GENE：TYROBP
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | TYROBP |
| FullNmae | transmembrane immune signaling adaptor TYROBP |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:12449 |
| EnsembleID | ENSG00000011600 |
| Uniprot | O43914 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| TYROBP | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| TYROBP | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| TYROBP | GO:0002222,GO:0002223,GO:0002274,GO:0002282,GO:0002282,GO:0002283,GO:0005102,GO:0005102,GO:0005102,GO:0005102,GO:0005515,GO:0005886,GO:0005886,GO:0005886,GO:0006968,GO:0007165,GO:0009986,GO:0009986,GO:0010628,GO:0016020,GO:0030036,GO:0030316,GO:0030667,GO:0030889,GO:0030889,GO:0030900,GO:0032480,GO:0032693,GO:0032731,GO:0032755,GO:0032760,GO:0032816,GO:0032911,GO:0032911,GO:0032930,GO:0034241,GO:0034241,GO:0035556,GO:0042802,GO:0042803,GO:0043277,GO:0046872,GO:0048678,GO:0050821,GO:0050821,GO:0060090,GO:1900272,GO:1902685,GO:1904151,GO:1904151,GO:2000010,GO:2001206 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| TYROBP | hsa:7305 | path:hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
| TYROBP | hsa:7305 | path:hsa04650 | Natural killer cell mediated cytotoxicity - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| TYROBP | TREM1 | 10799849 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| TYROBP | TREM2 | 11602640 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| TYROBP | CD300LB | 16920917 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| KLRC2 | TYROBP | 15845448 20890284 23180781 | physical association | anti tag coimmunoprecipitation,nuclear magnetic resonance | InnateDB |
| TYROBP | TYROBP | 20890284 23180781 | physical association | nuclear magnetic resonance,comigration in sds page | InnateDB |
| TYROBP | KLRC2 | 15845448 20890284 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| TYROBP | SIGLEC5 | 17012248 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| TYROBP | KIR2DL3 | 15845448 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| TYROBP | KLRD1 | 15845448 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| SMARCA4 | TYROBP | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | TYROBP | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | TYROBP | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | TYROBP | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | TYROBP | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| HCST | TYROBP | 25361965 | interaction type | N/A | PTMCode2 |
| TYROBP | HCST | 25361965 | interaction type | N/A | PTMCode2 |
| KLRK1 | TYROBP | 25361965 | interaction type | N/A | PTMCode2 |
| TYROBP | KLRK1 | 25361965 | interaction type | N/A | PTMCode2 |
| TYROBP | ZAP70 | 25361965 | interaction type | N/A | PTMCode2 |
| ZAP70 | TYROBP | 25361965 | interaction type | N/A | PTMCode2 |
| TYROBP | SIRPB1 | 25361965 | interaction type | N/A | PTMCode2 |
| SIRPB1 | TYROBP | 25361965 | interaction type | N/A | PTMCode2 |
| TYROBP | SYK | 25361965 | interaction type | N/A | PTMCode2 |
| SYK | TYROBP | 25361965 | interaction type | N/A | PTMCode2 |
| TYROBP | SIGLEC5 | 25361965 | interaction type | N/A | PTMCode2 |
| SIGLEC5 | TYROBP | 25361965 | interaction type | N/A | PTMCode2 |
| TREM1 | TYROBP | 25361965 | interaction type | N/A | PTMCode2 |
| TYROBP | TREM1 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| SYK | TYROBP | 10940905 14525934 24234451 25348397 9490415 | physical association | experimental interaction detection,pull down,physical interaction,in vitro,in vivo | ComPPI,HPRD,IntAct |
| ZAP70 | TYROBP | 14525934 25348397 9490415 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| TYROBP | KLRC3 | 10201920 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| TYROBP | SIRPB1 | 10604985 10940905 14525934 24234451 25348397 27898060 | physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD,IntAct,OmniPath |
| TYROBP | NCR2 | 10049942 14525934 14707061 24234451 25348397 | physical association | anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD,IntAct |
| TYROBP | KIR2DS2 | 11169398 14525934 25348397 27898060 9490415 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD,OmniPath |
| TYROBP | TREM1 | 10799849 11602640 14525934 24234451 25348397 27898060 | physical association | anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD,IntAct,OmniPath |
| TYROBP | TREM2 | 11602640 12080485 14525934 24234451 25348397 27898060 | physical association | anti bait coimmunoprecipitation,experimental interaction detection,in vivo | ComPPI,HPRD,IntAct,OmniPath |
| TYROBP | KLRC4 | 12426564 12426565 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| TYROBP | CD300E | 15557162 25348397 27898060 | N/A | in vitro | ComPPI,OmniPath |
| TYROBP | KLRK1 | 12426564 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| TYROBP | CLEC5A | 10449773 14525934 25348397 27898060 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD,OmniPath |
| TYROBP | SIGLEC14 | 14525934 17012248 24234451 25348397 | physical association | anti tag coimmunoprecipitation,experimental interaction detection,in vivo | ComPPI,HPRD,IntAct |
| TYROBP | KIR2DL3 | 25348397 | N/A | physical interaction | ComPPI |
| TYROBP | KIR2DS3 | 20890284 24234451 25348397 | physical association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| TYROBP | KLRC2 | 20890284 24234451 25348397 | physical association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| TYROBP | SLC35B4 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| TYROBP | TMEM86A | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| TYROBP | KIR2DS5 | 18624290 24234451 25348397 | physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,fluorescence-activated cell sorting | ComPPI,IntAct |
| TYROBP | TYROBP | 20890284 24234451 | N/A | nuclear magnetic resonance,comigration in non denaturing gel electrophoresis | IntAct |
| TYROBP | KIR3DS1 | 17202323 17301953 27898060 | N/A | N/A | OmniPath |
| SYK | TYROBP | 10940905 27898060 9490415 | N/A | N/A | OmniPath |
| SEMA6D | TYROBP | 16715077 27898060 | N/A | N/A | OmniPath |