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GENE：UBE4B

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol UBE4B
FullNmae ubiquitination factor E4B
LocusType gene with protein product
Status Approved
HGNC_id HGNC:12500
EnsembleID ENSG00000130939
Uniprot O95155

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
UBE4B apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
UBE4B apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
UBE4B GO:0000151,GO:0000209,GO:0005634,GO:0005737,GO:0005737,GO:0006511,GO:0008626,GO:0009411,GO:0016567,GO:0019899,GO:0030433,GO:0034450,GO:0043161

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
UBE4B hsa:10277 path:hsa04120 Ubiquitin mediated proteolysis - Homo sapiens (human)
UBE4B hsa:10277 path:hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
GZMB UBE4B 11802788 23180781 protein cleavage protease assay InnateDB
EGR1 UBE4B 19032775 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR UBE4B 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 UBE4B 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ETS1 UBE4B 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 UBE4B 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 UBE4B 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 UBE4B 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 UBE4B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA UBE4B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF UBE4B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 UBE4B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 UBE4B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 UBE4B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS UBE4B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A UBE4B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF UBE4B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 UBE4B 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 UBE4B 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00000BE495 UBE4B 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003AA845 UBE4B 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000004BACE UBE4B 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002394F5 UBE4B 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000065FDF UBE4B 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000308E4D UBE4B 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000209F04 UBE4B 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000020579D UBE4B 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000075B0F6 UBE4B 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001E96DA UBE4B 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000006BE7D UBE4B 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000021D7C8 UBE4B 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000024B619 UBE4B 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001F9A0F UBE4B 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000EEE35 UBE4B 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000039A052 UBE4B 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000049FAE8 UBE4B 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
UBE4B ATXN3 25361965 interaction type N/A PTMCode2
ATXN3 UBE4B 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
VPS4B UBE4B 25348397 N/A physical interaction ComPPI
ZNRD2 UBE4B 25348397 N/A physical interaction ComPPI
VCP UBE4B 10811609 12504083 14749733 15189447 18022694 19175675 20414249 21282470 22174917 25348397 26389662 27898060 N/A pull down,physical interaction ComPPI,OmniPath
NUDCD3 UBE4B 25348397 N/A physical interaction ComPPI
UBE2D1 UBE4B 25348397 N/A physical interaction ComPPI
SF3B4 UBE4B 25348397 N/A physical interaction ComPPI
UBL7 UBE4B 25348397 N/A physical interaction ComPPI
CBL UBE4B 25348397 N/A physical interaction ComPPI
VAV2 UBE4B 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CASP3 UBE4B 25348397 N/A in vitro ComPPI
CPNE1 UBE4B 25348397 N/A physical interaction ComPPI
UBE2D2 UBE4B 25348397 N/A isothermal titration calorimetry,nuclear magnetic resonance,physical interaction,physical interaction ComPPI
UBE2L3 UBE4B 25348397 N/A physical interaction ComPPI
FEZ1 UBE4B 25348397 N/A physical interaction ComPPI
CDKN2A UBE4B 17955473 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
HGS UBE4B 25348397 N/A physical interaction ComPPI
NTRK1 UBE4B 25348397 N/A physical interaction ComPPI
BTRC UBE4B 25348397 N/A physical interaction ComPPI
CASP6 UBE4B 25348397 N/A in vitro ComPPI
CASP7 UBE4B 25348397 N/A in vitro ComPPI
TRIP6 UBE4B 25348397 N/A physical interaction ComPPI
HDLBP UBE4B 25348397 N/A physical interaction ComPPI
HNRNPL UBE4B 25348397 N/A physical interaction ComPPI
TP73 UBE4B 25348397 N/A physical interaction ComPPI
UBA6 UBE4B 25348397 N/A physical interaction ComPPI
DNAJC7 UBE4B 25348397 N/A two hybrid ComPPI
RAD23A UBE4B 25348397 N/A physical interaction ComPPI
ZRANB2 UBE4B 25348397 N/A physical interaction ComPPI
MDM2 UBE4B 25348397 N/A physical interaction ComPPI
EGFR UBE4B 24189400 24234451 25348397 association tandem affinity purification ComPPI,IntAct
XPC UBE4B 25348397 N/A physical interaction ComPPI
TP63 UBE4B 25348397 N/A physical interaction ComPPI
ATXN3 UBE4B 25348397 N/A physical interaction,competition binding ComPPI
RAD23B UBE4B 15121879 15652483 16401726 16427015 19898607 20427284 21807993 25348397 27898060 N/A physical interaction ComPPI,OmniPath
IGBP1 UBE4B 25348397 N/A physical interaction ComPPI
STAM UBE4B 25348397 N/A physical interaction ComPPI
UBE2D3 UBE4B 11435423 15466860 20017557 20696396 23509263 23550736 25348397 27898060 N/A isothermal titration calorimetry,nuclear magnetic resonance,x-ray crystallography,physical interaction ComPPI,OmniPath
TRIM25 UBE4B 25348397 N/A physical interaction ComPPI
UBE4B TP53 25348397 N/A physical interaction ComPPI
UBE4B UBXN1 18775313 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UBE4B ELAVL1 25348397 N/A physical interaction ComPPI
UBE4B USP34 25348397 N/A physical interaction ComPPI
UBE4B NDUFA2 25348397 N/A physical interaction ComPPI
UBE4B VPS26A 25348397 N/A physical interaction ComPPI
UBE4B SRPRB 25348397 N/A physical interaction ComPPI
UBE4B ZPR1 25348397 N/A physical interaction ComPPI
UBE4B ATP6V1F 25348397 N/A physical interaction ComPPI
UBE4B VPS36 25348397 N/A physical interaction ComPPI
UBE4B AHCYL1 25348397 N/A physical interaction ComPPI
UBE4B UBQLN1 25348397 N/A physical interaction ComPPI
UBE4B TTC9C 25348397 N/A physical interaction ComPPI
UBE4B UBE2C 25348397 N/A physical interaction ComPPI
UBE4B USP9X 25348397 N/A physical interaction ComPPI
UBE4B UBXN7 25348397 N/A physical interaction ComPPI
UBE4B ZFYVE19 25348397 N/A physical interaction ComPPI
UBE4B UBE2V1 25348397 N/A physical interaction ComPPI
UBE4B UFM1 25348397 N/A physical interaction ComPPI
UBE4B SULT1A1 25348397 N/A physical interaction ComPPI
UBE4B SBDS 25348397 N/A physical interaction ComPPI
UBE4B UCHL3 25348397 N/A physical interaction ComPPI
UBE4B THY1 25348397 N/A physical interaction ComPPI
UBE4B NDUFA7 25348397 N/A physical interaction ComPPI
UBE4B PPIF 25348397 N/A physical interaction ComPPI
UBE4B SCO2 25348397 N/A physical interaction ComPPI
UBE4B VPS29 25348397 N/A physical interaction ComPPI
UBE4B TTK 25348397 N/A physical interaction ComPPI
UBE4B CDC27 25348397 N/A physical interaction ComPPI
UBE4B CDKN2A 25348397 N/A physical interaction ComPPI
UBE4B NUSAP1 25348397 N/A physical interaction ComPPI
UBE4B PDE3A 25348397 N/A physical interaction ComPPI
UBE4B RBM12 25348397 N/A physical interaction ComPPI
UBE4B TRIP12 25348397 N/A physical interaction ComPPI
UBE4B FBXW11 25348397 N/A physical interaction ComPPI
UBE4B AP5Z1 25348397 N/A physical interaction ComPPI
UBE4B FOXK1 25348397 N/A physical interaction ComPPI
UBE4B STUB1 25348397 N/A physical interaction ComPPI
UBE4B PCID2 25348397 N/A physical interaction ComPPI
UBE4B TTC4 25348397 N/A physical interaction ComPPI
UBE4B ESR1 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE4B CDC25A 25348397 N/A physical interaction ComPPI
VPS35 UBE4B 25348397 N/A physical interaction ComPPI
PSMB1 UBE4B 25348397 N/A physical interaction ComPPI
SARNP UBE4B 25348397 N/A physical interaction ComPPI
MRPL53 UBE4B 25348397 N/A physical interaction ComPPI
UBE4B ARRB1 26276098 27898060 N/A N/A OmniPath
UBE4B NPLOC4 16427015 21211725 27898060 N/A N/A OmniPath

Visualization










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