARAP 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
TRAP1 VCAM1 22623428 24234451 25348397 association cross-linking study ComPPI,IntAct
TRAP1 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
TRAP1 OTUB1 24234451 25348397 26752685 association anti tag coimmunoprecipitation ComPPI,IntAct
TRAP1 NFKB1 24234451 25348397 25609649 association tandem affinity purification ComPPI,IntAct
TRAP1 SIRT4 24234451 25348397 25525879 association anti tag coimmunoprecipitation ComPPI,IntAct
TRAP1 PHOSPHO1 24234451 25348397 28330616 association pull down ComPPI,IntAct
TRAP1 RRP1B 20926688 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
TRAP1 COQ2 24234451 25348397 29128334 association cross-linking study ComPPI,IntAct
ALDOC TRAP1 25348397 N/A physical interaction ComPPI
HSCB TRAP1 24234451 25348397 28380382 association anti tag coimmunoprecipitation ComPPI,IntAct
TGFBR1 TRAP1 11278302 14525934 9545258 N/A experimental interaction detection,two hybrid HPRD
METTL14 TRAP1 24234451 29507755 association anti tag coimmunoprecipitation IntAct
PTGER4 TRAP1 24234451 28298427 physical association ubiquitin reconstruction IntAct
MAPT TRAP1 24234451 26402096 association anti bait coimmunoprecipitation IntAct
TRAP1 SYTL4 24234451 30021884 physical association cross-linking study IntAct
HSPA9 TRAP1 24234451 30021884 physical association cross-linking study IntAct
ACTB TRAP1 24234451 30021884 physical association cross-linking study IntAct
GZMM TRAP1 17513296 27898060 N/A N/A OmniPath
PINK1 TRAP1 17579517 27898060 stimulant N/A OmniPath
TLR6 TRAP1 16482509 27898060 N/A N/A OmniPath
TLR1 TRAP1 16482509 27898060 N/A N/A OmniPath

Visualization










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