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GENE：TRIB3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TRIB3
FullNmae tribbles pseudokinase 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:16228
EnsembleID ENSG00000101255
Uniprot Q96RU7

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TRIB3 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TRIB3 ferroptosis 40169394 TRIB3 positively modulated ferroptosis proteins and the MEK/ERK signaling pathway, increasing the ferroptosis resistance of CRC cells. retulator signature
TRIB3 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TRIB3 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TRIB3 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
TRIB3 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TRIB3 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
TRIB3 GO:0000122,GO:0003714,GO:0004860,GO:0005515,GO:0005524,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005829,GO:0005886,GO:0006469,GO:0010506,GO:0010827,GO:0019901,GO:0019901,GO:0031434,GO:0031625,GO:0032092,GO:0032436,GO:0032869,GO:0034976,GO:0043405,GO:0043405,GO:0045599,GO:0045717,GO:0045892,GO:0051443,GO:0055106,GO:0070059,GO:0070059

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TRIB3 hsa:57761 path:hsa04931 Insulin resistance - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TRIB3 BMPR2 17576816 23180781 physical association anti tag coimmunoprecipitation InnateDB
ATF4 TRIB3 18408768 23180781 25416956 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
TRIB3 DDIT3 15775988 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 TRIB3 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 TRIB3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA TRIB3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF TRIB3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 TRIB3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 TRIB3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS TRIB3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A TRIB3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ATF4 TRIB3 15775988 20592469 21220698 trascriptional regulation,stimulation inferred by curator TFlink
DDIT3 TRIB3 15775988 18940792 trascriptional regulation,stimulation inferred by curator TFlink
RELA TRIB3 12736262 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 TRIB3 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 TRIB3 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00000F31F4 TRIB3 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B59A2 TRIB3 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS000003ABC4 TRIB3 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS0000001EB3 TRIB3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000075ABF4 TRIB3 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000041FA2C TRIB3 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000BF7F9 TRIB3 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00005DEC41 TRIB3 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000016FF9C TRIB3 24375867 25416803 mrna cleavage,inhibition experimental interaction detection,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00001FC26E TRIB3 20371350 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000077AED TRIB3 20371350 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000006BE7D TRIB3 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001FA076 TRIB3 20371350 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000C36BD TRIB3 20371350 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000381CEC TRIB3 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00002F74F1 TRIB3 20371350 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
KLHL38 TRIB3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TEKT4 TRIB3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SNRPC TRIB3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
EXOSC5 TRIB3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
LENG1 TRIB3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FAM90A1 TRIB3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CBX8 TRIB3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TCF19 TRIB3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
OIP5 TRIB3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HOXB5 TRIB3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BAG3 TRIB3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
EFEMP2 TRIB3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ATF4 TRIB3 12743605 14525934 24234451 25348397 25416956 25910212 physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,two hybrid array,in vitro,in vivo,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
BFSP2 TRIB3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRIB3 DDIT3 14525934 15775988 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
TRIB3 KAT5 14525934 16169070 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,in vitro,two hybrid ComPPI,HPRD,IntAct
TRIB3 GDF9 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
TRIB3 GIT1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
TRIB3 SETDB1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
TRIB3 EEF1G 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
TRIB3 RBM48 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
TRIB3 COPS6 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
TRIB3 RELA 12736262 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
TRIB3 AKT1 12791994 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
TRIB3 AKT2 25348397 N/A in vitro,in vivo ComPPI
TRIB3 ATF5 12743605 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TRIB3 CSNK2B 25348397 N/A physical interaction ComPPI
TRIB3 FN1 25348397 N/A physical interaction ComPPI
TRIB3 GRN 25348397 N/A physical interaction ComPPI
TRIB3 HLA-B 25348397 N/A physical interaction ComPPI
TRIB3 LTBP4 25348397 N/A physical interaction ComPPI
TRIB3 MCM3AP 25348397 N/A physical interaction ComPPI
TRIB3 SIAH1 25348397 N/A physical interaction ComPPI
TRIB3 RIDA 25348397 N/A physical interaction ComPPI
TRIB3 PSMA3 25348397 N/A physical interaction ComPPI
TRIB3 RBM4 25348397 N/A physical interaction ComPPI
TRIB3 RPSA 25348397 N/A physical interaction ComPPI
TRIB3 TIAF1 25348397 N/A physical interaction ComPPI
TRIB3 BCL6 16147992 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRIB3 COP1 25348397 N/A physical interaction ComPPI
TRIB3 SMAD3 25348397 N/A physical interaction ComPPI
TRIB3 BMPR2 25348397 N/A physical interaction ComPPI
TRIB3 SMURF1 25348397 N/A physical interaction ComPPI
TRIB3 CDC25A 25348397 N/A physical interaction ComPPI
TRIB3 APP 25348397 N/A physical interaction ComPPI
TRIB3 PRMT5 23455924 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
TRIB3 RPGRIP1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
TRIB3 STK40 25348397 N/A physical interaction ComPPI
TRIB3 GATD1 25348397 N/A physical interaction ComPPI
TRIB3 SQSTM1 25348397 N/A physical interaction ComPPI
TRIB3 MAP2K1 15299019 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
TRIB3 MAP2K7 15299019 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
TRIB3 UTP23 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRIB3 SPG21 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRIB3 SCNM1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRIB3 DTX2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRIB3 INO80B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRIB3 MISP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRIB3 PARD6B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRIB3 TEKT3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRIB3 SAXO1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRIB3 ZNF417 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRIB3 PADI4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRIB3 UBTD2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRIB3 C22ORF39 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRIB3 PRKAB2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRIB3 KANK2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRIB3 SAMD11 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRIB3 KRT26 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRIB3 INCA1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRIB3 CTAG1A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRIB3 ZNF587 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRIB3 PPP1R26 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRIB3 IRX6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRIB3 DPPA3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRIB3 SUOX 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRIB3 PKNOX2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRIB3 AKAP8L 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRIB3 MDFI 24234451 25348397 25910212 physical association two hybrid array,two hybrid bait and prey pooling approach,validated two hybrid ComPPI,IntAct
HAT1 TRIB3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CHAF1A TRIB3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HNRNPF TRIB3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
APOBEC3C TRIB3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ELAVL1 TRIB3 18408768 27898060 stimulant N/A OmniPath
TRIB3 AKT1 12791994 27898060 inhibition N/A OmniPath
TRIB3 DDIT3 15775988 17872950 27898060 N/A N/A OmniPath
ATF4 TRIB3 12743605 18276110 25416956 27898060 N/A N/A OmniPath
TRIB3 ATF4 12743605 18276110 25416956 27898060 N/A N/A OmniPath

Visualization










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